Nucleic acid polymerases use a general acid for nucleotidyl transfer
Uchida, Akira, Cameron, Craig E, Maksimchuk, Kenneth R, Götte, Matthias, Arnold, Jamie J, Moustafa, Ibrahim, Castro, Christian, Smidansky, Eric D, Konigsberg, William
Published in Nature structural & molecular biology (01.02.2009)
Published in Nature structural & molecular biology (01.02.2009)
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Structures, functions and adaptations of the human LINE-1 ORF2 protein
Baldwin, Eric T, van Eeuwen, Trevor, Hoyos, David, Zalevsky, Arthur, Tchesnokov, Egor P, Sánchez, Roberto, Miller, Bryant D, Di Stefano, Luciano H, Ruiz, Francesc Xavier, Hancock, Matthew, Işik, Esin, Mendez-Dorantes, Carlos, Walpole, Thomas, Nichols, Charles, Wan, Paul, Riento, Kirsi, Halls-Kass, Rowan, Augustin, Martin, Lammens, Alfred, Jestel, Anja, Upla, Paula, Xibinaku, Kera, Congreve, Samantha, Hennink, Maximiliaan, Rogala, Kacper B, Schneider, Anna M, Fairman, Jennifer E, Christensen, Shawn M, Desrosiers, Brian, Bisacchi, Gregory S, Saunders, Oliver L, Hafeez, Nafeeza, Miao, Wenyan, Kapeller, Rosana, Zaller, Dennis M, Sali, Andrej, Weichenrieder, Oliver, Burns, Kathleen H, Götte, Matthias, Rout, Michael P, Arnold, Eddy, Greenbaum, Benjamin D, Romero, Donna L, LaCava, John, Taylor, Martin S
Published in Nature (London) (01.02.2024)
Published in Nature (London) (01.02.2024)
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Sandacrabins – Structurally Unique Antiviral RNA Polymerase Inhibitors from a Rare Myxobacterium
Bader, Chantal D., Panter, Fabian, Garcia, Ronald, Tchesnokov, Egor P., Haid, Sibylle, Walt, Christine, Spröer, Cathrin, Kiefer, Alexander F., Götte, Matthias, Overmann, Jörg, Pietschmann, Thomas, Müller, Rolf
Published in Chemistry : a European journal (21.02.2022)
Published in Chemistry : a European journal (21.02.2022)
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Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance
Powdrill, Megan H, Tchesnokov, Egor P, Kozak, Robert A, Russell, Rodney S, Martin, Ross, Svarovskaia, Evguenia S, Mo, Hongmei, Kouyos, Roger D, Götte, Matthias
Published in Proceedings of the National Academy of Sciences - PNAS (20.12.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (20.12.2011)
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Rigid 2 ',4 '-Difluororibonucleosides: Synthesis, Conformational Analysis, and Incorporation into Nascent RNA by HCV Polymerase
Martinez-Montero, Saul, Deleavey, Glen F., Kulkarni, Anupriya, Martin-Pintado, Nerea, Lindovska, Petra, Thomson, Michael, Gonzalez, Carlos, Goette, Matthias, Damha, Masad J.
Published in Journal of organic chemistry (20.06.2014)
Published in Journal of organic chemistry (20.06.2014)
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Resistance patterns associated with HCV NS5A inhibitors provide limited insight into drug binding
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Book Review
Inhibition of the Ribonuclease H Activity of HIV-1 Reverse Transcriptase by GSK5750 Correlates with Slow Enzyme-Inhibitor Dissociation
Beilhartz, Greg L., Ngure, Marianne, Johns, Brian A., DeAnda, Felix, Gerondelis, Peter, Götte, Matthias
Published in The Journal of biological chemistry (06.06.2014)
Published in The Journal of biological chemistry (06.06.2014)
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Contrasting effects of W781V and W780V mutations in helix N of herpes simplex virus 1 and human cytomegalovirus DNA polymerases on antiviral drug susceptibility
Piret, Jocelyne, Goyette, Nathalie, Eckenroth, Brian E, Drouot, Emilien, Götte, Matthias, Boivin, Guy
Published in Journal of virology (01.04.2015)
Published in Journal of virology (01.04.2015)
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Dynamics of Hepatitis C Virus (HCV) RNA-dependent RNA Polymerase NS5B in Complex with RNA
Karam, Pierre, Powdrill, Megan H., Liu, Hsiao-Wei, Vasquez, Colins, Mah, Wayne, Bernatchez, Jean, Götte, Matthias, Cosa, Gonzalo
Published in The Journal of biological chemistry (16.05.2014)
Published in The Journal of biological chemistry (16.05.2014)
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Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α‑Carboxy Nucleoside Phosphonates
John, Jubi, Kim, Youngju, Bennett, Nicholas, Das, Kalyan, Liekens, Sandra, Naesens, Lieve, Arnold, Eddy, Maguire, Anita R, Götte, Matthias, Dehaen, Wim, Balzarini, Jan
Published in Journal of medicinal chemistry (22.10.2015)
Published in Journal of medicinal chemistry (22.10.2015)
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Binding Kinetics and Affinities of Heterodimeric versus Homodimeric HIV‑1 Reverse Transcriptase on DNA–DNA Substrates at the Single-Molecule Level
Marko, Ryan A, Liu, Hsiao-Wei, Ablenas, Christopher J, Ehteshami, Maryam, Götte, Matthias, Cosa, Gonzalo
Published in The journal of physical chemistry. B (25.04.2013)
Published in The journal of physical chemistry. B (25.04.2013)
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Formation of a Quaternary Complex of HIV-1 Reverse Transcriptase with a Nucleotide-competing Inhibitor and Its ATP Enhancer
Ehteshami, Maryam, Nijhuis, Monique, Bernatchez, Jean A., Ablenas, Christopher J., McCormick, Suzanne, de Jong, Dorien, Jochmans, Dirk, Götte, Matthias
Published in The Journal of biological chemistry (14.06.2013)
Published in The Journal of biological chemistry (14.06.2013)
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