Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants
Greasley, Samantha E., Noell, Stephen, Plotnikova, Olga, Ferre, RoseAnn, Liu, Wei, Bolanos, Ben, Fennell, Kimberly, Nicki, Jennifer, Craig, Tim, Zhu, Yuao, Stewart, Al E., Steppan, Claire M.
Published in The Journal of biological chemistry (01.06.2022)
Published in The Journal of biological chemistry (01.06.2022)
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An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19
Owen, Dafydd R, Allerton, Charlotte M N, Anderson, Annaliesa S, Aschenbrenner, Lisa, Avery, Melissa, Berritt, Simon, Boras, Britton, Cardin, Rhonda D, Carlo, Anthony, Coffman, Karen J, Dantonio, Alyssa, Li, Di, Eng, Heather, Ferre, RoseAnn, Gajiwala, Ketan S, Gibson, Scott A, Greasley, Samantha E, Hurst, Brett L, Kadar, Eugene P, Kalgutkar, Amit S, Lee, Jack C, Lee, Jisun, Liu, Wei, Mason, Stephen W, Noell, Stephen, Novak, Jonathan J, Obach, R Scott, Ogilvie, Kevin, Patel, Nandini C, Pettersson, Martin, Rai, Devendra K, Reese, Matthew R, Sammons, Matthew F, Sathish, Jean G, Singh, Ravi Shankar P, Steppan, Claire M, Stewart, Al E, Tuttle, Jamison B, Updyke, Lawrence, Verhoest, Patrick R, Wei, Liuqing, Yang, Qingyi, Zhu, Yuao
Published in Science (American Association for the Advancement of Science) (24.12.2021)
Published in Science (American Association for the Advancement of Science) (24.12.2021)
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Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors
Bagal, Sharan K, Omoto, Kiyoyuki, Blakemore, David C, Bungay, Peter J, Bilsland, James G, Clarke, Philip J, Corbett, Matthew S, Cronin, Ciaran N, Cui, J. Jean, Dias, Rebecca, Flanagan, Neil J, Greasley, Samantha E, Grimley, Rachel, Johnson, Eric, Fengas, David, Kitching, Linda, Kraus, Michelle L, McAlpine, Indrawan, Nagata, Asako, Waldron, Gareth J, Warmus, Joseph S
Published in Journal of medicinal chemistry (10.01.2019)
Published in Journal of medicinal chemistry (10.01.2019)
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Journal Article
Crystal Structures of Human Bifunctional Enzyme Aminoimidazole-4-carboxamide Ribonucleotide Transformylase/IMP Cyclohydrolase in Complex with Potent Sulfonyl-containing Antifolates
Cheong, Cheom-Gil, Wolan, Dennis W., Greasley, Samantha E., Horton, Patricia A., Beardsley, G. Peter, Wilson, Ian A.
Published in The Journal of biological chemistry (23.04.2004)
Published in The Journal of biological chemistry (23.04.2004)
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Journal Article
A Second-Generation Oral SARS-CoV‑2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19
Allerton, Charlotte M. N., Arcari, Joel T., Aschenbrenner, Lisa M., Avery, Melissa, Bechle, Bruce M., Behzadi, Mohammad Amin, Boras, Britton, Buzon, Leanne M., Cardin, Rhonda D., Catlin, Natasha R., Carlo, Anthony A., Coffman, Karen J., Dantonio, Alyssa, Di, Li, Eng, Heather, Farley, Kathleen A., Ferre, Rose Ann, Gernhardt, Steven S., Gibson, Scott A., Greasley, Samantha E., Greenfield, Siennah R., Hurst, Brett L., Kalgutkar, Amit S., Kimoto, Emi, Lanyon, Lorraine F., Lovett, Gabrielle H., Lian, Yajing, Liu, Wei, Martínez Alsina, Luis A., Noell, Stephen, Obach, R. Scott, Owen, Dafydd R., Patel, Nandini C., Rai, Devendra K., Reese, Matthew R., Rothan, Hussin A., Sakata, Sylvie, Sammons, Matthew F., Sathish, Jean G., Sharma, Raman, Steppan, Claire M., Tuttle, Jamison B., Verhoest, Patrick R., Wei, Liuqing, Yang, Qingyi, Yurgelonis, Irina, Zhu, Yuao
Published in Journal of medicinal chemistry (22.08.2024)
Published in Journal of medicinal chemistry (22.08.2024)
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Journal Article
Insights into mechanism of glucokinase activation: observation of multiple distinct protein conformations
Liu, Shenping, Ammirati, Mark J, Song, Xi, Knafels, John D, Zhang, Jeff, Greasley, Samantha E, Pfefferkorn, Jeffrey A, Qiu, Xiayang
Published in The Journal of biological chemistry (20.04.2012)
Published in The Journal of biological chemistry (20.04.2012)
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Journal Article
Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain
Bagal, Sharan K, Andrews, Mark, Bechle, Bruce M, Bian, Jianwei, Bilsland, James, Blakemore, David C, Braganza, John F, Bungay, Peter J, Corbett, Matthew S, Cronin, Ciaran N, Cui, Jingrong Jean, Dias, Rebecca, Flanagan, Neil J, Greasley, Samantha E, Grimley, Rachel, James, Kim, Johnson, Eric, Kitching, Linda, Kraus, Michelle L, McAlpine, Indrawan, Nagata, Asako, Ninkovic, Sacha, Omoto, Kiyoyuki, Scales, Stephanie, Skerratt, Sarah E, Sun, Jianmin, Tran-Dubé, Michelle, Waldron, Gareth J, Wang, Fen, Warmus, Joseph S
Published in Journal of medicinal chemistry (09.08.2018)
Published in Journal of medicinal chemistry (09.08.2018)
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Journal Article
An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19
Owen, Dafydd R, Allerton, Charlotte M N, Anderson, Annaliesa S, Aschenbrenner, Lisa, Avery, Melissa, Berritt, Simon, Boras, Britton, Cardin, Rhonda D, Carlo, Anthony, Coffman, Karen J, Dantonio, Alyssa, Di, Li, Eng, Heather, Ferre, RoseAnn, Gajiwala, Ketan S, Gibson, Scott A, Greasley, Samantha E, Hurst, Brett L, Kadar, Eugene P, Kalgutkar, Amit S, Lee, Jack C, Lee, Jisun, Liu, Wei, Mason, Stephen W, Noell, Stephen, Novak, Jonathan J, Obach, R Scott, Ogilvie, Kevin, Patel, Nandini C, Pettersson, Martin, Rai, Devendra K, Reese, Matthew R, Sammons, Matthew F, Sathish, Jean G, Singh, Ravi Shankar P, Steppan, Claire M, Stewart, Al E, Tuttle, Jamison B, Updyke, Lawrence, Verhoest, Patrick R, Wei, Liuqing, Yang, Qingyi, Zhu, Yuao
Published in Science (American Association for the Advancement of Science) (24.12.2021)
Published in Science (American Association for the Advancement of Science) (24.12.2021)
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Journal Article
Unexpected Formation of an Epoxide-Derived Multisubstrate Adduct Inhibitor on the Active Site of GAR Transformylase
Greasley, Samantha E, Marsilje, Thomas H, Cai, Hui, Baker, Stephen, Benkovic, Stephen J, Boger, Dale L, Wilson, Ian A
Published in Biochemistry (Easton) (13.11.2001)
Published in Biochemistry (Easton) (13.11.2001)
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Journal Article
In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance
Zhu, Yuao, Yurgelonis, Irina, Noell, Stephen, Yang, Qingyi, Guan, Shunjie, Li, Zhenghui, Hao, Li, Rothan, Hussin, Rai, Devendra K, McMonagle, Patricia, Baniecki, Mary Lynn, Greasley, Samantha E, Plotnikova, Olga, Lee, Jonathan, Nicki, Jennifer A, Ferre, RoseAnn, Byrnes, Laura J, Liu, Wei, Craig, Timothy K, Steppan, Claire M, Liberator, Paul, Soares, Holly D, Allerton, Charlotte M N, Anderson, Annaliesa S, Cardin, Rhonda D
Published in Science advances (26.07.2024)
Published in Science advances (26.07.2024)
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Journal Article
Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis
Wilson, Ian A, Greasley, Samantha E, Horton, Patricia, Ramcharan, Joseph, Beardsley, G. Peter, Benkovic, Stephen J
Published in Nature structural & molecular biology (01.05.2001)
Published in Nature structural & molecular biology (01.05.2001)
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Journal Article
Structural Insights into the Avian AICAR Transformylase Mechanism
Wolan, Dennis W, Greasley, Samantha E, Beardsley, G. Peter, Wilson, Ian A
Published in Biochemistry (Easton) (31.12.2002)
Published in Biochemistry (Easton) (31.12.2002)
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Journal Article
Crystal Structures of Human GAR Tfase at Low and High pH and with Substrate β-GAR
Zhang, Yan, Desharnais, Joel, Greasley, Samantha E, Beardsley, G. Peter, Boger, Dale L, Wilson, Ian A
Published in Biochemistry (Easton) (03.12.2002)
Published in Biochemistry (Easton) (03.12.2002)
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Journal Article
New Insights into Inhibitor Design from the Crystal Structure and NMR Studies of Escherichia coli GAR Transformylase in Complex with β-GAR and 10-Formyl-5,8,10-trideazafolic Acid
Greasley, Samantha E, Yamashita, Mason M, Cai, Hui, Benkovic, Stephen J, Boger, Dale L, Wilson, Ian A
Published in Biochemistry (Easton) (21.12.1999)
Published in Biochemistry (Easton) (21.12.1999)
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Journal Article
A pH-dependent stabilization of an active site loop observed from low and high ph crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 Å
Su, Ying, Yamashita, Mason M, Greasley, Samantha E, Mullen, Christine A, Shim, Jae Hoon, Jennings, Patricia A, Benkovic, Steven J, Wilson, Ian A
Published in Journal of molecular biology (21.08.1998)
Published in Journal of molecular biology (21.08.1998)
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Journal Article
Abstract 330: Engineering electrophile-sensitive kinase mutants to accelerate oncology target validation
Oyer, Jon A., Johnson, Ted W., Wang, Andrew C., Maestre, Michael F., Flores-Bojorquez, Ana, Melnychuk, Roksolana, Timofeevski, Sergei, Niessen, Sherry, Wang, Zhenxiong, Li, Jian, Diehl, Wade C., Eisele, Koleen J., Lee, Nathan V., Zou, Aihua, Davis, Carl, Greenwald, Eric C., DeForest, Jacob, Ornelas, Martha, Li, Bryan, Scales, Stephanie, Khamphavong, Penney L., Ambler, Catherine M., Huang, Yun, Salomon-Ferrer, Romelia, Greasley, Samantha E., Bolanos, Ben, Grodsky, Neil, Lum, Lawrence, VanArsdale, Todd L., McAlpine, Indrawan J.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors
Bagal, Sharan K., Omoto, Kiyoyuki, Blakemore, David C., Bungay, Peter J., Bilsland, James G., Clarke, Philip J., Corbett, Matthew S., Cronin, Ciaran N., Cui, J. Jean, Dias, Rebecca, Flanagan, Neil J., Greasley, Samantha E., Grimley, Rachel, Johnson, Eric, Fengas, David, Kitching, Linda, Kraus, Michelle L., McAlpine, Indrawan, Nagata, Asako, Waldron, Gareth J., Warmus, Joseph S.
Published in Journal of medicinal chemistry (19.04.2018)
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Published in Journal of medicinal chemistry (19.04.2018)
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