Discovery of TRPM8 Antagonist (S)‑6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine
Horne, Daniel B, Biswas, Kaustav, Brown, James, Bartberger, Michael D, Clarine, Jeffrey, Davis, Carl D, Gore, Vijay K, Harried, Scott, Horner, Michelle, Kaller, Matthew R, Lehto, Sonya G, Liu, Qingyian, Ma, Vu V, Monenschein, Holger, Nguyen, Thomas T, Yuan, Chester C, Youngblood, Beth D, Zhang, Maosheng, Zhong, Wenge, Allen, Jennifer R, Chen, Jian Jeffrey, Gavva, Narender R
Published in Journal of medicinal chemistry (27.09.2018)
Published in Journal of medicinal chemistry (27.09.2018)
Get full text
Journal Article
Design of Potent, Orally Available Antagonists of the Transient Receptor Potential Vanilloid 1. Structure−Activity Relationships of 2-Piperazin-1-yl-1H-benzimidazoles
Ognyanov, Vassil I, Balan, Chenera, Bannon, Anthony W, Bo, Yunxin, Dominguez, Celia, Fotsch, Christopher, Gore, Vijay K, Klionsky, Lana, Ma, Vu V, Qian, Yi-Xin, Tamir, Rami, Wang, Xianghong, Xi, Ning, Xu, Shimin, Zhu, Dawn, Gavva, Narender R, Treanor, James J. S, Norman, Mark H
Published in Journal of medicinal chemistry (15.06.2006)
Published in Journal of medicinal chemistry (15.06.2006)
Get full text
Journal Article
Optimization of Potency and Pharmacokinetic Properties of Tetrahydroisoquinoline Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists
Horne, Daniel B, Tamayo, Nuria A, Bartberger, Michael D, Bo, Yunxin, Clarine, Jeffrey, Davis, Carl D, Gore, Vijay K, Kaller, Matthew R, Lehto, Sonya G, Ma, Vu V, Nishimura, Nobuko, Nguyen, Thomas T, Tang, Phi, Wang, Weiya, Youngblood, Beth D, Zhang, Maosheng, Gavva, Narender R, Monenschein, Holger, Norman, Mark H
Published in Journal of medicinal chemistry (10.04.2014)
Published in Journal of medicinal chemistry (10.04.2014)
Get full text
Journal Article
Structure–activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists
Gore, Vijay K., Ma, Vu V., Tamir, Rami, Gavva, Narender R., Treanor, James J.S., Norman, Mark H.
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
Get full text
Journal Article
Design of Potent, Orally Available Antagonists of the Transient Receptor Potential Vanilloid 1. Structure−Activity Relationships of 2-Piperazin-1-yl-1 H -benzimidazoles
Ognyanov, Vassil I., Balan, Chenera, Bannon, Anthony W., Bo, Yunxin, Dominguez, Celia, Fotsch, Christopher, Gore, Vijay K., Klionsky, Lana, Ma, Vu V., Qian, Yi-Xin, Tamir, Rami, Wang, Xianghong, Xi, Ning, Xu, Shimin, Zhu, Dawn, Gavva, Narender R., Treanor, James J. S., Norman, Mark H.
Published in Journal of medicinal chemistry (01.06.2006)
Published in Journal of medicinal chemistry (01.06.2006)
Get full text
Journal Article
TRP-M8 receptor ligands and their use in treatments
NISHIMURA NOBUKO, TAMAYO NURIA, MA VU VAN, KALLER MATTHEW, BO YUNXIN Y, GORE VIJAY K, NGUYEN THOMAS, HORNE DANIEL, MONENSCHEIN HOLGER, NORMAN MARK H
Year of Publication 02.07.2013
Get full text
Year of Publication 02.07.2013
Patent
Vanilloid receptor ligands and their use in treatments
Balan, Chenera, Bo, Yunxin, Dominguez, Celia, Fotsch, Christopher H, Gore, Vijay K, Ma, Vu Van, Norman, Mark H, Ognyanov, Vassil I, Qian, Yi-xin, Wang, Xianghong, Xi, Ning, Xu, Shimin
Year of Publication 27.09.2011
Get full text
Year of Publication 27.09.2011
Patent
TRP-M8 RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS
NISHIMURA NOBUKO, TAMAYO NURIA, MA VU VAN, KALLER MATTHEW, BO YUNXIN Y, GORE VIJAY K, NGUYEN THOMAS, HORNE DANIEL, MONENSCHEIN HOLGER, NORMAN MARK H
Year of Publication 14.10.2010
Get full text
Year of Publication 14.10.2010
Patent
Vanilloid receptor ligands and their use in treatments
GORE VIJAY K, CHEN NING, DOHERTY ELIZABETH M, BALAN CHENERA, NORMAN MARK H, WANG HUI-LING
Year of Publication 18.08.2005
Get full text
Year of Publication 18.08.2005
Patent
Vanilloid receptor ligands and their use in treatments
WANG XIANGHONG, QIAN YI-XIN, MA VU VAN, OGNYANOV VASSIL I, BO YUNXIN, FOTSCH CHRISTOPHER H, GORE VIJAY K, XI NING, DOMINGUEZ CELIA, XU SHIMIN, BALAN CHENERA, NORMAN MARK H
Year of Publication 27.09.2011
Get full text
Year of Publication 27.09.2011
Patent
Vanilloid receptor ligands and their use in treatments
Balan, Chenera, Bo, Yunxin, Dominguez, Celia, Fotsch, Christopher H, Gore, Vijay K, Ma, Vu Van, Norman, Mark H, Ognyanov, Vassil I, Qian, Yi-xin, Wang, Xianghong, Xi, Ning, Xu, Shimin
Year of Publication 01.09.2009
Get full text
Year of Publication 01.09.2009
Patent
Vanilloid receptor ligands and their use in treatments
GORE VIJAY K, FALSEY JAMES R, DOHERTY ELIZABETH M, BALAN CHENERA, NORMAN MARK H, WANG HUI-LING, KATON JODIE
Year of Publication 11.08.2005
Get full text
Year of Publication 11.08.2005
Patent
Vanilloid receptor ligands and their use in treatments
WANG XIANGHONG, QIAN YI-XIN, MA VU VAN, OGNYANOV VASSIL I, BO YUNXIN, FOTSCH CHRISTOPHER H, GORE VIJAY K, XI NING, DOMINGUEZ CELIA, XU SHIMIN, BALAN CHENERA, NORMAN MARK H
Year of Publication 01.09.2009
Get full text
Year of Publication 01.09.2009
Patent
VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS
WANG XIANGHONG, QIAN YI-XIN, MA VU VAN, OGNYANOV VASSIL I, BO YUNXIN, FOTSCH CHRISTOPHER H, GORE VIJAY K, XI NING, DOMINGUEZ CELIA, XU SHIMIN, BALAN CHENERA, NORMAN MARK H
Year of Publication 04.06.2009
Get full text
Year of Publication 04.06.2009
Patent
Benzimidazole derivatives and their use as vanilloid receptor ligands
MARK H. NORMAN, YI-XIN QIAN, CELIA DOMINGUEZ, VASSIL I. OGNYANOV, YUNXIN BO, NING XI, SHIMIN XU, VU VAN MA, CHRISTOPHER H. FOTSCH, XIANGHONG WANG, VIJAY K. GORE, CHENERA BALAN
Year of Publication 12.06.2008
Get full text
Year of Publication 12.06.2008
Patent