Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody–Drug Conjugate Payloads
Hobson, Adrian D, McPherson, Michael J, Waegell, Wendy, Goess, Christian A, Stoffel, Robert H, Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Hernandez, Axel, Bryant, Shaughn H, Mathieu, Suzanne L, Bischoff, Agnieszka K, Fitzgibbons, Julia, Pawlikowska, Martyna, Puthenveetil, Sujiet, Santora, Ling C, Wang, Lu, Wang, Lu, Marvin, Christopher C, Hayes, Martin E, Shrestha, Anurupa, Sarris, Kathy A, Li, Biqin
Published in Journal of medicinal chemistry (24.03.2022)
Published in Journal of medicinal chemistry (24.03.2022)
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Journal Article
Optimization of Drug-Linker to Enable Long-term Storage of Antibody–Drug Conjugate for Subcutaneous Dosing
Hobson, Adrian D., Xu, Jianwen, Marvin, Christopher C., McPherson, Michael J., Hollmann, Markus, Gattner, Michael, Dzeyk, Kristina, Fettis, Margaret M., Bischoff, Agnieszka K., Wang, Lu, Fitzgibbons, Julia, Wang, Lu, Salomon, Paulin, Hernandez, Axel, Jia, Ying, Sarvaiya, Hetal, Goess, Christian A., Mathieu, Suzanne L., Santora, Ling C.
Published in Journal of medicinal chemistry (13.07.2023)
Published in Journal of medicinal chemistry (13.07.2023)
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Journal Article
Discovery of ABBV-154, an anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC)
Hobson, Adrian D., Xu, Jianwen, Welch, Dennie S., Marvin, Christopher C., McPherson, Michael J., Gates, Bradley, Liao, Xiaoli, Hollmann, Markus, Gattner, Michael J., Dzeyk, Kristina, Sarvaiya, Hetal, Shenoy, Vikram M., Fettis, Margaret M., Bischoff, Agnieszka K., Wang, Lu, Santora, Ling C., Wang, Lu, Fitzgibbons, Julia, Salomon, Paulin, Hernandez, Axel, Jia, Ying, Goess, Christian A., Mathieu, Suzanne L., Bryant, Shaughn H., Larsen, Mary E., Cui, Baoliang, Tian, Yu
Published in Journal of medicinal chemistry (14.09.2023)
Published in Journal of medicinal chemistry (14.09.2023)
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Journal Article
Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model
Marvin, Christopher C., Hobson, Adrian D., McPherson, Michael J., Hayes, Martin E., Patel, Meena V., Schmidt, Diana L., Li, Tongmei, Randolph, John T., Bischoff, Agnieszka K., Fitzgibbons, Julia, Wang, Lu, Wang, Lu, Hernandez, Axel, Jia, Ying, Goess, Christian A., Bryant, Shaughn H., Mathieu, Suzanne L., Xu, Jianwen
Published in Journal of medicinal chemistry (13.06.2024)
Published in Journal of medicinal chemistry (13.06.2024)
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Journal Article
Correction to “Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody–Drug Conjugate Payloads”
Hobson, Adrian D., McPherson, Michael J., Waegell, Wendy, Goess, Christian A., Stoffel, Robert H., Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Hernandez, Axel, Bryant, Shaughn H., Mathieu, Suzanne L., Bischoff, Agnieszka K., Fitzgibbons, Julia, Pawlikowska, Martyna, Puthenveetil, Sujiet, Santora, Ling C., Wang, Lu, Wang, Lu, Marvin, Christopher C., Hayes, Martin E., Shrestha, Anurupa, Sarris, Kathy A., Li, Biqin
Published in Journal of medicinal chemistry (27.04.2023)
Published in Journal of medicinal chemistry (27.04.2023)
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Journal Article
ABBV-105, a selective and irreversible inhibitor of Bruton's tyrosine kinase, is efficacious in multiple preclinical models of inflammation
Goess, Christian, Harris, Christopher M., Murdock, Sara, McCarthy, Richard W., Sampson, Erik, Twomey, Rachel, Mathieu, Suzanne, Mario, Regina, Perham, Matthew, Goedken, Eric R., Long, Andrew J.
Published in Modern rheumatology (04.05.2019)
Published in Modern rheumatology (04.05.2019)
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Journal Article
NRF2 activator A-1396076 ameliorates inflammation in autoimmune disease models by inhibiting antigen dependent T cell activation
Goess, Christian, Terrillon, Sonia, Mayo, Martha, Bousquet, Peter, Wallace, Craig, Hart, Michelle, Mathieu, Suzanne, Twomey, Rachel, Donnelly-Roberts, Diana, Namovic, Marian, Jung, Paul, Hu, Min, Richardson, Paul, Esbenshade, Tim, Cuff, Carolyn A.
Published in Journal of translational autoimmunity (Online) (01.01.2021)
Published in Journal of translational autoimmunity (Online) (01.01.2021)
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Journal Article
Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator
Hobson, Adrian D., McPherson, Michael J., Hayes, Martin E., Goess, Christian, Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Yang, Jindong, Sun, Liang, Zhang, Qiang, Qu, Pei, Yang, Shi, Hernandez, Axel, Bryant, Shaughn H., Mathieu, Suzanne L., Bischoff, Agnieszka K., Fitzgibbons, Julia, Santora, Ling C., Wang, Lu, Fettis, Margaret M., Li, Xiaofeng, Marvin, Christopher C., Wang, Zhi, V. Patel, Meena, Schmidt, Diana L., Li, Tongmei, Randolph, John T., Henry, Rodger F., Graff, Candace, Tian, Yu, Aguirre, Ana L., Shrestha, Anurupa
Published in Journal of medicinal chemistry (08.12.2022)
Published in Journal of medicinal chemistry (08.12.2022)
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Journal Article
Soy Protein Containing Diet Attenuates Murine Drug Exposure and Activity via Hepatic and Intestinal Cytochrome P450 Induction
Wetter, Jill M, Ciurlionis, Rita, Krause, Caitlin J, Liguori, Michael J, Goess, Christian, Mathieu, Suzanne, Kalvass, J Cory
Published in Drug metabolism and disposition (01.08.2023)
Published in Drug metabolism and disposition (01.08.2023)
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Journal Article
Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate
Hobson, Adrian D., McPherson, Michael J., Hayes, Martin E., Goess, Christian, Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Yang, Jindong, Sun, Liang, Zhang, Qiang, Qu, Pei, Yang, Shi, Hernandez, Axel, Bryant, Shaughn H., Mathieu, Suzanne L., Bischoff, Agnieszka K., Fitzgibbons, Julia, Santora, Ling C., Wang, Lu, Wang, Lu, Fettis, Margaret M., Li, Xiaofeng, Marvin, Christopher C., Wang, Zhi, Patel, Meena V., Schmidt, Diana L., Li, Tongmei, Randolph, John T., Henry, Rodger F., Graff, Candace, Tian, Yu, Aguirre, Ana L., Shrestha, Anurupa
Published in Journal of medicinal chemistry (08.12.2022)
Published in Journal of medicinal chemistry (08.12.2022)
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Journal Article
Fit-for-purpose LC-MS/MS quantification of leukotoxin and leukotoxin diol in mouse plasma without sample pre-concentration
Paul Savaryn, John, Qiu, Xiazi, Duignan, David B., Goess, Christian, Osman, Sami, Ji, Qin C., Jenkins, Gary
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.08.2021)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.08.2021)
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Journal Article
An anti-TNF-glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases
McPherson, Michael J, Hobson, Adrian D, Hernandez, Jr, Axel, Marvin, Christopher C, Waegell, Wendy, Goess, Christian, Oh, Jason Z, Shi, Dan, Hayes, Martin E, Wang, Lu, Wang, Lu, Schmidt, Diana, Wang, Zhi, Pitney, Victoria, McCarthy, Kimberley, Jia, Ying, Wang, Ce, Kang, Bit Na, Bryant, Shaughn, Mathieu, Suzanne, Ruzek, Melanie, Parmentier, Julie, D'Cunha, Ronilda R, Pang, Yinuo, Phillips, Lucy, Brown, Nathan J, Xu, Jianwen, Graff, Candace, Tian, Yu, Longenecker, Kenton L, Qiu, Wei, Zhu, Haizhong, Liu, Wei, Zheng, Pingping, Bi, Yingtao, Stoffel, Robert
Published in Science translational medicine (20.03.2024)
Published in Science translational medicine (20.03.2024)
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Journal Article
Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design
Dietrich, Justin D, Longenecker, Kenton L, Wilson, Noel S, Goess, Christian, Panchal, Sanjay C, Swann, Steven L, Petros, Andrew M, Hobson, Adrian D, Ihle, David, Song, Danying, Richardson, Paul, Comess, Kenneth M, Cox, Philip B, Dombrowski, Amanda, Sarris, Kathy, Donnelly-Roberts, Diana L, Duignan, David B, Gomtsyan, Arthur, Jung, Paul, Krueger, A Chris, Mathieu, Suzanne, McClure, Andrea, Stoll, Vincent S, Wetter, Jill, Mankovich, John A, Hajduk, Philip J, Vasudevan, Anil, Stoffel, Robert H, Sun, Chaohong
Published in Journal of medicinal chemistry (14.01.2021)
Published in Journal of medicinal chemistry (14.01.2021)
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Journal Article
Correction to “Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate”
Hobson, Adrian D., McPherson, Michael J., Hayes, Martin E., Goess, Christian, Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Yang, Jindong, Sun, Liang, Zhang, Qiang, Qu, Pei, Yang, Shi, Hernandez, Axel, Bryant, Shaughn H., Mathieu, Suzanne L., Bischoff, Agnieszka K., Fitzgibbons, Julia, Santora, Ling C., Wang, Lu, Wang, Lu, Fettis, Margaret M., Li, Xiaofeng, Marvin, Christopher C., Wang, Zhi, Patel, Meena V., Schmidt, Diana L., Li, Tongmei, Randolph, John T., Henry, Rodger F., Graff, Candace, Tian, Yu, Aguirre, Ana L., Shrestha, Anurupa
Published in Journal of medicinal chemistry (27.04.2023)
Published in Journal of medicinal chemistry (27.04.2023)
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Journal Article
Inhibition of Interleukin-23-Mediated Inflammation with a Novel Small Molecule Inverse Agonist of ROR γ t
Gauld, Stephen B, Jacquet, Sebastien, Gauvin, Donna, Wallace, Craig, Wang, Yibing, McCarthy, Richard, Goess, Christian, Leys, Laura, Huang, Susan, Su, Zhi, Edelmayer, Rebecca, Wetter, Joseph, Salte, Katherine, McGaraughty, Steven P, Argiriadi, Maria A, Honore, Prisca, Luccarini, Jean-Michel, Bressac, Didier, Desino, Kelly, Breinlinger, Eric, Cusack, Kevin, Potin, Dominique, Kort, Michael E, Masson, Philippe J
Published in The Journal of pharmacology and experimental therapeutics (01.10.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2019)
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Venetoclax (ABT-199), a potent and selective BCL-2 inhibitor, is efficacious in NZB/WF1 mouse model of lupus nephritis and reduces human lymphocyte lifespan in vitro (BA4P.127)
Grebe, Kristie, Perper, Stuart, O'Connor, Liz, Schwartz, Annette, Goess, Christian, Hartman, Dawna, Westmoreland, Susan, Graff, Candace, Souers, Andrew, Leverson, Joel, Elmore, Steven, Olson, Lisa, Wang, Lichun
Published in The Journal of immunology (1950) (01.05.2015)
Published in The Journal of immunology (1950) (01.05.2015)
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The Bcl-2 Family Antagonist ABT-737 Significantly Inhibits Multiple Animal Models of Autoimmunity
Bardwell, Philip D, Gu, Jijie, McCarthy, Donna, Wallace, Craig, Bryant, Shaughn, Goess, Christian, Mathieu, Suzanne, Grinnell, Chris, Erickson, Jamie, Rosenberg, Saul H, Schwartz, Annette J, Hugunin, Margaret, Tarcsa, Edit, Elmore, Steven W, McRae, Bradford, Murtaza, Anwar, Wang, Li Chun, Ghayur, Tariq
Published in The Journal of immunology (1950) (15.06.2009)
Published in The Journal of immunology (1950) (15.06.2009)
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Pain and inflammation coincide in a collagen-induced arthritis model in rats (171.17)
McCarthy, Richard, Goess, Christian, Rundell, Lian, Cuff, Carolyn, Prisca, Honore, Andrew, Long
Published in The Journal of immunology (1950) (01.05.2012)
Published in The Journal of immunology (1950) (01.05.2012)
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Journal Article
GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF
HAYES MARTIN E, OH JASON Z, HERNANDEZ JR. AXEL, WAEGELL WENDY, MCPHERSON MICHAEL J, HOBSON ADRIAN D, MARVIN CHRISTOPHER C, GOESS CHRISTIAN, RANDOLPH JOHN T, SCHMIDT DIANA
Year of Publication 29.08.2022
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Year of Publication 29.08.2022
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