Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity
Corrales, Leticia, Glickman, Laura Hix, McWhirter, Sarah M., Kanne, David B., Sivick, Kelsey E., Katibah, George E., Woo, Seng-Ryong, Lemmens, Edward, Banda, Tamara, Leong, Justin J., Metchette, Ken, Dubensky, Thomas W., Gajewski, Thomas F.
Published in Cell reports (Cambridge) (19.05.2015)
Published in Cell reports (Cambridge) (19.05.2015)
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NSG Mice Provide a Better Spontaneous Model of Breast Cancer Metastasis than Athymic (Nude) Mice
Puchalapalli, Madhavi, Zeng, Xianke, Mu, Liang, Anderson, Aubree, Hix Glickman, Laura, Zhang, Ming, Sayyad, Megan R, Mosticone Wangensteen, Sierra, Clevenger, Charles V, Koblinski, Jennifer E
Published in PloS one (23.09.2016)
Published in PloS one (23.09.2016)
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STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade
Fu, Juan, Kanne, David B, Leong, Meredith, Glickman, Laura Hix, McWhirter, Sarah M, Lemmens, Edward, Mechette, Ken, Leong, Justin J, Lauer, Peter, Liu, Weiqun, Sivick, Kelsey E, Zeng, Qi, Soares, Kevin C, Zheng, Lei, Portnoy, Daniel A, Woodward, Joshua J, Pardoll, Drew M, Dubensky, Jr, Thomas W, Kim, Young
Published in Science translational medicine (15.04.2015)
Published in Science translational medicine (15.04.2015)
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Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity
Sivick, Kelsey E., Desbien, Anthony L., Glickman, Laura Hix, Reiner, Gabrielle L., Corrales, Leticia, Surh, Natalie H., Hudson, Thomas E., Vu, Uyen T., Francica, Brian J., Banda, Tamara, Katibah, George E., Kanne, David B., Leong, Justin J., Metchette, Ken, Bruml, Jacob R., Ndubaku, Chudi O., McKenna, Jeffrey M., Feng, Yan, Zheng, Lianxing, Bender, Steven L., Cho, Charles Y., Leong, Meredith L., van Elsas, Andrea, Dubensky, Thomas W., McWhirter, Sarah M.
Published in Cell reports (Cambridge) (11.12.2018)
Published in Cell reports (Cambridge) (11.12.2018)
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Journal Article
Cyclic Dinucleotide-Adjuvanted Dengue Virus Nonstructural Protein 1 Induces Protective Antibody and T Cell Responses
Espinosa, Diego A, Beatty, P Robert, Reiner, Gabrielle L, Sivick, Kelsey E, Hix Glickman, Laura, Dubensky, Jr, Thomas W, Harris, Eva
Published in The Journal of immunology (1950) (15.02.2019)
Published in The Journal of immunology (1950) (15.02.2019)
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Journal Article
TNFα and Radioresistant Stromal Cells Are Essential for Therapeutic Efficacy of Cyclic Dinucleotide STING Agonists in Nonimmunogenic Tumors
Francica, Brian J, Ghasemzadeh, Ali, Desbien, Anthony L, Theodros, Debebe, Sivick, Kelsey E, Reiner, Gabrielle L, Hix Glickman, Laura, Marciscano, Ariel E, Sharabi, Andrew B, Leong, Meredith L, McWhirter, Sarah M, Dubensky, Jr, Thomas W, Pardoll, Drew M, Drake, Charles G
Published in Cancer immunology research (01.04.2018)
Published in Cancer immunology research (01.04.2018)
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ENGINEERED IMMUNOSTIMULATORY BACTERIAL STRAINS AND USES THEREOF
GLICKMAN LAURA HIX, IANNELLO ALEXANDRE CHARLES MICHEL, SKOBLE JUSTIN, THANOS CHRISTOPHER D
Year of Publication 17.05.2024
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Year of Publication 17.05.2024
Patent
면역자극성 박테리아-기초 백신, 치료제, 및 RNA 전달 플랫폼
GLICKMAN LAURA HIX, IANNELLO ALEXANDRE CHARLES MICHEL, PETERSON BRET NICHOLAS, THANOS CHRISTOPHER D, KEHOE HAIXING
Year of Publication 12.05.2023
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Year of Publication 12.05.2023
Patent
종양, 종양-상주 면역 세포, 및 종양 미세환경을 콜로니화하기 위해 조작된 면역자극성 박테리아
GLICKMAN LAURA HIX, IANNELLO ALEXANDRE CHARLES MICHEL, SKOBLE JUSTIN, THANOS CHRISTOPHER D, KEHOE HAIXING
Year of Publication 12.01.2022
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Year of Publication 12.01.2022
Patent
Direct activation of STING in the tumor microenvironment with synthetic cyclic dinucleotide derivatives leads to potent and systemic tumor-specific immunity
Corrales, Leticia, Glickman, Laura Hix, McWhirter, Sarah M, Kanne, David B, Sivick, Kelsey E, Lemmens, Edward, Leong, Justin J, Metchette, Ken, Dubensky, Thomas W, Gajewski, Thomas
Published in Journal for immunotherapy of cancer (06.11.2014)
Published in Journal for immunotherapy of cancer (06.11.2014)
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면역자극성 박테리아 전달 플랫폼 및 치료 제품의 전달을 위한 이의 용도
CHEUNG CHINGNAM, GLICKMAN LAURA HIX, IANNELLO ALEXANDRE CHARLES MICHEL, PETERSON BRET NICHOLAS, THANOS CHRISTOPHER D, KEHOE HAIXING, RAE CHRIS
Year of Publication 17.08.2022
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Year of Publication 17.08.2022
Patent
조작된 면역자극성 박테리아 균주 및 이의 용도
GLICKMAN LAURA HIX, IANNELLO ALEXANDRE CHARLES MICHEL, SKOBLE JUSTIN, THANOS CHRISTOPHER D
Year of Publication 18.03.2021
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Year of Publication 18.03.2021
Patent
인터페론 유전자의 자극인자＂-의존적 신호전달을 활성화하는 조성물 및 방법
SUNG LEONARD, MCWHIRTER SARAH M, GLICKMAN LAURA HIX, KANNE DAVID, GAUTHIER KELSEY, LEONG JUSTIN, DUBENSKY JR. THOMAS W, KATIBAH GEORGE EDWIN
Year of Publication 27.11.2017
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Year of Publication 27.11.2017
Patent
"인터페론 유전자의 자극제"-의존성 신호전달을 활성화시키기 위한 조성물 및 방법
SUNG LEONARD, MCWHIRTER SARAH M, NDUBAKU CHUDI OBIOMA, GLICKMAN LAURA HIX, KANNE DAVID, MCKENNA JEFFREY, GAUTHIER KELSEY, LEONG JUSTIN, DUBENSKY THOMAS W. JR, CANHAM STEPHEN M, KATIBAH GEORGE EDWIN
Year of Publication 18.06.2018
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Year of Publication 18.06.2018
Patent
Abstract 4782: STACT: A novel tumor-targeting, systemically-administered delivery platform capable of targeting intractable pathways and precise immunomodulation of the tumor microenvironment
Rae, Chris S., Besprozvannaya, Marina, Faulhaber, John, Makarova, Anastasia M., King, Beverly, Glickman, Laura Hix, Thanos, Christopher D., Skoble, Justin
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Cyclic dinucleotide-adjuvanted dengue virus nonstructural 1 protein induces protective antibody and T-cell responses
Espinosa, Diego A., Beatty, P. Robert, Reiner, Gabrielle L., Sivick, Kelsey E., Glickman, Laura Hix, Dubensky, Thomas W., Harris, Eva
Published in The Journal of immunology (1950) (14.01.2019)
Published in The Journal of immunology (1950) (14.01.2019)
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Journal Article
Abstract 5016: STACT-TREX1: A systemically-administered STING pathway agonist targets tumor-resident myeloid cells and induces adaptive anti-tumor immunity in multiple preclinical models
Makarova, Anastasia M., Iannello, Alexandre, Rae, Chris S., King, Beverly, Besprozvannaya, Marina, Faulhaber, John, Skoble, Justin, Thanos, Christopher D., Glickman, Laura Hix
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity
Sivick, Kelsey E., Desbien, Anthony L., Glickman, Laura Hix, Reiner, Gabrielle L., Corrales, Leticia, Surh, Natalie H., Hudson, Thomas E., Vu, Uyen T., Francica, Brian J., Banda, Tamara, Katibah, George E., Kanne, David B., Leong, Justin J., Metchette, Ken, Bruml, Jacob R., Ndubaku, Chudi O., McKenna, Jeffrey M., Feng, Yan, Zheng, Lianxing, Bender, Steven L., Cho, Charles Y., Leong, Meredith L., van Elsas, Andrea, Dubensky, Thomas W., McWhirter, Sarah M.
Published in Cell reports (Cambridge) (15.10.2019)
Published in Cell reports (Cambridge) (15.10.2019)
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