In Vivo Modeling of Patient Genetic Heterogeneity Identifies New Ways to Target Cholangiocarcinoma
Younger, Nicholas T, Wilson, Mollie L, Martinez Lyons, Anabel, Jarman, Edward J, Meynert, Alison M, Grimes, Graeme R, Gournopanos, Konstantinos, Waddell, Scott H, Tennant, Peter A, Wilson, David H, Guest, Rachel V, Wigmore, Stephen J, Acosta, Juan Carlos, Kendall, Timothy J, Taylor, Martin S, Sproul, Duncan, Mill, Pleasantine, Boulter, Luke
Published in Cancer research (Chicago, Ill.) (15.04.2022)
Published in Cancer research (Chicago, Ill.) (15.04.2022)
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Journal Article
Van Gogh-like 2 is essential for the architectural patterning of the mammalian biliary tree
Raab, Michaela, Christodoulou, Ersi, Krishnankutty, Roopesh, Gradinaru, Andreea, Walker, Alexander Daniel, Olaizola, Paula, Younger, Nicholas Thomas, Lyons, Anabel Martinez, Jarman, Edward Joseph, Gournopanos, Konstantinos, von Kriegsheim, Alexander, Waddell, Scott Hamilton, Boulter, Luke
Published in Journal of hepatology (01.07.2024)
Published in Journal of hepatology (01.07.2024)
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Journal Article
A TGFβ-ECM-integrin signaling axis drives structural reconfiguration of the bile duct to promote polycystic liver disease
Waddell, Scott H, Yao, Yuelin, Olaizola, Paula, Walker, Alexander, Jarman, Edward J, Gournopanos, Konstantinos, Gradinaru, Andreea, Christodoulou, Ersi, Gautier, Philippe, Boerrigter, Melissa M, Cadamuro, Massimiliano, Fabris, Luca, Drenth, Joost Ph, Kendall, Timothy J, Banales, Jesus M, Khamseh, Ava, Mill, Pleasantine, Boulter, Luke
Published in Science translational medicine (13.09.2023)
Published in Science translational medicine (13.09.2023)
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Journal Article
DKK1 drives immune suppressive phenotypes in intrahepatic cholangiocarcinoma and can be targeted with anti‐DKK1 therapeutic DKN‐01
Jarman, Edward J., Horcas‐Lopez, Marta, Waddell, Scott H., MacMaster, Stephanie, Gournopanos, Konstantinos, Soong, Daniel Y. H., Musialik, Kamila I., Tsokkou, Panagiota, Ng, Minn‐E, Cambridge, William A., Wilson, David H., Kagey, Michael H., Newman, Walter, Pollard, Jeffrey W., Boulter, Luke
Published in Liver international (01.01.2023)
Published in Liver international (01.01.2023)
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Journal Article
Planar cell polarity is essential for the architectural patterning of the mammalian biliary tree
Raab, Michaela, Christodoulou, Ersi, Krishnankutty, Roopesh, Younger, Nicholas T, Gournopanos, Konstantinos, Alexander Von Kriegsheim, Waddell, Scott H, Boulter, Luke
Published in bioRxiv (20.11.2023)
Published in bioRxiv (20.11.2023)
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Paper
Primary cilia loss promotes reactivation of morphogenesis and cyst-fission through a deregulated TGFβ-ECM-Integrin axis in polycystic liver disease
Waddell, Scott H, Yao, Yuelin, Olaizola, Paula, Jarman, Edward J, Gournopanos, Konstantinos, Christodoulou, Ersi, Gautier, Philippe, Joost Ph Drenth, Kendall, Timothy J, Banales, Jesus M, Khamseh, Ava, Mill, Pleasantine, Boulter, Luke
Published in bioRxiv (08.04.2022)
Published in bioRxiv (08.04.2022)
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Paper
In vivo modelling of patient genetic heterogeneity identifies concurrent Wnt and PI3K activity as a potent driver of invasive cholangiocarcinoma growth
Younger, Nicholas, Wilson, Mollie, Jarman, Edward, Meynert, Alison, Grimes, Graeme, Gournopanos, Konstantinos, Waddell, Scott, Tennant, Peter, Wilson, David, Guest, Rachel, Wigmore, Stephen, Acosta, Juan Carlos, Kendall, Timothy James, Taylor, Martin, Sproul, Duncan, Mill, Pleasantine, Boulter, Luke
Published in bioRxiv (05.07.2021)
Published in bioRxiv (05.07.2021)
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