Assessing the Safety of Stem Cell Therapeutics
Goldring, Chris E.P., Duffy, Paul A., Benvenisty, Nissim, Andrews, Peter W., Ben-David, Uri, Eakins, Rowena, French, Neil, Hanley, Neil A., Kelly, Lorna, Kitteringham, Neil R., Kurth, Jens, Ladenheim, Deborah, Laverty, Hugh, McBlane, James, Narayanan, Gopalan, Patel, Sara, Reinhardt, Jens, Rossi, Annamaria, Sharpe, Michaela, Park, B. Kevin
Published in Cell stem cell (03.06.2011)
Published in Cell stem cell (03.06.2011)
Get full text
Journal Article
Stem cell models as an in vitro model for predictive toxicology
Lynch, Stephen, Pridgeon, Chris S, Duckworth, Carrie A, Sharma, Parveen, Park, B Kevin, Goldring, Chris E P
Published in Biochemical journal (15.04.2019)
Published in Biochemical journal (15.04.2019)
Get more information
Journal Article
Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice
Randle, Laura E, Goldring, Chris E.P, Benson, Craig A, Metcalfe, Peter N, Kitteringham, Neil R, Park, B. Kevin, Williams, Dominic P
Published in Toxicology (Amsterdam) (20.01.2008)
Published in Toxicology (Amsterdam) (20.01.2008)
Get full text
Journal Article
Assessing the Safety of Stem Cell Therapeutics
Goldring, Chris E.P., Duffy, Paul A., Benvenisty, Nissim, Andrews, Peter W., Ben-David, Uri, Eakins, Rowena, French, Neil, Hanley, Neil A., Kelly, Lorna, Kitteringham, Neil R., Kurth, Jens, Ladenheim, Deborah, Laverty, Hugh, McBlane, James, Narayanan, Gopalan, Patel, Sara, Reinhardt, Jens, Rossi, Annamaria, Sharpe, Michaela, Park, B. Kevin
Published in Cell stem cell (05.08.2011)
Published in Cell stem cell (05.08.2011)
Get full text
Journal Article
Managing the challenge of chemically reactive metabolites in drug development
Park, B. Kevin, Tweedie, Donald J, Boobis, Alan, Clarke, Stephen, Goldring, Chris E. P, Jones, David, Kenna, J. Gerry, Lambert, Craig, Laverty, Hugh G, Naisbitt, Dean J, Nelson, Sidney, Nicoll-Griffith, Deborah A, Obach, R. Scott, Routledge, Philip, Smith, Dennis A, Vermeulen, Nico, Williams, Dominic P, Wilson, Ian D, Baillie, Thomas A
Published in Nature reviews. Drug discovery (01.04.2011)
Published in Nature reviews. Drug discovery (01.04.2011)
Get full text
Journal Article
Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury
Ali, Serat-E, Waddington, James C, Lister, Adam, Sison-Young, Rowena, Jones, Robert P, Rehman, Adeeb H, Goldring, Chris E P, Naisbitt, Dean J, Meng, Xiaoli
Published in Toxicological sciences (20.03.2023)
Published in Toxicological sciences (20.03.2023)
Get full text
Journal Article
Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile
Heslop, James A., Rowe, Cliff, Walsh, Joanne, Sison-Young, Rowena, Jenkins, Roz, Kamalian, Laleh, Kia, Richard, Hay, David, Jones, Robert P., Malik, Hassan Z., Fenwick, Stephen, Chadwick, Amy E., Mills, John, Kitteringham, Neil R., Goldring, Chris E. P., Kevin Park, B.
Published in Archives of toxicology (01.01.2017)
Published in Archives of toxicology (01.01.2017)
Get full text
Journal Article
Stem cell‐derived hepatocytes as a predictive model for drug‐induced liver injury: are we there yet?
Kia, Richard, Sison, Rowena L. C., Heslop, James, Kitteringham, Neil R., Hanley, Neil, Mills, John S., Park, B. Kevin, Goldring, Chris E. P.
Published in British journal of clinical pharmacology (01.04.2013)
Published in British journal of clinical pharmacology (01.04.2013)
Get full text
Journal Article
Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms
Pridgeon, Chris S., Schlott, Constanze, Wong, Min Wei, Heringa, Minne B., Heckel, Tobias, Leedale, Joe, Launay, Laurence, Gryshkova, Vitalina, Przyborski, Stefan, Bearon, Rachel N., Wilkinson, Emma L., Ansari, Tahera, Greenman, John, Hendriks, Delilah F. G., Gibbs, Sue, Sidaway, James, Sison-Young, Rowena L., Walker, Paul, Cross, Mike J., Park, B. Kevin, Goldring, Chris E. P.
Published in Archives of toxicology (01.02.2018)
Published in Archives of toxicology (01.02.2018)
Get full text
Journal Article
In Vivo Tumorigenicity of the 20q11.21 Amplicon in an Engraftment Model of hPSCs and Differentiated Liver Cells
Pridgeon, Chris S, Forootan, Shiva Seyed, Zhang, Fang, Harper, Nicholas, Palmer, Daniel, Weightmann, Richard, Gregory, Sian, Hewitt, Zoe, Baker, Duncan, Halliwell, Jason, Moore, Harry, Ricci, Emanuele, Andrews, Peter W, Poptani, Harish, Hay, David C, Park, B Kevin, Goldring, Chris E P
Published in Journal of stem cells & regenerative medicine (2023)
Published in Journal of stem cells & regenerative medicine (2023)
Get full text
Journal Article
MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity
Kia, Richard, Kelly, Lorna, Sison-Young, Rowena L C, Zhang, Fang, Pridgeon, Chris S, Heslop, James A, Metcalfe, Pete, Kitteringham, Neil R, Baxter, Melissa, Harrison, Sean, Hanley, Neil A, Burke, Zoë D, Storm, Mike P, Welham, Melanie J, Tosh, David, Küppers-Munther, Barbara, Edsbagge, Josefina, Starkey Lewis, Philip J, Bonner, Frank, Harpur, Ernie, Sidaway, James, Bowes, Joanne, Fenwick, Stephen W, Malik, Hassan, Goldring, Chris E P, Park, B Kevin
Published in Toxicological sciences (01.03.2015)
Published in Toxicological sciences (01.03.2015)
Get full text
Journal Article
Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies
Scarfe, Lauren, Brillant, Nathalie, Kumar, J Dinesh, Ali, Noura, Alrumayh, Ahmed, Amali, Mohammed, Barbellion, Stephane, Jones, Vendula, Niemeijer, Marije, Potdevin, Sophie, Roussignol, Gautier, Vaganov, Anatoly, Barbaric, Ivana, Barrow, Michael, Burton, Neal C, Connell, John, Dazzi, Francesco, Edsbagge, Josefina, French, Neil S, Holder, Julie, Hutchinson, Claire, Jones, David R, Kalber, Tammy, Lovatt, Cerys, Lythgoe, Mark F, Patel, Sara, Patrick, P Stephen, Piner, Jacqueline, Reinhardt, Jens, Ricci, Emanuelle, Sidaway, James, Stacey, Glyn N, Starkey Lewis, Philip J, Sullivan, Gareth, Taylor, Arthur, Wilm, Bettina, Poptani, Harish, Murray, Patricia, Goldring, Chris E P, Park, B Kevin
Published in npj Regenerative medicine (19.10.2017)
Published in npj Regenerative medicine (19.10.2017)
Get full text
Journal Article
Managing the challenge of chemically reactive metabolites in drug development
Park, B. Kevin, Boobis, Alan, Clarke, Stephen, Goldring, Chris E.P, Kenna, David Jones J. Gerry, Lambert, Craig, Laverty, Hugh G, Naisbitt, Dean J, Nelson, Sidney, Nicoll-Griffith, Deborah A, Obach, R. Scott, Routledgem, Philip, Smith, Dennis A, Tweedie, Donald J, Vermeulen, Nico, Williams, Dominic P, Wilson, Ian D, Baillie, Thomas A
Published in Nature reviews. Drug discovery (01.04.2011)
Published in Nature reviews. Drug discovery (01.04.2011)
Get full text
Journal Article
Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes
Goldring, Chris E. P, Kitteringham, Neil R, Jenkins, Rosalind, Lovatt, Cerys A, Randle, Laura E, Abdullah, Azman, Owen, Andrew, Liu, Xiaoping, Butler, Philip J, Williams, Dominic P, Metcalfe, Peter, Berens, Christian, Hillen, Wolfgang, Foster, Brian, Simpson, Alec, McLellan, Lesley, Park, B. Kevin
Published in American Journal of Physiology: Cell Physiology (01.01.2006)
Published in American Journal of Physiology: Cell Physiology (01.01.2006)
Get full text
Journal Article