Simplifying nature: Towards the design of broad spectrum kinetoplastid inhibitors, inspired by acetogenins
Gould, Eoin R., King, Elizabeth F.B., Menzies, Stefanie K., Fraser, Andrew L., Tulloch, Lindsay B., Zacharova, Marija K., Smith, Terry K., Florence, Gordon J.
Published in Bioorganic & medicinal chemistry (15.11.2017)
Published in Bioorganic & medicinal chemistry (15.11.2017)
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Journal Article
Photo-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues
Tulloch, Lindsay B, Menzies, Stefanie K, Fraser, Andrew L, Gould, Eoin R, King, Elizabeth F, Zacharova, Marija K, Florence, Gordon J, Smith, Terry K
Published in PLoS neglected tropical diseases (05.09.2017)
Published in PLoS neglected tropical diseases (05.09.2017)
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Journal Article
Structure‐Based Design, Synthesis and Biological Evaluation of Bis‐Tetrahydropyran Furan Acetogenin Mimics Targeting the Trypanosomatid F1 Component of ATP Synthase
Zacharova, Marija K., Tulloch, Lindsay B., Gould, Eoin R., Fraser, Andrew L., King, Elizabeth F., Menzies, Stefanie K., Smith, Terry K., Florence, Gordon J.
Published in European journal of organic chemistry (01.09.2019)
Published in European journal of organic chemistry (01.09.2019)
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Journal Article
Catalytic and Anticatalytic Snapshots of a Short-Form ATP Phosphoribosyltransferase
Alphey, Magnus S, Fisher, Gemma, Ge, Ying, Gould, Eoin R, Machado, Teresa F. G, Liu, Huanting, Florence, Gordon J, Naismith, James H, da Silva, Rafael G
Published in ACS catalysis (01.06.2018)
Published in ACS catalysis (01.06.2018)
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Journal Article
Kinetics and Structure of a Cold-Adapted Hetero-Octameric ATP Phosphoribosyltransferase
Stroek, Rozanne, Ge, Ying, Talbot, Paul D, Glok, Mateusz K, Bernaś, Klaudia E, Thomson, Catherine M, Gould, Eoin R, Alphey, Magnus S, Liu, Huanting, Florence, Gordon J, Naismith, James H, da Silva, Rafael G
Published in Biochemistry (Easton) (07.02.2017)
Published in Biochemistry (Easton) (07.02.2017)
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Journal Article
Development of Simplified Heterocyclic Acetogenin Analogues as Potent and Selective Trypanosoma brucei Inhibitors
Florence, Gordon J., Fraser, Andrew L., Gould, Eoin R., King, Elizabeth F., Menzies, Stefanie K., Morris, Joanne C., Thomson, Marie I., Tulloch, Lindsay B., Zacharova, Marija K., Smith, Terry K.
Published in ChemMedChem (19.07.2016)
Published in ChemMedChem (19.07.2016)
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Journal Article
Design and Synthesis of Broad Spectrum Trypanosomatid Selective Inhibitors
Fraser, Andrew L, Menzies, Stefanie K, King, Elizabeth F. B, Tulloch, Lindsay B, Gould, Eoin R, Zacharova, Marija K, Smith, Terry K, Florence, Gordon J
Published in ACS infectious diseases (13.04.2018)
Published in ACS infectious diseases (13.04.2018)
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