Discovery of N‑[4-[6-tert-Butyl-5-methoxy-8-(6-methoxy-2-oxo‑1H‑pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a Potent Inhibitor of the Hepatitis C Virus NS5B Polymerase
Talamas, Francisco X., Abbot, Sarah C., Anand, Shalini, Brameld, Ken A., Carter, David S., Chen, Jun, Davis, Dana, de Vicente, Javier, Fung, Amy D., Gong, Leyi, Harris, Seth F., Inbar, Petra, Labadie, Sharada S., Lee, Eun K., Lemoine, Remy, Le Pogam, Sophie, Leveque, Vincent, Li, Jim, McIntosh, Joel, Nájera, Isabel, Park, Jaehyeon, Railkar, Aruna, Rajyaguru, Sonal, Sangi, Michael, Schoenfeld, Ryan C., Staben, Leanna R., Tan, Yunchou, Taygerly, Joshua P., Villaseñor, Armando G., Weller, Paul E.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
Discovery of potent and bioavailable GSK-3β inhibitors
Gong, Leyi, Hirschfeld, Don, Tan, Yun-Chou, Heather Hogg, J., Peltz, Gary, Avnur, Zafrira, Dunten, Pete
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
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Journal Article
Discovery of a novel series of 4-quinolone JNK inhibitors
Gong, Leyi, Tan, Yun-Chou, Boice, Genevieve, Abbot, Sarah, McCaleb, Kristen, Iyer, Pravin, Zuo, Fengrong, Porto, Joseph Dal, Wong, Brian, Jin, Sue, Chang, Alice, Tran, Patricia, Hsieh, Gary, Niu, Linghao, Shao, Ada, Reuter, Deborah, Lukacs, Christine M., Ursula Kammlott, R., Kuglstatter, Andreas, Goldstein, David
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Journal Article
A new synthesis of 3-arylthioindoles as selective COX-2 inhibitors using PIFA
Campbell, JA, Broka, CA, Gong, L, Walker, KAM, Wang, JH
Published in Tetrahedron letters (17.05.2004)
Published in Tetrahedron letters (17.05.2004)
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Journal Article
Design and synthesis of novel CCR3 antagonists
LEYI GONG, HOGG, J. Heather, COLLIER, James, WILHELM, Robert S, SODERBERG, Carol
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
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Journal Article
Substituent effects on ketene structure and stability: an ab initio study
Gong, Leyi, McAllister, Michael A, Tidwell, Thomas T
Published in Journal of the American Chemical Society (01.07.1991)
Published in Journal of the American Chemical Society (01.07.1991)
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Journal Article
β‐Catenin Signaling Promotes Proliferation of Progenitor Cells in the Adult Mouse Subventricular Zone
Adachi, Kazuhide, Mirzadeh, Zaman, Sakaguchi, Masanori, Yamashita, Toru, Nikolcheva, Tania, Gotoh, Yukiko, Peltz, Gary, Gong, Leyi, Kawase, Takeshi, Alvarez‐Buylla, Arturo, Okano, Hideyuki, Sawamoto, Kazunobu
Published in Stem cells (Dayton, Ohio) (01.11.2007)
Published in Stem cells (Dayton, Ohio) (01.11.2007)
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Identification and bioevaluation of SRI-12742 as an antimicrobial agent against multidrug-resistant Acinetobacter baumannii
Shukla, Manjulika, Soni, Isha, Matsuyama, Karen, Tran, Tran, Tanga, Mary, Gong, Leyi, Chopra, Sidharth
Published in International journal of antimicrobial agents (01.07.2018)
Published in International journal of antimicrobial agents (01.07.2018)
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Journal Article
Synthesis and Optimization of Small Molecule Inhibitors of Prostate Specific Antigen
Erickson, Jeffery A., Jimmidi, Ravikumar, Anamthathmakula, Prashanth, Qin, Xuan, Wang, Jian, Gong, Leyi, Park, Jaehyeon, Koolpe, Gary, Tan, Caitlin, Matzuk, Martin M., Li, Feng, Chamakuri, Srinivas, Winuthayanon, Wipawee
Published in ACS medicinal chemistry letters (12.09.2024)
Published in ACS medicinal chemistry letters (12.09.2024)
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Journal Article
Short Communication: Preferential Killing of HIV Latently Infected CD4(+) T Cells by MALT1 Inhibitor
Li, Hongmei, He, Hui, Gong, Leyi, Fu, Mingui, Wang, Tony T
Published in AIDS research and human retroviruses (01.02.2016)
Published in AIDS research and human retroviruses (01.02.2016)
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Journal Article
Anti‐inflammatory effects of selective glucocorticoid receptor modulators are partially dependent on up‐regulation of dual specificity phosphatase 1
Joanny, Eugénie, Ding, Qize, Gong, Leyi, Kong, Philip, Saklatvala, Jeremy, Clark, Andrew R
Published in British journal of pharmacology (01.02.2012)
Published in British journal of pharmacology (01.02.2012)
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Journal Article
A comprehensive review of research progress in Chinese medicines for primary liver cancer treatment
Liao, Kui, Gong, LeYi, Yang, Yi, He, YiMei, Wang, FangLiang, Huang, YuanQiong, Wu, ZhiGui
Published in Traditional medicine research (01.03.2022)
Published in Traditional medicine research (01.03.2022)
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Journal Article
Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): Optimization for JNK potency and physicochemical properties
Gong, Leyi, Han, Xiaochun, Silva, Tania, Tan, Yun-Chou, Goyal, Bindu, Tivitmahaisoon, Parch, Trejo, Alejandra, Palmer, Wylie, Hogg, Heather, Jahagir, Alam, Alam, Muzaffar, Wagner, Paul, Stein, Karin, Filonova, Lubov, Loe, Brad, Makra, Ferenc, Rotstein, David, Rapatova, Lubica, Dunn, James, Zuo, Fengrong, Porto, Joseph Dal, Wong, Brian, Jin, Sue, Chang, Alice, Tran, Patricia, Hsieh, Gary, Niu, Linghao, Shao, Ada, Reuter, Deborah, Hermann, Johaness, Kuglstatter, Andreas, Goldstein, David
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
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Journal Article
Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): Kinase profiling guided optimization of a 1,2,3-benzotriazole lead
Palmer, Wylie S., Alam, Muzaffar, Arzeno, Humberto B., Chang, Kung-Ching, Dunn, James P., Goldstein, David M., Gong, Leyi, Goyal, Bindu, Hermann, Johannes C., Hogg, J. Heather, Hsieh, Gary, Jahangir, Alam, Janson, Cheryl, Jin, Sue, Ursula Kammlott, R., Kuglstatter, Andreas, Lukacs, Christine, Michoud, Christophe, Niu, Linghao, Reuter, Deborah C., Shao, Ada, Silva, Tania, Trejo-Martin, Teresa A., Stein, Karin, Tan, Yun-Chou, Tivitmahaisoon, Parcharee, Tran, Patricia, Wagner, Paul, Weller, Paul, Wu, Shao-Yong
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
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Journal Article
Nucleophilic additions to ketenes by (trimethylsilyl)lithium and by enolates
Gong, Leyi, Leung-Toung, Regis, Tidwell, Thomas T
Published in Journal of organic chemistry (01.05.1990)
Published in Journal of organic chemistry (01.05.1990)
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Journal Article
Synthesis of quinolines via ortho-lithiated N-acylanilines. A modified Friedlaender synthesis
Cho, In Seop, Gong, Leyi, Muchowski, Joseph M
Published in Journal of organic chemistry (01.12.1991)
Published in Journal of organic chemistry (01.12.1991)
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Journal Article
Discovery of potent and bioavailable GSK-3b inhibitors
Gong, Leyi, Hirschfeld, Don, Tan, Yun-Chou, Hogg, JHeather, Peltz, Gary, Avnur, Zafrira, Dunten, Pete
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
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