Two Approaches to the Chemical Development and Large-Scale Preparation of a Pyrimidyl Tetrazole Intermediate
Mullens, Peter, Cleator, Ed, McLaughlin, Mark, Bishop, Brian, Edwards, John, Goodyear, Adrian, Andreani, Teresa, Jin, Yan, Kong, Jongrock, Li, Hongmei, Williams, Michael, Zacuto, Michael
Published in Organic process research & development (17.06.2016)
Published in Organic process research & development (17.06.2016)
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A Novel Approach to 3-Methylindoles by a Heck/Cyclization/Isomerization Process
Baxter, Carl A, Cleator, Ed, Alam, Mahbub, Davies, Antony J, Goodyear, Adrian, O’Hagan, Michael
Published in Organic letters (19.02.2010)
Published in Organic letters (19.02.2010)
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Journal Article
Development of a Phase Transfer Catalyzed Asymmetric Synthesis for an Estrogen Receptor Beta Selective Agonist
Scott, Jeremy P, Ashwood, Michael S, Brands, Karel M. J, Brewer, Sarah E, Cowden, Cameron J, Dolling, Ulf-H, Emerson, Khateeta M, Gibb, Andrew D, Goodyear, Adrian, Oliver, Steven F, Stewart, Gavin W, Wallace, Debra J
Published in Organic process research & development (01.07.2008)
Published in Organic process research & development (01.07.2008)
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Journal Article
Thermal Hazard Evaluation of 4-Methoxybenzyl Chloride (PMB-Cl)
Brewer, Sarah E, Vickery, Thomas P, Bachert, Donald C, Brands, Karel M. J, Emerson, Khateeta M, Goodyear, Adrian, Kumke, Kathleen J, Lam, Thientu, Scott, Jeremy P
Published in Organic process research & development (01.11.2005)
Published in Organic process research & development (01.11.2005)
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Journal Article
Process Development of a Tricyclic Diazepine-Based IDH1 Mutant Inhibitor
Maddess, Matthew L., Cleator, Ed, Morimoto, Mariko, Goodyear, Adrian, Dieguez-Vazquez, Alejandro, Gibb, Andrew, Kirtley, Andy, Christensen, Melodie, Song, Chaohui, Peng, Feng, Alam, Mahbub, Keen, Stephen P., Oliver, Steven F.
Published in Organic process research & development (21.06.2024)
Published in Organic process research & development (21.06.2024)
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Journal Article
Development of a Stereoselective Synthesis of (1R,4R)- and (1S,4S)‑2-Oxa-5-azabicyclo[2.2.2]octane
Maddess, Matthew L, Cleator, Ed, Morimoto, Mariko, Goodyear, Adrian, Dieguez-Vazquez, Alejandro, Gibb, Andrew, Kirtley, Andy, Wang, Jie, Qi, Ji, Kong, Lingzhu, Alam, Mahbub, Keen, Stephen, Oliver, Steven F, Wen, Xin, Lam, Yu-Hong
Published in Organic process research & development (18.03.2022)
Published in Organic process research & development (18.03.2022)
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Journal Article
Practical Asymmetric Synthesis of a Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist Ubrogepant
Yasuda, Nobuyoshi, Cleator, Ed, Kosjek, Birgit, Yin, Jianguo, Xiang, Bangping, Chen, Frank, Kuo, Shen-Chun, Belyk, Kevin, Mullens, Peter R, Goodyear, Adrian, Edwards, John S, Bishop, Brian, Ceglia, Scott, Belardi, Justin, Tan, Lushi, Song, Zhiguo J, DiMichele, Lisa, Reamer, Robert, Cabirol, Fabien L, Tang, Weng Lin, Liu, Guiquan
Published in Organic process research & development (17.11.2017)
Published in Organic process research & development (17.11.2017)
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Journal Article
Asymmetric Synthesis of cis-2,5-Disubstituted Pyrrolidine, the Core Scaffold of beta(3)-AR Agonists
Xu, Feng, Chung, John Y. L., Moore, Jeffery C., Liu, Zhuqing, Yoshikawa, Naoki, Hoerrner, R. Scott, Lee, Jaemoon, Royzen, Maksim, Cleator, Ed, Gibson, Andrew G., Dunn, Robert, Maloney, Kevin M., Alam, Mahbub, Goodyear, Adrian, Lynch, Joseph, Yasuda, Nobuyashi, Devine, Paul N.
Published in Organic letters (15.03.2013)
Published in Organic letters (15.03.2013)
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Journal Article
Highly Diastereoselective Synthesis of a HCV NS5B Nucleoside Polymerase Inhibitor
Zhong, Yong-Li, Cleator, Ed, Liu, Zhijian, Yin, Jianguo, Morris, William J, Alam, Mahbub, Bishop, Brian, Dumas, Aaron M, Edwards, John, Goodyear, Adrian, Mullens, Peter, Song, Zhiguo Jake, Shevlin, Michael, Thaisrivongs, David A, Li, Hongming, Sherer, Edward C, Cohen, Ryan D, Yin, Jingjun, Tan, Lushi, Yasuda, Nobuyoshi, Limanto, John, Davies, Antony, Campos, Kevin R
Published in Journal of organic chemistry (19.04.2019)
Published in Journal of organic chemistry (19.04.2019)
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Journal Article
Asymmetric Synthesis of cis-2,5-Disubstituted Pyrrolidine, the Core Scaffold of β3‑AR Agonists
Xu, Feng, Chung, John Y. L, Moore, Jeffery C, Liu, Zhuqing, Yoshikawa, Naoki, Hoerrner, R. Scott, Lee, Jaemoon, Royzen, Maksim, Cleator, Ed, Gibson, Andrew G, Dunn, Robert, Maloney, Kevin M, Alam, Mahbub, Goodyear, Adrian, Lynch, Joseph, Yasuda, Nobuyashi, Devine, Paul N
Published in Organic letters (15.03.2013)
Published in Organic letters (15.03.2013)
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Journal Article
Mitsunobu Inversion of a Secondary Alcohol with Diphenylphosphoryl azide. Application to the Enantioselective Multikilogram Synthesis of a HCV Polymerase Inhibitor
Scott, Jeremy P, Alam, Mahbub, Bremeyer, Nadine, Goodyear, Adrian, Lam, Thientu, Wilson, Robert D, Zhou, George
Published in Organic process research & development (16.09.2011)
Published in Organic process research & development (16.09.2011)
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Journal Article
Development of a Safe and Practical N-Oxidation Procedure Using m-CPBA in Acetic Acid
Alam, Mahbub, Goodyear, Adrian, Scott, Jeremy P, Vickery, Thomas P
Published in Organic process research & development (18.03.2011)
Published in Organic process research & development (18.03.2011)
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Journal Article
Asymmetric Synthesis of cis -2,5-Disubstituted Pyrrolidine, the Core Scaffold of β 3 -AR Agonists
Xu, Feng, Chung, John Y. L., Moore, Jeffery C., Liu, Zhuqing, Yoshikawa, Naoki, Hoerrner, R. Scott, Lee, Jaemoon, Royzen, Maksim, Cleator, Ed, Gibson, Andrew G., Dunn, Robert, Maloney, Kevin M., Alam, Mahbub, Goodyear, Adrian, Lynch, Joseph, Yasuda, Nobuyashi, Devine, Paul N.
Published in Organic letters (15.03.2013)
Published in Organic letters (15.03.2013)
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Journal Article
Process Development and Large-Scale Synthesis of MK-6186, a Non-Nucleoside Reverse Transcriptase Inhibitor for the Treatment of HIV
Goodyear, Adrian, Linghu, Xin, Bishop, Brian, Chen, Cheng, Cleator, Ed, McLaughlin, Mark, Sheen, Faye J, Stewart, Gavin W, Xu, Yingju, Yin, Jingjun
Published in Organic process research & development (20.04.2012)
Published in Organic process research & development (20.04.2012)
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Crystalline forms of 1-[(3R,4S)-4-cyanotetrahydropyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridyl)amino]pyrazole-4-carboxamide
Varsolona, Richard J, Chassaing, Christophe Pierre Alain, Petrova, Rositza Iordanova, Jin, Xiaoling, Goodyear, Adrian, Schweisel, Tanja, Simmons, Jonathan, Codan, Lorenzo, Cleator, Edward
Year of Publication 25.06.2024
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Year of Publication 25.06.2024
Patent
Crystalline forms of 1-[(3R,4S)-4-cyanotetrahydropyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridyl)amino]pyrazole-4-carboxamide
CODAN, Lorenzo, CHASSAING, Christophe Pierre Alain, PETROVA, Rositza Iordanova, VARSOLONA, Richard J, SIMMONS, Jonathan, SCHWEISEL, Tanja, GOODYEAR, Adrian, CLEATOR, Edward, JIN, Xiaoling
Year of Publication 05.01.2023
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Year of Publication 05.01.2023
Patent
Crystalline Forms of 1-[(3R,4S)-4-Cyanotetrahydropyran-3-YL]-3-[(2-Fluoro-6-Methoxy-4-Pyridyl)Amino]Pyrazole-4-Carboxamide
Varsolona, Richard J, Chassaing, Christophe Pierre Alain, Petrova, Rositza Iordanova, Jin, Xiaoling, Goodyear, Adrian, Schweisel, Tanja, Simmons, Jonathan, Codan, Lorenzo, Cleator, Edward
Year of Publication 27.01.2022
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Year of Publication 27.01.2022
Patent
CRYSTALLINE FORMS OF 1-[(3R,4S)-4-CYANOTETRAHYDROPYRAN-3-YL]-3-[(2-FLUORO-6-METHOXY-4-PYRIDYL)AMINO]PYRAZOLE-4-CARBOXAMIDE
CODAN, Lorenzo, SIMMONS, Jonathan, SCHWEISEL, Tanja, CHASSAING, Christophe, Pierre, Alain, GOODYEAR, Adrian, CLEATOR, Edward, PETROVA, Rositza, Iordanova, JIN, Xiaoling, VARSOLONA, Richard, J
Year of Publication 20.10.2021
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Year of Publication 20.10.2021
Patent
Crystalline forms of 1-[(3R,4S)-4-cyanotetrahydropyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridyl)amino]pyrazole-4-carboxamide
CODAN, Lorenzo, CHASSAING, Christophe Pierre Alain, PETROVA, Rositza Iordanova, VARSOLONA, Richard J, SIMMONS, Jonathan, SCHWEISEL, Tanja, GOODYEAR, Adrian, CLEATOR, Edward, JIN, Xiaoling
Year of Publication 17.06.2021
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Year of Publication 17.06.2021
Patent
CRYSTALLINE FORMS OF 1-[(3R,4S)-4-CYANOTETRAHYDROPYRAN-3-YL]-3-[(2-FLUORO-6-METHOXY-4-PYRIDYL)AMINO]PYRAZOLE-4-CARBOXAMIDE
CODAN, Lorenzo, SIMMONS, Jonathan, SCHWEISEL, Tanja, VARSOLONA, Richard, GOODYEAR, Adrian, CHASSAING, Christophe, CLEATOR, Edward, JIN, Xiaoling, PETROVA, Rositza
Year of Publication 18.06.2020
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Year of Publication 18.06.2020
Patent