Direct-acting antiviral agents for hepatitis C: structural and mechanistic insights
Götte, Matthias, Feld, Jordan J.
Published in Nature reviews. Gastroenterology & hepatology (01.06.2016)
Published in Nature reviews. Gastroenterology & hepatology (01.06.2016)
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The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus
Gordon, Calvin J., Tchesnokov, Egor P., Feng, Joy Y., Porter, Danielle P., Götte, Matthias
Published in The Journal of biological chemistry (10.04.2020)
Published in The Journal of biological chemistry (10.04.2020)
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Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir
Tchesnokov, Egor P, Feng, Joy Y, Porter, Danielle P, Götte, Matthias
Published in Viruses (04.04.2019)
Published in Viruses (04.04.2019)
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Journal Article
Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template
Gordon, Calvin J., Tchesnokov, Egor P., Schinazi, Raymond F., Götte, Matthias
Published in The Journal of biological chemistry (01.07.2021)
Published in The Journal of biological chemistry (01.07.2021)
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Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency
Gordon, Calvin J., Tchesnokov, Egor P., Woolner, Emma, Perry, Jason K., Feng, Joy Y., Porter, Danielle P., Götte, Matthias
Published in The Journal of biological chemistry (15.05.2020)
Published in The Journal of biological chemistry (15.05.2020)
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Journal Article
Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action
Tchesnokov, Egor P., Gordon, Calvin J., Woolner, Emma, Kocinkova, Dana, Perry, Jason K., Feng, Joy Y., Porter, Danielle P., Götte, Matthias
Published in The Journal of biological chemistry (20.11.2020)
Published in The Journal of biological chemistry (20.11.2020)
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Journal Article
Zika Virus Hijacks Stress Granule Proteins and Modulates the Host Stress Response
Hou, Shangmei, Kumar, Anil, Xu, Zaikun, Airo, Adriana M, Stryapunina, Iryna, Wong, Cheung Pang, Branton, William, Tchesnokov, Egor, Götte, Matthias, Power, Christopher, Hobman, Tom C
Published in Journal of virology (15.08.2017)
Published in Journal of virology (15.08.2017)
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Journal Article
Recombinant RNA-Dependent RNA Polymerase Complex of Ebola Virus
Tchesnokov, Egor P., Raeisimakiani, Parisa, Ngure, Marianne, Marchant, David, Götte, Matthias
Published in Scientific reports (05.03.2018)
Published in Scientific reports (05.03.2018)
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Journal Article
Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms
Stevens, Laura J, Pruijssers, Andrea J, Lee, Hery W, Gordon, Calvin J, Tchesnokov, Egor P, Gribble, Jennifer, George, Amelia S, Hughes, Tia M, Lu, Xiaotao, Li, Jiani, Perry, Jason K, Porter, Danielle P, Cihlar, Tomas, Sheahan, Timothy P, Baric, Ralph S, Götte, Matthias, Denison, Mark R
Published in Science translational medicine (03.08.2022)
Published in Science translational medicine (03.08.2022)
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Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K-specific inhibition
Baldwin, Eric T, Götte, Matthias, Tchesnokov, Egor P, Arnold, Eddy, Hagel, Margit, Nichols, Charles, Dossang, Pam, Lamers, Marieke, Wan, Paul, Steinbacher, Stefan, Romero, Donna L
Published in Proceedings of the National Academy of Sciences - PNAS (05.07.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (05.07.2022)
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Resistance patterns associated with HCV NS5A inhibitors provide limited insight into drug binding
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Book Review
Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases
Lo, Michael K., Albariño, César G., Perry, Jason K., Chang, Silvia, Tchesnokov, Egor P., Guerrero, Lisa, Chakrabarti, Ayan, Shrivastava-Ranjan, Punya, Chatterjee, Payel, McMullan, Laura K., Martin, Ross, Jordan, Robert, Götte, Matthias, Montgomery, Joel M., Nichol, Stuart T., Flint, Mike, Porter, Danielle, Spiropoulou, Christina F.
Published in Proceedings of the National Academy of Sciences - PNAS (27.10.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (27.10.2020)
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Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir
Gordon, Calvin J., Lee, Hery W., Tchesnokov, Egor P., Perry, Jason K., Feng, Joy Y., Bilello, John P., Porter, Danielle P., Götte, Matthias
Published in The Journal of biological chemistry (01.02.2022)
Published in The Journal of biological chemistry (01.02.2022)
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The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2
Feng, Joy Y., Du Pont, Venice, Babusis, Darius, Gordon, Calvin J., Tchesnokov, Egor P., Perry, Jason K., Duong, Vincent, Vijjapurapu, Arya, Zhao, Xiaofeng, Chan, Julie, Cohen, Cal, Juneja, Kavita, Cihlar, Tomas, Götte, Matthias, Bilello, John P.
Published in Molecules (Basel, Switzerland) (30.06.2022)
Published in Molecules (Basel, Switzerland) (30.06.2022)
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