Investigating Immune Gene Signatures in Peripheral Blood from Subjects with Allergic Rhinitis Undergoing Nasal Allergen Challenge
Kim, Young Woong, Singh, Amrit, Shannon, Casey P, Thiele, Jenny, Steacy, Lisa M, Ellis, Anne K, Neighbour, Helen, Gliddon, Daniel R, Hickey, Pascal L C, Larché, Mark, Tebbutt, Scott J
Published in The Journal of immunology (1950) (15.11.2017)
Published in The Journal of immunology (1950) (15.11.2017)
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Journal Article
715 FS118, a tetravalent bispecific antibody targeting LAG-3 and PD-L1, induces LAG-3 shedding resulting in receptor downregulation by T cells via a novel mechanism of action
Morrow, Michelle, Faroudi, Mustapha, Chakraborty, Krishnendu, Liao, Wenjia, Winnewisser, Julia, Seal, Claire, Gliddon, Daniel, Brewis, Neil
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
DEC‐205 expression on migrating dendritic cells in afferent lymph
Gliddon, Daniel R., Hope, Jayne C., Brooke, Gareth P., Howard, Christopher J.
Published in Immunology (01.03.2004)
Published in Immunology (01.03.2004)
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Journal Article
In vitro cytokine release assays: reducing the risk of adverse events in man
Kirton, Christopher M, Gliddon, Daniel R, Bannish, Gregory, Bembridge, Gary P, Coney, Lee A
Published in Bioanalysis (01.12.2011)
Published in Bioanalysis (01.12.2011)
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Journal Article
FS118, a Bispecific Antibody Targeting LAG-3 and PD-L1, Enhances T-Cell Activation Resulting in Potent Antitumor Activity
Kraman, Matthew, Faroudi, Mustapha, Allen, Natalie L, Kmiecik, Katarzyna, Gliddon, Daniel, Seal, Claire, Koers, Alexander, Wydro, Mateusz M, Batey, Sarah, Winnewisser, Julia, Young, Lesley, Tuna, Mihriban, Doody, Jacqueline, Morrow, Michelle, Brewis, Neil
Published in Clinical cancer research (01.07.2020)
Published in Clinical cancer research (01.07.2020)
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Journal Article
FS222, a CD137/PD-L1 Tetravalent Bispecific Antibody, Exhibits Low Toxicity and Antitumor Activity in Colorectal Cancer Models
Lakins, Matthew A, Koers, Alexander, Giambalvo, Raffaella, Munoz-Olaya, Jose, Hughes, Robert, Goodman, Emma, Marshall, Sylwia, Wollerton, Francisca, Batey, Sarah, Gliddon, Daniel, Tuna, Mihriban, Brewis, Neil
Published in Clinical cancer research (01.08.2020)
Published in Clinical cancer research (01.08.2020)
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Abstract 1864: FS222, a tetravalent bispecific antibody targeting CD137 and PD-L1, is designed for optimal CD137 interactions resulting in potent T cell activation without toxicity
Lakins, Matthew A., Munoz-Olaya, Jose, Veyssier, Christel, Jones, Daniel, Goodman, Emma, Kaka, Quincy, Ofoedu, Jennifer, Hughes, Robert, Gliddon, Daniel, Morrow, Michelle, Brewis, Neil
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
A Phase 1 First-in-Human Study of FS118, a Tetravalent Bispecific Antibody Targeting LAG-3 and PD-L1 in Patients with Advanced Cancer and PD-L1 Resistance
Yap, Timothy A, LoRusso, Patricia M, Wong, Deborah J, Hu-Lieskovan, Siwen, Papadopoulos, Kyriakos P, Holz, Josefin-Beate, Grabowska, Urszula, Gradinaru, Cristian, Leung, Kin-Mei, Marshall, Sylwia, Reader, Claire S, Russell, Roslin, Sainson, Richard C A, Seal, Claire J, Shepherd, Christopher J, Germaschewski, Fiona, Gliddon, Daniel, Stern, Omer, Young, Lesley, Brewis, Neil, Kayitalire, Louis, Morrow, Michelle
Published in Clinical cancer research (01.03.2023)
Published in Clinical cancer research (01.03.2023)
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Abstract 4547: Clustering CD137 via cell-expressed PD-L1 crosslinking avoided Fc-mediated agonism and resulted in safe and potent conditional lymphocyte activation
Lakins, Matthew A., Koers, Alexander, Giambalvo, Raffaella, Hughes, Robert, Marshall, Sylwia, Wydro, Mateusz, Gradinaru, Cristian, Batey, Sarah, Gliddon, Daniel, Morrow, Michelle, Brewis, Neil
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Abstract 2399: LAG-3/PD-L1 mAb2 can overcome PD-L1-mediated compensatory upregulation of LAG-3 induced by single-agent checkpoint blockade
Faroudi, Mustapha, Kraman, Matthew, Fosh, Natalie, Reader, Claire, Gliddon, Daniel, Seal, Claire, Lucas, Christa, Koers, Alexander, Wydro, Mateusz, Morrow, Michelle, Brewis, Neil
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Abstract 2719: Dual blockade of PD-L1 and LAG-3 with FS118, a unique bispecific antibody, induces CD8+ T-cell activation and modulates the tumor microenvironment to promote antitumor immune responses
Kraman, Matthew, Fosh, Natalie, Kmiecik, Katarzyna, Everett, Katy, Zimarino, Carlo, Faroudi, Mustapha, Wydro, Mateusz, Koers, Alexander, Young, Lesley, Gliddon, Daniel, Morrow, Michelle, Doody, Jacqueline, Tuna, Mihriban, Brewis, Neil
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Abstract 1540: FS222 mAb2, a bispecific conditional agonist antibody targeting CD137 and PD-L1, induces potent lymphocyte activation and has a favorable safety profile
Lakins, Matthew A., Koers, Alexander, Olaya, Jose Munoz, Giambalvo, Raffaella, Jones, Daniel, Pechouckova, Sarka, Goodman, Emma, Marshall, Sylwia, Wydro, Mateusz, Gradinaru, Cristian, Wollerton, Francisca, Batey, Sarah, Gliddon, Daniel, Davies, Michael, Morrow, Michelle, Tuna, Mihriban, Brewis, Neil
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Cytokine release: A workshop proceedings on the state-of-the-science, current challenges and future directions
Grimaldi, Christine, Finco, Deborah, Fort, Madeline M., Gliddon, Daniel, Harper, Kirsty, Helms, Whitney S., Mitchell, Jane A., O’Lone, Raegan, Parish, Stanley T., Piche, Marie-Soleil, Reed, Daniel M., Reichmann, Gabriele, Ryan, Patricia C., Stebbings, Richard, Walker, Mindi
Published in Cytokine (Philadelphia, Pa.) (01.09.2016)
Published in Cytokine (Philadelphia, Pa.) (01.09.2016)
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Journal Article
LAG-3/PD-L1 이중특이적 항체의 투여를 위한 투여 요법
GERMASCHEWSKI FIONA, GLIDDON DANIEL, HOLZ JOSEFIN BEATE, KAYITALIRE LOUIS, GRADINARU CRISTIAN, LEUNG KIN MEI, SHEPHERD CHRISTOPHER, MORROW MICHELLE
Year of Publication 20.01.2022
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Year of Publication 20.01.2022
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