Contribution of ABL Kinase Domain Mutations to Imatinib Resistance in Different Subsets of Philadelphia-Positive Patients: By the GIMEMA Working Party on Chronic Myeloid Leukemia
SOVERINI, Simona, COLAROSSI, Sabrina, RADAELLI, Franca, CICCONE, Fabrizio, TIRIBELLI, Mario, DI LORENZO, Roberto, CARACCIOLO, Clementina, IZZO, Barbara, PANE, Fabrizio, SAGLIO, Giuseppe, BACCARANI, Michele, MARTINELLI, Giovanni, GNANI, Alessandra, ROSTI, Gianantonio, CASTAGNETTI, Fausto, POERIO, Angela, IACOBUCCI, Ilaria, AMABILE, Marilina, ABRUZZESE, Elisabetta, ORLANDI, Ester
Published in Clinical cancer research (15.12.2006)
Published in Clinical cancer research (15.12.2006)
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Journal Article
Resistance to dasatinib in Philadelphia-positive leukemia patients and the presence or the selection of mutations at residues 315 and 317 in the BCR-ABL kinase domain
Soverini, Simona, Colarossi, Sabrina, Gnani, Alessandra, Castagnetti, Fausto, Rosti, Gianantonio, Bosi, Costanza, Paolini, Stefania, Rondoni, Michela, Piccaluga, Pier Paolo, Palandri, Francesca, Giannoulia, Panagiota, Marzocchi, Giulia, Luatti, Simona, Testoni, Nicoletta, Iacobucci, Ilaria, Cilloni, Daniela, Saglio, Giuseppe, Baccarani, Michele, Martinelli, Giovanni
Published in Haematologica (Roma) (01.03.2007)
Published in Haematologica (Roma) (01.03.2007)
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Journal Article
Philadelphia-positive acute lymphoblastic leukemia patients already harbor BCR-ABL kinase domain mutations at low levels at the time of diagnosis
SOVERINI, Simona, VITALE, Antonella, PAOLINI, Stefania, MELONI, Giovanna, DI MAIO, Valeria, PAPAYANNIDIS, Cristina, AMABILE, Marilina, GUARINI, Anna, BACCARANI, Michele, MARTINELLI, Giovanni, FOA, Robin, POERIO, Angela, GNANI, Alessandra, COLAROSSI, Sabrina, IACOBUCCI, Ilaria, CIMINO, Giuseppe, ELIA, Loredana, LONETTI, Annalisa, VIGNETTI, Marco
Published in Haematologica (Roma) (01.04.2011)
Published in Haematologica (Roma) (01.04.2011)
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Journal Article
Second-line treatment with dasatinib in patients resistant to imatinib can select novel inhibitor-specific BCR-ABL mutants in Ph+ ALL
Soverini, Simona, Dr, Martinelli, Giovanni, MD, Colarossi, Sabrina, PhD, Gnani, Alessandra, PhD, Rondoni, Michela, MD, Castagnetti, Fausto, MD, Paolini, Stefania, MD, Rosti, Gianantonio, MD, Baccarani, Michele, Prof
Published in The lancet oncology (01.03.2007)
Published in The lancet oncology (01.03.2007)
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Journal Article
Philadelphia-positive patients who already harbor imatinib-resistant Bcr-Abl kinase domain mutations have a higher likelihood of developing additional mutations associated with resistance to second- or third-line tyrosine kinase inhibitors
Soverini, Simona, Gnani, Alessandra, Colarossi, Sabrina, Castagnetti, Fausto, Abruzzese, Elisabetta, Paolini, Stefania, Merante, Serena, Orlandi, Ester, de Matteis, Silvia, Gozzini, Antonella, Iacobucci, Ilaria, Palandri, Francesca, Gugliotta, Gabriele, Papayannidis, Cristina, Poerio, Angela, Amabile, Marilina, Cilloni, Daniela, Rosti, Gianantonio, Baccarani, Michele, Martinelli, Giovanni
Published in Blood (03.09.2009)
Published in Blood (03.09.2009)
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Journal Article
Presence or the emergence of a F317L BCR-ABL mutation may be associated with resistance to dasatinib in Philadelphia chromosome-positive leukemia
Soverini, Simona, Martinelli, Giovanni, Colarossi, Sabrina, Gnani, Alessandra, Castagnetti, Fausto, Rosti, Gianantonio, Bosi, Costanza, Paolini, Stefania, Rondoni, Michela, Piccaluga, Pier Paolo, Palandri, Francesca, Giannoulia, Panagiota, Marzocchi, Giulia, Luatti, Simona, Testoni, Nicoletta, Iacobucci, Ilaria, Cilloni, Daniela, Saglio, Giuseppe, Baccarani, Michele
Published in Journal of clinical oncology (20.11.2006)
Published in Journal of clinical oncology (20.11.2006)
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Journal Article
Abstract 1884: Resistance to second-line tyrosine kinase inhibitor treatment in imatinib-resistant Philadelphia-positive leukemia patients can be anticipated by ultra-deep sequencing of the BCR-ABL kinase domain using Roche 454 technology
Soverini, Simona, Benedittis, Caterina De, Gnani, Alessandra, Iacobucci, Ilaria, Castagnetti, Fausto, Gugliotta, Gabriele, Papayannidis, Cristina, Cattina, Federica, Russo, Domenico, Pantaleo, Maria Abbondanza, Rosti, Gianantonio, Baccarani, Michele, Martinelli, Giovanni
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
Durable molecular response despite F317L and E255K mutations: Successful treatment of chronic myeloid leukemia with sequential imatinib, nilotinib and dasatinib
Intermesoli, Tamara, Castagnetti, Fausto, Soverini, Simona, Bussini, Adelaide, Spinelli, Orietta, Gnani, Alessandra, Bassan, Renato, Rosti, Gianantonio
Published in Leukemia research (01.01.2012)
Published in Leukemia research (01.01.2012)
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Journal Article
BCR-ABL kinase domain mutations and resistance in Ph+ acute lymphoblastic leukemia from the imatinib to the second-generation TKI era
Soverini, Simona, Gnani, Alessandra, De Benedittis, Caterina, Iacobucci, Ilaria, Venturi, Claudia, Papayannidis, Cristina, Luppi, Mario, Merante, Serena, Malagola, Michele, Russo, Domenico, Tiribelli, Mario, Salvucci, Marzia, Vitale, Antonella, Elia, Loredana, Vignetti, Marco, Foà, Robin, Baccarani, Michele, Martinelli, Giovanni
Published in Journal of clinical oncology (20.05.2012)
Published in Journal of clinical oncology (20.05.2012)
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Journal Article
Low-level Bcr–Abl mutations are very rare in chronic myeloid leukemia patients who are in major molecular response on first-line nilotinib
Soverini, Simona, Gnani, Alessandra, De Benedittis, Caterina, Castagnetti, Fausto, Gugliotta, Gabriele, Iacobucci, Ilaria, Palandri, Francesca, Rosti, Gianantonio, Testoni, Nicoletta, Luatti, Simona, Marzocchi, Giulia, Baccarani, Michele, Martinelli, Giovanni
Published in Leukemia research (01.11.2011)
Published in Leukemia research (01.11.2011)
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Journal Article
Low-Level Bcr-Abl Kinase Domain Mutations Are Very Rare In Chronic Myeloid Leukemia Patients Who Are In Major Molecular Response After 12 Months of First-Line Nilotinib Therapy
Soverini, Simona, Poerio, Angela, Debenedittis, Caterina, Iacobucci, Ilaria, Colarossi, Sabrina, Gnani, Alessandra, Castagnetti, Fausto, Palandri, Francesca, Gugliotta, Gabriele, Amabile, Marilina, Rosti, Gianantonio, Baccarani, Michele, Martinelli, Giovanni
Published in Blood (19.11.2010)
Published in Blood (19.11.2010)
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Journal Article
Abstract 309: Whole-transcriptome sequencing in chronic myeloid leukemia reveals novel gene mutations that may be associated with disease pathogenesis and progression
Soverini, Simona, Poerio, Angela, Ferrarini, Alberto, Iacobucci, Ilaria, De Benedittis, Caterina, Sazzini, Marco, Giacomelli, Enrico, Xumerle, Luciano, Colarossi, Sabrina, Gnani, Alessandra, Castagnetti, Fausto, Palandri, Francesca, Gugliotta, Gabriele, Amabile, Marilina, Baccarani, Michele, Delledonne, Massimo, Martinelli, Giovanni
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Journal Article
Drug Resistance and Bcr-Abl Kinase Domain Mutations In Philadelphia-Positive Acute Lymphoblastic Leukemia From the Imatinib to the 2nd-Generation Tyrosine Kinase Inhibitor Era: The Main Changes Are In the Type of Mutations, but Not In the Frequency of Mutation Involvement
Soverini, Simona, Gnani, Alessandra, De Benedittis, Caterina, Iacobucci, Ilaria, Lonetti, Annalisa, Papayannidis, Cristina, Potenza, Leonardo, Luppi, Mario, Merante, Serena, Malagola, Michele, Russo, Domenico, Tiribelli, Mario, Salvucci, Marzia, Zaccaria, Alfonso, Giannini, Barbara, Poletti, Giovanni, Vitale, Antonella, Elia, Loredana, Vignetti, Marco, Foà, Robin, Baccarani, Michele, Martinelli, Giovanni
Published in Blood (18.11.2011)
Published in Blood (18.11.2011)
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Journal Article
Validation of the New European LeukemiaNet (ELN) Recommendations for Bcr-Abl Kinase Domain Mutation Analysis In Chronic Myeloid Leukemia: An Analysis of the GIMEMA CML Working Party Studies
Soverini, Simona, Gnani, Alessandra, De Benedittis, Caterina, Castagnetti, Fausto, Gugliotta, Gabriele, Bochicchio, Maria Teresa, Palandri, Francesca, Arpinati, Mario, Bonifazi, Francesca, Abruzzese, Elisabetta, Sorà, Federica, Alimena, Giuliana, Pregno, Patrizia, Specchia, Giorgina, Russo, Domenico, Pane, Fabrizio, Saglio, Giuseppe, Salvucci, Marzia, Zaccaria, Alfonso, Poletti, Giovanni, Giannini, Barbara, Iacobucci, Ilaria, Lonetti, Annalisa, Durante, Sandra, Rosti, Gianantonio, Baccarani, Michele, Martinelli, Giovanni
Published in Blood (18.11.2011)
Published in Blood (18.11.2011)
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Journal Article
Ultra-Deep Amplicon Sequencing Using Roche 454 Technology Allows High Sensitivity Bcr-Abl Kinase Domain Mutation Screening and Anticipates Emerging Mutations Leading to Resistance to Tyrosine Kinase Inhibitors in Philadelphia-Positive Leukemia Patients
Soverini, Simona, De Benedittis, Caterina, Gnani, Alessandra, Iacobucci, Ilaria, Russo, Domenico, Cattina, Federica, Castagnetti, Fausto, Gugliotta, Gabriele, Papayannidis, Cristina, Vitale, Antonella, Elia, Loredana, Foà, Robin, Palandri, Francesca, Lonetti, Annalisa, Bochicchio, Maria Teresa, Durante, Sandra, Rosti, Gianantonio, Baccarani, Michele, Martinelli, Giovanni
Published in Blood (18.11.2011)
Published in Blood (18.11.2011)
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Journal Article
Abstract 1804: Efficacy and clinical outcome of Philadelphia (Ph) positive acute lymphoblastic leukemia (ALL) patients treated with second generation tyrosine kinase inhibitors (TKIs): The Bologna experience
Papayannidis, Cristina, Iacobucci, Ilaria, Soverini, Simona, Colarossi, Sabrina, Gnani, Alessandra, Lonetti, Annalisa, Ferrari, Anna, Testoni, Nicoletta, Amabile, Marilina, Ottaviani, Emanuela, Abbenante, Maria Chiara, Curti, Antonio, Paolini, Stefania, Lama, Barbara, Clissa, Cristina, Parisi, Sarah, Guadagnuolo, Viviana, Baccarani, Michele, Martinelli, Giovanni
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Journal Article
Abstract 2143: High-Resolution Molecular Karyotyping of Chronic Myeloid Leukemia Patients in Blast Crisis by 6.0 SNP-Arrays Identifies Focal Copy Number Alterations Affecting the Whole Sequence or Specific Exons of Oncogenes and Tumor Suppressor Genes
Gnani, Alessandra, Soverini, Simona, Colarossi, Sabrina, Castagnetti, Fausto, Astolfi, Annalisa, Formica, Serena, Palandri, Francesca, Iacobucci, Ilaria, Gugliotta, Gabriele, Poerio, Angela, Amabile, Marilina, Marzocchi, Giulia, Testoni, Nicoletta, Abruzzese, Elisabetta, Rosti, Gianantonio, Capranico, Giovanni, Baccarani, Michele, Martinelli, Giovanni
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Journal Article
Interferon‐alpha may restore sensitivity to tyrosine‐kinase inhibitors in Philadelphia chromosome positive acute lymphoblastic leukaemia with F317L mutation
Potenza, Leonardo, Volzone, Francesco, Riva, Giovanni, Soverini, Simona, Martinelli, Silvia, Iacobucci, Ilaria, Gnani, Alessandra, Barozzi, Patrizia, Forghieri, Fabio, Morselli, Monica, Zanetti, Eleonora, Maccaferri, Monica, Baccarani, Michele, Martinelli, Giovanni, Torelli, Giuseppe, Luppi, Mario
Published in British journal of haematology (01.07.2009)
Published in British journal of haematology (01.07.2009)
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Journal Article
Bcr-Abl Kinase Domain Mutations in Imatinib and in Second-Generation Tyrosine Kinase Inhibitor Eras: Seven Years of Mutation Analysis, a Report by the GIMEMA CML Working Party
Soverini, Simona, Gnani, Alessandra, Colarossi, Sabrina, Castagnetti, Fausto, Iacobucci, Ilaria, Breccia, Massimo, Abruzzese, Elisabetta, Pane, Fabrizio, Saglio, Giuseppe, Russo, Domenico, Specchia, Giorgina, Pregno, Patrizia, Sorà, Federica, Tiribelli, Mario, Palandri, Francesca, Gugliotta, Gabriele, Amabile, Marilina, Rosti, Gianantonio, Baccarani, Michele, Martinelli, Giovanni
Published in Blood (19.11.2010)
Published in Blood (19.11.2010)
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Journal Article
Whole-Transcriptome Sequencing In Chronic Myeloid Leukemia Reveals Novel Gene Mutations That May Be Associated with Disease Pathogenesis and Progression
Soverini, Simona, Poerio, Angela, Ferrarini, Alberto, Iacobucci, Ilaria, Sazzini, Marco, Score, Joannah, Giacomelli, Enrico, Xumerle, Luciano, Colarossi, Sabrina, Gnani, Alessandra, Castagnetti, Fausto, Palandri, Francesca, Gugliotta, Gabriele, Amabile, Marilina, Rosti, Gianantonio, Baccarani, Michele, Cross, Nicholas C.P., Delledonne, Massimo, Martinelli, Giovanni
Published in Blood (19.11.2010)
Published in Blood (19.11.2010)
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