Establishing Transcriptional Signatures to Differentiate PXR-, CAR-, and AhR-Mediated Regulation of Drug Metabolism and Transport Genes in Cryopreserved Human Hepatocytes
Moscovitz, Jamie E, Kalgutkar, Amit S, Nulick, Kelly, Johnson, Nathaniel, Lin, Zhiwu, Goosen, Theunis C, Weng, Yan
Published in The Journal of pharmacology and experimental therapeutics (01.05.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2018)
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Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors
Walsky, Robert L, Bauman, Jonathan N, Bourcier, Karine, Giddens, Georgina, Lapham, Kimberly, Negahban, Andre, Ryder, Tim F, Obach, R Scott, Hyland, Ruth, Goosen, Theunis C
Published in Drug metabolism and disposition (01.05.2012)
Published in Drug metabolism and disposition (01.05.2012)
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Relative contributions of cytochrome CYP3A4 versus CYP3A5 for CYP3A-cleared drugs assessed in vitro using a CYP3A4-selective inactivator (CYP3cide)
Tseng, Elaine, Walsky, Robert L, Luzietti, Jr, Ricardo A, Harris, Jennifer J, Kosa, Rachel E, Goosen, Theunis C, Zientek, Michael A, Obach, R Scott
Published in Drug metabolism and disposition (01.07.2014)
Published in Drug metabolism and disposition (01.07.2014)
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Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA In Vitro Response Thresholds, Variability, and Clinical Relevance
Kenny, Jane R, Ramsden, Diane, Buckley, David B, Dallas, Shannon, Fung, Conrad, Mohutsky, Michael, Einolf, Heidi J, Chen, Liangfu, Dekeyser, Joshua G, Fitzgerald, Maria, Goosen, Theunis C, Siu, Y Amy, Walsky, Robert L, Zhang, George, Tweedie, Donald, Hariparsad, Niresh
Published in Drug metabolism and disposition (01.09.2018)
Published in Drug metabolism and disposition (01.09.2018)
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In Vitro Assessment of Metabolic Drug-Drug Interaction Potential of Apixaban through Cytochrome P450 Phenotyping, Inhibition, and Induction Studies
LIFEI WANG, DONGLU ZHANG, HUMPHREYS, W. Griffith, GROSSMAN, Scott J, RAGHAVAN, Nirmala, MING YAO, LI MA, FROST, Charles A, MAXWELL, Brad D, CHEN, Shiang-Yuan, KAN HE, GOOSEN, Theunis C
Published in Drug metabolism and disposition (01.03.2010)
Published in Drug metabolism and disposition (01.03.2010)
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Static and Dynamic Projections of Drug-Drug Interactions Caused by Cytochrome P450 3A Time-Dependent Inhibitors Measured in Human Liver Microsomes and Hepatocytes
Tseng, Elaine, Eng, Heather, Lin, Jian, Cerny, Matthew A, Tess, David A, Goosen, Theunis C, Obach, R Scott
Published in Drug metabolism and disposition (01.10.2021)
Published in Drug metabolism and disposition (01.10.2021)
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Physiologically‐Based Pharmacokinetic Modeling of the Drug–Drug Interaction of the UGT Substrate Ertugliflozin Following Co‐Administration with the UGT Inhibitor Mefenamic Acid
Callegari, Ernesto, Lin, Jian, Tse, Susanna, Goosen, Theunis C., Sahasrabudhe, Vaishali
Published in CPT: pharmacometrics and systems pharmacology (01.02.2021)
Published in CPT: pharmacometrics and systems pharmacology (01.02.2021)
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In Vitro Kinetic Characterization of Axitinib Metabolism
Zientek, Michael A, Goosen, Theunis C, Tseng, Elaine, Lin, Jian, Bauman, Jonathan N, Walker, Gregory S, Kang, Ping, Jiang, Ying, Freiwald, Sascha, Neul, David, Smith, Bill J
Published in Drug metabolism and disposition (01.01.2016)
Published in Drug metabolism and disposition (01.01.2016)
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Investigation of CYP3A induction by PF‐05251749 in early clinical development: comparison of linear slope physiologically based pharmacokinetic prediction and biomarker response
Lin, Jian, Gaudreault, Francois, Johnson, Nathaniel, Lin, Zhiwu, Nouri, Parya, Goosen, Theunis C., Sawant‐Basak, Aarti
Published in Clinical and translational science (01.09.2022)
Published in Clinical and translational science (01.09.2022)
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Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)
Futatsugi, Kentaro, Kung, Daniel W, Orr, Suvi T. M, Cabral, Shawn, Hepworth, David, Aspnes, Gary, Bader, Scott, Bian, Jianwei, Boehm, Markus, Carpino, Philip A, Coffey, Steven B, Dowling, Matthew S, Herr, Michael, Jiao, Wenhua, Lavergne, Sophie Y, Li, Qifang, Clark, Ronald W, Erion, Derek M, Kou, Kou, Lee, Kyuha, Pabst, Brandon A, Perez, Sylvie M, Purkal, Julie, Jorgensen, Csilla C, Goosen, Theunis C, Gosset, James R, Niosi, Mark, Pettersen, John C, Pfefferkorn, Jeffrey A, Ahn, Kay, Goodwin, Bryan
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in the metabolism of drugs
Walsky, Robert L, Obach, R Scott, Hyland, Ruth, Kang, Ping, Zhou, Sue, West, Michael, Geoghegan, Kieran F, Helal, Christopher J, Walker, Gregory S, Goosen, Theunis C, Zientek, Michael A
Published in Drug metabolism and disposition (01.09.2012)
Published in Drug metabolism and disposition (01.09.2012)
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Physicochemical property space of hepatobiliary transport and computational models for predicting rat biliary excretion
Varma, Manthena V S, Chang, George, Lai, Yurong, Feng, Bo, El-Kattan, Ayman F, Litchfield, John, Goosen, Theunis C
Published in Drug metabolism and disposition (01.08.2012)
Published in Drug metabolism and disposition (01.08.2012)
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Investigating the enteroenteric recirculation of apixaban, a factor Xa inhibitor: administration of activated charcoal to bile duct-cannulated rats and dogs receiving an intravenous dose and use of drug transporter knockout rats
Zhang, Donglu, Frost, Charles E, He, Kan, Rodrigues, A David, Wang, Xiaoli, Wang, Lifei, Goosen, Theunis C, Humphreys, W Griffith
Published in Drug metabolism and disposition (01.04.2013)
Published in Drug metabolism and disposition (01.04.2013)
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Quantitative prediction of repaglinide-rifampicin complex drug interactions using dynamic and static mechanistic models: delineating differential CYP3A4 induction and OATP1B1 inhibition potential of rifampicin
Varma, Manthena V S, Lin, Jian, Bi, Yi-An, Rotter, Charles J, Fahmi, Odette A, Lam, Justine L, El-Kattan, Ayman F, Goosen, Theunis C, Lai, Yurong
Published in Drug metabolism and disposition (01.05.2013)
Published in Drug metabolism and disposition (01.05.2013)
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Kinetics of Acetaminophen Glucuronidation by UDP-Glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential Implications in Acetaminophen−Induced Hepatotoxicity
Mutlib, Abdul E, Goosen, Theunis C, Bauman, Jonathan N, Williams, J. Andrew, Kulkarni, Shaila, Kostrubsky, Seva
Published in Chemical research in toxicology (01.05.2006)
Published in Chemical research in toxicology (01.05.2006)
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Intestinal targeting of drugs: rational design approaches and challenges
Filipski, Kevin J, Varma, Manthena V, El-Kattan, Ayman F, Ambler, Catherine M, Ruggeri, Roger B, Goosen, Theunis C, Cameron, Kimberly O
Published in Current topics in medicinal chemistry (01.04.2013)
Published in Current topics in medicinal chemistry (01.04.2013)
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