RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43
Mann, Jacob R., Gleixner, Amanda M., Mauna, Jocelyn C., Gomes, Edward, DeChellis-Marks, Michael R., Needham, Patrick G., Copley, Katie E., Hurtle, Bryan, Portz, Bede, Pyles, Noah J., Guo, Lin, Calder, Christopher B., Wills, Zachary P., Pandey, Udai B., Kofler, Julia K., Brodsky, Jeffrey L., Thathiah, Amantha, Shorter, James, Donnelly, Christopher J.
Published in Neuron (Cambridge, Mass.) (17.04.2019)
Published in Neuron (Cambridge, Mass.) (17.04.2019)
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Journal Article
NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility
Gleixner, Amanda M, Verdone, Brandie Morris, Otte, Charlton G, Anderson, Eric N, Ramesh, Nandini, Shapiro, Olivia R, Gale, Jenna R, Mauna, Jocelyn C, Mann, Jacob R, Copley, Katie E, Daley, Elizabeth L, Ortega, Juan A, Cicardi, Maria Elena, Kiskinis, Evangelos, Kofler, Julia, Pandey, Udai B, Trotti, Davide, Donnelly, Christopher J
Published in Nature communications (13.06.2022)
Published in Nature communications (13.06.2022)
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Journal Article
Optogenetic TDP-43 nucleation induces persistent insoluble species and progressive motor dysfunction in vivo
Otte, Charlton G., Fortuna, Tyler R., Mann, Jacob R., Gleixner, Amanda M., Ramesh, Nandini, Pyles, Noah J., Pandey, Udai B., Donnelly, Christopher J.
Published in Neurobiology of disease (01.12.2020)
Published in Neurobiology of disease (01.12.2020)
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Journal Article
Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization
Casci, Ian, Krishnamurthy, Karthik, Kour, Sukhleen, Tripathy, Vadreenath, Ramesh, Nandini, Anderson, Eric N, Marrone, Lara, Grant, Rogan A, Oliver, Stacie, Gochenaur, Lauren, Patel, Krishani, Sterneckert, Jared, Gleixner, Amanda M, Donnelly, Christopher J, Ruepp, Marc-David, Sini, Antonella M, Zuccaro, Emanuela, Pennuto, Maria, Pasinelli, Piera, Pandey, Udai Bhan
Published in Nature communications (06.12.2019)
Published in Nature communications (06.12.2019)
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Journal Article
Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology
Anderson, Eric N, Morera, Andrés A, Kour, Sukhleen, Cherry, Jonathan D, Ramesh, Nandini, Gleixner, Amanda, Schwartz, Jacob C, Ebmeier, Christopher, Old, William, Donnelly, Christopher J, Cheng, Jeffrey P, Kline, Anthony E, Kofler, Julia, Stein, Thor D, Pandey, Udai Bhan
Published in eLife (01.06.2021)
Published in eLife (01.06.2021)
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Journal Article
N -Acetyl-l-Cysteine Protects Astrocytes against Proteotoxicity without Recourse to Glutathione
Gleixner, Amanda M, Hutchison, Daniel F, Sannino, Sara, Bhatia, Tarun N, Leak, Lillian C, Flaherty, Patrick T, Wipf, Peter, Brodsky, Jeffrey L, Leak, Rehana K
Published in Molecular pharmacology (01.11.2017)
Published in Molecular pharmacology (01.11.2017)
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Journal Article
Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy
Khalil, Bilal, Chhangani, Deepak, Wren, Melissa C, Smith, Courtney L, Lee, Jannifer H, Li, Xingli, Puttinger, Christian, Tsai, Chih-Wei, Fortin, Gael, Morderer, Dmytro, Gao, Junli, Liu, Feilin, Lim, Chun Kim, Chen, Jingjiao, Chou, Ching-Chieh, Croft, Cara L, Gleixner, Amanda M, Donnelly, Christopher J, Golde, Todd E, Petrucelli, Leonard, Oskarsson, Björn, Dickson, Dennis W, Zhang, Ke, Shorter, James, Yoshimura, Shige H, Barmada, Sami J, Rincon-Limas, Diego E, Rossoll, Wilfried
Published in Molecular neurodegeneration (08.12.2022)
Published in Molecular neurodegeneration (08.12.2022)
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Journal Article
Astrocytes Do Not Forfeit Their Neuroprotective Roles After Surviving Intense Oxidative Stress
Bhatia, Tarun N, Pant, Deepti B, Eckhoff, Elizabeth A, Gongaware, Rachel N, Do, Timothy, Hutchison, Daniel F, Gleixner, Amanda M, Leak, Rehana K
Published in Frontiers in molecular neuroscience (05.04.2019)
Published in Frontiers in molecular neuroscience (05.04.2019)
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Journal Article
RNA dependent suppression of C9orf72 ALS/FTD associated neurodegeneration by Matrin-3
Ramesh, Nandini, Daley, Elizabeth L, Gleixner, Amanda M, Mann, Jacob R, Kour, Sukhleen, Mawrie, Darilang, Anderson, Eric N, Kofler, Julia, Donnelly, Christopher J, Kiskinis, Evangelos, Pandey, Udai Bhan
Published in Acta neuropathologica communications (31.10.2020)
Published in Acta neuropathologica communications (31.10.2020)
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Journal Article
Heat shock protein responses to aging and proteotoxicity in the olfactory bulb
Crum, Tyler S., Gleixner, Amanda M., Posimo, Jessica M., Mason, Daniel M., Broeren, Matthew T., Heinemann, Scott D., Wipf, Peter, Brodsky, Jeffrey L., Leak, Rehana K.
Published in Journal of neurochemistry (01.06.2015)
Published in Journal of neurochemistry (01.06.2015)
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Journal Article
Heat shock protein defenses in the neocortex and allocortex of the telencephalon
Posimo, Jessica M, Weilnau, Justin N, Gleixner, Amanda M, Broeren, Matthew T, Weiland, Nicole L, Brodsky, Jeffrey L, Wipf, Peter, Leak, Rehana K
Published in Neurobiology of aging (01.05.2015)
Published in Neurobiology of aging (01.05.2015)
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Journal Article
Viability assays for cells in culture
Posimo, Jessica M, Unnithan, Ajay S, Gleixner, Amanda M, Choi, Hailey J, Jiang, Yiran, Pulugulla, Sree H, Leak, Rehana K
Published in Journal of visualized experiments (20.01.2014)
Published in Journal of visualized experiments (20.01.2014)
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Journal Article
The Impact of Profilin-1 Mutations on Protein Homeostasis in Amyotrophic Lateral Sclerosis
Castle, Julianna, Ferrara, Jay, Gau, David, Gleixner, Amanda, Roy, Partha, Kolarcik, Christi L
Published in The FASEB journal (01.05.2022)
Published in The FASEB journal (01.05.2022)
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Journal Article
Heat shock protein defenses in the neo- and allocortex of the telencephalon
Posimo, Jessica M., Weilnau, Justin N., Gleixner, Amanda M., Broeren, Matthew T., Weiland, Nicole L., Brodsky, Jeffrey L., Wipf, Peter, Leak, Rehana K.
Published in Neurobiology of aging (18.02.2015)
Published in Neurobiology of aging (18.02.2015)
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Journal Article
Viability Assays for Cells in Culture
Posimo, Jessica M., Unnithan, Ajay S., Gleixner, Amanda M., Choi, Hailey J., Jiang, Yiran, Pulugulla, Sree H., Leak, Rehana K.
Published in Journal of visualized experiments (20.01.2014)
Published in Journal of visualized experiments (20.01.2014)
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Journal Article
Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains
Guo, Lin, Mann, Jacob R, Mauna, Jocelyn C, Copley, Katie E, Wang, Hejia, Rubien, Jack D, Odeh, Hana M, Lin, JiaBei, Lee, Bo Lim, Ganser, Laura, Robinson, Emma, Kim, Kevin M, Murthy, Anastasia C, Paul, Tapas, Portz, Bede, Gleixner, Amanda M, Diaz, Zamia, Carey, Jenny L, Smirnov, Ashleigh, Padilla, George, Lavorando, Ellen, Espy, Carolann, Shang, Yulei, Huang, Eric J, Chesi, Alessandra, Fawzi, Nicolas L, Myong, Sua, Donnelly, Christopher J, Shorter, James
Published in bioRxiv : the preprint server for biology (04.09.2023)
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Published in bioRxiv : the preprint server for biology (04.09.2023)
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