(-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a novel ATP-sensitive potassium channel opener: hemodynamic comparison to ZD-6169, WAY-133537, and nifedipine in the anesthetized canine
Fryer, Ryan M, Preusser, Lee C, Calzadilla, Samuel V, Hu, Yanhui, Xu, Hongyu, Marsh, Kennan C, Cox, Bryan F, Lin, C Thomas, Gopalakrishnan, Murali, Reinhart, Glenn A
Published in Journal of cardiovascular pharmacology (01.08.2004)
Published in Journal of cardiovascular pharmacology (01.08.2004)
Get more information
Journal Article
In vitro and in vivo characterization of a novel naphthylamide ATP‐sensitive K+ channel opener, A‐151892
Gopalakrishnan, Murali, Buckner, Steven A, Shieh, Char‐Chang, Fey, Thomas, Fabiyi, Adebola, Whiteaker, Kristi L, Davis‐Taber, Rachel, Milicic, Ivan, Daza, Anthony V, Scott, Victoria E S, Castle, Neil A, Printzenhoff, David, London, Brecht, Turner, Sean C, Carroll, William A, Sullivan, James P, Coghlan, Michael J, Brune, Michael E
Published in British journal of pharmacology (01.09.2004)
Published in British journal of pharmacology (01.09.2004)
Get full text
Journal Article
[3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity alpha7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain
Anderson, David J, Bunnelle, William, Surber, Bruce, Du, Jia, Surowy, Carol, Tribollet, Eliane, Marguerat, Anouk, Bertrand, Daniel, Gopalakrishnan, Murali
Published in The Journal of pharmacology and experimental therapeutics (01.01.2008)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.01.2008)
Journal Article
Role of channel activation in cognitive enhancement mediated by alpha7 nicotinic acetylcholine receptors
Briggs, Clark A, Grønlien, Jens Halvard, Curzon, Peter, Timmermann, Daniel B, Ween, Hilde, Thorin-Hagene, Kirsten, Kerr, Paige, Anderson, David J, Malysz, John, Dyhring, Tino, Olsen, Gunnar M, Peters, Dan, Bunnelle, William H, Gopalakrishnan, Murali
Published in British journal of pharmacology (01.11.2009)
Published in British journal of pharmacology (01.11.2009)
Get full text
Journal Article
Losartan improves renal function and pathology in obese ZSF-1 rats
Su, Zhi, Widomski, Deborah, Nikkel, Arthur, Leys, Laura, Namovic, Marian, Donnelly-Roberts, Diana, Gopalakrishnan, Murali, McGaraughty, Steve
Published in Journal of basic and clinical physiology and pharmacology (05.02.2018)
Get more information
Published in Journal of basic and clinical physiology and pharmacology (05.02.2018)
Journal Article
Structure-activity studies for a novel series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones as K(ATP) channel openers
Drizin, Irene, Altenbach, Robert J, Buckner, Steven A, Whiteaker, Kristi L, Scott, Victoria E, Darbyshire, John F, Jayanti, Venkata, Henry, Rodger F, Coghlan, Michael J, Gopalakrishnan, Murali, Carroll, William A
Published in Bioorganic & medicinal chemistry (15.04.2004)
Get full text
Published in Bioorganic & medicinal chemistry (15.04.2004)
Journal Article
Functional analysis of large conductance Ca2(+)-activated K(+) channels: ion flux studies by atomic absorption spectrometry
Parihar, Ashutosh S, Groebe, Duncan R, Scott, Victoria E, Feng, Jianlin, Zhang, Xu-Feng, Warrior, Usha, Gopalakrishnan, Murali, Shieh, Char-Chang
Published in Assay and drug development technologies (01.10.2003)
Published in Assay and drug development technologies (01.10.2003)
Get more information
Journal Article
In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107
Malysz, John, Anderson, David J, Grønlien, Jens H, Ji, Jianguo, Bunnelle, William H, Håkerud, Monika, Thorin-Hagene, Kirten, Ween, Hilde, Helfrich, Rosalind, Hu, Min, Gubbins, Earl, Gopalakrishnan, Sujatha, Puttfarcken, Pamela S, Briggs, Clark A, Li, Jinhe, Meyer, Michael D, Dyhring, Tino, Ahring, Philip K, Nielsen, Elsebet Ø, Peters, Dan, Timmermann, Daniel B, Gopalakrishnan, Murali
Published in The Journal of pharmacology and experimental therapeutics (01.09.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2010)
Get full text
Journal Article
Interaction of azimilide with neurohumoral and channel receptors 1 1Abbreviations:IKr, rapidly activating component of the delayed-rectifier current; IKs, slowly activating component of the delayed-rectifier current; ec50, concentration giving 50% of the maximum stimulation; Ki, inhibition constant; and HT, hydroxytryptamine (serotonin)
Brooks, Robert R., Pong, Schwe Fang, Izzo, Nicholas J., Moorehead, Thomas J., Gopalakrishnan, Murali, Triggle, David J.
Published in Biochemical pharmacology (01.10.2001)
Published in Biochemical pharmacology (01.10.2001)
Get full text
Journal Article
Evaluation of alpha7 nicotinic acetylcholine receptor agonists and positive allosteric modulators using the parallel oocyte electrophysiology test station
Malysz, John, Grønlien, Jens H, Timmermann, Daniel B, Håkerud, Monika, Thorin-Hagene, Kirsten, Ween, Hilde, Trumbull, Jonathan D, Xiong, Yongli, Briggs, Clark A, Ahring, Philip K, Dyhring, Tino, Gopalakrishnan, Murali
Published in Assay and drug development technologies (01.08.2009)
Published in Assay and drug development technologies (01.08.2009)
Get more information
Journal Article
Structure–activity relationship of a novel class of naphthyl amide KATP channel openers
Turner, Sean C, Carroll, William A, White, Tammie K, Brune, Michael E, Buckner, Steven A, Gopalakrishnan, Murali, Fabiyi, Adebola, Coghlan, Michael J, Scott, Victoria E, Castle, Neil A, Daza, Anthony V, Milicic, Ivan, Sullivan, James P
Published in Bioorganic & medicinal chemistry letters (19.05.2003)
Published in Bioorganic & medicinal chemistry letters (19.05.2003)
Get full text
Journal Article
Structure–activity studies for a novel series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones as K ATP channel openers
Drizin, Irene, Altenbach, Robert J., Buckner, Steven A., Whiteaker, Kristi L., Scott, Victoria E., Darbyshire, John F., Jayanti, Venkata, Henry, Rodger F., Coghlan, Michael J., Gopalakrishnan, Murali, Carroll, William A.
Published in Bioorganic & medicinal chemistry (2004)
Published in Bioorganic & medicinal chemistry (2004)
Get full text
Journal Article
Pharmacological characterization of the novel dihydropyridine potassium channel opener, (9R)-9-(3-iodo-4-methylphenyl)-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione (A-325100), and the regulation of cardiovascular function in conscious and anesthetized beagle dogs
Fryer, Ryan M, Rakestraw, Pamela A, Preusser, Lee C, Brune, Michael E, Carroll, William A, Buckner, Steven A, Shieh, Char-Chang, King, Linda L, Marsh, Kennan C, Gopalakrishnan, Murali, Cox, Bryan F, Reinhart, Glenn A
Published in Journal of cardiovascular pharmacology (01.08.2005)
Published in Journal of cardiovascular pharmacology (01.08.2005)
Get more information
Journal Article
Pharmacological characterization of a 1,4‐dihydropyridine analogue, 9‐(3,4‐dichlorophenyl)‐3,3,6,6‐tetramethyl‐3,4,6,7,9,10‐hexahydro‐1,8(2 H ,5 H )‐acridinedione (A‐184209) as a novel K ATP channel inhibitor
Gopalakrishnan, Murali, Miller, Thomas R, Buckner, Steven A, Milicic, Ivan, Molinari, Eduardo J, Whiteaker, Kristi L, Davis‐Taber, Rachel, Scott, Victoria E, Cassidy, Christopher, Sullivan, James P, Carroll, William A
Published in British journal of pharmacology (01.01.2003)
Published in British journal of pharmacology (01.01.2003)
Get full text
Journal Article
Preclinical Characterization of A-582941: A Novel alpha 7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition-Enhancing Properties
Tietje, Karin R, Anderson, David J, Bitner, RScott, Blomme, Eric A, Brackemeyer, Paul J, Briggs, Clark A, Browman, Kaitlin E, Bury, Dagmar, Curzon, Peter, Drescher, Karla U, Frost, Jennifer M, Fryer, Ryan M, Fox, Gerard B, Gronlien, Jens Halvard, Haakerud, Monika, Gubbins, Earl J, Halm, Sabine, Harris, Richard, Helfrich, Rosalind J, Kohlhaas, Kathy L, Law, Devalina, Malysz, John, Marsh, Kennan C, Martin, Ruth L, Meyer, Michael D, Molesky, Angela L, Nikkel, Arthur L, Otte, Stephani, Pan, Liping, Puttfarcken, Pamela S, Radek, Richard J, Robb, Holly M, Spies, Eva, Thorin-Hagene, Kirsten, Waring, Jeffrey F, Ween, Hilde, Xu, Hongyu, Gopalakrishnan, Murali, Bunnelle, William H
Published in CNS neuroscience & therapeutics (01.03.2008)
Published in CNS neuroscience & therapeutics (01.03.2008)
Get full text
Journal Article
Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide K(ATP) channel openers: discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a potent K(ATP) opener that selectively inhibits spontaneous bladder contractions
Carroll, William A, Altenbach, Robert J, Bai, Hao, Brioni, Jorge D, Brune, Michael E, Buckner, Steven A, Cassidy, Christopher, Chen, Yiyuan, Coghlan, Michael J, Daza, Anthony V, Drizin, Irene, Fey, Thomas A, Fitzgerald, Michael, Gopalakrishnan, Murali, Gregg, Robert J, Henry, Rodger F, Holladay, Mark W, King, Linda L, Kort, Michael E, Kym, Philip R, Milicic, Ivan, Tang, Rui, Turner, Sean C, Whiteaker, Kristi L, Yi, Lin, Zhang, Henry, Sullivan, James P
Published in Journal of medicinal chemistry (03.06.2004)
Get full text
Published in Journal of medicinal chemistry (03.06.2004)
Journal Article
Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties
Tietje, Karin R, Anderson, David J, Bitner, R Scott, Blomme, Eric A, Brackemeyer, Paul J, Briggs, Clark A, Browman, Kaitlin E, Bury, Dagmar, Curzon, Peter, Drescher, Karla U, Frost, Jennifer M, Fryer, Ryan M, Fox, Gerard B, Gronlien, Jens Halvard, Håkerud, Monika, Gubbins, Earl J, Halm, Sabine, Harris, Richard, Helfrich, Rosalind J, Kohlhaas, Kathy L, Law, Devalina, Malysz, John, Marsh, Kennan C, Martin, Ruth L, Meyer, Michael D, Molesky, Angela L, Nikkel, Arthur L, Otte, Stephani, Pan, Liping, Puttfarcken, Pamela S, Radek, Richard J, Robb, Holly M, Spies, Eva, Thorin-Hagene, Kirsten, Waring, Jeffrey F, Ween, Hilde, Xu, Hongyu, Gopalakrishnan, Murali, Bunnelle, William H
Published in CNS neuroscience & therapeutics (2008)
Published in CNS neuroscience & therapeutics (2008)
Get full text
Journal Article
Preclinical Characterization of A-582941 : A Novel a7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition-Enhancing Properties
TIETJE, Karin R, ANDERSON, David J, FROST, Jennifer M, FRYER, Ryan M, FOX, Gerard B, HALVARD GRONLIEN, Jens, HAKERUD, Monika, GUBBINS, Earl J, HALM, Sabine, HARRIS, Richard, HELFRICH, Rosalind J, KOHLHAAS, Kathy L, BITNER, R. Scott, LAW, Devalina, MALYSZ, John, MARSH, Kennan C, MARTIN, Ruth L, MEYER, Michael D, MOLESKY, Angela L, NIKKEL, Arthur L, OTTE, Stephani, PAN, Liping, PUTTFARCKEN, Pamela S, BLOMME, Eric A, RADEK, Richard J, ROBB, Holly M, SPIES, Eva, THORIN-HAGENE, Kirsten, WARING, Jeffrey F, WEEN, Hilde, HONGYU XU, GOPALAKRISHNAN, Murali, BUNNELLE, William H, BRACKEMEYER, Paul J, BRIGGS, Clark A, BROWMAN, Kaitlin E, BURY, Dagmar, CURZON, Peter, DRESCHER, Karla U
Published in CNS neuroscience & therapeutics (2008)
Get full text
Published in CNS neuroscience & therapeutics (2008)
Journal Article
Pharmacological characterization of a 1,4‐dihydropyridine analogue, 9‐(3,4‐dichlorophenyl)‐3,3,6,6‐tetramethyl‐3,4,6,7,9,10‐hexahydro‐1,8(2H,5H)‐acridinedione (A‐184209) as a novel KATP channel inhibitor
Gopalakrishnan, Murali, Miller, Thomas R, Buckner, Steven A, Milicic, Ivan, Molinari, Eduardo J, Whiteaker, Kristi L, Davis‐Taber, Rachel, Scott, Victoria E, Cassidy, Christopher, Sullivan, James P, Carroll, William A
Published in British journal of pharmacology (01.01.2003)
Published in British journal of pharmacology (01.01.2003)
Get full text
Journal Article
Pharmacological characterization of a 1,4-dihydropyridine analogue, 9-(3,4-dichlorophenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydro-1,8(2H, 5H)-acr idinedione (A-184209) as a novel KATP channel inhibitor
GOPALAKRISHNAN, Murali, MILLER, Thomas R, CARROLL, William A, BUCKNER, Steven A, MILICIC, Ivan, MOLINARI, Eduardo J, WHITEAKER, Kristi L, DAVIS-TABER, Rachel, SCOTT, Victoria E, CASSIDY, Christopher, SULLIVAN, James P
Published in British journal of pharmacology (2003)
Get full text
Published in British journal of pharmacology (2003)
Journal Article