Neurodegenerative disease: models, mechanisms, and a new hope
Gitler, Aaron D, Dhillon, Paraminder, Shorter, James
Published in Disease models & mechanisms (01.05.2017)
Published in Disease models & mechanisms (01.05.2017)
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Journal Article
Stress granules as crucibles of ALS pathogenesis
Li, Yun R, King, Oliver D, Shorter, James, Gitler, Aaron D
Published in The Journal of cell biology (29.04.2013)
Published in The Journal of cell biology (29.04.2013)
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Neurotoxic reactive astrocytes induce cell death via saturated lipids
Guttenplan, Kevin A, Weigel, Maya K, Prakash, Priya, Wijewardhane, Prageeth R, Hasel, Philip, Rufen-Blanchette, Uriel, Münch, Alexandra E, Blum, Jacob A, Fine, Jonathan, Neal, Mikaela C, Bruce, Kimberley D, Gitler, Aaron D, Chopra, Gaurav, Liddelow, Shane A, Barres, Ben A
Published in Nature (London) (04.11.2021)
Published in Nature (London) (04.11.2021)
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Journal Article
Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model
Guttenplan, Kevin A., Weigel, Maya K., Adler, Drew I., Couthouis, Julien, Liddelow, Shane A., Gitler, Aaron D., Barres, Ben A.
Published in Nature communications (27.07.2020)
Published in Nature communications (27.07.2020)
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Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice
Becker, Lindsay A, Huang, Brenda, Bieri, Gregor, Ma, Rosanna, Knowles, David A, Jafar-Nejad, Paymaan, Messing, James, Kim, Hong Joo, Soriano, Armand, Auburger, Georg, Pulst, Stefan M, Taylor, J Paul, Rigo, Frank, Gitler, Aaron D
Published in Nature (London) (20.04.2017)
Published in Nature (London) (20.04.2017)
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Journal Article
Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
Jovičić, Ana, Mertens, Jerome, Boeynaems, Steven, Bogaert, Elke, Chai, Noori, Yamada, Shizuka B, Paul, 3rd, Joseph W, Sun, Shuying, Herdy, Joseph R, Bieri, Gregor, Kramer, Nicholas J, Gage, Fred H, Van Den Bosch, Ludo, Robberecht, Wim, Gitler, Aaron D
Published in Nature neuroscience (01.09.2015)
Published in Nature neuroscience (01.09.2015)
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Journal Article
Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons
Blum, Jacob A, Klemm, Sandy, Shadrach, Jennifer L, Guttenplan, Kevin A, Nakayama, Lisa, Kathiria, Arwa, Hoang, Phuong T, Gautier, Olivia, Kaltschmidt, Julia A, Greenleaf, William J, Gitler, Aaron D
Published in Nature neuroscience (01.04.2021)
Published in Nature neuroscience (01.04.2021)
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Journal Article
A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation
Dorone, Yanniv, Boeynaems, Steven, Flores, Eduardo, Jin, Benjamin, Hateley, Shannon, Bossi, Flavia, Lazarus, Elena, Pennington, Janice G., Michiels, Emiel, De Decker, Mathias, Vints, Katlijn, Baatsen, Pieter, Bassel, George W., Otegui, Marisa S., Holehouse, Alex S., Exposito-Alonso, Moises, Sukenik, Shahar, Gitler, Aaron D., Rhee, Seung Y.
Published in Cell (05.08.2021)
Published in Cell (05.08.2021)
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Journal Article
A Cellular System that Degrades Misfolded Proteins and Protects against Neurodegeneration
Guo, Lili, Giasson, Benoit I., Glavis-Bloom, Alex, Brewer, Michael D., Shorter, James, Gitler, Aaron D., Yang, Xiaolu
Published in Molecular cell (03.07.2014)
Published in Molecular cell (03.07.2014)
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Journal Article
CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity
Kramer, Nicholas J, Haney, Michael S, Morgens, David W, Jovičić, Ana, Couthouis, Julien, Li, Amy, Ousey, James, Ma, Rosanna, Bieri, Gregor, Tsui, C Kimberly, Shi, Yingxiao, Hertz, Nicholas T, Tessier-Lavigne, Marc, Ichida, Justin K, Bassik, Michael C, Gitler, Aaron D
Published in Nature genetics (01.04.2018)
Published in Nature genetics (01.04.2018)
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Journal Article
Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis
Zhang, Yong-Jie, Gendron, Tania F, Ebbert, Mark T W, O'Raw, Aliesha D, Yue, Mei, Jansen-West, Karen, Zhang, Xu, Prudencio, Mercedes, Chew, Jeannie, Cook, Casey N, Daughrity, Lillian M, Tong, Jimei, Song, Yuping, Pickles, Sarah R, Castanedes-Casey, Monica, Kurti, Aishe, Rademakers, Rosa, Oskarsson, Bjorn, Dickson, Dennis W, Hu, Wenqian, Gitler, Aaron D, Fryer, John D, Petrucelli, Leonard
Published in Nature medicine (01.08.2018)
Published in Nature medicine (01.08.2018)
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Journal Article
suite of Gateway® cloning vectors for high-throughput genetic analysis in Saccharomyces cerevisiae
Alberti, Simon, Gitler, Aaron D, Lindquist, Susan
Published in Yeast (Chichester, England) (01.10.2007)
Published in Yeast (Chichester, England) (01.10.2007)
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The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems
Lasker, Keren, Boeynaems, Steven, Lam, Vinson, Scholl, Daniel, Stainton, Emma, Briner, Adam, Jacquemyn, Maarten, Daelemans, Dirk, Deniz, Ashok, Villa, Elizabeth, Holehouse, Alex S, Gitler, Aaron D, Shapiro, Lucy
Published in Nature communications (26.09.2022)
Published in Nature communications (26.09.2022)
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Journal Article
Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein
Dhungel, Nripesh, Eleuteri, Simona, Li, Ling-Bo, Kramer, Nicholas J, Chartron, Justin W, Spencer, Brian, Kosberg, Kori, Fields, Jerel Adam, Stafa, Klodjan, Adame, Anthony, Lashuel, Hilal, Frydman, Judith, Shen, Kang, Masliah, Eliezer, Gitler, Aaron D
Published in Neuron (Cambridge, Mass.) (07.01.2015)
Published in Neuron (Cambridge, Mass.) (07.01.2015)
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Journal Article
TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity
Johnson, Brian S., Snead, David, Lee, Jonathan J., McCaffery, J. Michael, Shorter, James, Gitler, Aaron D.
Published in The Journal of biological chemistry (24.07.2009)
Published in The Journal of biological chemistry (24.07.2009)
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Journal Article
Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD
Boeynaems, Steven, Bogaert, Elke, Michiels, Emiel, Gijselinck, Ilse, Sieben, Anne, Jovičić, Ana, De Baets, Greet, Scheveneels, Wendy, Steyaert, Jolien, Cuijt, Ivy, Verstrepen, Kevin J, Callaerts, Patrick, Rousseau, Frederic, Schymkowitz, Joost, Cruts, Marc, Van Broeckhoven, Christine, Van Damme, Philip, Gitler, Aaron D, Robberecht, Wim, Van Den Bosch, Ludo
Published in Scientific reports (12.02.2016)
Published in Scientific reports (12.02.2016)
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