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Yin, Jie, Babaoglu, Kerim, Brautigam, Chad A, Clark, Lindsay, Shao, Zhenhua, Scheuermann, Thomas H, Harrell, Charles M, Gotter, Anthony L, Roecker, Anthony J, Winrow, Christopher J, Renger, John J, Coleman, Paul J, Rosenbaum, Daniel M
Published in Nature structural & molecular biology (01.04.2016)
Published in Nature structural & molecular biology (01.04.2016)
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Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man
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Published in Scientific reports (03.06.2016)
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Orexin receptors as therapeutic drug targets
Gotter, Anthony L., Roecker, Anthony J., Hargreaves, Richard, Coleman, Paul J., Winrow, Christopher J., Renger, John J.
Published in Orexin/Hypocretin System (2012)
Published in Orexin/Hypocretin System (2012)
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Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia
Winrow, Christopher J., Gotter, Anthony L., Cox, Christopher D., Tannenbaum, Pamela L., Garson, Susan L., Doran, Scott M., Breslin, Michael J., Schreier, John D., Fox, Steven V., Harrell, Charles M., Stevens, Joanne, Reiss, Duane R., Cui, Donghui, Coleman, Paul J., Renger, John J.
Published in Neuropharmacology (01.02.2012)
Published in Neuropharmacology (01.02.2012)
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Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys
Tannenbaum, Pamela L, Tye, Spencer J, Stevens, Joanne, Gotter, Anthony L, Fox, Steven V, Savitz, Alan T, Coleman, Paul J, Uslaner, Jason M, Kuduk, Scott D, Hargreaves, Richard, Winrow, Christopher J, Renger, John J
Published in Sleep (New York, N.Y.) (01.03.2016)
Published in Sleep (New York, N.Y.) (01.03.2016)
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Mammalian TIMELESS and Tipin are Evolutionarily Conserved Replication Fork-associated Factors
Gotter, Anthony L., Suppa, Christine, Emanuel, Beverly S.
Published in Journal of molecular biology (09.02.2007)
Published in Journal of molecular biology (09.02.2007)
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Promotion of Sleep by Suvorexant-A Novel Dual Orexin Receptor Antagonist
Winrow, Christopher J., Gotter, Anthony L., Cox, Christopher D., Doran, Scott M., Tannenbaum, Pamela L., Breslin, Michael J., Garson, Susan L., Fox, Steven V., Harrell, Charles M., Stevens, Joanne, Reiss, Duane R., Cui, Donghui, Coleman, Paul J., Renger, John J.
Published in Journal of neurogenetics (01.03.2011)
Published in Journal of neurogenetics (01.03.2011)
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The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold
Gotter, Anthony L, Winrow, Christopher J, Brunner, Joseph, Garson, Susan L, Fox, Steven V, Binns, Jacquelyn, Harrell, Charles M, Cui, Donghui, Yee, Ka Lai, Stiteler, Mark, Stevens, Joanne, Savitz, Alan, Tannenbaum, Pamela L, Tye, Spencer J, McDonald, Terrence, Yao, Leon, Kuduk, Scott D, Uslaner, Jason, Coleman, Paul J, Renger, John J
Published in BMC neuroscience (28.08.2013)
Published in BMC neuroscience (28.08.2013)
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Discovery of highly potent and selective orexin 1 receptor antagonists (1-SORAs) suitable for in vivo interrogation of orexin 1 receptor pharmacology
Stump, Craig A., Cooke, Andrew J., Bruno, Joseph, Cabalu, Tamara D., Gotter, Anthony L., Harell, C. Meacham, Kuduk, Scott D., McDonald, Terrence P., O’Brien, Julie, Renger, John J., Williams, Peter D., Winrow, Christopher J., Coleman, Paul J.
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
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The dual orexin receptor antagonist, DORA‐22, lowers histamine levels in the lateral hypothalamus and prefrontal cortex without lowering hippocampal acetylcholine
Yao, Lihang, Ramirez, Andres D., Roecker, Anthony J., Fox, Steven V., Uslaner, Jason M., Smith, Sean M., Hodgson, Robert, Coleman, Paul J., Renger, John J., Winrow, Christopher J., Gotter, Anthony L.
Published in Journal of neurochemistry (01.07.2017)
Published in Journal of neurochemistry (01.07.2017)
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Discovery of 5′′-Chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2′:5′,3′′-terpyridine-3′-carboxamide (MK-1064): A Selective Orexin 2 Receptor Antagonist (2-SORA) for the Treatment of Insomnia
Roecker, Anthony J., Mercer, Swati P., Schreier, John D., Cox, Christopher D., Fraley, Mark E., Steen, Justin T., Lemaire, Wei, Bruno, Joseph G., Harrell, C. Meacham, Garson, Susan L., Gotter, Anthony L., Fox, Steven V., Stevens, Joanne, Tannenbaum, Pamela L., Prueksaritanont, Thomayant, Cabalu, Tamara D., Cui, Donghui, Stellabott, Joyce, Hartman, George D., Young, Steven D., Winrow, Christopher J., Renger, John J., Coleman, Paul J.
Published in ChemMedChem (01.02.2014)
Published in ChemMedChem (01.02.2014)
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Timeless links replication termination to mitotic kinase activation
Dheekollu, Jayaraju, Wiedmer, Andreas, Hayden, James, Speicher, David, Gotter, Anthony L, Yen, Tim, Lieberman, Paul M
Published in PloS one (06.05.2011)
Published in PloS one (06.05.2011)
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Illuminating the Circadian Clock in Monarch Butterfly Migration
Froy, Oren, Gotter, Anthony L., Casselman, Amy L., Reppert, Steven M.
Published in Science (American Association for the Advancement of Science) (23.05.2003)
Published in Science (American Association for the Advancement of Science) (23.05.2003)
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Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists
Skudlarek, Jason W., DiMarco, Christina N., Babaoglu, Kerim, Roecker, Anthony J., Bruno, Joseph G., Pausch, Mark A., O'Brien, Julie A., Cabalu, Tamara D., Stevens, Joanne, Brunner, Joseph, Tannenbaum, Pamela L., Wuelfing, W. Peter, Garson, Susan L., Fox, Steven V., Savitz, Alan T., Harrell, Charles M., Gotter, Anthony L., Winrow, Christopher J., Renger, John J., Kuduk, Scott D., Coleman, Paul J.
Published in Bioorganic & medicinal chemistry letters (15.03.2017)
Published in Bioorganic & medicinal chemistry letters (15.03.2017)
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Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure
Winrow, Christopher J., Tanis, Keith Q., Reiss, Duane R., Rigby, Alison M., Uslaner, Jason M., Uebele, Victor N., Doran, Scott M., Fox, Steven V., Garson, Susan L., Gotter, Anthony L., Levine, David M., Roecker, Anthony J., Coleman, Paul J., Koblan, Kenneth S., Renger, John J.
Published in Neuropharmacology (2010)
Published in Neuropharmacology (2010)
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Orexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs
Tannenbaum, Pamela L, Stevens, Joanne, Binns, Jacquelyn, Savitz, Alan T, Garson, Susan L, Fox, Steven V, Coleman, Paul, Kuduk, Scott D, Gotter, Anthony L, Marino, Michael, Tye, Spencer J, Uslaner, Jason M, Winrow, Christopher J, Renger, John J
Published in Frontiers in behavioral neuroscience (16.05.2014)
Published in Frontiers in behavioral neuroscience (16.05.2014)
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Discovery of a Pharmacologically Active Antagonist of the Two-Pore-Domain Potassium Channel K2P9.1 (TASK-3)
Coburn, Craig A., Luo, Yunfu, Cui, Mingxiang, Wang, Jiabing, Soll, Richard, Dong, Jingchao, Hu, Bin, Lyon, Michael A., Santarelli, Vincent P., Kraus, Richard L., Gregan, Yun, Wang, Yi, Fox, Steven V., Binns, Jacquelyn, Doran, Scott M., Reiss, Duane R., Tannenbaum, Pamela L., Gotter, Anthony L., Meinke, Peter T., Renger, John J.
Published in ChemMedChem (02.01.2012)
Published in ChemMedChem (02.01.2012)
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