SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease, Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Alpha Interferon in Replicon Cells
MALCOLM, B. A, LIU, R, INGRAVALLO, P, JIANG, C, KONG, R, LU, J, PICHARDO, J, PRONGAY, A, SKELTON, A, TONG, X, VENKATRAMAN, S, XIA, E, LAHSER, F, GIRIJAVALLABHAN, V, NJOROGE, F. G, AGRAWAL, S, BELANGER, B, BUTKIEWICZ, N, CHASE, R, GHEYAS, F, HART, A, HESK, D
Published in Antimicrobial Agents and Chemotherapy (01.03.2006)
Published in Antimicrobial Agents and Chemotherapy (01.03.2006)
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Journal Article
Characterization of resistance mutations against HCV ketoamide protease inhibitors
Tong, Xiao, Bogen, Stephane, Chase, Robert, Girijavallabhan, V., Guo, Zhuyan, Njoroge, F. George, Prongay, Andrew, Saksena, Anil, Skelton, Angela, Xia, Ellen, Ralston, Robert
Published in Antiviral research (01.03.2008)
Published in Antiviral research (01.03.2008)
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Journal Article
Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and Wap-ras transgenic mice
MING LIU, BRYANT, M. S, DELL, J, SINHA, D, SYED, J, KORFMACHER, W. A, NOMEIR, A. A, LIN, C.-C, WANG, L, TAVERAS, A. G, DOLL, R. J, NJOROGE, F. G, JIANPING CHEN, MALLAMS, A. K, REMISZEWSKI, S, CATINO, J. J, GIRIJAVALLABHAN, V. M, KIRSCHMEIER, P, BISHOP, W. R, SUINING LEE, YAREMKO, B, LIPARI, P, MALKOWSKI, M, FERRARI, E, NIELSEN, L, PRIOLI, N
Published in Cancer research (Chicago, Ill.) (01.11.1998)
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Published in Cancer research (Chicago, Ill.) (01.11.1998)
Journal Article
Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034
Bogen, S., Arasappan, A., Pan, W., Ruan, S., Padilla, A., Saksena, A.K., Girijavallabhan, V., Njoroge, F.G.
Published in Bioorganic & medicinal chemistry (15.07.2008)
Published in Bioorganic & medicinal chemistry (15.07.2008)
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Journal Article
Tricyclic Farnesyl Protein Transferase Inhibitors: Crystallographic and Calorimetric Studies of Structure−Activity Relationships
Strickland, Corey L, Weber, Patricia C, Windsor, William T, Wu, Zhen, Le, Hung V, Albanese, Margaret M, Alvarez, Carmen S, Cesarz, David, del Rosario, Joycelyn, Deskus, Jeffrey, Mallams, Alan K, Njoroge, F. George, Piwinski, John J, Remiszewski, Stacy, Rossman, Randall R, Taveras, Arthur G, Vibulbhan, Bancha, Doll, Ronald J, Girijavallabhan, Viyyoor M, Ganguly, Ashit K
Published in Journal of medicinal chemistry (17.06.1999)
Published in Journal of medicinal chemistry (17.06.1999)
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Journal Article
Structure of poliovirus type 2 Lansing complexed with antiviral agent SCH48973: comparison of the structural and biological properties of the three poliovirus serotypes
Lentz, Karen N, Smith, Allen D, Geisler, Sheila C, Cox, Stuart, Buontempo, Peter, Skelton, Angela, DeMartino, Jason, Rozhon, Edward, Schwartz, Jerome, Girijavallabhan, V, O’Connell, John, Arnold, Edward
Published in Structure (London) (15.07.1997)
Published in Structure (London) (15.07.1997)
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Journal Article
Farnesyl protein transferase inhibitors targeting the catalytic zinc for enhanced binding
Njoroge, F. George, Vibulbhan, Bancha, Pinto, Patrick, Strickland, Corey, Kirschmeier, Paul, Bishop, W. Robert, Girijavallabhan, V.
Published in Bioorganic & medicinal chemistry letters (06.12.2004)
Published in Bioorganic & medicinal chemistry letters (06.12.2004)
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Journal Article
Ras oncoprotein inhibitors: The discovery of potent, ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex
Taveras, A.G., Remiszewski, S.W., Doll, R.J., Cesarz, D., Huang, E.C., Kirschmeier, P., Pramanik, B.N., Snow, M.E., Wang, Y.-S., del Rosario, J.D., Vibulbhan, B., Bauer, B.B., Brown, J.E., Carr, D., Catino, J., Evans, C.A., Girijavallabhan, V., Heimark, L., James, L., Liberles, S., Nash, C., Perkins, L., Senior, M.M., Tsarbopoulos, A., Ganguly, A.K., Aust, R., Brown, E., Delisle, D., Fuhrman, S., Hendrickson, T., Kissinger, C., Love, R., Sisson, W., Villafranca, E., Webber, S.E.
Published in Bioorganic & medicinal chemistry (01.01.1997)
Published in Bioorganic & medicinal chemistry (01.01.1997)
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Journal Article
Hepatitis C virus NS3-4A serine protease inhibitors : Use of a P2-P1 cyclopropyl alanine combination for improved potency
BOGEN, S, SAKSENA, A. K, ARASAPPAN, A, GU, H, NJOROGE, F. G, GIRIJAVALLABHAN, V, PICHARDO, J, BUTKIEWICZ, N, PRONGAY, A, MADISON, V
Published in Bioorganic & medicinal chemistry letters (15.10.2005)
Published in Bioorganic & medicinal chemistry letters (15.10.2005)
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Journal Article
SCH 48973: a potent, broad-spectrum, antienterovirus compound
BUONTEMPO, P. J, COX, S, O'CONNELL, J. F, WRIGHT-MINOGUE, J, DEMARTINO, J. L, SKELTON, A. M, FERRARI, E, ALBIN, R, ROZHON, E. J, GIRIJAVALLABHAN, V, MODLIN, J. F
Published in Antimicrobial Agents and Chemotherapy (01.06.1997)
Published in Antimicrobial Agents and Chemotherapy (01.06.1997)
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Journal Article
Binding affinities and geometries of various metal ligands in peptide deformylase inhibitors
Madison, V, Duca, J, Bennett, F, Bohanon, S, Cooper, A, Chu, M, Desai, J, Girijavallabhan, V, Hare, R, Hruza, A, Hendrata, S, Huang, Y, Kravec, C, Malcolm, B, McCormick, J, Miesel, L, Ramanathan, L, Reichert, P, Saksena, A, Wang, J, Weber, P.C, Zhu, H, Fischmann, T
Published in Biophysical chemistry (10.12.2002)
Published in Biophysical chemistry (10.12.2002)
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Journal Article
Trihalobenzocycloheptapyridine analogues of Sch 66336 as potent inhibitors of farnesyl protein transferase
Njoroge, F.George, Vibulbhan, Bancha, Pinto, Patrick, Strickland, Corey L, Bishop, W.Robert, Kirschmeir, Paul, Girijavallabhan, V, Ganguly, Ashit K
Published in Bioorganic & medicinal chemistry (02.01.2003)
Published in Bioorganic & medicinal chemistry (02.01.2003)
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Journal Article
Structure−Activity Relationship of 3-Substituted N-(Pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)- piperidine Inhibitors of Farnesyl-Protein Transferase: Design and Synthesis of in Vivo Active Antitumor Compounds
Njoroge, F. George, Vibulbhan, Bancha, Rane, Dinananth F, Bishop, W. Robert, Petrin, Joanne, Patton, Robert, Bryant, Mathew S, Chen, K.-J, Nomeir, Amin A, Lin, C.-C, Liu, Ming, King, Ivan, Chen, Jianping, Lee, Suining, Yaremko, Bohdan, Dell, Janet, Lipari, Philip, Malkowski, Michael, Li, Zujun, Catino, Joseph, Doll, Ronald J, Girijavallabhan, V, Ganguly, Ashit K
Published in Journal of medicinal chemistry (19.12.1997)
Published in Journal of medicinal chemistry (19.12.1997)
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Journal Article
Enzymatic Kinetic Resolution of Piperidine Atropisomers: Synthesis of a Key Intermediate of the Farnesyl Protein Transferase Inhibitor, SCH66336
Morgan, Brian, Zaks, Aleksey, Dodds, David R, Liu, Jinchu, Jain, Rama, Megati, Sreeni, Njoroge, F. George, Girijavallabhan, Viyyoor M
Published in Journal of organic chemistry (08.09.2000)
Published in Journal of organic chemistry (08.09.2000)
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Journal Article
Identification of Pharmacokinetically Stable 3,10-Dibromo-8-chlorobenzocycloheptapyridine Farnesyl Protein Transferase Inhibitors with Potent Enzyme and Cellular Activities
Taveras, Arthur G, Deskus, Jeff, Chao, Jianping, Vaccaro, Cynthia J, Njoroge, F. George, Vibulbhan, Bancha, Pinto, Pat, Remiszewski, Stacy, del Rosario, Jocelyn, Doll, Ronald J, Alvarez, Carmen, Lalwani, Tarik, Mallams, Alan K, Rossman, Randall R, Afonso, Adriano, Girijavallabhan, Viyyoor M, Ganguly, Ashit K, Pramanik, Birendra, Heimark, Larry, Bishop, W. Robert, Wang, Lynn, Kirschmeier, Paul, James, Linda, Carr, Donna, Patton, Robert, Bryant, Mathew S, Nomeir, Amin A, Liu, Ming
Published in Journal of medicinal chemistry (15.07.1999)
Published in Journal of medicinal chemistry (15.07.1999)
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Journal Article
Potent, Selective, and Orally Bioavailable Tricyclic Pyridyl Acetamide N-Oxide Inhibitors of Farnesyl Protein Transferase with Enhanced in Vivo Antitumor Activity
Njoroge, F. George, Vibulbhan, Bancha, Pinto, Patrick, Bishop, W. Robert, Bryant, Mathew S, Nomeir, Amin A, Lin, C.-C, Liu, Ming, Doll, Ronald J, Girijavallabhan, V, Ganguly, Ashit K
Published in Journal of medicinal chemistry (07.05.1998)
Published in Journal of medicinal chemistry (07.05.1998)
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Journal Article
Synthesis of 5,6-dihydro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidine-N-cyanoguanidine derivatives as inhibitors of ras farnesyl protein transferase
Cooper, Alan B, Strickland, Corey L, Wang, James, Desai, Jagdish, Kirschmeier, Paul, Patton, Robert, Bishop, W Robert, Weber, Patricia C, Girijavallabhan, V
Published in Bioorganic & medicinal chemistry letters (25.02.2002)
Published in Bioorganic & medicinal chemistry letters (25.02.2002)
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Journal Article
Effects of SCH 59228, an orally bioavailable farnesyl protein transferase inhibitor, on the growth of oncogene-transformed fibroblasts and a human colon carcinoma xenograft in nude mice
MING LIU, BRYANT, M. S, ROSSMAN, R. R, KORFMACHER, W. A, NOMEIR, A. A, LIN, C.-C, MALLAMS, A. K, DOLL, R. J, CATINO, J. J, GIRIJAVALLABHAN, V. M, KIRSCHMEIER, P, BISHOP, W. R, JIANPING CHEN, SUININHG LEE, YAREMKO, B, ZUJUN LI, DELL, J, LIPARI, P, MALKOWSKI, M, PRIOLI, N
Published in Cancer chemotherapy and pharmacology (1999)
Published in Cancer chemotherapy and pharmacology (1999)
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Journal Article
Discovery of novel nonpeptide tricyclic inhibitors of ras farnesyl protein transferase
Njoroge, F. George, Doll, Ronald J., Vibulbhan, Bancha, Alvarez, Carmen S., Bishop, W. Robert, Petrin, Joanne, Kirschmeier, Paul, Carruthers, Nicholas I., Wong, Jesse K., Albanese, Margaret M., Piwinski, John J., Catino, Joseph, Girijavallabhan, V., Ganguly, Ashit K.
Published in Bioorganic & medicinal chemistry (01.01.1997)
Published in Bioorganic & medicinal chemistry (01.01.1997)
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