DNA damage repair as a target in pancreatic cancer: state-of-the-art and future perspectives
Perkhofer, Lukas, Gout, Johann, Roger, Elodie, Kude de Almeida, Fernando, Baptista Simões, Carolina, Wiesmüller, Lisa, Seufferlein, Thomas, Kleger, Alexander
Published in Gut (01.03.2021)
Published in Gut (01.03.2021)
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Journal Article
Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer
Gout, Johann, Perkhofer, Lukas, Morawe, Mareen, Arnold, Frank, Ihle, Michaela, Biber, Stephanie, Lange, Sebastian, Roger, Elodie, Kraus, Johann M, Stifter, Katja, Hahn, Stephan A, Zamperone, Andrea, Engleitner, Thomas, Müller, Martin, Walter, Karolin, Rodriguez-Aznar, Eva, Sainz Jr, Bruno, Hermann, Patrick C, Hessmann, Elisabeth, Müller, Sebastian, Azoitei, Ninel, Lechel, André, Liebau, Stefan, Wagner, Martin, Simeone, Diane M, Kestler, Hans A, Seufferlein, Thomas, Wiesmüller, Lisa, Rad, Roland, Frappart, Pierre-Olivier, Kleger, Alexander
Published in Gut (01.04.2021)
Published in Gut (01.04.2021)
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Journal Article
Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution
Le Calvé, Benjamin, Griveau, Audrey, Vindrieux, David, Maréchal, Raphaël, Wiel, Clotilde, Svrcek, Magali, Gout, Johann, Azzi, Lamia, Payen, Léa, Cros, Jérôme, de la Fouchardière, Christelle, Dubus, Pierre, Guitton, Jérôme, Bartholin, Laurent, Bachet, Jean-Baptiste, Bernard, David
Published in Oncotarget (31.05.2016)
Published in Oncotarget (31.05.2016)
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Journal Article
TBX3 is dynamically expressed in pancreatic organogenesis and fine-tunes regeneration
Melzer, Michael Karl, Schirge, Silvia, Gout, Johann, Arnold, Frank, Srinivasan, Dharini, Burtscher, Ingo, Allgöwer, Chantal, Mulaw, Medhanie, Zengerling, Friedemann, Günes, Cagatay, Lickert, Heiko, Christoffels, Vincent M, Liebau, Stefan, Wagner, Martin, Seufferlein, Thomas, Bolenz, Christian, Moon, Anne M, Perkhofer, Lukas, Kleger, Alexander
Published in BMC biology (20.03.2023)
Published in BMC biology (20.03.2023)
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Journal Article
Pancreatic cancer-derived organoids – a disease modeling tool to predict drug response
Frappart, Pierre-Olivier, Walter, Karolin, Gout, Johann, Beutel, Alica K, Morawe, Mareen, Arnold, Frank, Breunig, Markus, Barth, Thomas FE, Marienfeld, Ralf, Schulte, Lucas, Ettrich, Thomas, Hackert, Thilo, Svinarenko, Michael, Rösler, Reinhild, Wiese, Sebastian, Wiese, Heike, Perkhofer, Lukas, Müller, Martin, Lechel, André, Sainz, Bruno, Hermann, Patrick C, Seufferlein, Thomas, Kleger, Alexander
Published in United European gastroenterology journal (01.06.2020)
Published in United European gastroenterology journal (01.06.2020)
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Journal Article
Maintenance Therapy for ATM-Deficient Pancreatic Cancer by Multiple DNA Damage Response Interferences after Platinum-Based Chemotherapy
Roger, Elodie, Gout, Johann, Arnold, Frank, Beutel, Alica K, Müller, Martin, Abaei, Alireza, Barth, Thomas F E, Rasche, Volker, Seufferlein, Thomas, Perkhofer, Lukas, Kleger, Alexander
Published in Cells (Basel, Switzerland) (16.09.2020)
Published in Cells (Basel, Switzerland) (16.09.2020)
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Journal Article
Isolation and culture of mouse primary pancreatic acinar cells
Gout, Johann, Pommier, Roxane M, Vincent, David F, Kaniewski, Bastien, Martel, Sylvie, Valcourt, Ulrich, Bartholin, Laurent
Published in Journal of visualized experiments (13.08.2013)
Published in Journal of visualized experiments (13.08.2013)
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Journal Article
IFN-γ treatment protocol for MHC-Ilo/PD-L1+ pancreatic tumor cells selectively restores their TAP-mediated presentation competence and CD8 T-cell priming potential
Stifter, Katja, Krieger, Jana, Ruths, Leonie, Gout, Johann, Mulaw, Medhanie, Lechel, Andre, Kleger, Alexander, Seufferlein, Thomas, Wagner, Martin, Schirmbeck, Reinhold
Published in Journal for immunotherapy of cancer (31.08.2020)
Published in Journal for immunotherapy of cancer (31.08.2020)
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Journal Article
Pancreatic Ductal Organoids React Kras Dependent to the Removal of Tumor Suppressive Roadblocks
Frappart, Pierre-Olivier, Kleger, Alexander, Breunig, Markus, Morawe, Mareen, Arnold, Frank, Gout, Johann, Engler, Melanie, Perkhofer, Lukas, Seufferlein, Thomas
Published in Stem cells international (01.01.2019)
Published in Stem cells international (01.01.2019)
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Journal Article
MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo
Schulte, Lucas-Alexander, Seufferlein, Thomas, Sainz, Bruno, Siveke, Jens T., Rodriguez-Aznar, Eva, Hermann, Patrick C., Gout, Johann, Gu, Jiangning, Liffers, Sven T., Dierichs, Laura, Hidalgo-Sastre, Ana, Trajkovic-Arsic, Marija, Tiwary, Kanishka, Walter, Karolin, Münch, Jan
Published in Stem cells international (01.01.2019)
Published in Stem cells international (01.01.2019)
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Journal Article
Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration
Arnold, Frank, Mahaddalkar, Pallavi U, Kraus, Johann M., Zhong, Xiaowei, Bergmann, Wendy, Srinivasan, Dharini, Gout, Johann, Roger, Elodie, Beutel, Alica K., Zizer, Eugen, Tharehalli, Umesh, Daiss, Nora, Russell, Ronan, Perkhofer, Lukas, Oellinger, Rupert, Lin, Qiong, Azoitei, Ninel, Weiss, Frank‐Ulrich, Lerch, Markus M., Liebau, Stefan, Katz, Sarah‐Fee, Lechel, André, Rad, Roland, Seufferlein, Thomas, Kestler, Hans A., Ott, Michael, Sharma, Amar Deep, Hermann, Patrick C., Kleger, Alexander
Published in Advanced science (01.07.2021)
Published in Advanced science (01.07.2021)
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Journal Article
A Novel Inhibitory Protein in Adipose Tissue, the Aldo-Keto Reductase AKR1B7: Its Role in Adipogenesis
Tirard, Julien, Gout, Johann, Lefrançois-Martinez, Anne Marie, Martinez, Antoine, Begeot, Martine, Naville, Danielle
Published in Endocrinology (Philadelphia) (01.05.2007)
Published in Endocrinology (Philadelphia) (01.05.2007)
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Journal Article
Leptin Infusion and Obesity in Mouse Cause Alterations in the Hypothalamic Melanocortin System
Gout, Johann, Sarafian, Delphine, Tirard, Julien, Blondet, Antonine, Vigier, Michele, Rajas, Fabienne, Mithieux, Gilles, Begeot, Martine, Naville, Danielle
Published in Obesity (Silver Spring, Md.) (01.08.2008)
Published in Obesity (Silver Spring, Md.) (01.08.2008)
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Journal Article
Isolation and Culture of Mouse Primary Pancreatic Acinar Cells
Gout, Johann, Pommier, Roxane M., Vincent, David F., Kaniewski, Bastien, Martel, Sylvie, Valcourt, Ulrich, Bartholin, Laurent
Published in Journal of visualized experiments (13.08.2013)
Published in Journal of visualized experiments (13.08.2013)
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Journal Article
Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRAS G12D -driven Pancreatic Tumorigenesis
Chuvin, Nicolas, Vincent, David F, Pommier, Roxane M, Alcaraz, Lindsay B, Gout, Johann, Caligaris, Cassandre, Yacoub, Karam, Cardot, Victoire, Roger, Elodie, Kaniewski, Bastien, Martel, Sylvie, Cintas, Celia, Goddard-Léon, Sophie, Colombe, Amélie, Valantin, Julie, Gadot, Nicolas, Servoz, Emilie, Morton, Jennifer, Goddard, Isabelle, Couvelard, Anne, Rebours, Vinciane, Guillermet, Julie, Sansom, Owen J, Treilleux, Isabelle, Valcourt, Ulrich, Sentis, Stéphanie, Dubus, Pierre, Bartholin, Laurent
Published in Cellular and molecular gastroenterology and hepatology (01.09.2017)
Published in Cellular and molecular gastroenterology and hepatology (01.09.2017)
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Journal Article
Loss of ATM facilitates nutrient stress-induced metabolic reprogramming supporting pancreatic cancer aggressiveness
Härle, Anna, Roger, Elodie, Srinivasan, Dharini, Perkhofer, Lukas, Gout, Johann, Kleger, Alexander
Published in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] (05.11.2023)
Published in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] (05.11.2023)
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Journal Article
Pharmacotyping, response prediction and tumour evolution in pancreatic cancer organoids
Gout, Johann, Resheq, Yazid J., Merkle, Jessica, Ettrich, Thomas, Perkhofer, Lukas, Seufferlein, Thomas, Kleger, Alexander
Published in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] (05.11.2023)
Published in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] (05.11.2023)
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Journal Article
Homologous recombination-deficient pancreatic cancer coordinates cancer-associated fibroblast programming to support cancer aggressiveness and chemoresistance
Gout, Johann, Roger, Elodie, Zimmer, Eleni, Srinivasan, Dharini, Härle, Anna, Asuzano, Ariel, Melzer, Michael K., Perkhofer, Lukas, Kleger, Alexander
Published in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] (05.11.2023)
Published in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] (05.11.2023)
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Journal Article
Abstract B088: Epigenetic reprograming in ATM-deficient pancreatic cancer: targeting EZH2- mediated oncogenic traits
Roger, Elodie, Härle, Anna, Perkhofer, Lukas, Hessmann, Elisabeth, Kleger, Alexander, Gout, Johann
Published in Cancer research (Chicago, Ill.) (15.09.2024)
Published in Cancer research (Chicago, Ill.) (15.09.2024)
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Journal Article
Abstract C061: Therapeutic profiling, patient response prediction, and tumor evolution in pancreatic cancer organoids
Gout, Johann, Resheq, Yazid J., Lindenmayer, Jessica, Ettrich, Thomas, Perkhofer, Lukas, Seufferlein, Thomas, Kleger, Alexander
Published in Cancer research (Chicago, Ill.) (16.01.2024)
Published in Cancer research (Chicago, Ill.) (16.01.2024)
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