Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations
Birkinshaw, Richard W., Gong, Jia-nan, Luo, Cindy S., Lio, Daisy, White, Christine A., Anderson, Mary Ann, Blombery, Piers, Lessene, Guillaume, Majewski, Ian J., Thijssen, Rachel, Roberts, Andrew W., Huang, David C. S., Colman, Peter M., Czabotar, Peter E.
Published in Nature communications (03.06.2019)
Published in Nature communications (03.06.2019)
Get full text
Journal Article
Characterization of a novel venetoclax resistance mutation (BCL2 Phe104Ile) observed in follicular lymphoma
Blombery, Piers, Birkinshaw, Richard W., Nguyen, Tamia, Gong, Jia‐nan, Thompson, Ella R., Xu, Zhen, Westerman, David A., Czabotar, Peter E., Dickinson, Michael, Huang, David C.S., Seymour, John F., Roberts, Andrew W.
Published in British journal of haematology (01.09.2019)
Published in British journal of haematology (01.09.2019)
Get full text
Journal Article
MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex
Djajawi, Tirta Mario, Liu, Lei, Gong, Jia-nan, Huang, Allan Shuai, Luo, Ming-jie, Xu, Zhen, Okamoto, Toru, Call, Melissa J., Huang, David C. S., van Delft, Mark F.
Published in Cell death and differentiation (01.08.2020)
Published in Cell death and differentiation (01.08.2020)
Get full text
Journal Article
IMiDs prime myeloma cells for daratumumab-mediated cytotoxicity through loss of Ikaros and Aiolos
Fedele, Pasquale L., Willis, Simon N., Liao, Yang, Low, Michael S., Rautela, Jai, Segal, David H., Gong, Jia-Nan, Huntington, Nicholas D., Shi, Wei, Huang, David C.S., Grigoriadis, George, Tellier, Julie, Nutt, Stephen L.
Published in Blood (15.11.2018)
Published in Blood (15.11.2018)
Get full text
Journal Article
Deep profiling of apoptotic pathways with mass cytometry identifies a synergistic drug combination for killing myeloma cells
Teh, Charis E., Gong, Jia-Nan, Segal, David, Tan, Tania, Vandenberg, Cassandra J., Fedele, Pasquale L., Low, Michael S. Y., Grigoriadis, George, Harrison, Simon J., Strasser, Andreas, Roberts, Andrew W., Huang, David C. S., Nolan, Garry P., Gray, Daniel H. D., Ko, Melissa E.
Published in Cell death and differentiation (01.07.2020)
Published in Cell death and differentiation (01.07.2020)
Get full text
Journal Article
MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemia
Wang, Xiao-Shuang, Gong, Jia-Nan, Yu, Jia, Wang, Fang, Zhang, Xin-Hua, Yin, Xiao-Lin, Tan, Zhen-Qing, Luo, Zi-Mian, Yang, Gui-Hua, Shen, Chao, Zhang, Jun-Wu
Published in Blood (24.05.2012)
Published in Blood (24.05.2012)
Get full text
Journal Article
Anti‐apoptotic protein BCL‐XL as a therapeutic vulnerability in gastric cancer
Wei, Yumin, Zhang, Liping, Wang, Chao, Li, Zefeng, Luo, Mingjie, Xie, Guomin, Yang, Xingjiu, Li, Mengyuan, Ren, Shuyue, Zhao, Dongbing, Gao, Ran, Gong, Jia‐Nan
Published in Animal models and experimental medicine (01.06.2023)
Published in Animal models and experimental medicine (01.06.2023)
Get full text
Journal Article
The transcription factor IRF4 represses proapoptotic BMF and BIM to licence multiple myeloma survival
Fedele, Pasquale L., Liao, Yang, Gong, Jia-nan, Yao, Yuan, van Delft, Mark F., Low, Michael S. Y., Tai, Lin, Herold, Marco J., Jackson, Jacob T., Teh, Charis E., Tan, Tania, O’Reilly, Lorraine A., Tellier, Julie, Grigoriadis, George, Huang, David C. S., Shi, Wei, Nutt, Stephen L., Willis, Simon N.
Published in Leukemia (01.07.2021)
Published in Leukemia (01.07.2021)
Get full text
Journal Article
Multiple myeloma with 1q21 amplification is highly sensitive to MCL-1 targeting
Slomp, Anne, Moesbergen, Laura M., Gong, Jia-nan, Cuenca, Marta, von dem Borne, Peter A., Sonneveld, Pieter, Huang, David C.S., Minnema, Monique C., Peperzak, Victor
Published in Blood advances (23.12.2019)
Published in Blood advances (23.12.2019)
Get full text
Journal Article
Co-operation of MCL-1 and BCL-XL anti-apoptotic proteins in stromal protection of MM cells from carfilzomib mediated cytotoxicity
Galas-Filipowicz, Daria, Chavda, Selina J., Gong, Jia-Nan, Huang, David C. S., Khwaja, Asim, Yong, Kwee
Published in Frontiers in oncology (08.04.2024)
Published in Frontiers in oncology (08.04.2024)
Get full text
Journal Article
High Engraftment and Metastatic Rates in Orthotopic Xenograft Models of Gastric Cancer via Direct Implantation of Tumor Cell Suspensions
Wang, Chao, Xie, Guo-Min, Zhang, Li-Ping, Yan, Shuo, Xu, Jia-Li, Han, Yun-Lin, Luo, Ming-Jie, Gong, Jia-Nan
Published in Cancers (01.02.2024)
Published in Cancers (01.02.2024)
Get full text
Journal Article
Defining the susceptibility of colorectal cancers to BH3-mimetic compounds
Luo, Ming-Jie, Palmieri, Michelle, Riffkin, Chris D., Sakthianandeswaren, Anuratha, Djajawi, Tirta Mario, Hirokawa, Yumiko, Shuttleworth, Victoria, Segal, David H., White, Christine A., Nhu, Duong, Lessene, Guillaume, Lee, Margaret, Gibbs, Peter, Huang, David C. S., Sieber, Oliver M., Gong, Jia-nan
Published in Cell death & disease (10.09.2020)
Published in Cell death & disease (10.09.2020)
Get full text
Journal Article
miR‐199a‐5p inhibits monocyte/macrophage differentiation by targeting the activin A type 1B receptor gene and finally reducing C/EBPα expression
Lin, Hai‐Shuang, Gong, Jia‐Nan, Su, Rui, Chen, Ming‐Tai, Song, Li, Shen, Chao, Wang, Fang, Ma, Yan‐Ni, Zhao, Hua‐Lu, Yu, Jia, Li, Wei‐Wei, Huang, Li‐Xia, Xu, Xin‐Hua, Zhang, Jun‐Wu
Published in Journal of leukocyte biology (01.12.2014)
Published in Journal of leukocyte biology (01.12.2014)
Get full text
Journal Article
Trio-based genome sequencing identifies candidate causal genes in lifelong premature ejaculation
Wang, Dao-Qi, Jiao, Yang-Tian, Ling, Le, Wang, Jia-Xin, Niu, Yong-Hua, Tang, Zhe, Chen, Yin-Wei, Gong, Jia-Nan, Wang, Tao, Liu, Ji-Hong, Ling, Qing
Published in Asian journal of andrology (01.05.2021)
Published in Asian journal of andrology (01.05.2021)
Get full text
Journal Article
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
Kotschy, András, Szlavik, Zoltán, Murray, James, Davidson, James, Maragno, Ana Leticia, Le Toumelin-Braizat, Gaëtane, Chanrion, Maïa, Kelly, Gemma L., Gong, Jia-Nan, Moujalled, Donia M., Bruno, Alain, Csekei, Márton, Paczal, Attila, Szabo, Zoltán B., Sipos, Szabolcs, Radics, Gábor, Proszenyak, Agnes, Balint, Balázs, Ondi, Levente, Blasko, Gábor, Robertson, Alan, Surgenor, Allan, Dokurno, Pawel, Chen, Ijen, Matassova, Natalia, Smith, Julia, Pedder, Christopher, Graham, Christopher, Studeny, Aurélie, Lysiak-Auvity, Gaëlle, Girard, Anne-Marie, Gravé, Fabienne, Segal, David, Riffkin, Chris D., Pomilio, Giovanna, Galbraith, Laura C. A., Aubrey, Brandon J., Brennan, Margs S., Herold, Marco J., Chang, Catherine, Guasconi, Ghislaine, Cauquil, Nicolas, Melchiore, Fabien, Guigal-Stephan, Nolwen, Lockhart, Brian, Colland, Frédéric, Hickman, John A., Roberts, Andrew W., Huang, David C. S., Wei, Andrew H., Strasser, Andreas, Lessene, Guillaume, Geneste, Olivier
Published in Nature (London) (27.10.2016)
Published in Nature (London) (27.10.2016)
Get full text
Journal Article
Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia
Blombery, Piers, Anderson, Mary Ann, Gong, Jia-Nan, Thijssen, Rachel, Birkinshaw, Richard W, Thompson, Ella R, Teh, Charis E, Nguyen, Tamia, Xu, Zhen, Flensburg, Christoffer, Lew, Thomas E, Majewski, Ian J, Gray, Daniel H D, Westerman, David A, Tam, Constantine S, Seymour, John F, Czabotar, Peter E, Huang, David C S, Roberts, Andrew W
Published in Cancer discovery (01.03.2019)
Published in Cancer discovery (01.03.2019)
Get full text
Journal Article
Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax
Blombery, Piers, Thompson, Ella R., Nguyen, Tamia, Birkinshaw, Richard W., Gong, Jia-nan, Chen, Xiangting, McBean, Michelle, Thijssen, Rachel, Conway, Thomas, Anderson, Mary Ann, Seymour, John F., Westerman, David A., Czabotar, Peter E., Huang, David C.S., Roberts, Andrew W.
Published in Blood (05.03.2020)
Published in Blood (05.03.2020)
Get full text
Journal Article
Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1
Gong, Jia-Nan, Khong, Tiffany, Segal, David, Yao, Yuan, Riffkin, Chris D., Garnier, Jean-Marc, Khaw, Seong Lin, Lessene, Guillaume, Spencer, Andrew, Herold, Marco J., Roberts, Andrew W., Huang, David C.S.
Published in Blood (06.10.2016)
Published in Blood (06.10.2016)
Get full text
Journal Article
Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer
Merino, Delphine, Whittle, James R, Vaillant, François, Serrano, Antonin, Gong, Jia-Nan, Giner, Goknur, Maragno, Ana Leticia, Chanrion, Maïa, Schneider, Emilie, Pal, Bhupinder, Li, Xiang, Dewson, Grant, Gräsel, Julius, Liu, Kevin, Lalaoui, Najoua, Segal, David, Herold, Marco J, Huang, David C S, Smyth, Gordon K, Geneste, Olivier, Lessene, Guillaume, Visvader, Jane E, Lindeman, Geoffrey J
Published in Science translational medicine (02.08.2017)
Published in Science translational medicine (02.08.2017)
Get more information
Journal Article
Mitochondrial E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteins
Huang, Allan Shuai, Chin, Hui San, Reljic, Boris, Djajawi, Tirta M., Tan, Iris K. L., Gong, Jia-Nan, Stroud, David A., Huang, David C. S., van Delft, Mark F., Dewson, Grant
Published in Cell death and differentiation (01.03.2023)
Published in Cell death and differentiation (01.03.2023)
Get full text
Journal Article