N-(4-Tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a Novel, Orally Effective Vanilloid Receptor 1 Antagonist with Analgesic Properties: I. In Vitro Characterization and Pharmacokinetic Properties
Valenzano, Kenneth J, Grant, Elfrida R, Wu, Gang, Hachicha, Mohamed, Schmid, Lori, Tafesse, Laykea, Sun, Qun, Rotshteyn, Yakov, Francis, Joseph, Limberis, James, Malik, Shiazah, Whittemore, Edward R, Hodges, Dianne
Published in The Journal of pharmacology and experimental therapeutics (01.07.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2003)
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Journal Article
Simultaneous Intracellular Calcium and Sodium Flux Imaging in Human Vanilloid Receptor 1 (VR1)-Transfected Human Embryonic Kidney Cells: A Method to Resolve Ionic Dependence of VR1-Mediated Cell Death
Grant, Elfrida R, Dubin, Adrienne E, Zhang, Sui-Po, Zivin, Robert A, Zhong, Zhong
Published in The Journal of pharmacology and experimental therapeutics (01.01.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2002)
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Journal Article
Apolipoprotein E Protects against NMDA Excitotoxicity
Aono, Mitsuo, Lee, Yoonki, Grant, Elfrida R., Zivin, Robert A., Pearlstein, Robert D., Warner, David S., Bennett, Ellen R., Laskowitz, Daniel T.
Published in Neurobiology of disease (01.10.2002)
Published in Neurobiology of disease (01.10.2002)
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Journal Article
Cytochrome P450 Induction in Rat Hepatocytes Assessed by Quantitative Real-Time Reverse-Transcription Polymerase Chain Reaction and the RNA Invasive Cleavage Assay
BURCZYNSKI, Michael E, MCMILLIAN, Michael, PARKER, James B, BRYANT, Stewart, LEONE, Angelique, GRANT, Elfrida R, THORNE, Jacqueline M, ZHONG ZHONG, ZIVIN, Robert A, JOHNSON, Mark D
Published in Drug metabolism and disposition (01.09.2001)
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Published in Drug metabolism and disposition (01.09.2001)
Journal Article
Protection against glutamate toxicity through inhibition of the p44/42 mitogen-activated protein kinase pathway in neuronally differentiated P19 cells
Grant, Elfrida R., Errico, Monica A., Emanuel, Stuart L., Benjamin, Daniel, McMillian, Michael K., Wadsworth, Scott A., Zivin, Robert A., Zhong, Zhong
Published in Biochemical pharmacology (01.08.2001)
Published in Biochemical pharmacology (01.08.2001)
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Journal Article
N-Methyl-D-aspartate Receptors Expressed in a Nonneuronal Cell Line Mediate Subunit-specific Increases in Free Intracellular Calcium
Grant, E R, Bacskai, B J, Pleasure, D E, Pritchett, D B, Gallagher, M J, Kendrick, S J, Kricka, L J, Lynch, D R
Published in The Journal of biological chemistry (03.01.1997)
Published in The Journal of biological chemistry (03.01.1997)
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Journal Article
The NR2B-specific interactions of polyamines and protons with the N-methyl-D-aspartate receptor
Gallagher, M J, Huang, H, Grant, E R, Lynch, D R
Published in The Journal of biological chemistry (03.10.1997)
Published in The Journal of biological chemistry (03.10.1997)
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Journal Article
Protection against glutamate toxicity through inhibition of the p44/42 mitogen-activated protein kinase pathway in neuronally differentiated P19 cells22Abbreviations: AMPA, (±)-α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid; NMDA, N-methyl-d-aspartate; MAP, mitogen-activated protein; ERK1/2, extracellular signal regulated kinase 1/2; MEK, mitogen-activated protein kinase kinase; JNK, Jun N-terminal kinase; NO, nitric oxide; CDK1, cyclin-dependent kinase I; PKA, protein kinase A; PKC, prote
Grant, Elfrida R., Errico, Monica A., Emanuel, Stuart L., Benjamin, Daniel, McMillian, Michael K., Wadsworth, Scott A., Zivin, Robert A., Zhong, Zhong
Published in Biochemical pharmacology (01.08.2001)
Published in Biochemical pharmacology (01.08.2001)
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Journal Article
N-Methyl- d-aspartate receptor mediated toxicity in nonneuronal cell lines: characterization using fluorescent measures of cell viability and reactive oxygen species production
Anegawa, Norifusa J., Guttmann, Rodney P., Grant, Elfrida R., Anand, Rene, Lindstrom, Jon, Lynch, David R.
Published in Brain research. Molecular brain research. (05.05.2000)
Published in Brain research. Molecular brain research. (05.05.2000)
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Journal Article
Neuroprotective 2-pyridinamine compositions and related methods
ZIVIN ROBERT ALLAN, BROWN FRANK K, ZHONG ZHONG, MCMILLIAN MICHAEL, GRANT ELFRIDA R, BENJAMIN DANIEL
Year of Publication 06.07.2005
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Year of Publication 06.07.2005
Patent
2-pyridinamine compositions and related methods
DANIEL BENJAMIN, ZHONG ZHONG, ROBERT ALLAN ZIVIN, ELFRIDA R. GRANT, FRANK K. BROWN, MICHAEL MCMILLAN
Year of Publication 07.07.2004
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Year of Publication 07.07.2004
Patent
2-pyridinamine compositions and related methods
ZIVIN ROBERT ALLAN, BROWN FRANK K, ZHONG ZHONG, MCMILLIAN MICHAEL, GRANT ELFRIDA R, BENJAMIN DANIEL
Year of Publication 04.12.2003
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Year of Publication 04.12.2003
Patent
NEUROPROTECTIVE 2-PYRIDINAMINE COMPOSITIONS AND RELATED METHODS
ZIVIN, ROBERT, ALLAN, BENJAMIN, DANIEL, BROWN, FRANK, K, ZHONG, ZHONG, GRANT, ELFRIDA, R, MCMILLAN, MICHAEL
Year of Publication 11.06.2003
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Year of Publication 11.06.2003
Patent