KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements
Au, Yan Zi, Gu, Muxin, De Braekeleer, Etienne, Gozdecka, Malgorzata, Aspris, Demetrios, Tarumoto, Yusuke, Cooper, Jonathan, Yu, Jason, Ong, Swee Hoe, Chen, Xi, Tzelepis, Konstantinos, Huntly, Brian J P, Vassiliou, George, Yusa, Kosuke
Published in Leukemia (01.04.2021)
Published in Leukemia (01.04.2021)
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The roles of ATF2 (activating transcription factor 2) in tumorigenesis
Gozdecka, Malgorzata, Breitwieser, Wolfgang
Published in Biochemical Society transactions (01.02.2012)
Published in Biochemical Society transactions (01.02.2012)
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A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia
Tzelepis, Konstantinos, Koike-Yusa, Hiroko, De Braekeleer, Etienne, Li, Yilong, Metzakopian, Emmanouil, Dovey, Oliver M., Mupo, Annalisa, Grinkevich, Vera, Li, Meng, Mazan, Milena, Gozdecka, Malgorzata, Ohnishi, Shuhei, Cooper, Jonathan, Patel, Miten, McKerrell, Thomas, Chen, Bin, Domingues, Ana Filipa, Gallipoli, Paolo, Teichmann, Sarah, Ponstingl, Hannes, McDermott, Ultan, Saez-Rodriguez, Julio, Huntly, Brian J.P., Iorio, Francesco, Pina, Cristina, Vassiliou, George S., Yusa, Kosuke
Published in Cell reports (Cambridge) (18.10.2016)
Published in Cell reports (Cambridge) (18.10.2016)
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Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML
Basheer, Faisal, Giotopoulos, George, Meduri, Eshwar, Yun, Haiyang, Mazan, Milena, Sasca, Daniel, Gallipoli, Paolo, Marando, Ludovica, Gozdecka, Malgorzata, Asby, Ryan, Sheppard, Olivia, Dudek, Monika, Bullinger, Lars, Döhner, Hartmut, Dillon, Richard, Freeman, Sylvie, Ottmann, Oliver, Burnett, Alan, Russell, Nigel, Papaemmanuil, Elli, Hills, Robert, Campbell, Peter, Vassiliou, George S, Huntly, Brian J P
Published in The Journal of experimental medicine (01.04.2019)
Published in The Journal of experimental medicine (01.04.2019)
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SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4
Tzelepis, Konstantinos, De Braekeleer, Etienne, Aspris, Demetrios, Barbieri, Isaia, Vijayabaskar, M S, Liu, Wen-Hsin, Gozdecka, Malgorzata, Metzakopian, Emmanouil, Toop, Hamish D, Dudek, Monika, Robson, Samuel C, Hermida-Prado, Francisco, Yang, Yu Hsuen, Babaei-Jadidi, Roya, Garyfallos, Dimitrios A, Ponstingl, Hannes, Dias, Joao M L, Gallipoli, Paolo, Seiler, Michael, Buonamici, Silvia, Vick, Binje, Bannister, Andrew J, Rad, Roland, Prinjha, Rab K, Marioni, John C, Huntly, Brian, Batson, Jennifer, Morris, Jonathan C, Pina, Cristina, Bradley, Allan, Jeremias, Irmela, Bates, David O, Yusa, Kosuke, Kouzarides, Tony, Vassiliou, George S
Published in Nature communications (19.12.2018)
Published in Nature communications (19.12.2018)
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JNK Suppresses Tumor Formation via a Gene-Expression Program Mediated by ATF2
Gozdecka, Malgorzata, Lyons, Stephen, Kondo, Saki, Taylor, Janet, Li, Yaoyong, Walczynski, Jacek, Thiel, Gerald, Breitwieser, Wolfgang, Jones, Nic
Published in Cell reports (Cambridge) (20.11.2014)
Published in Cell reports (Cambridge) (20.11.2014)
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Heme oxygenase-1 accelerates cutaneous wound healing in mice
Grochot-Przeczek, Anna, Lach, Radoslaw, Mis, Jacek, Skrzypek, Klaudia, Gozdecka, Malgorzata, Sroczynska, Patrycja, Dubiel, Milena, Rutkowski, Andrzej, Kozakowska, Magdalena, Zagorska, Anna, Walczynski, Jacek, Was, Halina, Kotlinowski, Jerzy, Drukala, Justyna, Kurowski, Krzysztof, Kieda, Claudine, Herault, Yann, Dulak, Jozef, Jozkowicz, Alicja
Published in PloS one (04.06.2009)
Published in PloS one (04.06.2009)
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P1334: THE IMPACT OF SMALL MOLECULE INHIBITION OF METTL3 ON NORMAL HAEMATOPOIESIS
Sturgess, Katherine, Vijayabaskar, Ms, Yankova, Eliza, Rak, Justyna, Eleftheriou, Maria, Isobe, Tomoya, Barile, Melania, Gozdecka, Malgorzata, Gottgens, Berthold, Wilson, Nicola, Tzelepis, Kostas
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia
Yankova, Eliza, Blackaby, Wesley, Albertella, Mark, Rak, Justyna, De Braekeleer, Etienne, Tsagkogeorga, Georgia, Pilka, Ewa S, Aspris, Demetrios, Leggate, Dan, Hendrick, Alan G, Webster, Natalie A, Andrews, Byron, Fosbeary, Richard, Guest, Patrick, Irigoyen, Nerea, Eleftheriou, Maria, Gozdecka, Malgorzata, Dias, Joao M L, Bannister, Andrew J, Vick, Binje, Jeremias, Irmela, Vassiliou, George S, Rausch, Oliver, Tzelepis, Konstantinos, Kouzarides, Tony
Published in Nature (London) (27.05.2021)
Published in Nature (London) (27.05.2021)
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NPM1c Mutations Are Associated with Reduced Levels of Multiple Ribosome Biogenesis Factors Leading to Therapeutic Vulnerabilities
Damaskou, Aristi, Wilson, Rachael, Shanmugiah, Vijay, Rak, Justyna, Tzelepis, Konstantinos, Gottgens, Berthold, Gozdecka, Malgorzata, Vassiliou, George
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs
Gozdecka, Malgorzata, Meduri, Eshwar, Mazan, Milena, Tzelepis, Konstantinos, Dudek, Monika, Knights, Andrew J, Pardo, Mercedes, Yu, Lu, Choudhary, Jyoti S, Metzakopian, Emmanouil, Iyer, Vivek, Yun, Haiyang, Park, Naomi, Varela, Ignacio, Bautista, Ruben, Collord, Grace, Dovey, Oliver, Garyfallos, Dimitrios A, De Braekeleer, Etienne, Kondo, Saki, Cooper, Jonathan, Göttgens, Berthold, Bullinger, Lars, Northcott, Paul A, Adams, David, Vassiliou, George S, Huntly, Brian J P
Published in Nature genetics (01.06.2018)
Published in Nature genetics (01.06.2018)
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Abstract 14547: Genetically Predicted Inhibition of HMG-CoA Reductase Reduces Risk of DNMT3A Clonal Hematopoiesis
Carter, Paul R, Gozdecka, Malgorzata, Quirós, Pedro, Lockhart, Samuel M, Gray, Victoria, Richenberg, George, Owen, Carina, Jansen, Joop, van Bergen, Maaike, Larsson, Susanna, Huntly, Brian, Libby, Peter, Clarke, Murray C, Vassiliou, George, Burgess, Stephen, Kar, Siddhartha
Published in Circulation (New York, N.Y.) (07.11.2023)
Published in Circulation (New York, N.Y.) (07.11.2023)
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Inactivation of DNA Polymerase Theta (PolΘ) Is Synthetic Lethal in DNMT3A Mutated Myeloid Malignancies - Potential Clinical Applications
Le, Bac Viet, Vekariya, Umeshkumar, Toma, Monika, Nieborowska-Skorska, Margaret, Caron, Marie-Christine, Vassiliou, George, Gozdecka, Malgorzata, Haydar, Zayd, Chandramouly, Gurushankar, Hadzijusufovic, Emir, Sperr, Wolfgang R., Pomerantz, Richard, Valent, Peter, Masson, Jean-Yves, Gupta, Gaorav, Challen, Grant A, Skorski, Tomasz
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages
Sturgess, Katherine, Yankova, Eliza, Vijayabaskar, M S, Isobe, Tomoya, Rak, Justyna, Kucinski, Iwo, Barile, Melania, Webster, Natalie A, Eleftheriou, Maria, Hannah, Rebecca, Gozdecka, Malgorzata, Vassiliou, George, Rausch, Oliver, Wilson, Nicola K, Göttgens, Berthold, Tzelepis, Konstantinos
Published in Leukemia (01.10.2023)
Published in Leukemia (01.10.2023)
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Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression
Yun, Haiyang, Narayan, Nisha, Vohra, Shabana, Giotopoulos, George, Mupo, Annalisa, Madrigal, Pedro, Sasca, Daniel, Lara-Astiaso, David, Horton, Sarah J, Agrawal-Singh, Shuchi, Meduri, Eshwar, Basheer, Faisal, Marando, Ludovica, Gozdecka, Malgorzata, Dovey, Oliver M, Castillo-Venzor, Aracely, Wang, Xiaonan, Gallipoli, Paolo, Müller-Tidow, Carsten, Osborne, Cameron S, Vassiliou, George S, Huntly, Brian J P
Published in Nature genetics (01.10.2021)
Published in Nature genetics (01.10.2021)
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Mutational synergy during leukemia induction remodels chromatin accessibility, modification and 3-Dimensional DNA topology to alter gene expression
Yun, Haiyang, Narayan, Nisha, Vohra, Shabana, Giotopoulos, George, Mupo, Annalisa, Madrigal, Pedro, Sasca, Daniel, Lara-Astiaso, David, Horton, Sarah J., Agrawal-Singh, Shuchi, Meduri, Eshwar, Basheer, Faisal, Marando, Ludovica, Gozdecka, Malgorzata, Dovey, Oliver M., Castillo-Venzor, Aracely, Wang, Xiaonan, Gallipoli, Paolo, Müller-Tidow, Carsten, Osborne, Cameron S., Vassiliou, George S., Huntly, Brian J. P.
Published in Nature genetics (23.09.2021)
Published in Nature genetics (23.09.2021)
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Publisher Correction: UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs
Gozdecka, Malgorzata, Meduri, Eshwar, Mazan, Milena, Tzelepis, Konstantinos, Dudek, Monika, Knights, Andrew J, Pardo, Mercedes, Yu, Lu, Choudhary, Jyoti S, Metzakopian, Emmanouil, Iyer, Vivek, Yun, Haiyang, Park, Naomi, Varela, Ignacio, Bautista, Ruben, Collord, Grace, Dovey, Oliver, Garyfallos, Dimitrios A, De Braekeleer, Etienne, Kondo, Saki, Cooper, Jonathan, Göttgens, Berthold, Bullinger, Lars, Northcott, Paul A, Adams, David, Vassiliou, George S, Huntly, Brian J P
Published in Nature genetics (01.07.2022)
Published in Nature genetics (01.07.2022)
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Genetic Vulnerabilities of DNMT3AR882H in Myeloid Malignancies
Gozdecka, Malgorzata, Dudek, Monika, Tzelepis, Konstantinos, Damaskou, Aristi, Baskar, Vijay, Wright, Penny, Duddy, Graham, Meduri, Eshwar, Mazan, Milena, Yusa, Kosuke, Huntly, Brian J.P., Vassiliou, George S.
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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2008 – INTEGRATIVE SINGLE-CELL ANALYSIS OF PRELEUKAEMIC MUTANT MOUSE MODELS ILLUSTRATES MUTATION-SPECIFIC HAEMATOPOIETIC PERTURBATIONS
Isobe, Tomoya, Kucinski, Iwo, Wang, Xiaonan, Barile, Melania, Hannah, Rebecca, Giotopoulos, George, Horton, Sarah, Marando, Ludovica, Li, Juan, Rak, Justyna, Gozdecka, Malgorzata, Wang, Meng, Prins, Daniel, Park, Hyun Jung, Watcham, Sam, Patel, Ketan, Green, Anthony, Kent, David, Vassiliou, George, Huntly, Brian, Wilson, Nicola, Göttgens, Berthold
Published in Experimental hematology (2022)
Published in Experimental hematology (2022)
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Setbp1 Overexpression Acts in the Place of Class-Defining Somatic Mutations to Drive Mouse and Human FLT3-ITD-Mutant AMLs
Pacharne, Suruchi, Dovey, Oliver M., Cooper, Jonathan L, Gu, Muxin, Baskar, Vijay, Friedrich, Mathias J, Gozdecka, Malgorzata, Rajan, Sandeep S, De Braekeleer, Etienne, Barenboim, Maxim, Collord, Grace, Postingl, Hannes, Bautista, Ruben, Mazan, Milena, Rad, Roland, Tzelepis, Konstantinos, Wright, Penny, Vassiliou, George S.
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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