Exploration of Allosteric Agonism Structure–Activity Relationships within an Acetylene Series of Metabotropic Glutamate Receptor 5 (mGlu5) Positive Allosteric Modulators (PAMs): Discovery of 5‑((3-Fluorophenyl)ethynyl)‑N‑(3-methyloxetan-3-yl)picolinamide (ML254)
Turlington, Mark, Noetzel, Meredith J, Chun, Aspen, Zhou, Ya, Gogliotti, Rocco D, Nguyen, Elizabeth D, Gregory, Karen J, Vinson, Paige N, Rook, Jerri M, Gogi, Kiran K, Xiang, Zixiu, Bridges, Thomas M, Daniels, J. Scott, Jones, Carrie, Niswender, Colleen M, Meiler, Jens, Conn, P. Jeffrey, Lindsley, Craig W, Stauffer, Shaun R
Published in Journal of medicinal chemistry (24.10.2013)
Published in Journal of medicinal chemistry (24.10.2013)
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Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM
Sheffler, Douglas J., Wenthur, Cody J., Bruner, Joshua A., Carrington, Sheridan J.S., Vinson, Paige N., Gogi, Kiran K., Blobaum, Anna L., Morrison, Ryan D., Vamos, Mitchell, Cosford, Nicholas D.P., Stauffer, Shaun R., Scott Daniels, J., Niswender, Colleen M., Jeffrey Conn, P., Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (15.06.2012)
Published in Bioorganic & medicinal chemistry letters (15.06.2012)
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Journal Article