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Structural basis for the oligomerization-facilitated NLRP3 activation
Yu, Xiaodi, Matico, Rosalie E., Miller, Robyn, Chauhan, Dhruv, Van Schoubroeck, Bertrand, Grauwen, Karolien, Suarez, Javier, Pietrak, Beth, Haloi, Nandan, Yin, Yanting, Tresadern, Gary John, Perez-Benito, Laura, Lindahl, Erik, Bottelbergs, Astrid, Oehlrich, Daniel, Van Opdenbosch, Nina, Sharma, Sujata
Published in Nature communications (07.02.2024)
Published in Nature communications (07.02.2024)
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Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome
Matico, Rosalie, Grauwen, Karolien, Chauhan, Dhruv, Yu, Xiaodi, Abdiaj, Irini, Adhikary, Suraj, Adriaensen, Ine, Aranzazu, Garcia Molina, Alcázar, Jesus, Bassi, Michela, Brisse, Ellen, Cañellas, Santiago, Chaudhuri, Shubhra, Delgado, Francisca, Diéguez-Vázquez, Alejandro, Du Jardin, Marc, Eastham, Victoria, Finley, Michael, Jacobs, Tom, Keustermans, Ken, Kuhn, Robert, Llaveria, Josep, Leenaerts, Jos, Linares, Maria Lourdes, Martín, Maria Luz, Martín-Pérez, Rosa, Martínez, Carlos, Miller, Robyn, Muñoz, Frances M, Muratore, Michael E, Nooyens, Amber, Perez-Benito, Laura, Perrier, Mathieu, Pietrak, Beth, Serré, Jef, Sharma, Sujata, Somers, Marijke, Suarez, Javier, Tresadern, Gary, Trabanco, Andres A, Van den Bulck, Dries, Van Gool, Michiel, Van Hauwermeiren, Filip, Varghese, Teena, Vega, Juan Antonio, Youssef, Sameh A, Edwards, Matthew J, Oehlrich, Daniel, Van Opdenbosch, Nina
Published in EMBO molecular medicine (13.01.2025)
Published in EMBO molecular medicine (13.01.2025)
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NLRP3 inflammasome activation and pyroptosis are dispensable for tau pathology
Paesmans, Ine, Van Kolen, Kristof, Vandermeeren, Marc, Shih, Pei-Yu, Wuyts, Dirk, Boone, Fleur, Garcia Sanchez, Sergio, Grauwen, Karolien, Van Hauwermeiren, Filip, Van Opdenbosch, Nina, Lamkanfi, Mohamed, van Loo, Geert, Bottelbergs, Astrid
Published in Frontiers in aging neuroscience (24.09.2024)
Published in Frontiers in aging neuroscience (24.09.2024)
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Biological Activity of CXCL8 Forms Generated by Alternative Cleavage of the Signal Peptide or by Aminopeptidase-Mediated Truncation
Mortier, Anneleen, Berghmans, Nele, Ronsse, Isabelle, Grauwen, Karolien, Stegen, Steve, Van Damme, Jo, Proost, Paul
Published in PloS one (31.08.2011)
Published in PloS one (31.08.2011)
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Development of immunoprecipitation – two-dimensional liquid chromatography – mass spectrometry methodology as biomarker read-out to quantify phosphorylated tau in cerebrospinal fluid from Alzheimer disease patients
Bijttebier, Sebastiaan, Theunis, Clara, Jahouh, Farid, Martins, Dina Rodrigues, Verhemeldonck, Marc, Grauwen, Karolien, Dillen, Lieve, Mercken, Marc
Published in Journal of Chromatography A (16.08.2021)
Published in Journal of Chromatography A (16.08.2021)
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CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
Mancuso, Renzo, Fryatt, Gemma, Cleal, Madeleine, Obst, Juliane, Pipi, Elena, Monzón-Sandoval, Jimena, Ribe, Elena, Winchester, Laura, Webber, Caleb, Nevado, Alejo, Jacobs, Tom, Austin, Nigel, Theunis, Clara, Grauwen, Karolien, Daniela Ruiz, Eva, Mudher, Amrit, Vicente-Rodriguez, Marta, Parker, Christine A, Simmons, Camilla, Cash, Diana, Richardson, Jill, Bullmore, Edward T, Bhatti, Junaid, Chamberlain, Samuel J, Correia, Marta M, Crofts, Anna L, Dickinson, Amber, Foster, Andrew C, Kitzbichler, Manfred G, Knight, Clare, Lynall, Mary-Ellen, Maurice, Christina, O'Donnell, Ciara, Pointon, Linda J, Hyslop, Peter St George, Turner, Lorinda, Vertes, Petra, Widmer, Barry, Williams, Guy B, Morgan, B Paul, Leckey, Claire A, Morgan, Angharad R, O'Hagan, Caroline, Touchard, Samuel, Cavanagh, Jonathan, Deith, Catherine, Farmer, Scott, McClean, John, McColl, Alison, McPherson, Andrew, Scouller, Paul, Sutherland, Murray, Boddeke, H W G M (Erik), Richardson, Jill C, Khan, Shahid, Murphy, Phil, Parker, Christine A, Patel, Jai, Jones, Declan, de Boer, Peter, Kemp, John, Drevets, Wayne C, Nye, Jeffrey S, Wittenberg, Gayle, Isaac, John, Bhattacharya, Anindya, Carruthers, Nick, Kolb, Hartmuth, Pariante, Carmine M, Turkheimer, Federico, Barker, Gareth J, Byrom, Heidi, Cash, Diana, Cattaneo, Annamaria, Gee, Antony, Hastings, Caitlin, Mariani, Nicole, McLaughlin, Anna, Mondelli, Valeria, Nettis, Maria, Nikkheslat, Naghmeh, Randall, Karen, Sheridan, Hannah, Simmons, Camilla, Singh, Nisha, Loo, Victoria Van, Vicente-Rodriguez, Marta, Wood, Tobias C, Worrell, Courtney, Zajkowska, Zuzanna, Plath, Niels, Egebjerg, Jan, Eriksson, Hans, Gastambide, Francois, Adams, Karen Husted, Jeggo, Ross, Thomsen, Christian, Pederson, Jan Torleif, Campbell, Brian, Möller, Thomas
Published in Brain (London, England : 1878) (01.10.2019)
Published in Brain (London, England : 1878) (01.10.2019)
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IP-LC-MSMS Enables Identification of Three Tau O‑GlcNAcylation Sites as O‑GlcNAcase Inhibition Pharmacodynamic Readout in Transgenic Mice Overexpressing Human Tau
Bijttebier, Sebastiaan, Rodrigues Martins, Dina, Mertens, Liesbeth, Grauwen, Karolien, Bruinzeel, Wouter, Willems, Roland, Bartolomé-Nebreda, José Manuel, Theunis, Clara, Bretteville, Alexis, Ebneth, Andreas, Dillen, Lieve
Published in Journal of proteome research (07.04.2023)
Published in Journal of proteome research (07.04.2023)
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Nanoparticle-sensitized photoporation enables inflammasome activation studies in targeted single cells
Harizaj, Aranit, Van Hauwermeiren, Filip, Stremersch, Stephan, De Rycke, Riet, De Keersmaecker, Herlinde, Brans, Toon, Fraire, Juan C, Grauwen, Karolien, De Smedt, Stefaan C, Lentacker, Ine, Lamkanfi, Mohamed, Braeckmans, Kevin
Published in Nanoscale (07.04.2021)
Published in Nanoscale (07.04.2021)
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Citrullination of TNF-α by peptidylarginine deiminases reduces its capacity to stimulate the production of inflammatory chemokines
Moelants, Eva A.V., Mortier, Anneleen, Grauwen, Karolien, Ronsse, Isabelle, Van Damme, Jo, Proost, Paul
Published in Cytokine (Philadelphia, Pa.) (01.01.2013)
Published in Cytokine (Philadelphia, Pa.) (01.01.2013)
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Citrullination of TNF-[alpha] by peptidylarginine deiminases reduces its capacity to stimulate the production of inflammatory chemokines
Moelants, Eva AV, Mortier, Anneleen, Grauwen, Karolien, Ronsse, Isabelle, Van Damme, Jo, Proost, Paul
Published in Cytokine (Philadelphia, Pa.) (01.01.2013)
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Published in Cytokine (Philadelphia, Pa.) (01.01.2013)
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