Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer
Kather, Jakob Nikolas, Pearson, Alexander T., Halama, Niels, Jäger, Dirk, Krause, Jeremias, Loosen, Sven H., Marx, Alexander, Boor, Peter, Tacke, Frank, Neumann, Ulf Peter, Grabsch, Heike I., Yoshikawa, Takaki, Brenner, Hermann, Chang-Claude, Jenny, Hoffmeister, Michael, Trautwein, Christian, Luedde, Tom
Published in Nature medicine (01.07.2019)
Published in Nature medicine (01.07.2019)
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Gastric cancer
Smyth, Elizabeth C, Nilsson, Magnus, Grabsch, Heike I, van Grieken, Nicole CT, Lordick, Florian
Published in The Lancet (British edition) (29.08.2020)
Published in The Lancet (British edition) (29.08.2020)
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EORTC-1203-GITCG - the "INNOVATION"-trial: Effect of chemotherapy alone versus chemotherapy plus trastuzumab, versus chemotherapy plus trastuzumab plus pertuzumab, in the perioperative treatment of HER2 positive, gastric and gastroesophageal junction adenocarcinoma on pathologic response rate: a randomized phase II-intergroup trial of the EORTC-Gastrointestinal Tract Cancer Group, Korean Cancer Study Group and Dutch Upper GI-Cancer group
Wagner, Anna Dorothea, Grabsch, Heike I, Mauer, Murielle, Marreaud, Sandrine, Caballero, Carmela, Thuss-Patience, Peter, Mueller, Lothar, Elme, Annelie, Moehler, Markus Hermann, Martens, Uwe, Kang, Yoon-Koo, Rha, Sun Young, Cats, Annemieke, Tokunaga, Masanori, Lordick, Florian
Published in BMC cancer (24.05.2019)
Published in BMC cancer (24.05.2019)
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Swarm learning for decentralized artificial intelligence in cancer histopathology
Saldanha, Oliver Lester, Quirke, Philip, West, Nicholas P., James, Jacqueline A., Loughrey, Maurice B., Grabsch, Heike I., Salto-Tellez, Manuel, Alwers, Elizabeth, Cifci, Didem, Ghaffari Laleh, Narmin, Seibel, Tobias, Gray, Richard, Hutchins, Gordon G. A., Brenner, Hermann, van Treeck, Marko, Yuan, Tanwei, Brinker, Titus J., Chang-Claude, Jenny, Khader, Firas, Schuppert, Andreas, Luedde, Tom, Trautwein, Christian, Muti, Hannah Sophie, Foersch, Sebastian, Hoffmeister, Michael, Truhn, Daniel, Kather, Jakob Nikolas
Published in Nature medicine (01.06.2022)
Published in Nature medicine (01.06.2022)
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Individual Patient Data Meta-Analysis of the Value of Microsatellite Instability As a Biomarker in Gastric Cancer
Pietrantonio, Filippo, Miceli, Rosalba, Raimondi, Alessandra, Kim, Young Woo, Kang, Won Ki, Langley, Ruth E, Choi, Yoon Young, Kim, Kyoung-Mee, Nankivell, Matthew Guy, Morano, Federica, Wotherspoon, Andrew, Valeri, Nicola, Kook, Myeong-Cherl, An, Ji Yeong, Grabsch, Heike I, Fucà, Giovanni, Noh, Sung Hoon, Sohn, Tae Sung, Kim, Sung, Di Bartolomeo, Maria, Cunningham, David, Lee, Jeeyun, Cheong, Jae-Ho, Smyth, Elizabeth Catherine
Published in Journal of clinical oncology (10.12.2019)
Published in Journal of clinical oncology (10.12.2019)
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AQP5 enriches for stem cells and cancer origins in the distal stomach
Tan, Si Hui, Swathi, Yada, Tan, Shawna, Goh, Jasmine, Seishima, Ryo, Murakami, Kazuhiro, Oshima, Masanobu, Tsuji, Toshikatsu, Phuah, Phyllis, Tan, Liang Thing, Wong, Esther, Fatehullah, Aliya, Sheng, Taotao, Ho, Shamaine Wei Ting, Grabsch, Heike I., Srivastava, Supriya, Teh, Ming, Denil, Simon L. I. J., Mustafah, Seri, Tan, Patrick, Shabbir, Asim, So, Jimmy, Yeoh, Khay Guan, Barker, Nick
Published in Nature (London) (20.02.2020)
Published in Nature (London) (20.02.2020)
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Peri-operative chemotherapy with or without bevacizumab in operable oesophagogastric adenocarcinoma (UK Medical Research Council ST03): primary analysis results of a multicentre, open-label, randomised phase 2–3 trial
Cunningham, David, Prof, Stenning, Sally P, Prof, Smyth, Elizabeth C, MBBCh, Okines, Alicia F, MD, Allum, William H, MD, Rowley, Sam, MSc, Stevenson, Laura, MSc, Grabsch, Heike I, Prof, Alderson, Derek, Prof, Crosby, Thomas, FRCR, Griffin, S Michael, Prof, Mansoor, Wasat, PhD, Coxon, Fareeda Y, MBBS, Falk, Stephen J, MD, Darby, Suzanne, MBChB, Sumpter, Kate A, MD, Blazeby, Jane M, Prof, Langley, Ruth E, Prof
Published in The lancet oncology (01.03.2017)
Published in The lancet oncology (01.03.2017)
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Weakly supervised annotation‐free cancer detection and prediction of genotype in routine histopathology
Schrammen, Peter Leonard, Ghaffari Laleh, Narmin, Echle, Amelie, Truhn, Daniel, Schulz, Volkmar, Brinker, Titus J, Brenner, Hermann, Chang‐Claude, Jenny, Alwers, Elizabeth, Brobeil, Alexander, Kloor, Matthias, Heij, Lara R, Jäger, Dirk, Trautwein, Christian, Grabsch, Heike I, Quirke, Philip, West, Nicholas P, Hoffmeister, Michael, Kather, Jakob Nikolas
Published in The Journal of pathology (01.01.2022)
Published in The Journal of pathology (01.01.2022)
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Deep learning detects genetic alterations in cancer histology generated by adversarial networks
Krause, Jeremias, Grabsch, Heike I, Kloor, Matthias, Jendrusch, Michael, Echle, Amelie, Buelow, Roman David, Boor, Peter, Luedde, Tom, Brinker, Titus J, Trautwein, Christian, Pearson, Alexander T, Quirke, Philip, Jenniskens, Josien, Offermans, Kelly, Brandt, Piet A, Kather, Jakob Nikolas
Published in The Journal of pathology (01.05.2021)
Published in The Journal of pathology (01.05.2021)
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Batch Effects in MALDI Mass Spectrometry Imaging
Balluff, Benjamin, Hopf, Carsten, Porta Siegel, Tiffany, Grabsch, Heike I, Heeren, Ron M. A
Published in Journal of the American Society for Mass Spectrometry (03.03.2021)
Published in Journal of the American Society for Mass Spectrometry (03.03.2021)
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Immunophenotypes of pancreatic ductal adenocarcinoma: Meta‐analysis of transcriptional subtypes
Santiago, Ines, Yau, Christopher, Heij, Lara, Middleton, Mark R., Markowetz, Florian, Grabsch, Heike I., Dustin, Michael L., Sivakumar, Shivan
Published in International journal of cancer (15.08.2019)
Published in International journal of cancer (15.08.2019)
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Neoadjuvant cisplatin and fluorouracil versus epirubicin, cisplatin, and capecitabine followed by resection in patients with oesophageal adenocarcinoma (UK MRC OE05): an open-label, randomised phase 3 trial
Alderson, Derek, Cunningham, David, Nankivell, Matthew, Blazeby, Jane M, Griffin, S Michael, Crellin, Adrian, Grabsch, Heike I, Langer, Rupert, Pritchard, Susan, Okines, Alicia, Krysztopik, Richard, Coxon, Fareeda, Thompson, Joyce, Falk, Stephen, Robb, Clare, Stenning, Sally, Langley, Ruth E
Published in The lancet oncology (01.09.2017)
Published in The lancet oncology (01.09.2017)
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Pan-cancer image-based detection of clinically actionable genetic alterations
Kather, Jakob Nikolas, Heij, Lara R, Grabsch, Heike I, Loeffler, Chiara, Echle, Amelie, Muti, Hannah Sophie, Krause, Jeremias, Niehues, Jan M, Sommer, Kai A J, Bankhead, Peter, Kooreman, Loes F S, Schulte, Jefree J, Cipriani, Nicole A, Buelow, Roman D, Boor, Peter, Ortiz-Brüchle, Nadi-Na, Hanby, Andrew M, Speirs, Valerie, Kochanny, Sara, Patnaik, Akash, Srisuwananukorn, Andrew, Brenner, Hermann, Hoffmeister, Michael, van den Brandt, Piet A, Jäger, Dirk, Trautwein, Christian, Pearson, Alexander T, Luedde, Tom
Published in Nature cancer (01.08.2020)
Published in Nature cancer (01.08.2020)
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Effect of Pathologic Tumor Response and Nodal Status on Survival in the Medical Research Council Adjuvant Gastric Infusional Chemotherapy Trial
Smyth, Elizabeth C, Fassan, Matteo, Cunningham, David, Allum, William H, Okines, Alicia F C, Lampis, Andrea, Hahne, Jens C, Rugge, Massimo, Peckitt, Clare, Nankivell, Matthew, Langley, Ruth, Ghidini, Michele, Braconi, Chiara, Wotherspoon, Andrew, Grabsch, Heike I, Valeri, Nicola
Published in Journal of clinical oncology (10.08.2016)
Published in Journal of clinical oncology (10.08.2016)
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Efficacy of Dose-Escalated Chemoradiation on Complete Tumor Response in Patients with Locally Advanced Rectal Cancer (RECTAL-BOOST): A Phase 2 Randomized Controlled Trial
Couwenberg, Alice M., Burbach, Johannes P.M., Berbee, Maaike, Lacle, Miangela M., Arensman, René, Raicu, Mihaela G., Wessels, Frank J., Verdult, Joanne, Roodhart, Jeanine, Reerink, Onne, Hoendervangers, Sieske, Buijsen, Jeroen, Grabsch, Heike I., Pronk, Apollo, Consten, Esther C.J., Smits, Anke B., Heikens, Joost T., Appelt, Ane L., van Grevenstein, Wilhelmina M.U., Verkooijen, Helena M., Intven, Martijn P.W.
Published in International journal of radiation oncology, biology, physics (15.11.2020)
Published in International journal of radiation oncology, biology, physics (15.11.2020)
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Machine-learning model derived gene signature predictive of paclitaxel survival benefit in gastric cancer: results from the randomised phase III SAMIT trial
Sundar, Raghav, Barr Kumarakulasinghe, Nesaretnam, Huak Chan, Yiong, Yoshida, Kazuhiro, Yoshikawa, Takaki, Miyagi, Yohei, Rino, Yasushi, Masuda, Munetaka, Guan, Jia, Sakamoto, Junichi, Tanaka, Shiro, Tan, Angie Lay-Keng, Hoppe, Michal Marek, Jeyasekharan, Anand D., Ng, Cedric Chuan Young, De Simone, Mark, Grabsch, Heike I., Lee, Jeeyun, Oshima, Takashi, Tsuburaya, Akira, Tan, Patrick
Published in Gut (01.04.2022)
Published in Gut (01.04.2022)
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Impact of sex and age on chemotherapy efficacy, toxicity and survival in localised oesophagogastric cancer: A pooled analysis of 3265 individual patient data from four large randomised trials (OE02, OE05, MAGIC and ST03)
Athauda, Avani, Nankivell, Matthew, Langley, Ruth E., Alderson, Derek, Allum, William, Grabsch, Heike I., Starling, Naureen, Chau, Ian, Cunningham, David
Published in European journal of cancer (1990) (01.09.2020)
Published in European journal of cancer (1990) (01.09.2020)
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Computational Image Analysis of T-Cell Infiltrates in Resectable Gastric Cancer: Association with Survival and Molecular Subtypes
Challoner, Benjamin R, von Loga, Katharina, Woolston, Andrew, Griffiths, Beatrice, Sivamanoharan, Nanna, Semiannikova, Maria, Newey, Alice, Barber, Louise J, Mansfield, David, Hewitt, Lindsay C, Saito, Yuichi, Davarzani, Naser, Starling, Naureen, Melcher, Alan, Grabsch, Heike I, Gerlinger, Marco
Published in JNCI : Journal of the National Cancer Institute (04.01.2021)
Published in JNCI : Journal of the National Cancer Institute (04.01.2021)
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