Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans
Winchester, Wendy J, Gore, Katrina, Glatt, Sophie, Petit, Wendy, Gardiner, Jennifer C, Conlon, Kelly, Postlethwaite, Michael, Saintot, Pierre-Philippe, Roberts, Sonia, Gosset, James R, Matsuura, Tomomi, Andrews, Mark D, Glossop, Paul A, Palmer, Michael J, Clear, Nicola, Collins, Susie, Beaumont, Kevin, Reynolds, David S
Published in The Journal of pharmacology and experimental therapeutics (01.11.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2014)
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A formal synthesis of (+)-lactacystin from 4-hydroxyproline
Mycock, David K., Glossop, Paul A., Lewis, William, Hayes, Christopher J.
Published in Tetrahedron letters (02.01.2013)
Published in Tetrahedron letters (02.01.2013)
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Journal Article
Pyridine-N-Oxide as a Mild Reoxidant Which Transforms Osmium-Catalyzed Oxidative Cyclization
Donohoe, Timothy J, Wheelhouse (née Gosby), Katherine M.P, Lindsay-Scott, Peter J, Glossop, Paul A, Nash, Ian A, Parker, Jeremy S
Published in Angewandte Chemie (International ed.) (31.03.2008)
Published in Angewandte Chemie (International ed.) (31.03.2008)
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Journal Article
DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis
Mowbray, Charles E, Braillard, Stéphanie, Glossop, Paul A, Whitlock, Gavin A, Jacobs, Robert T, Speake, Jason, Pandi, Bharathi, Nare, Bakela, Maes, Louis, Yardley, Vanessa, Freund, Yvonne, Wall, Richard J, Carvalho, Sandra, Bello, Davide, Van den Kerkhof, Magali, Caljon, Guy, Gilbert, Ian H, Corpas-Lopez, Victoriano, Lukac, Iva, Patterson, Stephen, Zuccotto, Fabio, Wyllie, Susan
Published in Journal of medicinal chemistry (11.11.2021)
Published in Journal of medicinal chemistry (11.11.2021)
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Journal Article
Design and synthesis of long acting inhaled corticosteroids for the treatment of asthma
Millan, David S., Ballard, Stephen A., Chunn, Sara, Dybowski, Joseph A., Fulton, Craig K., Glossop, Paul A., Guillabert, Edouard, Hewson, Christopher A., Jones, Rhys M., Lamb, David J., Napier, Carolyn M., Payne-Cook, Toby A., Renery, Emmanuelle R., Selby, Matthew D., Tutt, Michelle F., Yeadon, Michael
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
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Journal Article
Osmium-mediated oxidative cyclizations: a study into the range of initiators that facilitate cyclization
Donohoe, Timothy J, Wheelhouse, Katherine M P, Lindsay-Scott, Peter J, Churchill, Gwydion H, Connolly, Matthew J, Butterworth, Sam, Glossop, Paul A
Published in Chemistry, an Asian journal (03.08.2009)
Published in Chemistry, an Asian journal (03.08.2009)
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Journal Article
Novel Amino-pyrazole Ureas with Potent In Vitro and In Vivo Antileishmanial Activity
Mowbray, Charles E, Braillard, Stéphanie, Speed, William, Glossop, Paul A, Whitlock, Gavin A, Gibson, Karl R, Mills, James E. J, Brown, Alan D, Gardner, J. Mark F, Cao, Yafeng, Hua, Wen, Morgans, Garreth L, Feijens, Pim-Bart, Matheeussen, An, Maes, Louis J
Published in Journal of medicinal chemistry (24.12.2015)
Published in Journal of medicinal chemistry (24.12.2015)
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Journal Article
Discovery of a First-In-Class Small Molecule Antagonist against the Adrenomedullin‑2 Receptor: Structure–Activity Relationships and Optimization
Zirimwabagabo, Jean-Olivier, Jailani, Ameera B. A, Avgoustou, Paris, Tozer, Matthew J, Gibson, Karl R, Glossop, Paul A, Mills, James E. J, Porter, Roderick A, Blaney, Paul, Wang, Ning, Skerry, Timothy M, Richards, Gareth O, Harrity, Joseph P. A
Published in Journal of medicinal chemistry (25.03.2021)
Published in Journal of medicinal chemistry (25.03.2021)
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Journal Article
Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain
Andrews, Mark D, af Forselles, Kerry, Beaumont, Kevin, Galan, Sébastien R. G, Glossop, Paul A, Grenie, Mathilde, Jessiman, Alan, Kenyon, Amy S, Lunn, Graham, Maw, Graham, Owen, Robert M, Pryde, David C, Roberts, Dannielle, Tran, Thien Duc
Published in ACS medicinal chemistry letters (09.04.2015)
Published in ACS medicinal chemistry letters (09.04.2015)
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Journal Article
Inhalation by Design: Novel Ultra-Long-Acting beta(2)-Adrenoreceptor Agonists for Inhaled Once-Daily Treatment of Asthma and Chronic Obstructive Pulmonary Disease That Utilize a Sulfonamide Agonist Headgroup
Glossop, Paul A., Lane, Charlotte A. L., Price, David A., Bunnage, Mark E., Lewthwaite, Russell A., James, Kim, Brown, Alan D., Yeadon, Michael, Perros-Huguet, Christelle, Trevethick, Michael A., Clarke, Nicholas P., Webster, Robert, Jones, Rhys M., Burrows, Jane L., Feeder, Neil, Taylor, Stefan C. J., Spence, Fiona J.
Published in Journal of medicinal chemistry (23.09.2010)
Published in Journal of medicinal chemistry (23.09.2010)
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Journal Article
Inhalation by Design: Novel Ultra-Long-Acting β2-Adrenoreceptor Agonists for Inhaled Once-Daily Treatment of Asthma and Chronic Obstructive Pulmonary Disease That Utilize a Sulfonamide Agonist Headgroup
Glossop, Paul A, Lane, Charlotte A. L, Price, David A, Bunnage, Mark E, Lewthwaite, Russell A, James, Kim, Brown, Alan D, Yeadon, Michael, Perros-Huguet, Christelle, Trevethick, Michael A, Clarke, Nicholas P, Webster, Robert, Jones, Rhys M, Burrows, Jane L, Feeder, Neil, Taylor, Stefan C. J, Spence, Fiona J
Published in Journal of medicinal chemistry (23.09.2010)
Published in Journal of medicinal chemistry (23.09.2010)
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Journal Article
Discovery of a First-in-Class Potent Small Molecule Antagonist against the Adrenomedullin‑2 Receptor
Avgoustou, Paris, Jailani, Ameera B. A, Zirimwabagabo, Jean-Olivier, Tozer, Matthew J, Gibson, Karl R, Glossop, Paul A, Mills, James E. J, Porter, Roderick A, Blaney, Paul, Bungay, Peter J, Wang, Ning, Shaw, Alice P, Bigos, Kamilla J. A, Holmes, Joseph L, Warrington, Jessica I, Skerry, Timothy M, Harrity, Joseph P. A, Richards, Gareth O
Published in ACS pharmacology & translational science (14.08.2020)
Published in ACS pharmacology & translational science (14.08.2020)
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Journal Article
Identification of Type-II Inhibitors Using Kinase Structures
Lovering, Frank, McDonald, Joseph, Whitlock, Gavin A., Glossop, Paul A., Phillips, Chris, Bent, Andrew, Sabnis, Yogesh, Ryan, Mark, Fitz, Lori, Lee, Julie, Chang, Jeanne S., Han, Seungil, Kurumbail, Ravi, Thorarensen, Atli
Published in Chemical biology & drug design (01.11.2012)
Published in Chemical biology & drug design (01.11.2012)
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Journal Article
The discovery of long acting β2-adrenoreceptor agonists
BROWN, Alan D, BUNNAGE, Mark E, TREVETHICK, Mike, WEBSTER, Rob, GLOSSOP, Paul A, JAMES, Kim, JONES, Rhys, LANE, Charlotte A. L, LEWTHWAITE, Russell A, MANTELL, Simon, PERROS-HUGUET, Christelle, PRICE, David A
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
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Journal Article
Development of a Scaleable Synthesis of a Geminal Dimethyl Tertiary Amine as an Inhaled Muscarinic Antagonist for the Treatment of COPD
Dillon, Barry R, Roberts, Dannielle F, Entwistle, David A, Glossop, Paul A, Knight, Craig J, Laity, Daniel A, James, Kim, Praquin, Celine F, Strang, Ross S, Watson, Christine A. L
Published in Organic process research & development (17.02.2012)
Published in Organic process research & development (17.02.2012)
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Journal Article
The discovery of adamantyl-derived, inhaled, long acting β2-adrenoreceptor agonists
BROWN, Alan D, BUNNAGE, Mark E, TREVETHICK, Mike, WEBSTER, Rob, GLOSSOP, Paul A, JAMES, Kim, JONES, Rhys, LANE, Charlotte A. L, LEWTHWAITE, Russell A, MANTELL, Simon, PERROS-HUGUET, Christelle, PRICE, David A
Published in Bioorganic & medicinal chemistry letters (15.02.2008)
Published in Bioorganic & medicinal chemistry letters (15.02.2008)
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Journal Article
The discovery of adamantyl-derived, inhaled, long acting beta(2)-adrenoreceptor agonists
Brown, Alan D, Bunnage, Mark E, Glossop, Paul A, James, Kim, Jones, Rhys, Lane, Charlotte A L, Lewthwaite, Russell A, Mantell, Simon, Perros-Huguet, Christelle, Price, David A, Trevethick, Mike, Webster, Rob
Published in Bioorganic & medicinal chemistry letters (15.02.2008)
Published in Bioorganic & medicinal chemistry letters (15.02.2008)
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Journal Article
The discovery of indole-derived long acting β2-adrenoceptor agonists for the treatment of asthma and COPD
BROWN, Alan D, BUNNAGE, Mark E, WEBSTER, Rob, GLOSSOP, Paul A, HOLBROOK, Mark, JONES, Rhys D, LANE, Charlotte A. L, LEWTHWAITE, Russell A, MANTELL, Simon, PERROS-HUGUET, Christelle, PRICE, David A
Published in Bioorganic & medicinal chemistry letters (15.11.2007)
Published in Bioorganic & medicinal chemistry letters (15.11.2007)
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Journal Article
A highly selective method for 11β-OH protection of steroidal 11β, 17α-diols
Glossop, Paul A., Hoogenraad, Marcel, Peakman, Torren M., Roberts, Dannielle F.
Published in Steroids (01.05.2008)
Published in Steroids (01.05.2008)
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Journal Article