Glucagon from the phylogenetically ancient paddlefish provides a template for the design of a long-acting peptide with effective anti-diabetic and anti-obesity activities
Graham, Galyna V., Conlon, J. Michael, Abdel-Wahab, Yasser H., Flatt, Peter R.
Published in European journal of pharmacology (05.07.2020)
Published in European journal of pharmacology (05.07.2020)
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Journal Article
Glucagon-related peptides from phylogenetically ancient fish reveal new approaches to the development of dual GCGR and GLP1R agonists for type 2 diabetes therapy
Graham, Galyna V., Conlon, J. Michael, Abdel-Wahab, Yasser H., Flatt, Peter R.
Published in Peptides (New York, N.Y. : 1980) (01.12.2018)
Published in Peptides (New York, N.Y. : 1980) (01.12.2018)
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Journal Article
Glucagon-like peptides-1 from phylogenetically ancient fish show potent anti-diabetic activities by acting as dual GLP1R and GCGR agonists
Graham, Galyna V., Conlon, J. Michael, Abdel-Wahab, Yasser H., Flatt, Peter R.
Published in Molecular and cellular endocrinology (15.01.2019)
Published in Molecular and cellular endocrinology (15.01.2019)
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A long-acting, dual-agonist analogue of lamprey GLP-1 shows potent insulinotropic, β-cell protective, and anorexic activities and improves glucose homeostasis in high fat-fed mice
Graham, Galyna V., McCloskey, Andrew, Abdel-Wahab, Yasser H., Conlon, J. Michael, Flatt, Peter R.
Published in Molecular and cellular endocrinology (01.01.2020)
Published in Molecular and cellular endocrinology (01.01.2020)
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Journal Article
Evaluation of the insulinotropic and glucose-lowering actions of zebrafish GIP in mammalian systems: Evidence for involvement of the GLP-1 receptor
Graham, Galyna V., Conlon, J. Michael, Abdel-Wahab, Yasser H., Gault, Victor A., Flatt, Peter R.
Published in Peptides (New York, N.Y. : 1980) (01.02.2018)
Published in Peptides (New York, N.Y. : 1980) (01.02.2018)
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Effects of long‐acting analogues of lamprey GLP‐1 and paddlefish glucagon on alpha‐ to beta‐cell transdifferentiation in an insulin‐deficient transgenic mouse model
Graham, Galyna V., Conlon, J. Michael, Moffett, R. Charlotte, Abdel‐Wahab, Yasser H., Flatt, Peter R.
Published in Journal of peptide science (01.08.2021)
Published in Journal of peptide science (01.08.2021)
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