Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice
Milnerwood, Austen J., Gladding, Clare M., Pouladi, Mahmoud A., Kaufman, Alexandra M., Hines, Rochelle M., Boyd, Jamie D., Ko, Rebecca W.Y., Vasuta, Oana C., Graham, Rona K., Hayden, Michael R., Murphy, Timothy H., Raymond, Lynn A.
Published in Neuron (Cambridge, Mass.) (28.01.2010)
Published in Neuron (Cambridge, Mass.) (28.01.2010)
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Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin
Talantova, Maria, Kaul, Marcus, Yao, Dongdong, Xia, Peng, Ehrnhoefer, Dagmar E, Zaidi, Rameez, Lipton, Stuart A, Graham, Rona K, Tong, Gary, Zhang, Dongxian, Clemente, Arjay, Okamoto, Shu-ichi, Hayden, Michael R, Pouladi, Mahmoud A, Vincent Chen, H-S
Published in Nature medicine (01.12.2009)
Published in Nature medicine (01.12.2009)
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Cleavage at the Caspase-6 Site Is Required for Neuronal Dysfunction and Degeneration Due to Mutant Huntingtin
Graham, Rona K., Deng, Yu, Slow, Elizabeth J., Haigh, Brendan, Bissada, Nagat, Lu, Ge, Pearson, Jacqueline, Shehadeh, Jacqueline, Bertram, Lisa, Murphy, Zoe, Warby, Simon C., Doty, Crystal N., Roy, Sophie, Wellington, Cheryl L., Leavitt, Blair R., Raymond, Lynn A., Nicholson, Donald W., Hayden, Michael R.
Published in Cell (16.06.2006)
Published in Cell (16.06.2006)
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Activation of caspase‐6 and cleavage of caspase‐6 substrates is an early event in NMDA receptor–mediated excitotoxicity
Girling, Kimberly D., Demers, Marie‐Josee, Laine, Jean, Zhang, Shu, Wang, Yu Tian, Graham, Rona K.
Published in Journal of neuroscience research (01.03.2018)
Published in Journal of neuroscience research (01.03.2018)
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Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice
Wong, Bibiana K.Y, Ehrnhoefer, Dagmar E, Graham, Rona K, Martin, Dale D.O, Ladha, Safia, Uribe, Valeria, Stanek, Lisa M, Franciosi, Sonia, Qiu, Xiaofan, Deng, Yu, Kovalik, Vlad, Zhang, Weining, Pouladi, Mahmoud A, Shihabuddin, Lamya S, Hayden, Michael R
Published in Neurobiology of disease (01.04.2015)
Published in Neurobiology of disease (01.04.2015)
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Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease
Zhang, Hua, Li, Qin, Graham, Rona K, Slow, Elizabeth, Hayden, Michael R, Bezprozvanny, Ilya
Published in Neurobiology of disease (01.07.2008)
Published in Neurobiology of disease (01.07.2008)
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Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease
Wang, Chuan-En, Tydlacka, Suzanne, Orr, Adam L., Yang, Shang-Hsun, Graham, Rona K., Hayden, Michael R., Li, Shihua, Chan, Anthony W.S., Li, Xiao-Jiang
Published in Human molecular genetics (01.09.2008)
Published in Human molecular genetics (01.09.2008)
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Absence of Behavioral Abnormalities and Neurodegeneration in vivo despite Widespread Neuronal Huntingtin Inclusions
Slow, Elizabeth J., Graham, Rona K., Osmand, Alexander P., Devon, Rebecca S., Lu, Ge, Deng, Yu, Pearson, Jacqui, Vaid, Kuljeet, Bissada, Nagat, Wetzel, Ronald, Leavitt, Blair R., Hayden, Michael R., Palmiter, Richard D.
Published in Proceedings of the National Academy of Sciences - PNAS (09.08.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (09.08.2005)
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Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice
URIBE, Valeria, WONG, Bibiana K. Y, YU DENG, FRANCIOSI, Sonia, BISSADA, Nagat, SPREEUW, Amanda, WEINING ZHANG, EHRNHOEFER, Dagmar E, VAID, Kuljeet, MILLER, Freda D, DESHMUKH, Mohanish, HOWLAND, David, GRAHAM, Rona K, HARDEN, Michael R, CUSACK, Corey L, SKOTTE, Niels H, POULADI, Mahmoud A, YUANYUN XIE, FEINBERG, Konstantin, YIMIAO OU, YINGBIN OUYANG
Published in Human molecular genetics (01.05.2012)
Published in Human molecular genetics (01.05.2012)
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Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin
Waldron-Roby, Elaine, Ratovitski, Tamara, Wang, XiaoFang, Jiang, Mali, Watkin, Erin, Arbez, Nikolas, Graham, Rona K, Hayden, Michael R, Hou, Zhipeng, Mori, Susumu, Swing, Deborah, Pletnikov, Mikhail, Duan, Wenzhen, Tessarollo, Lino, Ross, Christopher A
Published in The Journal of neuroscience (04.01.2012)
Published in The Journal of neuroscience (04.01.2012)
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NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease
Pouladi, Mahmoud A, Brillaud, Elsa, Xie, Yuanyun, Conforti, Paola, Graham, Rona K, Ehrnhoefer, Dagmar E, Franciosi, Sonia, Zhang, Weining, Poucheret, Patrick, Compte, Elsa, Maurel, Jean-Claude, Zuccato, Chiara, Cattaneo, Elena, Néri, Christian, Hayden, Michael R
Published in Neurobiology of disease (01.12.2012)
Published in Neurobiology of disease (01.12.2012)
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Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity
Stroedicke, Martin, Bounab, Yacine, Strempel, Nadine, Klockmeier, Konrad, Yigit, Sargon, Friedrich, Ralf P, Chaurasia, Gautam, Li, Shuang, Hesse, Franziska, Riechers, Sean-Patrick, Russ, Jenny, Nicoletti, Cecilia, Boeddrich, Annett, Wiglenda, Thomas, Haenig, Christian, Schnoegl, Sigrid, Fournier, David, Graham, Rona K, Hayden, Michael R, Sigrist, Stephan, Bates, Gillian P, Priller, Josef, Andrade-Navarro, Miguel A, Futschik, Matthias E, Wanker, Erich E
Published in Genome research (01.05.2015)
Published in Genome research (01.05.2015)
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Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice
Guidetti, Paolo, Bates, Gillian P., Graham, Rona K., Hayden, Michael R., Leavitt, Blair R., MacDonald, Marcy E., Slow, Elizabeth J., Wheeler, Vanessa C., Woodman, Ben, Schwarcz, Robert
Published in Neurobiology of disease (01.07.2006)
Published in Neurobiology of disease (01.07.2006)
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Journal Article
Wild‐type huntingtin protects neurons from excitotoxicity
Leavitt, Blair R., Raamsdonk, Jeremy M., Shehadeh, Jacqueline, Fernandes, Herman, Murphy, Zoe, Graham, Rona K., Wellington, Cheryl L., Hayden, Michael R.
Published in Journal of neurochemistry (01.02.2006)
Published in Journal of neurochemistry (01.02.2006)
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Journal Article
Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain
Van Raamsdonk, Jeremy M, Metzler, Martina, Slow, Elizabeth, Pearson, Jacqueline, Schwab, Claudia, Carroll, Jeffrey, Graham, Rona K, Leavitt, Blair R, Hayden, Michael R
Published in Neurobiology of disease (01.04.2007)
Published in Neurobiology of disease (01.04.2007)
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Journal Article
Polyglutamine-Modulated Striatal Calpain Activity in YAC Transgenic Huntington Disease Mouse Model: Impact on NMDA Receptor Function and Toxicity
Cowan, Catherine M, Fan, Mannie M. Y, Fan, Jing, Shehadeh, Jacqueline, Zhang, Lily Y. J, Graham, Rona K, Hayden, Michael R, Raymond, Lynn A
Published in The Journal of neuroscience (26.11.2008)
Published in The Journal of neuroscience (26.11.2008)
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Journal Article
Caspase Cleavage of Mutant Huntingtin Precedes Neurodegeneration in Huntington's Disease
Wellington, Cheryl L, Ellerby, Lisa M, Gutekunst, Claire-Anne, Rogers, Danny, Warby, Simon, Graham, Rona K, Loubser, Odell, van Raamsdonk, Jeremy, Singaraja, Roshni, Yang, Yu-Zhou, Gafni, Juliette, Bredesen, Dale, Hersch, Steven M, Leavitt, Blair R, Roy, Sophie, Nicholson, Donald W, Hayden, Michael R
Published in The Journal of neuroscience (15.09.2002)
Published in The Journal of neuroscience (15.09.2002)
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