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Neurodegenerative disease: models, mechanisms, and a new hope
Gitler, Aaron D., Dhillon, Paraminder, Shorter, James
Published in Disease models & mechanisms (01.05.2017)
Published in Disease models & mechanisms (01.05.2017)
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Neurotoxic reactive astrocytes induce cell death via saturated lipids
Guttenplan, Kevin A., Weigel, Maya K., Prakash, Priya, Wijewardhane, Prageeth R., Hasel, Philip, Rufen-Blanchette, Uriel, Münch, Alexandra E., Blum, Jacob A., Fine, Jonathan, Neal, Mikaela C., Bruce, Kimberley D., Gitler, Aaron D., Chopra, Gaurav, Liddelow, Shane A., Barres, Ben A.
Published in Nature (London) (04.11.2021)
Published in Nature (London) (04.11.2021)
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Stress granules as crucibles of ALS pathogenesis
Li, Yun R., King, Oliver D., Shorter, James, Gitler, Aaron D.
Published in The Journal of cell biology (29.04.2013)
Published in The Journal of cell biology (29.04.2013)
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Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model
Guttenplan, Kevin A., Weigel, Maya K., Adler, Drew I., Couthouis, Julien, Liddelow, Shane A., Gitler, Aaron D., Barres, Ben A.
Published in Nature communications (27.07.2020)
Published in Nature communications (27.07.2020)
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Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons
Blum, Jacob A., Klemm, Sandy, Shadrach, Jennifer L., Guttenplan, Kevin A., Nakayama, Lisa, Kathiria, Arwa, Hoang, Phuong T., Gautier, Olivia, Kaltschmidt, Julia A., Greenleaf, William J., Gitler, Aaron D.
Published in Nature neuroscience (01.04.2021)
Published in Nature neuroscience (01.04.2021)
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Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice
Becker, Lindsay A., Huang, Brenda, Bieri, Gregor, Ma, Rosanna, Knowles, David A., Jafar-Nejad, Paymaan, Messing, James, Kim, Hong Joo, Soriano, Armand, Auburger, Georg, Pulst, Stefan M., Taylor, J. Paul, Rigo, Frank, Gitler, Aaron D.
Published in Nature (London) (20.04.2017)
Published in Nature (London) (20.04.2017)
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A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation
Dorone, Yanniv, Boeynaems, Steven, Flores, Eduardo, Jin, Benjamin, Hateley, Shannon, Bossi, Flavia, Lazarus, Elena, Pennington, Janice G., Michiels, Emiel, De Decker, Mathias, Vints, Katlijn, Baatsen, Pieter, Bassel, George W., Otegui, Marisa S., Holehouse, Alex S., Exposito-Alonso, Moises, Sukenik, Shahar, Gitler, Aaron D., Rhee, Seung Y.
Published in Cell (05.08.2021)
Published in Cell (05.08.2021)
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A Cellular System that Degrades Misfolded Proteins and Protects against Neurodegeneration
Guo, Lili, Giasson, Benoit I., Glavis-Bloom, Alex, Brewer, Michael D., Shorter, James, Gitler, Aaron D., Yang, Xiaolu
Published in Molecular cell (03.07.2014)
Published in Molecular cell (03.07.2014)
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The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems
Lasker, Keren, Boeynaems, Steven, Lam, Vinson, Scholl, Daniel, Stainton, Emma, Briner, Adam, Jacquemyn, Maarten, Daelemans, Dirk, Deniz, Ashok, Villa, Elizabeth, Holehouse, Alex S., Gitler, Aaron D., Shapiro, Lucy
Published in Nature communications (26.09.2022)
Published in Nature communications (26.09.2022)
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Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
Jovičić, Ana, Mertens, Jerome, Boeynaems, Steven, Bogaert, Elke, Chai, Noori, Yamada, Shizuka B, Paul, Joseph W, Sun, Shuying, Herdy, Joseph R, Bieri, Gregor, Kramer, Nicholas J, Gage, Fred H, Van Den Bosch, Ludo, Robberecht, Wim, Gitler, Aaron D
Published in Nature neuroscience (01.09.2015)
Published in Nature neuroscience (01.09.2015)
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CRISPR–Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity
Kramer, Nicholas J., Haney, Michael S., Morgens, David W., Jovičić, Ana, Couthouis, Julien, Li, Amy, Ousey, James, Ma, Rosanna, Bieri, Gregor, Tsui, C. Kimberly, Shi, Yingxiao, Hertz, Nicholas T., Tessier-Lavigne, Marc, Ichida, Justin K., Bassik, Michael C., Gitler, Aaron D.
Published in Nature genetics (01.04.2018)
Published in Nature genetics (01.04.2018)
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Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis
Zhang, Yong-Jie, Gendron, Tania F, Ebbert, Mark T W, O'Raw, Aliesha D, Yue, Mei, Jansen-West, Karen, Zhang, Xu, Prudencio, Mercedes, Chew, Jeannie, Cook, Casey N, Daughrity, Lillian M, Tong, Jimei, Song, Yuping, Pickles, Sarah R, Castanedes-Casey, Monica, Kurti, Aishe, Rademakers, Rosa, Oskarsson, Bjorn, Dickson, Dennis W, Hu, Wenqian, Gitler, Aaron D, Fryer, John D, Petrucelli, Leonard
Published in Nature medicine (01.08.2018)
Published in Nature medicine (01.08.2018)
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suite of Gateway® cloning vectors for high-throughput genetic analysis in Saccharomyces cerevisiae
Alberti, Simon, Gitler, Aaron D, Lindquist, Susan
Published in Yeast (Chichester, England) (01.10.2007)
Published in Yeast (Chichester, England) (01.10.2007)
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TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity
Johnson, Brian S., Snead, David, Lee, Jonathan J., McCaffery, J. Michael, Shorter, James, Gitler, Aaron D.
Published in The Journal of biological chemistry (24.07.2009)
Published in The Journal of biological chemistry (24.07.2009)
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Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD
Boeynaems, Steven, Bogaert, Elke, Michiels, Emiel, Gijselinck, Ilse, Sieben, Anne, Jovičić, Ana, De Baets, Greet, Scheveneels, Wendy, Steyaert, Jolien, Cuijt, Ivy, Verstrepen, Kevin J., Callaerts, Patrick, Rousseau, Frederic, Schymkowitz, Joost, Cruts, Marc, Van Broeckhoven, Christine, Van Damme, Philip, Gitler, Aaron D., Robberecht, Wim, Van Den Bosch, Ludo
Published in Scientific reports (12.02.2016)
Published in Scientific reports (12.02.2016)
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Prion-like disorders: blurring the divide between transmissibility and infectivity
Cushman, Mimi, Johnson, Brian S, King, Oliver D, Gitler, Aaron D, Shorter, James
Published in Journal of cell science (15.04.2010)
Published in Journal of cell science (15.04.2010)
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