Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches
Xiao, Hai-Yun, Li, Ning, Duan, James J.-W, Jiang, Bin, Lu, Zhonghui, Ngu, Khehyong, Tino, Joseph, Kopcho, Lisa M, Lu, Hao, Chen, Jing, Tebben, Andrew J, Sheriff, Steven, Chang, ChiehYing Y, Yanchunas, Joseph, Calambur, Deepa, Gao, Mian, Shuster, David J, Susulic, Vojkan, Xie, Jenny H, Guarino, Victor R, Wu, Dauh-Rurng, Gregor, Kurt R, Goldstine, Christine B, Hynes, John, Macor, John E, Salter-Cid, Luisa, Burke, James R, Shaw, Patrick J, Dhar, T. G. Murali
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
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Discovery and SAR of pyrrolo[2,1-f][1,2,4]triazin-4-amines as potent and selective PI3Kδ inhibitors
Bhide, Rajeev S., Neels, James, Qin, Lan-Ying, Ruan, Zheming, Stachura, Sylwia, Weigelt, Carolyn, Sack, John S., Stefanski, Kevin, Gu, Xiaomei, Xie, Jenny H., Goldstine, Christine B., Skala, Stacey, Pedicord, Donna L., Ruepp, Stefan, Dhar, T.G. Murali, Carter, Percy H., Salter-Cid, Luisa M., Poss, Michael A., Davies, Paul
Published in Bioorganic & medicinal chemistry letters (01.09.2016)
Published in Bioorganic & medicinal chemistry letters (01.09.2016)
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