A Phase 1, Placebo-controlled, Randomized, Single Ascending Dose Study and a Volunteer Infection Study to Characterize the Safety, Pharmacokinetics, and Antimalarial Activity of the Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048
McCarthy, James S, Donini, Cristina, Chalon, Stephan, Woodford, John, Marquart, Louise, Collins, Katharine A, Rozenberg, Felix D, Fidock, David A, Cherkaoui-Rbati, Mohammed H, Gobeau, Nathalie, Möhrle, Jörg J
Published in Clinical infectious diseases (17.12.2020)
Published in Clinical infectious diseases (17.12.2020)
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Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study
McCarthy, James S, Prof, Lotharius, Julie, PhD, Rückle, Thomas, PhD, Chalon, Stephan, MD, Phillips, Margaret A, Prof, Elliott, Suzanne, PhD, Sekuloski, Silvana, PhD, Griffin, Paul, MD, Ng, Caroline L, PhD, Fidock, David A, Prof, Marquart, Louise, PhD, Williams, Noelle S, PhD, Gobeau, Nathalie, PhD, Bebrevska, Lidiya, PhD, Rosario, Maria, PhD, Marsh, Kennan, PhD, Möhrle, Jörg J, Dr
Published in The Lancet infectious diseases (01.06.2017)
Published in The Lancet infectious diseases (01.06.2017)
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Ensemble modeling highlights importance of understanding parasite-host behavior in preclinical antimalarial drug development
Burgert, Lydia, Rottmann, Matthias, Wittlin, Sergio, Gobeau, Nathalie, Krause, Andreas, Dingemanse, Jasper, Möhrle, Jörg J, Penny, Melissa A
Published in Scientific reports (10.03.2020)
Published in Scientific reports (10.03.2020)
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DSM265 for Plasmodium falciparum chemoprophylaxis: a randomised, double blinded, phase 1 trial with controlled human malaria infection
Sulyok, Mihály, Dr, Rückle, Thomas, PhD, Roth, Alexandra, PhD, Mürbeth, Raymund E, MD, Chalon, Stephan, PhD, Kerr, Nicola, BA(Mod), Samec, Sonia Schnieper, PhD, Gobeau, Nathalie, PhD, Calle, Carlos Lamsfus, MSc, Ibáñez, Javier, MSc, Sulyok, Zita, MD, Held, Jana, PhD, Gebru, Tamirat, MSc, Granados, Patricia, MSc, Brückner, Sina, PhD, Nguetse, Christian, PhD, Mengue, Juliana, MSc, Lalremruata, Albert, MSc, Sim, Kim Lee, PhD, Hoffman, Stephen L, MD, Möhrle, Jörg J, PhD, Kremsner, Peter G, Prof, Mordmüller, Benjamin, MD
Published in The Lancet infectious diseases (01.06.2017)
Published in The Lancet infectious diseases (01.06.2017)
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The Parasite Reduction Ratio (PRR) Assay Version 2: Standardized Assessment of Plasmodium falciparum Viability after Antimalarial Treatment In Vitro
Walz, Annabelle, Duffey, Maëlle, Aljayyoussi, Ghaith, Sax, Sibylle, Leroy, Didier, Besson, Dominique, Burrows, Jeremy N, Cherkaoui-Rbati, Mohammed H, Gobeau, Nathalie, Westwood, Marie-Anne, Siethoff, Christoph, Gamo, Francisco-Javier, Mäser, Pascal, Wittlin, Sergio
Published in Pharmaceuticals (Basel, Switzerland) (23.01.2023)
Published in Pharmaceuticals (Basel, Switzerland) (23.01.2023)
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Efficient simulation of clinical target response surfaces
Lill, Daniel, Kümmel, Anne, Mitov, Venelin, Kaschek, Daniel, Gobeau, Nathalie, Schmidt, Henning, Timmer, Jens
Published in CPT: pharmacometrics and systems pharmacology (01.04.2022)
Published in CPT: pharmacometrics and systems pharmacology (01.04.2022)
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A pharmacokinetic–pharmacodynamic model for chemoprotective agents against malaria
Cherkaoui‐Rbati, Mohammed H., Andenmatten, Nicole, Burgert, Lydia, Egbelowo, Oluwaseun F., Fendel, Rolf, Fornari, Chiara, Gabel, Michael, Ward, John, Möhrle, Jörg J., Gobeau, Nathalie
Published in CPT: pharmacometrics and systems pharmacology (01.01.2023)
Published in CPT: pharmacometrics and systems pharmacology (01.01.2023)
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Retrospective Analysis Using Pharmacokinetic/Pharmacodynamic Modeling and Simulation Offers Improvements in Efficiency of the Design of Volunteer Infection Studies for Antimalarial Drug Development
Andrews, Kayla Ann, Owen, Joel S., McCarthy, James, Wesche, David, Gobeau, Nathalie, Grasela, Thaddeus H., Möhrle, Jörg J.
Published in Clinical and translational science (01.03.2021)
Published in Clinical and translational science (01.03.2021)
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Development and application of a PBPK modeling strategy to support antimalarial drug development
Abla, Nada, Howgate, Eleanor, Rowland‐Yeo, Karen, Dickins, Maurice, Bergagnini‐Kolev, Mackenzie C., Chen, Kuan‐Fu, McFeely, Savannah, Bonner, Jennifer J., Santos, Laura G. A., Gobeau, Nathalie, Burt, Howard, Barter, Zoe, Jones, Hannah M., Wesche, David, Charman, Susan A., Möhrle, Jörg J., Burrows, Jeremy N., Almond, Lisa M.
Published in CPT: pharmacometrics and systems pharmacology (01.09.2023)
Published in CPT: pharmacometrics and systems pharmacology (01.09.2023)
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Application of PBPK modeling to evaluate pharmacokinetic drug-drug interactions during the development of new antimalarial combination therapies
Abla, Nada, Almond, Lisa, Dickins, Maurice, Gobeau, Nathalie, Charman, Susan A., Rowland-Yeo, Karen, El Gaaloul, Myriam, Barter, Zoe, Moehrle, Joerg, Wesche, David, Burrows, Jeremy
Published in Drug metabolism and pharmacokinetics (01.01.2019)
Published in Drug metabolism and pharmacokinetics (01.01.2019)
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977Mechanistic within-host modelling to fast-track the selection of new antimalarial combination therapies
Simpson, Julie, Dini, Saber, Zaloumis, Sophie, Price, David, McCarthy, James, Cherkaoui, Mohammed, Kummel, Anne, Gobeau, Nathalie
Published in International journal of epidemiology (01.09.2021)
Published in International journal of epidemiology (01.09.2021)
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Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study
Llanos-Cuentas, Alejandro, Casapia, Martin, Chuquiyauri, Raúl, Hinojosa, Juan-Carlos, Kerr, Nicola, Rosario, Maria, Toovey, Stephen, Arch, Robert H, Phillips, Margaret A, Rozenberg, Felix D, Bath, Jade, Ng, Caroline L, Cowell, Annie N, Winzeler, Elizabeth A, Fidock, David A, Baker, Mark, Möhrle, Jörg J, Hooft van Huijsduijnen, Rob, Gobeau, Nathalie, Araeipour, Nada, Andenmatten, Nicole, Rückle, Thomas, Duparc, Stephan
Published in The Lancet infectious diseases (01.08.2018)
Published in The Lancet infectious diseases (01.08.2018)
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New In Vitro Interaction-Parasite Reduction Ratio Assay for Early Derisk in Clinical Development of Antimalarial Combinations
Wicha, Sebastian G, Walz, Annabelle, Cherkaoui-Rbati, Mohammed H, Bundgaard, Nils, Kuritz, Karsten, Gumpp, Christin, Gobeau, Nathalie, Möhrle, Jörg, Rottmann, Matthias, Demarta-Gatsi, Claudia
Published in Antimicrobial agents and chemotherapy (15.11.2022)
Published in Antimicrobial agents and chemotherapy (15.11.2022)
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Antimalarial Activity of Artefenomel Against Asexual Parasites and Transmissible Gametocytes During Experimental Blood-Stage Plasmodium vivax Infection
Collins, Katharine A, Abd-Rahman, Azrin N, Marquart, Louise, Ballard, Emma, Gobeau, Nathalie, Griffin, Paul, Chalon, Stephan, Möhrle, Jörg J, McCarthy, James S
Published in The Journal of infectious diseases (15.03.2022)
Published in The Journal of infectious diseases (15.03.2022)
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Characterising the blood-stage antimalarial activity of pyronaridine in healthy volunteers experimentally infected with Plasmodium falciparum
Barber, Bridget E., Webster, Rebecca, Potter, Adam J., Llewellyn, Stacey, Sahai, Nischal, Leelasena, Indika, Mathison, Susan, Kuritz, Karsten, Flynn, Julia, Chalon, Stephan, Marrast, Anne Claire, Gobeau, Nathalie, Moehrle, Joerg J.
Published in International journal of antimicrobial agents (01.07.2024)
Published in International journal of antimicrobial agents (01.07.2024)
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Seeking an optimal dosing regimen for OZ439/DSM265 combination therapy for treating uncomplicated falciparum malaria
Dini, Saber, Zaloumis, Sophie G., Price, David J., Gobeau, Nathalie, Kümmel, Anne, Cherkaoui, Mohammed, Moehrle, Joerg J., McCarthy, James S., Simpson, Julie A.
Published in Journal of antimicrobial chemotherapy (12.08.2021)
Published in Journal of antimicrobial chemotherapy (12.08.2021)
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Simulated rat intestinal fluid improves oral exposure prediction for poorly soluble compounds over a wide dose range
Berghausen, Joerg, Seiler, Frank Hans, Gobeau, Nathalie, Faller, Bernard
Published in ADMET & DMPK (01.04.2016)
Published in ADMET & DMPK (01.04.2016)
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Parasite-Host Dynamics throughout Antimalarial Drug Development Stages Complicate the Translation of Parasite Clearance
Burgert, Lydia, Zaloumis, Sophie, Dini, Saber, Marquart, Louise, Cao, Pengxing, Cherkaoui, Mohammed, Gobeau, Nathalie, McCarthy, James, Simpson, Julie A, Möhrle, Jörg J, Penny, Melissa A
Published in Antimicrobial agents and chemotherapy (18.03.2021)
Published in Antimicrobial agents and chemotherapy (18.03.2021)
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Population Pharmacokinetics and Pharmacodynamics of Chloroquine in a Plasmodium vivax Volunteer Infection Study
Abd‐Rahman, Azrin N., Marquart, Louise, Gobeau, Nathalie, Kümmel, Anne, Simpson, Julie A., Chalon, Stephan, Möhrle, Jörg J., McCarthy, James S.
Published in Clinical pharmacology and therapeutics (01.11.2020)
Published in Clinical pharmacology and therapeutics (01.11.2020)
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Predicting Optimal Antimalarial Drug Combinations from a Standardized Plasmodium falciparum Humanized Mouse Model
Demarta-Gatsi, Claudia, Andenmatten, Nicole, Jiménez-Díaz, María-Belén, Gobeau, Nathalie, Cherkaoui-Rabti, Mohammed H, Fuchs, Aline, Díaz, Pablo, Berja, Sandra, Sánchez, Rebeca, Gómez, Hazel, Ruiz, Estíbaliz, Sainz, Paula, Salazar, Eider, Gil-Merino, Rodrigo, Mendoza, Luis Manuel, Eguizabal, Cristina, Leroy, Didier, Moehrle, Joerg J, Tornesi, Belen, Angulo-Barturen, Iñigo
Published in Antimicrobial agents and chemotherapy (15.06.2023)
Published in Antimicrobial agents and chemotherapy (15.06.2023)
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