Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors
Powers, Rani K., Culp-Hill, Rachel, Ludwig, Michael P., Smith, Keith P., Waugh, Katherine A., Minter, Ross, Tuttle, Kathryn D., Lewis, Hannah C., Rachubinski, Angela L., Granrath, Ross E., Carmona-Iragui, María, Wilkerson, Rebecca B., Kahn, Darcy E., Joshi, Molishree, Lleó, Alberto, Blesa, Rafael, Fortea, Juan, D’Alessandro, Angelo, Costello, James C., Sullivan, Kelly D., Espinosa, Joaquin M.
Published in Nature communications (18.10.2019)
Published in Nature communications (18.10.2019)
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Journal Article
Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome
Waugh, Katherine A., Araya, Paula, Pandey, Ahwan, Jordan, Kimberly R., Smith, Keith P., Granrath, Ross E., Khanal, Santosh, Butcher, Eric T., Estrada, Belinda Enriquez, Rachubinski, Angela L., McWilliams, Jennifer A., Minter, Ross, Dimasi, Tiana, Colvin, Kelley L., Baturin, Dmitry, Pham, Andrew T., Galbraith, Matthew D., Bartsch, Kyle W., Yeager, Michael E., Porter, Christopher C., Sullivan, Kelly D., Hsieh, Elena W., Espinosa, Joaquin M.
Published in Cell reports (Cambridge) (12.11.2019)
Published in Cell reports (Cambridge) (12.11.2019)
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Journal Article
Variegated overexpression of chromosome 21 genes reveals molecular and immune subtypes of Down syndrome
Donovan, Micah G., Eduthan, Neetha P., Smith, Keith P., Britton, Eleanor C., Lyford, Hannah R., Araya, Paula, Granrath, Ross E., Waugh, Katherine A., Enriquez Estrada, Belinda, Rachubinski, Angela L., Sullivan, Kelly D., Galbraith, Matthew D., Espinosa, Joaquin M.
Published in Nature communications (28.06.2024)
Published in Nature communications (28.06.2024)
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Journal Article
Seroconversion stages COVID19 into distinct pathophysiological states
Galbraith, Matthew D, Kinning, Kohl T, Sullivan, Kelly D, Baxter, Ryan, Araya, Paula, Jordan, Kimberly R, Russell, Seth, Smith, Keith P, Granrath, Ross E, Shaw, Jessica R, Dzieciatkowska, Monika, Ghosh, Tusharkanti, Monte, Andrew A, D'Alessandro, Angelo, Hansen, Kirk C, Benett, Tellen D, Hsieh, Elena Wy, Espinosa, Joaquín M
Published in eLife (16.03.2021)
Published in eLife (16.03.2021)
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Journal Article
Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome
Donovan, Micah G., Rachubinski, Angela L., Smith, Keith P., Araya, Paula, Waugh, Katherine A., Enriquez-Estrada, Belinda, Britton, Eleanor C., Lyford, Hannah R., Granrath, Ross E., Schade, Kyndal A., Kinning, Kohl T., Paul Eduthan, Neetha, Sullivan, Kelly D., Galbraith, Matthew D., Espinosa, Joaquin M.
Published in Cell reports (Cambridge) (27.08.2024)
Published in Cell reports (Cambridge) (27.08.2024)
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Journal Article
Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity
Araya, Paula, Waugh, Katherine A., Sullivan, Kelly D., Núñez, Nicolás G., Roselli, Emiliano, Smith, Keith P., Granrath, Ross E., Rachubinski, Angela L., Estrada, Belinda Enriquez, Butcher, Eric T., Minter, Ross, Tuttle, Kathryn D., Bruno, Tullia C., Maccioni, Mariana, Espinosa, Joaquín M.
Published in Proceedings of the National Academy of Sciences - PNAS (26.11.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (26.11.2019)
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Journal Article
Specialized interferon action in COVID-19
Galbraith, Matthew D, Kinning, Kohl T, Sullivan, Kelly D, Araya, Paula, Smith, Keith P, Granrath, Ross E, Shaw, Jessica R, Baxter, Ryan, Jordan, Kimberly R, Russell, Seth, Dzieciatkowska, Monika, Reisz, Julie A, Gamboni, Fabia, Cendali, Francesca, Ghosh, Tusharkanti, Guo, Kejun, Wilson, Cara C, Santiago, Mario L, Monte, Andrew A, Bennett, Tellen D, Hansen, Kirk C, Hsieh, Elena W Y, D'Alessandro, Angelo, Espinosa, Joaquin M
Published in Proceedings of the National Academy of Sciences - PNAS (15.03.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (15.03.2022)
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Journal Article
Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model
Waugh, Katherine A., Minter, Ross, Baxter, Jessica, Chi, Congwu, Galbraith, Matthew D., Tuttle, Kathryn D., Eduthan, Neetha P., Kinning, Kohl T., Andrysik, Zdenek, Araya, Paula, Dougherty, Hannah, Dunn, Lauren N., Ludwig, Michael, Schade, Kyndal A., Tracy, Dayna, Smith, Keith P., Granrath, Ross E., Busquet, Nicolas, Khanal, Santosh, Anderson, Ryan D., Cox, Liza L., Estrada, Belinda Enriquez, Rachubinski, Angela L., Lyford, Hannah R., Britton, Eleanor C., Fantauzzo, Katherine A., Orlicky, David J., Matsuda, Jennifer L., Song, Kunhua, Cox, Timothy C., Sullivan, Kelly D., Espinosa, Joaquin M.
Published in Nature genetics (01.06.2023)
Published in Nature genetics (01.06.2023)
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Journal Article
IGF1 deficiency integrates stunted growth and neurodegeneration in Down syndrome
Araya, Paula, Kinning, Kohl T., Coughlan, Christina, Smith, Keith P., Granrath, Ross E., Enriquez-Estrada, Belinda A., Worek, Kayleigh, Sullivan, Kelly D., Rachubinski, Angela L., Wolter-Warmerdam, Kristine, Hickey, Francis, Galbraith, Matthew D., Potter, Huntington, Espinosa, Joaquin M.
Published in Cell reports (Cambridge) (27.12.2022)
Published in Cell reports (Cambridge) (27.12.2022)
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Journal Article
Multidimensional definition of the interferonopathy of Down syndrome and its response to JAK inhibition
Galbraith, Matthew D, Rachubinski, Angela L, Smith, Keith P, Araya, Paula, Waugh, Katherine A, Enriquez-Estrada, Belinda, Worek, Kayleigh, Granrath, Ross E, Kinning, Kohl T, Paul Eduthan, Neetha, Ludwig, Michael P, Hsieh, Elena W Y, Sullivan, Kelly D, Espinosa, Joaquin M
Published in Science advances (28.06.2023)
Published in Science advances (28.06.2023)
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Journal Article
Precocious clonal hematopoiesis in Down syndrome is accompanied by immune dysregulation
Liggett, L. Alexander, Galbraith, Matthew D., Smith, Keith P., Sullivan, Kelly D., Granrath, Ross E., Enriquez-Estrada, Belinda, Kinning, Kohl T., Shaw, Jessica R., Rachubinski, Angela L., Espinosa, Joaquin M., DeGregori, James
Published in Blood advances (13.04.2021)
Published in Blood advances (13.04.2021)
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Journal Article
Seroconversion stages COVID19 into distinct pathophysiological states
Galbraith, Matthew D, Kinning, Kohl T, Sullivan, Kelly D, Baxter, Ryan, Araya, Paula, Jordan, Kimberly R, Russell, Seth, Smith, Keith P, Granrath, Ross E, Shaw, Jessica, Dzieciatkowska, Monika, Ghosh, Tusharkanti, Monte, Andrew A, D'Alessandro, Angelo, Hansen, Kirk C, Bennett, Tellen D, Hsieh, Elena W Y, Espinosa, Joaquin M
Published in medRxiv : the preprint server for health sciences (07.12.2020)
Published in medRxiv : the preprint server for health sciences (07.12.2020)
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Journal Article
The COVIDome Explorer Researcher Portal
Sullivan, Kelly D, Galbraith, Matthew D, Kinning, Kohl T, Bartsch, Kyle, Levinsky, Nik, Araya, Paula, Smith, Keith P, Granrath, Ross E, Shaw, Jessica R, Baxter, Ryan, Jordan, Kimberly R, Russell, Seth, Dzieciatkowska, Monika, Reisz, Julie A, Gamboni, Fabia, Cendali, Francesca, Ghosh, Tusharkanti, Monte, Andrew A, Bennett, Tellen D, Miller, Michael G, Hsieh, Elena W Y, D'Alessandro, Angelo, Hansen, Kirk C, Espinosa, Joaquin M
Published in medRxiv : the preprint server for health sciences (08.03.2021)
Published in medRxiv : the preprint server for health sciences (08.03.2021)
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The COVIDome Explorer researcher portal
Sullivan, Kelly Daniel, Galbraith, Matthew Dominic, Kinning, Kohl Thomas, Bartsch, Kyle William, Levinsky, Nik Caldwell, Araya, Paula, Smith, Keith Patrick, Granrath, Ross Erich, Shaw, Jessica Rose, Baxter, Ryan Michael, Jordan, Kimberly Rae, Russell, Seth Aaron, Dzieciatkowska, Monika Ewa, Reisz, Julie Ann, Gamboni, Fabia, Cendali, Francesca Isabelle, Ghosh, Tusharkanti, Monte, Andrew Albert, Bennett, Tellen Demeke, Miller, Michael George, Hsieh, Elena Wen-Yuan, D’Alessandro, Angelo, Hansen, Kirk Charles, Espinosa, Joaquin Maximiliano
Published in Cell reports (Cambridge) (17.08.2021)
Published in Cell reports (Cambridge) (17.08.2021)
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Journal Article
Mass-cytometry reveals global immune remodeling with multi-lineage hypersensitivity to Type I Interferon in Down syndrome
Waugh, Katherine A., Pandey, Ahwan, Jordan, Kimberly R, Smith, Keith P, Granrath, Ross E, Khanal, Santosh, Butcher, Eric T, Rachubinski, Angela L, McWilliams, Jennifer A, Araya, Paula, Minter, Ross, Dimasi, Tiana, Colvin, Kelley L., Baturin, Dmitry, Pham, Andrew T, Galbraith, Matthew D, Yeager, Michael E., Sullivan, Kelly D, Porter, Christopher C, Hsieh, Elena W, Espinosa, Joaquin M
Published in The Journal of immunology (1950) (01.05.2019)
Published in The Journal of immunology (1950) (01.05.2019)
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Journal Article
Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors
Powers, Rani K, Sullivan, Kelly D, Culp-Hill, Rachel, Ludwig, Michael P, Smith, Keith P, Waugh, Katherine A, Minter, Ross, Tuttle, Kathryn D, Lewis, Hannah C, Rachubinski, Angela L, Granrath, Ross E, Wilkerson, Rebecca B, Kahn, Darcy E, Joshi, Molishree, D'alessandro, Angelo, Costello, James C, Espinosa, Joaquín M
Published in bioRxiv (11.01.2019)
Published in bioRxiv (11.01.2019)
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Paper
JAK inhibition decreases the autoimmune burden in Down syndrome
Rachubinski, Angela L, Wallace, Elizabeth, Gurnee, Emily, Enriquez Estrada, Belinda A, Worek, Kayleigh R, Smith, Keith P, Araya, Paula, Waugh, Katherine A, Granrath, Ross E, Britton, Eleanor, Lyford, Hannah R, Donovan, Micah G, Eduthan, Neetha Paul, Hill, Amanda A, Martin, Barry, Sullivan, Kelly D, Patel, Lina, Fidler, Deborah J, Galbraith, Matthew D, Dunnick, Cory A, Norris, David A, Espinosa, Joaquin M
Published in medRxiv : the preprint server for health sciences (14.06.2024)
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Published in medRxiv : the preprint server for health sciences (14.06.2024)
Journal Article
Interferon receptor gene dosage determines multiple hallmarks of Down syndrome
Waugh, Katherine A, Minter, Ross, Baxter, Jessica, Chi, Congwu, Tuttle, Kathryn D, Eduthan, Neetha P, Galbraith, Matthew D, Kinning, Kohl T, Andrysik, Zdenek, Araya, Paula, Dougherty, Hannah, Dunn, Lauren N, Ludwig, Michael, Schade, Kyndal A, Tracy, Dayna, Smith, Keith P, Granrath, Ross E, Busquet, Nicolas, Khanal, Santosh, Anderson, Ryan D, Cox, Liza L, Belinda Enriquez Estrada, Rachubinski, Angela L, Lyford, Hannah R, Britton, Eleanor C, Orlicky, David J, Matsuda, Jennifer L, Song, Kunhua, Cox, Timothy C, Sullivan, Kelly D, Espinosa, Joaquin M
Published in bioRxiv (05.02.2022)
Published in bioRxiv (05.02.2022)
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