Discovery of Dapagliflozin: A Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes
Meng, Wei, Ellsworth, Bruce A, Nirschl, Alexandra A, McCann, Peggy J, Patel, Manorama, Girotra, Ravindar N, Wu, Gang, Sher, Philip M, Morrison, Eamonn P, Biller, Scott A, Zahler, Robert, Deshpande, Prashant P, Pullockaran, Annie, Hagan, Deborah L, Morgan, Nathan, Taylor, Joseph R, Obermeier, Mary T, Humphreys, William G, Khanna, Ashish, Discenza, Lorell, Robertson, James G, Wang, Aiying, Han, Songping, Wetterau, John R, Janovitz, Evan B, Flint, Oliver P, Whaley, Jean M, Washburn, William N
Published in Journal of medicinal chemistry (13.03.2008)
Published in Journal of medicinal chemistry (13.03.2008)
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BMS-201620: a selective beta 3 agonist
Washburn, W.N., Sun, C.-Q., Bisacchi, G., Wu, G., Cheng, P.T., Sher, P.M., Ryono, D., Gavai, A.V., Poss, K., Girotra, R.N., McCann, P.J., Mikkilineni, A.B., Dejneka, T.C., Wang, T.C., Merchant, Z., Morella, M., Arbeeny, C.M., Harper, T.W., Slusarchyk, D.A., Skwish, S., Russell, A.D., Allen, G.T., Tesfamariam, B., Frohlich, B.H., Abboa-Offei, B.E., Cap, M., Waldron, T.L., George, R.J., Young, D., Dickinson, K.E., Seymour, A.A.
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
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Inhibition of Stromelysin-1 (MMP-3) by P1‘-Biphenylylethyl Carboxyalkyl Dipeptides
Esser, Craig K, Bugianesi, Robert L, Caldwell, Charles G, Chapman, Kevin T, Durette, Philippe L, Girotra, Narindar N, Kopka, Ihor E, Lanza, Thomas J, Levorse, Dorothy A, MacCoss, Malcolm, Owens, Karen A, Ponpipom, Mitree M, Simeone, Joseph P, Harrison, Richard K, Niedzwiecki, Lisa, Becker, Joseph W, Marcy, Alice I, Axel, Melinda G, Christen, Amy J, McDonnell, Joseph, Moore, Vernon L, Olszewski, Julie M, Saphos, Cheryl, Visco, Denise M, Shen, Frank, Colletti, Adria, Krieter, Philip A, Hagmann, William K
Published in Journal of medicinal chemistry (14.03.1997)
Published in Journal of medicinal chemistry (14.03.1997)
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Aglycone exploration of C-arylglucoside inhibitors of renal sodium-dependent glucose transporter SGLT2
Ellsworth, Bruce A., Meng, Wei, Patel, Manorama, Girotra, Ravindar N., Wu, Gang, Sher, Philip M., Hagan, Deborah L., Obermeier, Mary T., Humphreys, William G., Robertson, James G., Wang, Aiying, Han, Songping, Waldron, Thomas L., Morgan, Nathan N., Whaley, Jean M., Washburn, William N.
Published in Bioorganic & medicinal chemistry letters (01.09.2008)
Published in Bioorganic & medicinal chemistry letters (01.09.2008)
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Journal Article
Discovery and Structure-Activity Relationships of Sulfonamide ETA-Selective Antagonists
Stein, Philip D, Floyd, David M, Bisaha, Sharon, Dickey, Joyce, Girotra, Ravindar N, Gougoutas, Jack Z, Kozlowski, Michael, Lee, Ving G, Liu, Eddie C.-K
Published in Journal of medicinal chemistry (01.04.1995)
Published in Journal of medicinal chemistry (01.04.1995)
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Journal Article
Structure-Activity Relationships of C1 and C6 Side Chains of Zaragozic Acid A Derivatives
Ponpipom, Mitree M., Girotra, Narindar N., Bugianesi, Robert L., Roberts, Cathleen D., Berger, Gregory D., Burk, Robert M., Marquis, Robert W., Parsons, William H., Bartizal, Kenneth F.
Published in Journal of medicinal chemistry (01.11.1994)
Published in Journal of medicinal chemistry (01.11.1994)
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Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3-hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester
Girotra, N. N, Biftu, T, Ponpipom, M. M, Acton, J. J, Alberts, A. W, Bach, T. N, Ball, R. G, Bugianesi, R. L, Chabala, J. C
Published in Journal of medicinal chemistry (01.09.1992)
Published in Journal of medicinal chemistry (01.09.1992)
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Journal Article
Rearrangement of zaragozic acid a derivatives
Girotra, Narindar N., Reamer, Robert A., Ponpipom, Mitree M.
Published in Tetrahedron letters (02.07.1993)
Published in Tetrahedron letters (02.07.1993)
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Journal Article
Synthesis and biological activity of flavipucine analogs
Girotra, N. N, Patchett, A. A, Zimmerman, S. B, Achimov, D. L, Wendler, N. L
Published in Journal of medicinal chemistry (01.02.1980)
Published in Journal of medicinal chemistry (01.02.1980)
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Inhibition of stromelysin-1 (MMP-3) by P-1'-biphenylylethyl carboxyalkyl dipeptides
Esser, CK, Bugianesi, RL, Caldwell, CG, Chapman, KT, Durette, PL, Girotra, NN, Kopka, IE, Lanza, TJ, Levorse, DA, MacCoss, M, Owens, KA, Ponpipom, MM, Simeone, JP, Harrison, RK, Niedzwiecki, L, Becker, JW, Marcy, AI, Axel, MG, Christen, AJ, McDonnell, J, Moore, VL, Olszewski, JM, Saphos, C, Visco, DM, Shen, F, Colletti, A, Krieter, PA, Hagmann, WK
Published in Journal of medicinal chemistry (14.03.1997)
Published in Journal of medicinal chemistry (14.03.1997)
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Journal Article
Total synthesis of dl-cedrene and dl-cedrol
Corey, Elias J, Girotra, Narindar N, Mathew, C. Thomas
Published in Journal of the American Chemical Society (01.03.1969)
Published in Journal of the American Chemical Society (01.03.1969)
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Journal Article
Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents
Biftu, Tesfaye, Feng, Dennis, Ponpipom, Mitree, Girotra, Narindar, Liang, Gui-Bai, Qian, Xiaoxia, Bugianesi, Robert, Simeone, Joseph, Chang, Linda, Gurnett, Anne, Liberator, Paul, Dulski, Paula, Leavitt, Penny Sue, Crumley, Tami, Misura, Andrew, Murphy, Terence, Rattray, Sandra, Samaras, Samantha, Tamas, Tamas, Mathew, John, Brown, Christine, Thompson, Don, Schmatz, Dennis, Fisher, Michael, Wyvratt, Matthew
Published in Bioorganic & medicinal chemistry letters (01.07.2005)
Published in Bioorganic & medicinal chemistry letters (01.07.2005)
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Journal Article
Beta 3 agonists. Part 1: evolution from inception to BMS-194449
Washburn, W.N., Sher, P.M., Poss, K.M., Girotra, R.N., McCann, P.J., Gavai, A.V., Mikkilineni, A.B., Mathur, A., Cheng, P., Dejneka, T.C., Sun, C.Q., Wang, T.C., Harper, T.W., Russell, A.D., Slusarchyk, D.A., Skwish, S., Allen, G.T., Hillyer, D.E., Frohlich, B.H., Abboa-Offei, B.E., Cap, M., Waldron, T.L., George, R.J., Tesfamariam, B., Ciosek, C.P., Ryono, D., Young, D.A., Dickinson, K.E., Seymour, A.A., Arbeeny, C.M., Gregg, R.E.
Published in Bioorganic & medicinal chemistry letters (03.12.2001)
Published in Bioorganic & medicinal chemistry letters (03.12.2001)
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Journal Article
BMS-196085 : A potent and selective full agonist of the human β3 adrenergic receptor
GAVAI, A. V, SHER, P. M, WANG, T. C, SUN, C. Q, SLUSARCHYK, D. A, SKWISH, S, ALLEN, G. T, HILLYER, D. E, FROHLICH, B. H, ABBOA-OFFEI, B. E, CAP, M, WALDRON, T. L, MIKKILINENI, A. B, GEORGE, R. J, TESFAMARIAM, B, HARPER, T. W, CIOSEK, C. P, YOUNG, D. A, DICKINSON, K. E, SEYMOUR, A. A, ARBEENY, C. M, WASHBURN, W. N, POSS, K. M, MCCANN, P. J, GIROTRA, R. N, FISHER, L. G, WU, G, BEDNARZ, M. S, MATHUR, A
Published in Bioorganic & medicinal chemistry letters (03.12.2001)
Published in Bioorganic & medicinal chemistry letters (03.12.2001)
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Journal Article
Immunochemical studies on carcinoembryonic antigen-reactive glycoproteins from carcinomas of the colon and breast separated by concanavalin A affinity chromatography
Harvey, S R, Girotra, R N, Nemoto, T, Ciani, F, Chu, T M
Published in Cancer research (Chicago, Ill.) (01.09.1976)
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Published in Cancer research (Chicago, Ill.) (01.09.1976)
Journal Article
Total synthesis of the macrolide, zearalenone
Taub, D, Girotra, N N, Hoffsommer, R D, Kuo, C H, Slates, H L, Weber, S, Wendler, N L
Published in Tetrahedron (01.01.1968)
Published in Tetrahedron (01.01.1968)
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