Mixed lineage kinase 3 mediates release of C‐X‐C motif ligand 10–bearing chemotactic extracellular vesicles from lipotoxic hepatocytes
Ibrahim, Samar H., Hirsova, Petra, Tomita, Kyoko, Bronk, Steven F., Werneburg, Nathan W., Harrison, Stephen A., Goodfellow, Val S., Malhi, Harmeet, Gores, Gregory J.
Published in Hepatology (Baltimore, Md.) (01.03.2016)
Published in Hepatology (Baltimore, Md.) (01.03.2016)
Get full text
Journal Article
Discovery, Synthesis, and Characterization of an Orally Bioavailable, Brain Penetrant Inhibitor of Mixed Lineage Kinase 3
Goodfellow, Val S, Loweth, Colin J, Ravula, Satheesh B, Wiemann, Torsten, Nguyen, Thong, Xu, Yang, Todd, Daniel E, Sheppard, David, Pollack, Scott, Polesskaya, Oksana, Marker, Daniel F, Dewhurst, Stephen, Gelbard, Harris A
Published in Journal of medicinal chemistry (24.10.2013)
Published in Journal of medicinal chemistry (24.10.2013)
Get full text
Journal Article
The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy
Zhang, Gang, PhD, Guo, Dongwei, MS, Dash, Prasanta K., PhD, Araínga, Mariluz, DVM, MSc, PhD, Wiederin, Jayme L., MS, Haverland, Nicole A., PhD, Knibbe-Hollinger, Jaclyn, MPH, Martinez-Skinner, Andrea, PhD, Ciborowski, Pawel, PhD, Goodfellow, Val S., PhD, Wysocki, Tadeusz A., PhD, Wysocki, Beata J., PhD, Poluektova, Larisa Y., MD, PhD, Liu, Xin-Ming, PhD, McMillan, JoEllyn M., PhD, Gorantla, Santhi, PhD, Gelbard, Harris A., MD, PhD, Gendelman, Howard E., MD
Published in Nanomedicine (01.01.2016)
Published in Nanomedicine (01.01.2016)
Get full text
Journal Article
The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders
Marker, Daniel F, Tremblay, Marie-Ève, Puccini, Jenna M, Barbieri, Justin, Gantz Marker, Mary A, Loweth, Colin J, Muly, E Chris, Lu, Shao-Ming, Goodfellow, Val S, Dewhurst, Stephen, Gelbard, Harris A
Published in The Journal of neuroscience (12.06.2013)
Published in The Journal of neuroscience (12.06.2013)
Get full text
Journal Article
Potent and orally active non-peptide antagonists of the human melanocortin-4 receptor based on a series of trans-2-disubstituted cyclohexylpiperazines
Tucci, Fabio C., White, Nicole S., Markison, Stacy, Joppa, Margaret, Tran, Joe A., Fleck, Beth A., Madan, Ajay, Dyck, Brian P., Parker, Jessica, Pontillo, Joseph, Melissa Arellano, L., Marinkovic, Dragan, Jiang, Wanlong, Chen, Caroline W., Gogas, Kathleen R., Goodfellow, Val S., Saunders, John, Foster, Alan C., Chen, Chen
Published in Bioorganic & medicinal chemistry letters (01.10.2005)
Published in Bioorganic & medicinal chemistry letters (01.10.2005)
Get full text
Journal Article
Potent imidazole and triazole CB1 receptor antagonists related to SR141716
DYCK, Brian, GOODFELLOW, Val S, PHILLIPS, Teresa, GREY, Jonathan, HADDACH, Mustapha, ROWBOTTOM, Martin, NAEVE, Gregory S, BROWN, Brock, SAUNDERS, John
Published in Bioorganic & medicinal chemistry letters (08.03.2004)
Published in Bioorganic & medicinal chemistry letters (08.03.2004)
Get full text
Journal Article
A Thienopyridazinone-Based Melanin-Concentrating Hormone Receptor 1 Antagonist with Potent in Vivo Anorectic Properties
Dyck, Brian, Markison, Stacy, Zhao, Liren, Tamiya, Junko, Grey, Jonathan, Rowbottom, Martin W, Zhang, Mingzhu, Vickers, Troy, Sorensen, Katie, Norton, Christi, Wen, Jenny, Heise, Christopher E, Saunders, John, Conlon, Paul, Madan, Ajay, Schwarz, David, Goodfellow, Val S
Published in Journal of medicinal chemistry (29.06.2006)
Published in Journal of medicinal chemistry (29.06.2006)
Get full text
Journal Article
Bradykinin Receptor Antagonists Containing N-Substituted Amino Acids: In Vitro and in Vivo B2 and B1 Receptor Antagonist Activity
Goodfellow, Val S, Marathe, Manoj V, Kuhlman, Karen G, Fitzpatrick, Timothy D, Cuadrado, David, Hanson, Wendy, Zuzack, John S, Ross, Sherman E, Wieczorek, Maciej, Burkard, Michael, Whalley, Eric T
Published in Journal of medicinal chemistry (29.03.1996)
Published in Journal of medicinal chemistry (29.03.1996)
Get full text
Journal Article
Thienopyrimidinone bis-aminopyrrolidine ureas as potent melanin-concentrating hormone receptor-1 (MCH-R1) antagonists
Zhang, Mingzhu, Tamiya, Junko, Nguyen, Linh, Rowbottom, Martin W., Dyck, Brian, Vickers, Troy D., Grey, Jonathan, Schwarz, David A., Heise, Christopher E., Haelewyn, Jason, Mistry, Monica S., Goodfellow, Val S.
Published in Bioorganic & medicinal chemistry letters (01.05.2007)
Published in Bioorganic & medicinal chemistry letters (01.05.2007)
Get full text
Journal Article
Substituted chromones and quinolones as potent melanin-concentrating hormone receptor 1 antagonists
Dyck, Brian, Zhao, Liren, Tamiya, Junko, Pontillo, Joseph, Hudson, Sarah, Ching, Brett, Heise, Christopher E., Wen, Jenny, Norton, Christi, Madan, Ajay, Schwarz, David, Wade, Warren, Goodfellow, Val S.
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
Get full text
Journal Article
1-(4-Amino-phenyl)-pyrrolidin-3-yl-amine and 6-(3-amino-pyrrolidin-1-yl)-pyridin-3-yl-amine derivatives as melanin-concentrating hormone receptor-1 antagonists
Huang, Charles Q., Baker, Tracy, Schwarz, David, Fan, Jun, Heise, Christopher E., Zhang, Mingzhu, Goodfellow, Val S., Markison, Stacy, Gogas, Kathleen R., Chen, Takung, Wang, Xiao-Chuan, Zhu, Yun-Fei
Published in Bioorganic & medicinal chemistry letters (15.08.2005)
Published in Bioorganic & medicinal chemistry letters (15.08.2005)
Get full text
Journal Article
Assessment of a small molecule melanocortin-4 receptor-specific agonist on energy homeostasis
Cepoi, David, Phillips, Teresa, Cismowski, Mary, Goodfellow, Val S, Ling, Nick, Cone, Roger D, Fan, Wei
Published in Brain research (12.03.2004)
Published in Brain research (12.03.2004)
Get full text
Journal Article
Synthesis and structure–activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1)
Rowbottom, Martin W., Vickers, Troy D., Tamiya, Junko, Zhang, Mingzhu, Dyck, Brian, Grey, Jonathan, Schwarz, David, Heise, Christopher E., Hedrick, Michael, Wen, Jenny, Tang, Hui, Wang, Hua, Fisher, Andrew, Aparicio, Anna, Saunders, John, Goodfellow, Val S.
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
Get full text
Journal Article
Synthesis and structure–activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 2
Hudson, Sarah, Kiankarimi, Mehrak, Rowbottom, Martin W., Vickers, Troy D., Wu, Dongpei, Pontillo, Joseph, Ching, Brett, Dwight, Wesley, Goodfellow, Val S., Schwarz, David, Heise, Christopher E., Madan, Ajay, Wen, Jenny, Ban, William, Wang, Hua, Wade, Warren S.
Published in Bioorganic & medicinal chemistry letters (15.09.2006)
Published in Bioorganic & medicinal chemistry letters (15.09.2006)
Get full text
Journal Article
Bis(aminopyrrolidine)-derived ureas (APUs) as potent MCH1 receptor antagonists
Grey, Jonathan, Dyck, Brian, Rowbottom, Martin W, Tamiya, Junko, Vickers, Troy D, Zhang, Mingzhu, Zhao, Liren, Heise, Christopher E, Schwarz, David, Saunders, John, Goodfellow, Val S
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
Get full text
Journal Article
Synthesis and structure–activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 1
Rowbottom, Martin W., Vickers, Troy D., Dyck, Brian, Grey, Jonathan, Tamiya, Junko, Zhang, Mingzhu, Kiankarimi, Mehrak, Wu, Dongpei, Dwight, Wesley, Wade, Warren S., Schwarz, David, Heise, Christopher E., Madan, Ajay, Fisher, Andrew, Petroski, Robert, Goodfellow, Val S.
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Get full text
Journal Article
Synthesis and structure–activity relationships of biarylcarboxamide bis-aminopyrrolidine urea derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1)
Rowbottom, Martin W., Vickers, Troy D., Dyck, Brian, Tamiya, Junko, Zhang, Mingzhu, Zhao, Liren, Grey, Jonathan, Provencal, David, Schwarz, David, Heise, Christopher E., Mistry, Monica, Fisher, Andrew, Dong, Teresa, Hu, Tao, Saunders, John, Goodfellow, Val S.
Published in Bioorganic & medicinal chemistry letters (15.07.2005)
Published in Bioorganic & medicinal chemistry letters (15.07.2005)
Get full text
Journal Article
Body Weight Regulation by Selective MC4 Receptor Agonists and Antagonists
FOSTER, ALAN C., JOPPA, MARGARET, MARKISON, STACY, GOGAS, KATHY R., FLECK, BETH A., MURPHY, BRIAN J., WOLFF, MEIRA, CISMOWSKI, MARY J., LING, NICHOLAS, GOODFELLOW, VAL S., CHEN, CHEN, SAUNDERS, JOHN, CONLON, PAUL J.
Published in Annals of the New York Academy of Sciences (01.06.2003)
Published in Annals of the New York Academy of Sciences (01.06.2003)
Get full text
Journal Article
Manipulation of small-molecule inhibitory kinetics modulates MCH-R1 function
Schwarz, David A., Allen, Molly M., Petroski, Robert E., Pomeroy, Jordan E., Heise, Christopher E., Mistry, Monica S., Selkirk, Julie V., Nottebaum, Lisa M., Grey, Jonathan, Zhang, Mingzhu, Goodfellow, Val S., Maki, Richard A.
Published in Molecular and cellular endocrinology (19.10.2006)
Published in Molecular and cellular endocrinology (19.10.2006)
Get full text
Journal Article