A Systematic Approach to the Optimization of Substrate-Based Inhibitors of the Hepatitis C Virus NS3 Protease: Discovery of Potent and Specific Tripeptide Inhibitors
Llinàs-Brunet, Montse, Bailey, Murray D, Ghiro, Elise, Gorys, Vida, Halmos, Ted, Poirier, Martin, Rancourt, Jean, Goudreau, Nathalie
Published in Journal of medicinal chemistry (16.12.2004)
Published in Journal of medicinal chemistry (16.12.2004)
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Structure−Activity Study on a Novel Series of Macrocyclic Inhibitors of the Hepatitis C Virus NS3 Protease Leading to the Discovery of BILN 2061
Llinàs-Brunet, Montse, Bailey, Murray D, Bolger, Gordon, Brochu, Christian, Faucher, Anne-Marie, Ferland, Jean Marie, Garneau, Michel, Ghiro, Elise, Gorys, Vida, Grand-Maître, Chantal, Halmos, Ted, Lapeyre-Paquette, Nicole, Liard, Francine, Poirier, Martin, Rhéaume, Manon, Tsantrizos, Youla S, Lamarre, Daniel
Published in Journal of medicinal chemistry (25.03.2004)
Published in Journal of medicinal chemistry (25.03.2004)
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A systematic approach to the optimization of substrate-based inhibitors of the hepatitis C virus NS3 protease: Discovery of potent and specific tripeptide
Llinas-Brunet, M, Bailey, MD, Ghiro, E, Gorys, Halmos, T, Poirier, M, Rancourt, J, Goudreau, N
Published in Journal of medicinal chemistry (16.12.2004)
Published in Journal of medicinal chemistry (16.12.2004)
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Discovery of Hepatitis C Virus NS3-4A Protease Inhibitors with Improved Barrier to Resistance and Favorable Liver Distribution
Moreau, Benoît, O’Meara, Jeff A., Bordeleau, Josée, Garneau, Michel, Godbout, Cedrickx, Gorys, Vida, Leblanc, Mélissa, Villemure, Elisia, White, Peter W., Llinàs-Brunet, Montse
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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L1CAM promotes enrichment of immunosuppressive T cells in human pancreatic cancer correlating with malignant progression
Grage-Griebenow, Evelin, Jerg, Elfi, Gorys, Artur, Wicklein, Daniel, Wesch, Daniela, Freitag-Wolf, Sandra, Goebel, Lisa, Vogel, Ilka, Becker, Thomas, Ebsen, Michael, Röcken, Christoph, Altevogt, Peter, Schumacher, Udo, Schäfer, Heiner, Sebens, Susanne
Published in Molecular oncology (01.07.2014)
Published in Molecular oncology (01.07.2014)
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CD4+ T cells potently induce epithelial-mesenchymal-transition in premalignant and malignant pancreatic ductal epithelial cells-novel implications of CD4+ T cells in pancreatic cancer development
Goebel, Lisa, Grage-Griebenow, Evelin, Gorys, Artur, Helm, Ole, Genrich, Geeske, Lenk, Lennart, Wesch, Daniela, Ungefroren, Hendrik, Freitag-Wolf, Sandra, Sipos, Bence, Röcken, Christoph, Schäfer, Heiner, Sebens, Susanne
Published in Oncoimmunology (03.04.2015)
Published in Oncoimmunology (03.04.2015)
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Discovery of a Potent and Selective Noncovalent Linear Inhibitor of the Hepatitis C Virus NS3 Protease (BI 201335)
Llinàs-Brunet, Montse, Bailey, Murray D, Goudreau, Nathalie, Bhardwaj, Punit K, Bordeleau, Josée, Bös, Michael, Bousquet, Yves, Cordingley, Michael G, Duan, Jiamin, Forgione, Pat, Garneau, Michel, Ghiro, Elise, Gorys, Vida, Goulet, Sylvie, Halmos, Ted, Kawai, Stephen H, Naud, Julie, Poupart, Marc-André, White, Peter W
Published in Journal of medicinal chemistry (09.09.2010)
Published in Journal of medicinal chemistry (09.09.2010)
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Peptide-Based Inhibitors of the Hepatitis C Virus NS3 Protease: Structure−Activity Relationship at the C-Terminal Position
Rancourt, Jean, Cameron, Dale R, Gorys, Vida, Lamarre, Daniel, Poirier, Martin, Thibeault, Diane, Llinàs-Brunet, Montse
Published in Journal of medicinal chemistry (06.05.2004)
Published in Journal of medicinal chemistry (06.05.2004)
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Highly potent and selective peptide-based inhibitors of the hepatitis C virus serine protease: towards smaller inhibitors
Llinàs-Brunet, Montse, Bailey, Murray, Fazal, Gulrez, Ghiro, Elise, Gorys, Vida, Goulet, Sylvie, Halmos, Ted, Maurice, Roger, Poirier, Martin, Poupart, Marc-André, Rancourt, Jean, Thibeault, Diane, Wernic, Dominik, Lamarre, Daniel
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
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NMR Structural Characterization of Peptide Inhibitors Bound to the Hepatitis C Virus NS3 Protease: Design of a New P2 Substituent
Goudreau, Nathalie, Cameron, Dale R, Bonneau, Pierre, Gorys, Vida, Plouffe, Céline, Poirier, Martin, Lamarre, Daniel, Llinas-Brunet, Montse
Published in Journal of medicinal chemistry (01.01.2004)
Published in Journal of medicinal chemistry (01.01.2004)
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Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus
Décor, Anne, Grand-Maître, Chantal, Hucke, Oliver, O’Meara, Jeff, Kuhn, Cyrille, -Forget, Léa Constantineau, Brochu, Christian, Malenfant, Eric, Bertrand-Laperle, Mégan, Bordeleau, Josée, Ghiro, Elise, Pesant, Marc, Fazal, Gulrez, Gorys, Vida, Little, Michael, Boucher, Colette, Bordeleau, Sylvain, Turcotte, Pascal, Guo, Tim, Garneau, Michel, Spickler, Catherine, Gauthier, Annick
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
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Studies on the C-terminal of hexapeptide inhibitors of the hepatitis C virus serine protease
Llinàs-Brunet, Montse, Bailey, Murray, Déziel, Robert, Fazal, Gulrez, Gorys, Vida, Goulet, Sylvie, Halmos, Ted, Maurice, Roger, Poirier, Martin, Poupart, Marc-André, Rancourt, Jean, Thibeault, Diane, Wernic, Dominik, Lamarre, Daniel
Published in Bioorganic & medicinal chemistry letters (06.10.1998)
Published in Bioorganic & medicinal chemistry letters (06.10.1998)
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Synthesis of BILN 2061, an HCV NS3 Protease Inhibitor with Proven Antiviral Effect in Humans
Faucher, Anne-Marie, Bailey, Murray D, Beaulieu, Pierre L, Brochu, Christian, Duceppe, Jean-Simon, Ferland, Jean-Marie, Ghiro, Elise, Gorys, Vida, Halmos, Ted, Kawai, Stephen H, Poirier, Martin, Simoneau, Bruno, Tsantrizos, Youla S, Llinàs-Brunet, Montse
Published in Organic letters (19.08.2004)
Published in Organic letters (19.08.2004)
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Journal Article
Synthesis of BILN 2061, an HCVNS3 protease inhibitor with proven antiviral effect in humans
Faucher, AM, Bailey, MD, Beaulieu, PL, Brochu, C, Duceppe, JS, Ferland, JM, Ghiro, E, Gorys, Halmos, T, Kawai, SH, Poirier, M, Simoneau, B, Tsantrizos, YS, Llinas-Brunet, M
Published in Organic letters (19.08.2004)
Published in Organic letters (19.08.2004)
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Synthesis and optimization of a novel series of HCV NS3 protease inhibitors: 4-Arylproline analogs
Bilodeau, François, Bailey, Murray D., Bhardwaj, Punit K., Bordeleau, Josée, Forgione, Pat, Garneau, Michel, Ghiro, Elise, Gorys, Vida, Halmos, Ted, Jolicoeur, Eric S., Leblanc, Mélissa, Lemke, Christopher T., Naud, Julie, O’Meara, Jeff, White, Peter W., Llinàs-Brunet, Montse
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
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Discovery of Potent, Orally Bioavailable Inhibitors of Human Cytomegalovirus
Fader, Lee, Brault, Martine, Desjardins, Jessica, Dansereau, Nathalie, Lamorte, Louie, Tremblay, Sonia, Bilodeau, François, Bordeleau, Josée, Duplessis, Martin, Gorys, Vida, Gillard, James, Gleason, James L, James, Clint, Joly, Marc-André, Kuhn, Cyrille, Llinas-Brunet, Montse, Luo, Laibin, Morency, Louis, Morin, Sébastien, Parisien, Mathieu, Poirier, Maude, Thibeault, Carl, Trinh, Thao, Sturino, Claudio, Srivastava, Sanjay, Yoakim, Christiane, Franti, Michael
Published in ACS medicinal chemistry letters (12.05.2016)
Published in ACS medicinal chemistry letters (12.05.2016)
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Hepatitis C virus serine protease: synthesis of radioactive and stable isotope-labeled potent inhibitors
Latli, Bachir, Hrapchak, Matt, Gorys, Vida, Llinàs-Brunet, Montse, Campbell, Scot S., Song, Jinhua, Senanayake, Chris H.
Published in Journal of labelled compounds & radiopharmaceuticals (15.05.2014)
Published in Journal of labelled compounds & radiopharmaceuticals (15.05.2014)
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Ligands for the tyrosine kinase p56(lck) SH2 domain: Discovery of potent dipeptide derivatives with monocharged, nonhydrolyzable phosphate replacements
Beaulieu, PL, Cameron, DR, Ferland, JM, Gauthier, J, Ghiro, E, Gillard, J, Gorys, Poirier, M, Rancourt, J, Wernic, D, Llinas-Brunet, M, Betageri, R, Cardozo, M, Hickey, ER, Ingraham, R, Jakes, S, Kabcenell, A, Kirrane, T, Lukas, S, Patel, U, Proudfoot, J, Sharma, R, Tong, L, Moss, N
Published in Journal of medicinal chemistry (20.05.1999)
Published in Journal of medicinal chemistry (20.05.1999)
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Opening of Tartrate Acetals Using Dialkylboron Bromide: Evidence for Stereoselectivity Downstream from Ring Fission
Guindon, Yvan, Ogilvie, William W, Bordeleau, Josée, Cui, Wei Li, Durkin, Kathy, Gorys, Vida, Juteau, Hélène, Lemieux, René, Liotta, Dennis, Simoneau, Bruno, Yoakim, Christiane
Published in Journal of the American Chemical Society (15.01.2003)
Published in Journal of the American Chemical Society (15.01.2003)
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Practical, Stereoselective Synthesis of Palinavir, a Potent HIV Protease Inhibitor
Beaulieu, Pierre L, Lavallée, Pierre, Abraham, Anderson, Paul C, Boucher, Colette, Bousquet, Yves, Duceppe, Jean-Simon, Gillard, James, Gorys, Vida, Grand-Maître, Chantal, Grenier, Louis, Guindon, Yvan, Guse, Ingrid, Plamondon, Louis, Soucy, François, Valois, Serge, Wernic, Dominik, Yoakim, Christiane
Published in Journal of organic chemistry (30.05.1997)
Published in Journal of organic chemistry (30.05.1997)
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