Design of HIV Protease Inhibitors Based on Inorganic Polyhedral Metallacarboranes
Řezáčová, Pavlína, Pokorná, Jana, Brynda, Jiří, Kožíšek, Milan, Cígler, Petr, Lepšík, Martin, Fanfrlík, Jindřich, Řezáč, Jan, Grantz Šašková, Klára, Sieglová, Irena, Plešek, Jaromír, Šícha, Václav, Grüner, Bohumír, Oberwinkler, Heike, Sedláček’, Juraj, Kräusslich, Hans-Georg, Hobza, Pavel, Král, Vladimír, Konvalinka, Jan
Published in Journal of medicinal chemistry (26.11.2009)
Published in Journal of medicinal chemistry (26.11.2009)
Get full text
Journal Article
Inorganic Polyhedral Metallacarborane Inhibitors of HIV Protease: A New Approach to Overcoming Antiviral Resistance
Kožíšek, Milan, Cígler, Petr, Lepšík, Martin, Fanfrlík, Jindřich, Řezáčová, Pavlína, Brynda, Jiří, Pokorná, Jana, Plešek, Jaromír, Grüner, Bohumír, Grantz Šašková, Klára, Václavíková, Jana, Král, Vladimír, Konvalinka, Jan
Published in Journal of medicinal chemistry (14.08.2008)
Published in Journal of medicinal chemistry (14.08.2008)
Get full text
Journal Article
Specific Inhibitors of HIV Capsid Assembly Binding to the C‑Terminal Domain of the Capsid Protein: Evaluation of 2‑Arylquinazolines as Potential Antiviral Compounds
Machara, Aleš, Lux, Vanda, Kožíšek, Milan, Grantz Šašková, Klára, Štěpánek, Ondřej, Kotora, Martin, Parkan, Kamil, Pávová, Marcela, Glass, Bärbel, Sehr, Peter, Lewis, Joe, Müller, Barbara, Kräusslich, Hans-Georg, Konvalinka, Jan
Published in Journal of medicinal chemistry (28.01.2016)
Published in Journal of medicinal chemistry (28.01.2016)
Get full text
Journal Article
Quantitative proteomics reveals neuronal ubiquitination of Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for the complexity of Angelman syndrome
Ramirez, Juanma, Lectez, Benoit, Osinalde, Nerea, Sivá, Monika, Elu, Nagore, Aloria, Kerman, Procházková, Michaela, Perez, Coralia, Martínez-Hernández, Jose, Barrio, Rosa, Šašková, Klára Grantz, Arizmendi, Jesus M, Mayor, Ugo
Published in Human molecular genetics (01.06.2018)
Published in Human molecular genetics (01.06.2018)
Get full text
Journal Article
Mutations in HIV-1 gag and pol Compensate for the Loss of Viral Fitness Caused by a Highly Mutated Protease
Kozísek, Milan, Henke, Sandra, Sasková, Klára Grantz, Jacobs, Graeme Brendon, Schuch, Anita, Buchholz, Bernd, Müller, Viktor, Kräusslich, Hans-Georg, Rezácová, Pavlína, Konvalinka, Jan, Bodem, Jochen
Published in Antimicrobial Agents and Chemotherapy (01.08.2012)
Published in Antimicrobial Agents and Chemotherapy (01.08.2012)
Get full text
Journal Article
Structure-Aided Design of Novel Inhibitors of HIV Protease Based on a Benzodiazepine Scaffold
Schimer, Jiří, Cígler, Petr, Veselý, Jan, Grantz Šašková, Klára, Lepšík, Martin, Brynda, Jiří, Řezáčová, Pavlína, Kožíšek, Milan, Císařová, Ivana, Oberwinkler, Heike, Kraeusslich, Hans-Georg, Konvalinka, Jan
Published in Journal of medicinal chemistry (26.11.2012)
Published in Journal of medicinal chemistry (26.11.2012)
Get full text
Journal Article
Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir
SASKOVA, Klara Grantz, KOZISEK, Milan, REZACOVA, Pavlina, BRYNDA, Jirí, YASHINA, Tatyana, KAGAN, Ron M, KONVALINKA, Jan
Published in Journal of Virology (01.09.2009)
Published in Journal of Virology (01.09.2009)
Get full text
Journal Article
Structural studies of the yeast DNA damage-inducible protein Ddi1 reveal domain architecture of this eukaryotic protein family
Trempe, Jean-François, Šašková, Klára Grantz, Sivá, Monika, Ratcliffe, Colin D H, Veverka, Václav, Hoegl, Annabelle, Ménade, Marie, Feng, Xin, Shenker, Solomon, Svoboda, Michal, Kožíšek, Milan, Konvalinka, Jan, Gehring, Kalle
Published in Scientific reports (20.09.2016)
Published in Scientific reports (20.09.2016)
Get full text
Journal Article
Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog
Sivá, Monika, Svoboda, Michal, Veverka, Václav, Trempe, Jean-François, Hofmann, Kay, Kožíšek, Milan, Hexnerová, Rozálie, Sedlák, František, Belza, Jan, Brynda, Jiří, Šácha, Pavel, Hubálek, Martin, Starková, Jana, Flaisigová, Iva, Konvalinka, Jan, Šašková, Klára Grantz
Published in Scientific reports (27.07.2016)
Published in Scientific reports (27.07.2016)
Get full text
Journal Article
Ninety-Nine Is Not Enough: Molecular Characterization of Inhibitor-Resistant Human Immunodeficiency Virus Type 1 Protease Mutants with Insertions in the Flap Region
KOZISEK, Milan, GRANTZ SASKOVA, Klara, REZACOVA, Pavlina, BRYNDA, Jiri, VAN MAARSEVEEN, Noortje M, DE JONG, Dorien, BOUCHER, Charles A, KAGAN, Ron M, NIJHUIS, Monique, KONVALINKA, Jan
Published in Journal of Virology (01.06.2008)
Published in Journal of Virology (01.06.2008)
Get full text
Journal Article
Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir
Šašková, Klára Grantz, Kožíšek, Milan, Lepšík, Martin, Brynda, Jiří, Řezáčová, Pavlína, Václavíková, Jana, Kagan, Ron M., Machala, Ladislav, Konvalinka, Jan
Published in Protein science (01.09.2008)
Published in Protein science (01.09.2008)
Get full text
Journal Article
Capturing a dynamically interacting inhibitor by paramagnetic NMR spectroscopy
Srb, Pavel, Svoboda, Michal, Benda, Ladislav, Lepšík, Martin, Tarábek, Ján, Šícha, Václav, Grüner, Bohumír, Grantz-Šašková, Klára, Brynda, Jiří, Řezáčová, Pavlína, Konvalinka, Jan, Veverka, Václav
Published in Physical chemistry chemical physics : PCCP (06.03.2019)
Published in Physical chemistry chemical physics : PCCP (06.03.2019)
Get full text
Journal Article
Potent inhibition of drug-resistant HIV protease variants by monoclonal antibodies
Bartoňová, Vanda, Král, Vlastimil, Sieglová, Irena, Brynda, Jiří, Fábry, Milan, Hořejší, Magdalena, Kožíšek, Milan, Šašková, Klára Grantz, Konvalinka, Jan, Sedláček, Juraj, Řezáčová, Pavlína
Published in Antiviral research (01.06.2008)
Published in Antiviral research (01.06.2008)
Get full text
Journal Article
Nelfinavir Inhibits the TCF11/Nrf1-Mediated Proteasome Recovery Pathway in Multiple Myeloma
Fassmannová, Dominika, Sedlák, František, Sedláček, Jindřich, Špička, Ivan, Grantz Šašková, Klára
Published in Cancers (25.04.2020)
Published in Cancers (25.04.2020)
Get full text
Journal Article
Backbone (1)H, (13)C, and (15)N NMR assignment for the inactive form of the retroviral protease of the murine intracisternal A-type particle, inMIA-14 PR
Motácková, Veronika, Kubícková, Monika, Kozísek, Milan, Sasková, Klára Grantz, Svec, Martin, Zídek, Lukás, Sklenár, Vladimír
Published in Biomolecular NMR assignments (01.12.2009)
Published in Biomolecular NMR assignments (01.12.2009)
Get full text
Journal Article
Backbone ¹H, ¹³C, and ¹⁵N NMR assignment for the inactive form of the retroviral protease of the murine intracisternal A-type particle, inMIA-14 PR
Motáčková, Veronika, Kubíčková, Monika, Kožíšek, Milan, Šašková, Klára Grantz, Švec, Martin, Žídek, Lukáš, Sklenář, Vladimír
Published in Biomolecular NMR assignments (01.12.2009)
Published in Biomolecular NMR assignments (01.12.2009)
Get full text
Journal Article
Capturing a dynamically interacting inhibitor by paramagnetic NMR spectroscopyElectronic supplementary information (ESI) available. See DOI: 10.1039/c9cp00416e
Srb, Pavel, Svoboda, Michal, Benda, Ladislav, Lepšík, Martin, Tarábek, Ján, Šícha, Václav, Grüner, Bohumír, Grantz-Šašková, Klára, Brynda, Ji í, ezá ová, Pavlína, Konvalinka, Jan, Veverka, Václav
Year of Publication 06.03.2019
Year of Publication 06.03.2019
Get full text
Journal Article
GS-8374, a Prototype Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits Protease Mutants with Amino Acid Insertions
Grantz Šašková, Klára, Kozíšek, Milan, Stray, Kirsten, de Jong, Dorien, Rezáová, Pavlína, Brynda, Jirí, van Maarseveen, Noortje M, Nijhuis, Monique, Cihlár, Tomáš, Konvalinka, Jan
Published in Journal of Virology (01.03.2014)
Published in Journal of Virology (01.03.2014)
Get full text
Journal Article
Lipid Nanoparticles for Broad‐Spectrum Nucleic Acid Delivery
Hejdankova, Zuzana, Vanek, Vaclav, Sedlak, Frantisek, Prochazka, Jan, Diederichs, Audrey, Kereïche, Sami, Novotna, Barbora, Budesinsky, Milos, Birkus, Gabriel, Grantz Saskova, Klara, Cigler, Petr
Published in Advanced functional materials (01.11.2021)
Published in Advanced functional materials (01.11.2021)
Get full text
Journal Article
The yeast proteases Ddi1 and Wss1 are both involved in the DNA replication stress response
Svoboda, Michal, Konvalinka, Jan, Trempe, Jean-François, Grantz Saskova, Klara
Published in DNA repair (01.08.2019)
Published in DNA repair (01.08.2019)
Get full text
Journal Article