Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion
Zhang, Yi, Guo, Yiran, Gough, Sheryl M, Zhang, Jinyong, Vann, Kendra R, Li, Kuai, Cai, Ling, Shi, Xiaobing, Aplan, Peter D, Wang, Gang Greg, Kutateladze, Tatiana G
Published in Nature communications (03.07.2020)
Published in Nature communications (03.07.2020)
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Journal Article
Age-related epigenetic drift in the pathogenesis of MDS and AML
Maegawa, Shinji, Gough, Sheryl M, Watanabe-Okochi, Naoko, Lu, Yue, Zhang, Nianxiang, Castoro, Ryan J, Estecio, Marcos R H, Jelinek, Jaroslav, Liang, Shoudan, Kitamura, Toshio, Aplan, Peter D, Issa, Jean-Pierre J
Published in Genome research (01.04.2014)
Published in Genome research (01.04.2014)
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Journal Article
Progenitor B-1 B-cell acute lymphoblastic leukemia is associated with collaborative mutations in 3 critical pathways
Gough, Sheryl M., Goldberg, Liat, Pineda, Marbin, Walker, Robert L., Zhu, Yuelin J., Bilke, Sven, Chung, Yang Jo, Dufraine, Joseph, Kundu, Subhadip, Jacoby, Elad, Fry, Terry J., Fischer, Susanna, Panzer-Grümayer, Renate, Meltzer, Paul S., Aplan, Peter D.
Published in Blood advances (12.09.2017)
Published in Blood advances (12.09.2017)
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Journal Article
Oral estrogen receptor PROTAC® vepdegestrant (ARV-471) is highly efficacious as monotherapy and in combination with CDK4/6 or PI3K/mTOR pathway inhibitors in preclinical ER+ breast cancer models
Gough, Sheryl M, Flanagan, John J, Teh, Jessica, Andreoli, Monica, Rousseau, Emma, Pannone, Melissa, Bookbinder, Mark, Willard, Ryan, Davenport, Kim, Bortolon, Elizabeth, Cadelina, Gregory, Gordon, Deborah, Pizzano, Jennifer, Macaluso, Jennifer, Soto, Leofal, Corradi, John, Digianantonio, Katherine, Drulyte, Ieva, Morgan, Alicia, Quinn, Connor, Békés, Miklós, Ferraro, Caterina, Chen, Xin, Wang, Gan, Dong, Hanqing, Wang, Jing, Langley, David R, Houston, John, Gedrich, Richard, Taylor, Ian C
Published in Clinical cancer research (15.08.2024)
Published in Clinical cancer research (15.08.2024)
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Journal Article
NUP98-PHF23 is a chromatin-modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD histone reader function
Gough, Sheryl M, Lee, Fan, Yang, Fan, Walker, Robert L, Zhu, Yeulin J, Pineda, Marbin, Onozawa, Masahiro, Chung, Yang Jo, Bilke, Sven, Wagner, Elise K, Denu, John M, Ning, Yi, Xu, Bowen, Wang, Gang Greg, Meltzer, Paul S, Aplan, Peter D
Published in Cancer discovery (01.05.2014)
Published in Cancer discovery (01.05.2014)
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Journal Article
Oxidative stress leads to increased mutation frequency in a murine model of myelodysplastic syndrome
Chung, Yang Jo, Robert, Carine, Gough, Sheryl M, Rassool, Feyruz V, Aplan, Peter D
Published in Leukemia research (01.01.2014)
Published in Leukemia research (01.01.2014)
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Journal Article
Somatic mutations in murine models of leukemia and lymphoma: Disease specificity and clinical relevance
Goldberg, Liat, Gough, Sheryl M., Lee, Fan, Dang, Christine, Walker, Robert L., Zhu, Yuelin J., Bilke, Sven, Pineda, Marbin, Onozawa, Masahiro, Jo Chung, Yang, Meltzer, Paul S., Aplan, Peter D.
Published in Genes chromosomes & cancer (01.06.2017)
Published in Genes chromosomes & cancer (01.06.2017)
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Journal Article
Refined physical map of the human PAX2/HOX11/NFKB2 cancer gene region at 10q24 and relocalization of the HPV6AI1 viral integration site to 14q13.3-q21.1
Gough, Sheryl M, McDonald, Margaret, Chen, Xiao-Ning, Korenberg, Julie R, Neri, Antonino, Kahn, Tomas, Eccles, Michael R, Morris, Christine M
Published in BMC genomics (03.03.2003)
Published in BMC genomics (03.03.2003)
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Journal Article
Cloning, Sequence Analysis, and Chromosomal Localization of the Novel Human Integrin α11 Subunit (ITGA11)
Lehnert, Klaus, Ni, Jian, Leung, Euphemia, Gough, Sheryl M., Weaver, Alison, Yao, Wei-Ping, Liu, Ding, Wang, Shu-Xia, Morris, Christine M., Krissansen, Geoffrey W.
Published in Genomics (San Diego, Calif.) (01.09.1999)
Published in Genomics (San Diego, Calif.) (01.09.1999)
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Journal Article
Potent and Orally Bioavailable BCL6 PROTAC TM Degraders Demonstrate Efficacy in Pre-Clinical Models of Diffuse Large B-Cell Lymphoma (DLBCL)
Gough, Sheryl M, Sherman, Dan, DeCarr, Lynn, Eaton, Sarah, Milanovic, Maja, Bookbinder, Mark, Pizzano, Jennifer, Altieri, Martha, Corradi, John, Xiao, Hong, Gallego, Felipe, Soto, Leofal, Lingamaneni, Ram, Chen, Xin, Zhang, Wei, Wang, Gan, Dong, Hanqing, Chirnomas, Deborah, Berlin, Michael, Hornberger, Keith, Snyder, Lawrence, Taylor, Ian
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Abstract 44: The discovery of ARV-471, an orally bioavailable estrogen receptor degrading PROTAC for the treatment of patients with breast cancer
Snyder, Lawrence B., Flanagan, John J., Qian, Yimin, Gough, Sheryl M., Andreoli, Monica, Bookbinder, Mark, Cadelina, Gregory, Bradley, John, Rousseau, Emma, Chandler, Julian, Willard, Ryan, Pizzano, Jennifer, Crews, Craig M., Crew, Andrew P., Houston, John, Moore, Marcia Dougan, Peck, Ron, Taylor, Ian
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Abstract 5076: IHC and flow cytometry quantifies BRD4 levels in surrogate tissues after ex-vivo and in-vivo dosing with a BRD4 degrading PROTAC
Gough, Sheryl M., Raina, Kanak, Gordon, Debbie, Willard, Ryan, Altieri, Martha, Shen, Angela, Qian, Yimin, Neklesa, Taavi, Coleman, Kevin, Taylor, Ian
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Spontaneous Mutations of Bcor and Jak1/2 genes Lead to an Aggressive Leukemia of B-1 Progenitor B Cells
Gough, Sheryl M, Goldberg, Liat, Pineda, Marbin, Walker, Robert L, Zhu, Yuelin J, Bilke, Sven, Meltzer, Paul S, Aplan, Peter D
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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Journal Article
Illegitimate V(D)J Recombination Involving Notch1 and Bcl11b in Precursor T-Cell Lymphoblastic Leukemia/Lymphoma
Onozawa, Masahiro, Kim, Hyunkyung, Gough, Sheryl M, Lin, Yingwei, Cui, Yongzhi, Beachy, Sarah H, Mackall, Crystal L, Aplan, Peter
Published in Blood (16.11.2012)
Published in Blood (16.11.2012)
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Journal Article
Increased Mutation Frequency Induced by Oxidative Stress in the NUP98-HOXD13 MDS Mouse Model
Chung, Yang Jo, Robert, Carine, Gough, Sheryl M, Rassool, Feyruz, Aplan, Peter
Published in Blood (18.11.2011)
Published in Blood (18.11.2011)
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Journal Article
Abstract 3851: NUP98-PHF23 (NP23) binds H3K4me3 and causes a wide spectrum of leukemias, including AML, T-ALL, and pre-B1 ALL
Gough, Sheryl M., Lee, Fan, Chung, Yang Jo, Walker, Robert L., Yang, Fan, Zhu, Jack, Ning, Yi, Meltzer, Paul S., Aplan, Peter D.
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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