Abstract 2644: AP32788, a potent, selective inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, in preclinical models
Gonzalvez, Francois, Zhu, Xiaotian, Huang, Wei-Sheng, Baker, Theresa E., Ning, Yaoyu, Wardwell, Scott D., Nadworny, Sara, Zhang, Sen, Das, Biplab, Gong, Yongjin, Greenfield, Matthew T., Jang, Hyun G., Kohlmann, Anna, Li, Feng, Taslimi, Paul M., Tugnait, Meera, Xu, Yongjin, Ye, Emily Y., Youngsaye, Willmen W., Zech, Stephan G., Zhang, Yun, Zhou, Tianjun, Narasimhan, Narayana I., Dalgarno, David C., Shakespeare, William C., Rivera, Victor M.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Mobocertinib (TAK-788): A Targeted Inhibitor of EGFR Exon 20 Insertion Mutants in Non-Small Cell Lung Cancer
Gonzalvez, Francois, Vincent, Sylvie, Baker, Theresa E, Gould, Alexandra E, Li, Shuai, Wardwell, Scott D, Nadworny, Sara, Ning, Yaoyu, Zhang, Sen, Huang, Wei-Sheng, Hu, Yongbo, Li, Feng, Greenfield, Matthew T, Zech, Stephan G, Das, Biplab, Narasimhan, Narayana I, Clackson, Tim, Dalgarno, David, Shakespeare, William C, Fitzgerald, Michael, Chouitar, Johara, Griffin, Robert J, Liu, Shengwu, Wong, Kwok-Kin, Zhu, Xiaotian, Rivera, Victor M
Published in Cancer discovery (01.07.2021)
Published in Cancer discovery (01.07.2021)
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High-relaxivity magnetic resonance imaging contrast agents. Part 2. Optimization of inner- and second-sphere relaxivity
Jacques, Vincent, Dumas, Stéphane, Sun, Wei-Chuan, Troughton, Jeffrey S, Greenfield, Matthew T, Caravan, Peter
Published in Investigative radiology (01.10.2010)
Published in Investigative radiology (01.10.2010)
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Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non–small cell lung cancer
Huang, Wei-Sheng, Li, Feng, Gong, Yongjin, Zhang, Yun, Youngsaye, Willmen, Xu, Yongjin, Zhu, Xiaotian, Greenfield, Matthew T., Kohlmann, Anna, Taslimi, Paul M., Toms, Angela, Zech, Stephan G., Zhou, Tianjun, Das, Biplab, Jang, Hyun G., Tugnait, Meera, Ye, Yihua E., Gonzalvez, Francois, Baker, Theresa E., Nadworny, Sara, Ning, Yaoyu, Wardwell, Scott D., Zhang, Sen, Gould, Alexandra E., Hu, Yongbo, Lane, Weston, Skene, Robert J., Zou, Hua, Clackson, Tim, Narasimhan, Narayana I., Rivera, Victor M., Dalgarno, David C., Shakespeare, William C.
Published in Bioorganic & medicinal chemistry letters (15.01.2023)
Published in Bioorganic & medicinal chemistry letters (15.01.2023)
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Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery
Zech, Stephan G, Kohlmann, Anna, Zhou, Tianjun, Li, Feng, Squillace, Rachel M, Parillon, Lois E, Greenfield, Matthew T, Miller, David P, Qi, Jiwei, Thomas, R. Mathew, Wang, Yihan, Xu, Yongjin, Miret, Juan J, Shakespeare, William C, Zhu, Xiaotian, Dalgarno, David C
Published in Journal of medicinal chemistry (28.01.2016)
Published in Journal of medicinal chemistry (28.01.2016)
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The Interaction of MS-325 with Human Serum Albumin and Its Effect on Proton Relaxation Rates
Caravan, Peter, Cloutier, Normand J, Greenfield, Matthew T, McDermid, Sarah A, Dunham, Stephen U, Bulte, Jeff W. M, Amedio, John C, Looby, Richard J, Supkowski, Ronald M, Horrocks, William DeW, McMurry, Thomas J, Lauffer, Randall B
Published in Journal of the American Chemical Society (27.03.2002)
Published in Journal of the American Chemical Society (27.03.2002)
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Molecular Magnetic Resonance Imaging of Myocardial Perfusion With EP-3600, a Collagen-Specific Contrast Agent : Initial Feasibility Study in a Swine Model
SPUENTRUP, Elmar, RUHL, Karl M, CARAVAN, Peter, BOTNAR, Rene M, WIETHOFF, Andrea J, BUHL, Alexandra, JACQUES, Vincent, GREENFIELD, Matthew T, KROMBACH, Gabriele A, GÜNTHER, Rolf W, VANGEL, Mark G
Published in Circulation (New York, N.Y.) (07.04.2009)
Published in Circulation (New York, N.Y.) (07.04.2009)
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Synthesis and Evaluation of a High Relaxivity Manganese(II)-Based MRI Contrast Agent
Troughton, Jeffrey S, Greenfield, Matthew T, Greenwood, Jaclyn M, Dumas, Stéphane, Wiethoff, Andrea J, Wang, Jufeng, Spiller, Marga, McMurry, Thomas J, Caravan, Peter
Published in Inorganic chemistry (04.10.2004)
Published in Inorganic chemistry (04.10.2004)
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Fragment Growing and Linking Lead to Novel Nanomolar Lactate Dehydrogenase Inhibitors
Kohlmann, Anna, Zech, Stephan G, Li, Feng, Zhou, Tianjun, Squillace, Rachel M, Commodore, Lois, Greenfield, Matthew T, Lu, Xiaohui, Miller, David P, Huang, Wei-Sheng, Qi, Jiwei, Thomas, R. Mathew, Wang, Yihan, Zhang, Sen, Dodd, Rory, Liu, Shuangying, Xu, Rongsong, Xu, Yongjin, Miret, Juan J, Rivera, Victor, Clackson, Tim, Shakespeare, William C, Zhu, Xiaotian, Dalgarno, David C
Published in Journal of medicinal chemistry (14.02.2013)
Published in Journal of medicinal chemistry (14.02.2013)
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Effect of Peptide-Chelate Architecture on Metabolic Stability of Peptide-based MRI Contrast Agents
Zhang, Zhaoda, Kolodziej, Andrew F, Qi, Jianfeng, Nair, Shrikumar A, Wang, Xifang, Case, April W, Greenfield, Matthew T, Graham, Philip B, McMurry, Thomas J, Caravan, Peter
Published in New journal of chemistry (12.02.2010)
Published in New journal of chemistry (12.02.2010)
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Enzyme-Activated Gd3+ Magnetic Resonance Imaging Contrast Agents with a Prominent Receptor-Induced Magnetization Enhancement
Nivorozhkin, Alexander L., Kolodziej, Andrew F., Caravan, Peter, Greenfield, Matthew T., Lauffer, Randall B., McMurry, Thomas J.
Published in Angewandte Chemie (International ed.) (03.08.2001)
Published in Angewandte Chemie (International ed.) (03.08.2001)
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The effect of the amide substituent on the biodistribution and tolerance of lanthanide(III) DOTA-tetraamide derivatives
Woods, Mark, Caravan, Peter, Geraldes, Carlos F G C, Greenfield, Matthew T, Kiefer, Garry E, Lin, Mai, McMillan, Kenneth, Prata, M Isabel M, Santos, Ana C, Sun, Xiankai, Wang, Jufeng, Zhang, Shanrong, Zhao, Piyu, Sherry, A Dean
Published in Investigative radiology (01.12.2008)
Published in Investigative radiology (01.12.2008)
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When are Two Waters Worse Than One? Doubling the Hydration Number of a Gd-DTPA Derivative Decreases Relaxivity
Caravan, Peter, Amedio Jr, John C., Dunham, Stephen U., Greenfield, Matthew T., Cloutier, Normand J., McDermid, Sarah A., Spiller, Marga, Zech, Stephan G., Looby, Richard J., Raitsimring, Arnold M., McMurry, Thomas J., Lauffer, Randall B.
Published in Chemistry : a European journal (07.10.2005)
Published in Chemistry : a European journal (07.10.2005)
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207 Molecular MR-Imaging of myocardium using EP-3600, a collagen specific contrast agent: assessment of myocardial perfusion defects in a swine model
Spuentrup, Elmar, Ruhl, Karl M, Botnar, Rene M, Wiethoff, Andrea J, Buhl, Alexandra, Jacques, Vincent, Greenfield, Matthew T, Krombach, Gabriele A, Guenther, Rolf W, Caravan, Peter
Published in Journal of cardiovascular magnetic resonance (01.10.2008)
Published in Journal of cardiovascular magnetic resonance (01.10.2008)
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Heteroditopic Binding of Magnetic Resonance Contrast Agents for Increased Relaxivity
Zhang, Zhaoda, Kolodziej, Andrew F., Greenfield, Matthew T., Caravan, Peter
Published in Angewandte Chemie (07.03.2011)
Published in Angewandte Chemie (07.03.2011)
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Multilocus Binding Increases the Relaxivity of Protein-Bound MRI Contrast Agents
Zhang, Zhaoda, Greenfield, Matthew T., Spiller, Marga, McMurry, Thomas J., Lauffer, Randall B., Caravan, Peter
Published in Angewandte Chemie (21.10.2005)
Published in Angewandte Chemie (21.10.2005)
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