Inhibitors of the acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridylyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 2: Optimization of physical properties leading to antibacterial aryl sulfonamides
Stokes, Suzanne S., Albert, Robert, Buurman, Ed T., Andrews, Beth, Shapiro, Adam B., Green, Oluyinka M., McKenzie, Andrew R., Otterbein, Ludovic R.
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
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Pyrrolamide DNA Gyrase Inhibitors: Fragment-Based Nuclear Magnetic Resonance Screening To Identify Antibacterial Agents
Eakin, Ann E, Green, Oluyinka, Hales, Neil, Walkup, Grant K, Bist, Shanta, Singh, Alok, Mullen, George, Bryant, Joanna, Embrey, Kevin, Gao, Ning, Breeze, Alex, Timms, Dave, Andrews, Beth, Uria-Nickelsen, Maria, Demeritt, Julie, Loch, James T., III, Hull, Ken, Blodgett, April, Illingworth, Ruth N, Prince, Bryan, Boriack-Sjodin, P. Ann, Hauck, Sheila, MacPherson, Lawrence J, Ni, Haihong, Sherer, Brian
Published in Antimicrobial Agents and Chemotherapy (01.03.2012)
Published in Antimicrobial Agents and Chemotherapy (01.03.2012)
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Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase: Structure–Activity Relationships and Chiral Preference of a New Hydrophobic Binding Region
Kawatkar, Sameer P, Keating, Thomas A, Olivier, Nelson B, Breen, John N, Green, Oluyinka M, Guler, Satenig Y, Hentemann, Martin F, Loch, James T, McKenzie, Andrew R, Newman, Joseph V, Otterson, Linda G, Martínez-Botella, Gabriel
Published in Journal of medicinal chemistry (12.06.2014)
Published in Journal of medicinal chemistry (12.06.2014)
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Discovery of Selective and Potent Inhibitors of Gram-Positive Bacterial Thymidylate Kinase (TMK)
Martínez-Botella, Gabriel, Breen, John N, Duffy, James E. S, Dumas, Jacques, Geng, Bolin, Gowers, Ian K, Green, Oluyinka M, Guler, Satenig, Hentemann, Martin F, Hernandez-Juan, Felix A, Joseph-McCarthy, Diane, Kawatkar, Sameer, Larsen, Nicholas A, Lazari, Ovadia, Loch, James T, Macritchie, Jacqueline A, McKenzie, Andrew R, Newman, Joseph V, Olivier, Nelson B, Otterson, Linda G, Owens, Andrew P, Read, Jon, Sheppard, David W, Keating, Thomas A
Published in Journal of medicinal chemistry (26.11.2012)
Published in Journal of medicinal chemistry (26.11.2012)
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Sulfonylpiperidines as novel, antibacterial inhibitors of Gram-positive thymidylate kinase (TMK)
Martínez-Botella, Gabriel, Loch, James T., Green, Oluyinka M., Kawatkar, Sameer P., Olivier, Nelson B., Boriack-Sjodin, P. Ann, Keating, Thomas A.
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
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Inhibitors of acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 1: Hit to lead evaluation of a novel arylsulfonamide series
Green, Oluyinka M., McKenzie, Andrew R., Shapiro, Adam B., Otterbein, Ludovic, Ni, Haihong, Patten, Arthur, Stokes, Suzanne, Albert, Robert, Kawatkar, Sameer, Breed, Jason
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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In Vivo Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound
Keating, Thomas A, Newman, Joseph V, Olivier, Nelson B, Otterson, Linda G, Andrews, Beth, Boriack-Sjodin, P. Ann, Breen, John N, Doig, Peter, Dumas, Jacques, Gangl, Eric, Green, Oluyinka M, Guler, Satenig Y, Hentemann, Martin F, Joseph-McCarthy, Diane, Kawatkar, Sameer, Kutschke, Amy, Loch, James T, McKenzie, Andrew R, Pradeepan, Selvi, Prasad, Swati, Martínez-Botella, Gabriel
Published in ACS chemical biology (16.11.2012)
Published in ACS chemical biology (16.11.2012)
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Optimization of Pyrrolamide Topoisomerase II Inhibitors Toward Identification of an Antibacterial Clinical Candidate (AZD5099)
Basarab, Gregory S, Hill, Pamela J, Garner, C. Edwin, Hull, Ken, Green, Oluyinka, Sherer, Brian A, Dangel, P. Brian, Manchester, John I, Bist, Shanta, Hauck, Sheila, Zhou, Fei, Uria-Nickelsen, Maria, Illingworth, Ruth, Alm, Richard, Rooney, Mike, Eakin, Ann E
Published in Journal of medicinal chemistry (24.07.2014)
Published in Journal of medicinal chemistry (24.07.2014)
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Pyrrolamide DNA gyrase inhibitors: Optimization of antibacterial activity and efficacy
Sherer, Brian A., Hull, Kenneth, Green, Oluyinka, Basarab, Gregory, Hauck, Sheila, Hill, Pamela, Loch, James T., Mullen, George, Bist, Shanta, Bryant, Joanna, Boriack-Sjodin, Ann, Read, Jon, DeGrace, Nancy, Uria-Nickelsen, Maria, Illingworth, Ruth N., Eakin, Ann E.
Published in Bioorganic & medicinal chemistry letters (15.12.2011)
Published in Bioorganic & medicinal chemistry letters (15.12.2011)
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Journal Article
Inhibitors of the acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridylyltransferase/glucosamine-1- p hosphate-acetyltransferase (GlmU). Part 2: Optimization of physical properties leading to antibacterial aryl sulfonamides
Stokes, Suzanne S, Albert, Robert, Buurman, Ed T, Andrews, Beth, Shapiro, Adam B, Green, Oluyinka M, McKenzie, Andrew R, Otterbein, Ludovic R
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
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Journal Article
Inhibitors of acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-ph o sphate-acetyltransferase (GlmU). Part 1: Hit to lead evaluation of a novel arylsulfonamide series
Green, Oluyinka M, McKenzie, Andrew R, Shapiro, Adam B, Otterbein, Ludovic, Ni, Haihong, Patten, Arthur, Stokes, Suzanne, Albert, Robert, Kawatkar, Sameer, Breed, Jason
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Journal Article
ANTIBACTERIAL PIPERIDINE DERIVATIVES
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Year of Publication 21.08.2013
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Year of Publication 21.08.2013
Patent
ANTIBACTERIAL PIPERIDINE DERIVATIVES
GRAVESTOCK, MICHAEL BARRY, HAUCK, SHEILA IRENE, NI, HAIHONG, BASARAB, GREG, SHERER, BRIAN, HILL, PAMELA, FLEMING, PAUL ROBERT, MULLEN, GEORGE, GREEN, OLUYINKA, ZHOU, FEI, DANGEL, BRIAN, HULL, KENNETH GREGORY
Year of Publication 27.05.2014
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Year of Publication 27.05.2014
Patent
ANTIBACTERIAL PIPERIDINE DERIVATIVES
GRAVESTOCK, MICHAEL BARRY, HAUCK, SHEILA IRENE, NI, HAIHONG, BASARAB, GREG, SHERER, BRIAN, HILL, PAMELA, FLEMING, PAUL ROBERT, MULLEN, GEORGE, GREEN, OLUYINKA, ZHOU, FEI, DANGEL, BRIAN, HULL, KENNETH GREGORY
Year of Publication 24.07.2013
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Year of Publication 24.07.2013
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CHEMICAL COMPOUNDS
HAUCK SHEILA IRENE, BASARAB GREGORY STEVEN, DANGEL BRIAN, ZHOU FEI, HILL PAMELA, HULL KENNETH GREGORY, GREEN OLUYINKA, MULLEN GEORGE, GRAVESTOCK MICHAEL BARRY, SHERER BRIAN, FLEMING PAUL ROBERT, NI HAIHONG
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Year of Publication 13.06.2013
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Antibacterial piperdine derivatives
HAUCK SHEILA IRENE, DANGEL BRIAN, ZHOU FEI, HILL PAMELA, HULL KENNETH GREGORY, GREEN OLUYINKA, MULLEN GEORGE, BASARAB GREGORY, GRAVESTOCK MICHAEL BARRY, SHERER BRIAN, FLEMING PAUL ROBERT, NI HAIHONG
Year of Publication 19.03.2013
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Year of Publication 19.03.2013
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ANTIBACTERIAL PIPERIDINE DERIVATIVES
Green Oluyinka, Sherer Brian, Hill Pamela, Gravestock Michael Barry, Fleming Paul Robert, Mullen George, Hull Kenneth Gregory, Zhou Fei, Dangel Brian, Basarab Greg, Hauck Sheila Irene
Year of Publication 25.06.2011
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Year of Publication 25.06.2011
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Antibacterial piperidine derivatives
PAMELA HILL, BRIAN SHERER, PAUL ROBERT FLEMING, MICHAEL BARRY GRAVESTOCK, BRIAN DANGEL, KENNETH GREGORY HULL, OLUYINKA GREEN, GREG BASARAB, GEORGE MULLEN, FEI ZHOU, SHEILA IRENE HAUCK
Year of Publication 09.12.2010
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Year of Publication 09.12.2010
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