Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026
NUTLEY, B. P, SMITH, N. F, HAYES, A, KELLAND, L. R, BRUNTON, L, GOLDING, B. T, SMITH, G. C. M, MARTIN, N. M. B, WORKMAN, P, RAYNAUD, F. I
Published in British journal of cancer (31.10.2005)
Published in British journal of cancer (31.10.2005)
Get full text
Journal Article
Resistance-Modifying Agents. 9. Synthesis and Biological Properties of Benzimidazole Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase
White, Alex W, Almassy, Robert, Calvert, A. Hilary, Curtin, Nicola J, Griffin, Roger J, Hostomsky, Zdenek, Maegley, Karen, Newell, David R, Srinivasan, Sheila, Golding, Bernard T
Published in Journal of medicinal chemistry (02.11.2000)
Published in Journal of medicinal chemistry (02.11.2000)
Get full text
Journal Article
Measurements of photo-oxidation products from the reaction of a series of alkyl-benzenes with hydroxyl radicals during EXACT using comprehensive gas chromatography
Hamilton, J. F., Lewis, A. C., Bloss, C., Wagner, V., Henderson, A. P., Golding, B. T., Wirtz, K., Martin-Reviejo, M., Pilling, M. J.
Published in Atmospheric chemistry and physics (13.11.2003)
Published in Atmospheric chemistry and physics (13.11.2003)
Get full text
Journal Article
Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles
Arris, Christine E, Boyle, F. Thomas, Calvert, A. Hilary, Curtin, Nicola J, Endicott, Jane A, Garman, Elspeth F, Gibson, Ashleigh E, Golding, Bernard T, Grant, Sharon, Griffin, Roger J, Jewsbury, Philip, Johnson, Louise N, Lawrie, Alison M, Newell, David R, Noble, Martin E. M, Sausville, Edward A, Schultz, Robert, Yu, Wyatt
Published in Journal of medicinal chemistry (27.07.2000)
Published in Journal of medicinal chemistry (27.07.2000)
Get full text
Journal Article
Potentiation of temozolomide-induced cytotoxicity: a comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors
Boulton, S, Pemberton, L C, Porteous, J K, Curtin, N J, Griffin, R J, Golding, B T, Durkacz, B W
Published in British journal of cancer (01.10.1995)
Published in British journal of cancer (01.10.1995)
Get full text
Journal Article
Reaction-kinetic parameters of glycidamide as determinants of mutagenic potency
Silvari, V., Haglund, J., Jenssen, D., Golding, B.T., Ehrenberg, L., Törnqvist, M.
Published in Mutation research (07.02.2005)
Published in Mutation research (07.02.2005)
Get full text
Journal Article
Measurement of benzene oxide in the blood of rats following administration of benzene
LINDSTROM, A. B, YEOWELL-O'CONNELL, K, WAIDYANATHA, S, GOLDING, B. T, TORNERO-VELEZ, R, RAPPAPORT, S. M
Published in Carcinogenesis (New York) (01.08.1997)
Published in Carcinogenesis (New York) (01.08.1997)
Get full text
Journal Article
Discovery of Potent Chromen-4-one Inhibitors of the DNA-Dependent Protein Kinase (DNA-PK) Using a Small-Molecule Library Approach
Hardcastle, Ian R, Cockcroft, Xiaoling, Curtin, Nicola J, El-Murr, Marine Desage, Leahy, Justin J. J, Stockley, Martin, Golding, Bernard T, Rigoreau, Laurent, Richardson, Caroline, Smith, Graeme C. M, Griffin, Roger J
Published in Journal of medicinal chemistry (01.12.2005)
Published in Journal of medicinal chemistry (01.12.2005)
Get full text
Journal Article
Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced α1-acid glycoprotein binding
CURTIN, N. J, BOWMAN, K. J, TURNER, R. N, HUANG, B, LOUGHLIN, P. J, CALVERT, A. H, GOLDING, B. T, GRIFFIN, R. J, NEWELL, D. R
Published in British journal of cancer (01.08.1999)
Published in British journal of cancer (01.08.1999)
Get full text
Journal Article
Selective Benzopyranone and Pyrimido[2,1-a]isoquinolin-4-one Inhibitors of DNA-Dependent Protein Kinase: Synthesis, Structure−Activity Studies, and Radiosensitization of a Human Tumor Cell Line in Vitro
Griffin, Roger J, Fontana, Gabriele, Golding, Bernard T, Guiard, Sophie, Hardcastle, Ian R, Leahy, Justin J. J, Martin, Niall, Richardson, Caroline, Rigoreau, Laurent, Stockley, Martin, Smith, Graeme C. M
Published in Journal of medicinal chemistry (27.01.2005)
Published in Journal of medicinal chemistry (27.01.2005)
Get full text
Journal Article
Tricyclic Benzimidazoles as Potent Poly(ADP-ribose) Polymerase-1 Inhibitors
Skalitzky, Donald J, Marakovits, Joseph T, Maegley, Karen A, Ekker, Anne, Yu, Xiao-Hong, Hostomsky, Zdenek, Webber, Stephen E, Eastman, Brian W, Almassy, Robert, Li, Jianke, Curtin, Nicola J, Newell, David R, Calvert, A. Hilary, Griffin, Roger J, Golding, Bernard T
Published in Journal of medicinal chemistry (16.01.2003)
Published in Journal of medicinal chemistry (16.01.2003)
Get full text
Journal Article
Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine
Griffin, R J, Arris, C E, Bleasdale, C, Boyle, F T, Calvert, A H, Curtin, N J, Dalby, C, Kanugula, S, Lembicz, N K, Newell, D R, Pegg, A E, Golding, B T
Published in Journal of medicinal chemistry (02.11.2000)
Published in Journal of medicinal chemistry (02.11.2000)
Get full text
Journal Article
In vitro studies of the influence of glutathione transferases and epoxide hydrolase on the detoxification of acrylamide and glycidamide in blood
Paulsson, Birgit, Rannug, Agneta, Henderson, Alistair P., Golding, Bernard T., Törnqvist, Margareta, Warholm, Margareta
Published in Mutation research (07.02.2005)
Published in Mutation research (07.02.2005)
Get full text
Journal Article