Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy
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Published in Journal of medicinal chemistry (08.04.2021)
Published in Journal of medicinal chemistry (08.04.2021)
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Novel Inhibitor Binding Site Discovery on HIV‑1 Capsid N‑Terminal Domain by NMR and X‑ray Crystallography
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Published in ACS chemical biology (17.05.2013)
Published in ACS chemical biology (17.05.2013)
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Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly
Fader, Lee D., Bethell, Richard, Bonneau, Pierre, Bös, Michael, Bousquet, Yves, Cordingley, Michael G., Coulombe, René, Deroy, Patrick, Faucher, Anne-Marie, Gagnon, Alexandre, Goudreau, Nathalie, Grand-Maître, Chantal, Guse, Ingrid, Hucke, Oliver, Kawai, Stephen H., Lacoste, Jean-Eric, Landry, Serge, Lemke, Christopher T., Malenfant, Eric, Mason, Stephen, Morin, Sébastien, O’Meara, Jeff, Simoneau, Bruno, Titolo, Steve, Yoakim, Christiane
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Monitoring Binding of HIV-1 Capsid Assembly Inhibitors Using 19F Ligand-and 15N Protein-Based NMR and X-ray Crystallography: Early Hit Validation of a Benzodiazepine Series
Goudreau, Nathalie, Coulombe, René, Faucher, Anne-Marie, Grand-Maître, Chantal, Lacoste, Jean-Eric, Lemke, Christopher T., Malenfant, Eric, Bousquet, Yves, Fader, Lee, Simoneau, Bruno, Mercier, Jean-François, Titolo, Steve, Mason, Stephen W.
Published in ChemMedChem (01.03.2013)
Published in ChemMedChem (01.03.2013)
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Potent Inhibitors of the Hepatitis C Virus NS3 Protease: Design and Synthesis of Macrocyclic Substrate-Based β-Strand Mimics
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Published in Journal of organic chemistry (17.09.2004)
Published in Journal of organic chemistry (17.09.2004)
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Year of Publication 22.05.2023
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Year of Publication 22.05.2023
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Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease
Terrett, Jack A., Ly, Justin Q., Katavolos, Paula, Hasselgren, Catrin, Laing, Steven, Zhong, Fiona, Villemure, Elisia, Déry, Martin, Larouche-Gauthier, Robin, Chen, Huifen, Shore, Daniel G., Lee, Wyne P., Suto, Eric, Johnson, Kevin, Brooks, Marjory, Stablein, Alyssa, Beaumier, Francis, Constantineau-Forget, Léa, Grand-Maître, Chantal, Lépissier, Luce, Ciblat, Stéphane, Sturino, Claudio, Chen, Yong, Hu, Baihua, Elstrott, Justin, Gandham, Vineela, Joseph, Victory, Booler, Helen, Cain, Gary, Chou, Carolina, Fullerton, Aaron, Lepherd, Michelle, Stainton, Shannon, Torres, Elizabeth, Urban, Konnie, Yu, Lanlan, Zhong, Yu, Bao, Linda, Chou, Kang-Jye, Lin, Jessica, Zhang, Wei, La, Hank, Liu, Liling, Mulder, Teresa, Chen, Jun, Chernov-Rogan, Tania, Johnson, Adam R., Hackos, David H., Leahey, Rebecca, Shields, Shannon D., Balestrini, Alessia, Riol-Blanco, Lorena, Safina, Brian S., Volgraf, Matthew, Magnuson, Steven, Kakiuchi-Kiyota, Satoko
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
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옥사디아졸 일시적 수용체 전위 채널 억제제
LEPISSIER LUCE, DERY MARTIN, LAROUCHE GAUTHIER ROBIN, VOLGRAF MATTHEW, BEAUMIER FRANCIS, CHEN HUIFEN, CONSTANTINEAU FORGET LEA, GRAND MAITRE CHANTAL, STURINO CLAUDIO, TERRETT JACK ALEXANDER, VILLEMURE ELISIA
Year of Publication 27.11.2020
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Year of Publication 27.11.2020
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Discovery and Structural Characterization of a New Inhibitor Series of HIV-1 Nucleocapsid Function: NMR Solution Structure Determination of a Ternary Complex Involving a 2:1 Inhibitor/NC Stoichiometry
Goudreau, Nathalie, Hucke, Oliver, Faucher, Anne-Marie, Grand-Maître, Chantal, Lepage, Olivier, Bonneau, Pierre R., Mason, Stephen W., Titolo, Steve
Published in Journal of molecular biology (12.06.2013)
Published in Journal of molecular biology (12.06.2013)
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Structure−Activity Study on a Novel Series of Macrocyclic Inhibitors of the Hepatitis C Virus NS3 Protease Leading to the Discovery of BILN 2061
Llinàs-Brunet, Montse, Bailey, Murray D, Bolger, Gordon, Brochu, Christian, Faucher, Anne-Marie, Ferland, Jean Marie, Garneau, Michel, Ghiro, Elise, Gorys, Vida, Grand-Maître, Chantal, Halmos, Ted, Lapeyre-Paquette, Nicole, Liard, Francine, Poirier, Martin, Rhéaume, Manon, Tsantrizos, Youla S, Lamarre, Daniel
Published in Journal of medicinal chemistry (25.03.2004)
Published in Journal of medicinal chemistry (25.03.2004)
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Preparation of 3-O-aryl chloramphenicol derivatives via chemoselective copper-catalyzed O-arylation of (1R,2R)-(-)-N-BOC2-amino-1-(4-nitropheny1)-1,3-propanediol using triarylbismuthines
Ahmad, Tabinda, Dansereau, Julien, Hebert, Martin, Grand-Maitre, Chantal, Larivee, Alexandre, Siddiqui, Arshad, Gagnon, Alexandre
Published in Tetrahedron letters (21.09.2016)
Published in Tetrahedron letters (21.09.2016)
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QUINAZOLINE BASED RESPIRATORY SYNCYTIAL VIRUS INHIBITORS
JAKALIAN ARAZ, BROCHU CHRISTIAN, DEROY PATRICK, HALMOS TEDDY, MORENCY LOUIS, TREMBLAY MARTIN, DECOR ANNE, GRAND MAITRE CHANTAL, KUHN CYRILLE, STURINO CLAUDIO, DUPLESSIS MARTIN
Year of Publication 29.06.2016
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Year of Publication 29.06.2016
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Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus
Décor, Anne, Grand-Maître, Chantal, Hucke, Oliver, O’Meara, Jeff, Kuhn, Cyrille, -Forget, Léa Constantineau, Brochu, Christian, Malenfant, Eric, Bertrand-Laperle, Mégan, Bordeleau, Josée, Ghiro, Elise, Pesant, Marc, Fazal, Gulrez, Gorys, Vida, Little, Michael, Boucher, Colette, Bordeleau, Sylvain, Turcotte, Pascal, Guo, Tim, Garneau, Michel, Spickler, Catherine, Gauthier, Annick
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
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1-Thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives as antitumor agents
Cooper, Alan B., Ciblat, Stephane, Shipps, Gerald, Levine, Jedd, Kostura, Matthew, Oza, Vibha, Constantineau-Forget, Lea, Dery, Martin, Grand-Maitre, Chantal, Bruneau-Latour, Nicolas, Bellavance, Edith, Patane, Michael, Siddiqui, Arshad, Luther, Michael
Published in Bioorganic & medicinal chemistry letters (15.09.2017)
Published in Bioorganic & medicinal chemistry letters (15.09.2017)
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Corrigendum to “1-Thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives as antitumor agents” [Bioorg. Med. Chem. Lett. 27 (2017) 4471–4477]
Cooper, Alan B., Ciblat, Stephane, Shipps, Gerald, Levine, Jedd, Kostura, Matthew, Oza, Vibha, Constantineau-Forget, Lea, Dery, Martin, Grand-Maitre, Chantal, Bruneau-Latour, Nicolas, Bellavance, Edith, Patane, Michael, Siddiqui, Arshad, Luther, Michael
Published in Bioorganic & medicinal chemistry letters (01.03.2018)
Published in Bioorganic & medicinal chemistry letters (01.03.2018)
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Journal Article
Monitoring Binding of HIV-1 Capsid Assembly Inhibitors Using super(19)F Ligand-and super(15)N Protein-Based NMR and X-ray Crystallography: Early Hit Validation of a Benzodiazepine Series
Goudreau, Nathalie, Coulombe, Rene, Faucher, Anne-Marie, Grand-Maitre, Chantal, Lacoste, Jean-Eric, Lemke, Christopher T, Malenfant, Eric, Bousquet, Yves, Fader, Lee, Simoneau, Bruno, Mercier, Jean-Francois, Titolo, Steve, Mason, Stephen W
Published in ChemMedChem (01.03.2013)
Published in ChemMedChem (01.03.2013)
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Characterization of the Human Cytomegalovirus Protease As an Induced-Fit Serine Protease and the Implications to the Design of Mechanism-Based Inhibitors
LaPlante, Steven R, Bonneau, Pierre R, Aubry, Norman, Cameron, Dale R, Déziel, Robert, Grand-Maître, Chantal, Plouffe, Céline, Tong, Liang, Kawai, Stephen H
Published in Journal of the American Chemical Society (07.04.1999)
Published in Journal of the American Chemical Society (07.04.1999)
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Journal Article
Preparation of 3-O-aryl chloramphenicol derivatives via chemoselective copper-catalyzed O-arylation of (1R,2R)-(−)-N-BOC-2-amino-1-(4-nitrophenyl)-1,3-propanediol using triarylbismuthines
Ahmad, Tabinda, Dansereau, Julien, Hébert, Martin, Grand-Maître, Chantal, Larivée, Alexandre, Siddiqui, Arshad, Gagnon, Alexandre
Published in Tetrahedron letters (21.09.2016)
Published in Tetrahedron letters (21.09.2016)
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