Selective ablation of primary and paracrine senescent cells by targeting iron dyshomeostasis
Admasu, Tesfahun Dessale, Kim, Kristie, Rae, Michael, Avelar, Roberto, Gonciarz, Ryan L., Rebbaa, Abdelhadi, Pedro de Magalhães, João, Renslo, Adam R., Stolzing, Alexandra, Sharma, Amit
Published in Cell reports (Cambridge) (28.02.2023)
Published in Cell reports (Cambridge) (28.02.2023)
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Journal Article
Regioselective Pyridine to Benzene Edit Inspired by Water-Displacement
Boswell, Benjamin R., Zhao, Zhensheng, Gonciarz, Ryan L., Pandya, Keyur M.
Published in Journal of the American Chemical Society (24.07.2024)
Published in Journal of the American Chemical Society (24.07.2024)
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Journal Article
Ferrous Iron-Dependent Pharmacology
Gonciarz, Ryan L., Collisson, Eric A., Renslo, Adam R.
Published in Trends in pharmacological sciences (Regular ed.) (01.01.2021)
Published in Trends in pharmacological sciences (Regular ed.) (01.01.2021)
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Journal Article
Elevated labile iron in castration–resistant prostate cancer is targetable with ferrous iron–activatable antiandrogen therapy
Gonciarz, Ryan L., Sakhamuri, Sasank, Hooshdaran, Nima, Kumar, Garima, Kim, Hyunjung, Evans, Michael J., Renslo, Adam R.
Published in European journal of medicinal chemistry (05.03.2023)
Published in European journal of medicinal chemistry (05.03.2023)
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Journal Article
Ferrous iron-activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors
Jiang, Honglin, Muir, Ryan K, Gonciarz, Ryan L, Olshen, Adam B, Yeh, Iwei, Hann, Byron C, Zhao, Ning, Wang, Yung-Hua, Behr, Spencer C, Korkola, James E, Evans, Michael J, Collisson, Eric A, Renslo, Adam R
Published in The Journal of experimental medicine (04.04.2022)
Published in The Journal of experimental medicine (04.04.2022)
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Journal Article
In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin
Gonciarz, Ryan L., Jiang, Honglin, Tram, Linh, Hugelshofer, Cedric L., Ekpenyong, Oscar, Knemeyer, Ian, Aron, Allegra T., Chang, Christopher J., Flygare, John A., Collisson, Eric A., Renslo, Adam R.
Published in Cell chemical biology (16.11.2023)
Published in Cell chemical biology (16.11.2023)
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Journal Article
Antimalarial Trioxolanes with Superior Drug-Like Properties and In Vivo Efficacy
Blank, Brian R, Gonciarz, Ryan L, Talukder, Poulami, Gut, Jiri, Legac, Jennifer, Rosenthal, Philip J, Renslo, Adam R
Published in ACS infectious diseases (10.07.2020)
Published in ACS infectious diseases (10.07.2020)
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Journal Article
The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2
Suryawanshi, Rahul K, Jaishankar, Priyadarshini, Correy, Galen J, Rachman, Moira M, O'Leary, Patrick C, Taha, Taha Y, Zapatero-Belinchón, Francisco J, McCavitt-Malvido, Maria, Doruk, Yagmur U, Stevens, Maisie G V, Diolaiti, Morgan E, Jogalekar, Manasi P, Richards, Alicia L, Montano, Mauricio, Rosecrans, Julia, Matthay, Michael, Togo, Takaya, Gonciarz, Ryan L, Gopalkrishnan, Saumya, Neitz, R Jeffrey, Krogan, Nevan J, Swaney, Danielle L, Shoichet, Brian K, Ott, Melanie, Renslo, Adam R, Ashworth, Alan, Fraser, James S
Published in bioRxiv (29.08.2024)
Published in bioRxiv (29.08.2024)
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Journal Article
Synthesis and In Vivo Profiling of Desymmetrized Antimalarial Trioxolanes with Diverse Carbamate Side Chains
Klope, Matthew T., Tapia Cardona, Juan A., Chen, Jun, Gonciarz, Ryan L., Cheng, Ke, Jaishankar, Priyadarshini, Kim, Julie, Legac, Jenny, Rosenthal, Philip J., Renslo, Adam R.
Published in ACS medicinal chemistry letters (05.09.2024)
Published in ACS medicinal chemistry letters (05.09.2024)
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Journal Article
In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin
Gonciarz, Ryan L, Jiang, Honglin, Tram, Linh, Hugelshofer, Cedric L, Ekpenyong, Oscar, Knemeyer, Ian, Aron, Allegra T, Chang, Christopher J, Flygare, John A, Collisson, Eric A, Renslo, Adam R
Published in Cell chemical biology (16.11.2023)
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Published in Cell chemical biology (16.11.2023)
Journal Article
COMPOUNDS THAT INHIBIT PKMYT1
XU, Wei, RICO, Alice, COLE, David, PAYANDEH, Jian, BOSWELL, Benjamin, MAUNG, Jack, JIANG, Faming, GONCIARZ, Ryan L, PIPER, Derek, RAIKAR, Sandeep, GILLESPIE, Paul, MA, Sunghoon, WO, Guosheng, NG, Danny, ZHAO, Zhensheng, MAHANEY, Paige, ST. AMANT, Andre, BANNEN, Lynne Canne, SALVANT, Justin, WANG, Yong, LIN, Xiaodong
Year of Publication 27.06.2024
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Year of Publication 27.06.2024
Patent
Exploiting KRAS-driven Ferroaddiction in Cancer Through Ferrous Iron-Activatable Drug Conjugates (FeADC)
Jiang, Honglin, Muir, Ryan K, Gonciarz, Ryan L, Olshen, Adam B, Yeh, Iwei, Hann, Byron C, Zhao, Ning, Yung-Hua, Wang, Korkola, James, Behr, Spencer C, Evans, Michael J, Collisson, Eric, Renslo, Adam
Published in bioRxiv (14.05.2020)
Published in bioRxiv (14.05.2020)
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Paper