Myocardial Stiffness in Patients With Heart Failure and a Preserved Ejection Fraction: Contributions of Collagen and Titin
Zile, Michael R, Baicu, Catalin F, S. Ikonomidis, John, Stroud, Robert E, Nietert, Paul J, Bradshaw, Amy D, Slater, Rebecca, Palmer, Bradley M, Van Buren, Peter, Meyer, Markus, M. Redfield, Margaret, A. Bull, David, L. Granzier, Henk, LeWinter, Martin M
Published in Circulation (New York, N.Y.) (07.04.2015)
Published in Circulation (New York, N.Y.) (07.04.2015)
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Journal Article
Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism
Jeong, Mark Y, Lin, Ying H, Wennersten, Sara A, Demos-Davies, Kimberly M, Cavasin, Maria A, Mahaffey, Jennifer H, Monzani, Valmen, Saripalli, Chandrasekhar, Mascagni, Paolo, Reece, T Brett, Ambardekar, Amrut V, Granzier, Henk L, Dinarello, Charles A, McKinsey, Timothy A
Published in Science translational medicine (07.02.2018)
Published in Science translational medicine (07.02.2018)
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Journal Article
Titin-based tension in the cardiac sarcomere: Molecular origin and physiological adaptations
Anderson, Brian R., Granzier, Henk L.
Published in Progress in biophysics and molecular biology (01.10.2012)
Published in Progress in biophysics and molecular biology (01.10.2012)
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Journal Article
Effect of exercise training on post-translational and post-transcriptional regulation of titin stiffness in striated muscle of wild type and IG KO mice
Hidalgo, Carlos, Saripalli, Chandra, Granzier, Henk L.
Published in Archives of biochemistry and biophysics (15.06.2014)
Published in Archives of biochemistry and biophysics (15.06.2014)
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Journal Article
Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice
Chiao, Ying Ann, Zhang, Huiliang, Sweetwyne, Mariya, Whitson, Jeremy, Ting, Ying Sonia, Basisty, Nathan, Pino, Lindsay K, Quarles, Ellen, Nguyen, Ngoc-Han, Campbell, Matthew D, Zhang, Tong, Gaffrey, Matthew J, Merrihew, Gennifer, Wang, Lu, Yue, Yongping, Duan, Dongsheng, Granzier, Henk L, Szeto, Hazel H, Qian, Wei-Jun, Marcinek, David, MacCoss, Michael J, Rabinovitch, Peter
Published in eLife (10.07.2020)
Published in eLife (10.07.2020)
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Journal Article
Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy
Brynnel, Ambjorn, Hernandez, Yaeren, Kiss, Balazs, Lindqvist, Johan, Adler, Maya, Kolb, Justin, van der Pijl, Robbert, Gohlke, Jochen, Strom, Joshua, Smith, John, Ottenheijm, Coen, Granzier, Henk L
Published in eLife (19.12.2018)
Published in eLife (19.12.2018)
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Journal Article
HDAC6 modulates myofibril stiffness and diastolic function of the heart
Lin, Ying-Hsi, Major, Jennifer L, Liebner, Tim, Hourani, Zaynab, Travers, Joshua G, Wennersten, Sara A, Haefner, Korey R, Cavasin, Maria A, Wilson, Cortney E, Jeong, Mark Y, Han, Yu, Gotthardt, Michael, Ferguson, Scott K, Ambardekar, Amrut V, Lam, Maggie Py, Choudhary, Chunaram, Granzier, Henk L, Woulfe, Kathleen C, McKinsey, Timothy A
Published in The Journal of clinical investigation (16.05.2022)
Published in The Journal of clinical investigation (16.05.2022)
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Journal Article
Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality
Pappas, Christopher T., Mayfield, Rachel M., Henderson, Christine, Jamilpour, Nima, Cover, Cathleen, Hernandez, Zachary, Hutchinson, Kirk R., Chu, Miensheng, Nam, Ki-Hwan, Valdez, Jose M., Wong, Pak Kin, Granzier, Henk L., Gregorio, Carol C.
Published in Proceedings of the National Academy of Sciences - PNAS (03.11.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (03.11.2015)
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Journal Article
Deleting titin’s I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function
Granzier, Henk L., Hutchinson, Kirk R., Tonino, Paola, Methawasin, Mei, Li, Frank W., Slater, Rebecca E., Bull, Mathew M., Saripalli, Chandra, Pappas, Christopher T., Gregorio, Carol C., Smith, John E.
Published in Proceedings of the National Academy of Sciences - PNAS (07.10.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (07.10.2014)
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Journal Article
Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease
Sheikh, Farah, Ouyang, Kunfu, Campbell, Stuart G, Lyon, Robert C, Chuang, Joyce, Fitzsimons, Dan, Tangney, Jared, Hidalgo, Carlos G, Chung, Charles S, Cheng, Hongqiang, Dalton, Nancy D, Gu, Yusu, Kasahara, Hideko, Ghassemian, Majid, Omens, Jeffrey H, Peterson, Kirk L, Granzier, Henk L, Moss, Richard L, McCulloch, Andrew D, Chen, Ju
Published in The Journal of clinical investigation (01.04.2012)
Published in The Journal of clinical investigation (01.04.2012)
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Journal Article
Shortening of the Elastic Tandem Immunoglobulin Segment of Titin Leads to Diastolic Dysfunction
Chung, Charles S, Hutchinson, Kirk R, Methawasin, Mei, Saripalli, Chandra, Smith, John E, Hidalgo, Carlos G, Luo, Xiuju, Labeit, Siegfried, Guo, Caiying, Granzier, Henk L
Published in Circulation (New York, N.Y.) (02.07.2013)
Published in Circulation (New York, N.Y.) (02.07.2013)
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Journal Article
Increased Expression of N2BA Titin Corresponds to More Compliant Myofibrils in Athlete's Heart
Kellermayer, Dalma, Kiss, Bálint, Tordai, Hedvig, Oláh, Attila, Granzier, Henk L, Merkely, Béla, Kellermayer, Miklós, Radovits, Tamás
Published in International journal of molecular sciences (15.10.2021)
Published in International journal of molecular sciences (15.10.2021)
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Journal Article
Rbm20 ΔRRM Mice, Expressing a Titin Isoform with Lower Stiffness, Are Protected from Mechanical Ventilation-Induced Diaphragm Weakness
van den Berg, Marloes, Peters, Eva L, van der Pijl, Robbert J, Shen, Shengyi, Heunks, Leo M A, Granzier, Henk L, Ottenheijm, Coen A C
Published in International journal of molecular sciences (10.12.2022)
Published in International journal of molecular sciences (10.12.2022)
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Journal Article
Transforming growth factor beta signaling in adult cardiovascular diseases and repair
Doetschman, Thomas, Barnett, Joey V, Runyan, Raymond B, Camenisch, Todd D, Heimark, Ronald L, Granzier, Henk L, Conway, Simon J, Azhar, Mohamad
Published in Cell and tissue research (01.01.2012)
Published in Cell and tissue research (01.01.2012)
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Journal Article
Myosin light chain phosphorylation to the rescue
Granzier, Henk L., de Tombe, Pieter P.
Published in Proceedings of the National Academy of Sciences - PNAS (28.07.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (28.07.2015)
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Journal Article
Functional Characterization of the Intact Diaphragm in a Nebulin-Based Nemaline Myopathy (NM) Model-Effects of the Fast Skeletal Muscle Troponin Activator tirasemtiv
Lee, Eun-Jeong, Kolb, Justin, Hwee, Darren T, Malik, Fady I, Granzier, Henk L
Published in International journal of molecular sciences (10.10.2019)
Published in International journal of molecular sciences (10.10.2019)
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