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The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets
El, Kimberley, Douros, Jonathan D., Willard, Francis S., Novikoff, Aaron, Sargsyan, Ashot, Perez-Tilve, Diego, Wainscott, David B., Yang, Bin, Chen, Alex, Wothe, Donald, Coupland, Callum, Tschöp, Mattias H., Finan, Brian, D’Alessio, David A., Sloop, Kyle W., Müller, Timo D., Campbell, Jonathan E.
Published in Nature metabolism (01.06.2023)
Published in Nature metabolism (01.06.2023)
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TCF1 links GIPR signaling to the control of beta cell function and survival
Campbell, Jonathan E, Ussher, John R, Mulvihill, Erin E, Kolic, Jelena, Baggio, Laurie L, Cao, Xiemen, Liu, Yu, Lamont, Benjamin J, Morii, Tsukasa, Streutker, Catherine J, Tamarina, Natalia, Philipson, Louis H, Wrana, Jeffrey L, MacDonald, Patrick E, Drucker, Daniel J
Published in Nature medicine (01.01.2016)
Published in Nature medicine (01.01.2016)
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Predictive effect of GIPR SNP rs10423928 on glucose metabolism liver fat and adiposity in prediabetic and diabetic subjects
Barbosa-Yañez, Renate Luzía, Markova, Mariya, Dambeck, Ulrike, Honsek, Caroline, Machann, Jürgen, Schüler, Rita, Kabisch, Stefan, Pfeiffer, Andreas F.H.
Published in Peptides (New York, N.Y. : 1980) (01.03.2020)
Published in Peptides (New York, N.Y. : 1980) (01.03.2020)
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Disruption of GIP/GIPR Axis in Human Adipose Tissue Is Linked to Obesity and Insulin Resistance
Ceperuelo-Mallafré, Victòria, Duran, Xavier, Pachón, Gisela, Roche, Kelly, Garrido-Sánchez, Lourdes, Vilarrasa, Nuria, Tinahones, Francisco J., Vicente, Vicente, Pujol, Jordi, Vendrell, Joan, Fernández-Veledo, Sonia
Published in The journal of clinical endocrinology and metabolism (01.05.2014)
Published in The journal of clinical endocrinology and metabolism (01.05.2014)
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The Link between Three Single Nucleotide Variants of the GIPR Gene and Metabolic Health
Michałowska, Joanna, Miller-Kasprzak, Ewa, Seraszek-Jaros, Agnieszka, Mostowska, Adrianna, Bogdański, Paweł
Published in Genes (26.08.2022)
Published in Genes (26.08.2022)
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Variants from GIPR, TCF7L2, DGKB, MADD, CRY2, GLIS3, PROX1, SLC30A8 and IGF1 Are Associated with Glucose Metabolism in the Chinese
Hu, Cheng, Zhang, Rong, Wang, Congrong, Wang, Jie, Ma, Xiaojing, Hou, Xuhong, Lu, Jingyi, Yu, Weihui, Jiang, Feng, Bao, Yuqian, Xiang, Kunsan, Jia, Weiping
Published in PloS one (17.11.2010)
Published in PloS one (17.11.2010)
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1009-P: The Dual GIP and GLP-1 Receptor Agonist Tirzepatide Regulates Lipid and Carbohydrate Metabolism through GIPR in Adipose Tissue
SAMMS, RICARDO JUSTIN, CHRISTE, MICHAEL E., RUAN, XIAOPING, MOYERS, JULIE, REGMI, AJIT, ROELL, WILLIAM C.
Published in Diabetes (New York, N.Y.) (01.06.2019)
Published in Diabetes (New York, N.Y.) (01.06.2019)
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Association analyses of GIP and GIPR polymorphisms with traits of the metabolic syndrome
Nitz, Inke, Fisher, Eva, Weikert, Cornelia, Burwinkel, Barbara, Li, Yun, Möhlig, Matthias, Boeing, Heiner, Schreiber, Stefan, Schrezenmeir, Jürgen, Döring, Frank
Published in Molecular nutrition & food research (01.08.2007)
Published in Molecular nutrition & food research (01.08.2007)
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Metabolite targeting: development of a comprehensive targeted metabolomics platform for the assessment of diabetes and its complications
Meiss, Ernst, Werner, Philipp, John, Clara, Scheja, Ludger, Herbach, Nadja, Heeren, Jörg, Fischer, Markus
Published in Metabolomics (01.03.2016)
Published in Metabolomics (01.03.2016)
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Association of the GIPR Glu354Gln (rs1800437) polymorphism with hypertension in a brazilian population
Alexandro M rcio Da Silva Mattos, Sarah Conchon Costa, Outuki, Giovana, Gustavo Kendi Camargo Koga, Cl udia Nascimento Montemor, Longo, Giana Zarbato, Maria Ang lica Ehara Watanabe, Amarante, Marla Karine, T nia Longo Mazzuco
Published in bioRxiv (06.06.2018)
Published in bioRxiv (06.06.2018)
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METHOD OF TREATING OR AMELIORATING METABOLIC DISORDERS USING BINDING PROTEINS FOR GASTRIC INHIBITORY PEPTIDE RECEPTOR (GIPR) IN COMBINATION WITH GLP-1 AGONISTS
YIE JUNMING, HO SHU-YIN, MIN XIAOSHAN, GLENN N SIVITS JR, SHI DONGHUI, DAVID J LLOYD, DARREN L BATES, RENEE KOMOROWSKI, IAN N FOLTZ, NEERAJ AGRAWAL, WANG ZHULUN, CHRISTOPHER MURAWSKY, BRANDON C P CLAVETTE, WANG JINGHONG, VENIANTMURIELLE M -ELLISON
Year of Publication 23.12.2021
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Year of Publication 23.12.2021
Patent
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Structural determinants of dual incretin receptor agonism by tirzepatide
Sun, Bingfa, Willard, Francis S., Feng, Dan, Alsina-Fernandez, Jorge, Chen, Qi, Vieth, Michal, Ho, Joseph D., Showalter, Aaron D., Stutsman, Cynthia, Ding, Liyun, Suter, Todd M., Dunbar, James D., Carpenter, John W., Mohammed, Faiz Ahmad, Aihara, Eitaro, Brown, Robert A., Bueno, Ana B., Emmerson, Paul J., Moyers, Julie S., Kobilka, Tong Sun, Coghlan, Matthew P., Kobilka, Brian K., Sloop, Kyle W.
Published in Proceedings of the National Academy of Sciences - PNAS (29.03.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (29.03.2022)
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A Naturally Occurring GIP Receptor Variant Undergoes Enhanced Agonist-Induced Desensitization, Which Impairs GIP Control of Adipose Insulin Sensitivity
Mohammad, Sameer, Patel, Rajesh T., Bruno, Joanne, Panhwar, Muhammad Siyab, Wen, Jennifer, McGraw, Timothy E.
Published in Molecular and cellular biology (01.10.2014)
Published in Molecular and cellular biology (01.10.2014)
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Genetic Variation in the Glucose-Dependent Insulinotropic Polypeptide Receptor Modifies the Association between Carbohydrate and Fat Intake and Risk of Type 2 Diabetes in the Malmö Diet and Cancer Cohort
Sonestedt, Emily, Lyssenko, Valeriya, Ericson, Ulrika, Gullberg, Bo, Wirfält, Elisabet, Groop, Leif, Orho-Melander, Marju
Published in The journal of clinical endocrinology and metabolism (01.05.2012)
Published in The journal of clinical endocrinology and metabolism (01.05.2012)
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Genetic variability of incretin receptors affects the occurrence of neurodegenerative diseases and their characteristics
Vogrinc, David, Redenšek Trampuž, Sara, Blagus, Tanja, Trošt, Maja, Gregorič Kramberger, Milica, Emeršič, Andreja, Čučnik, Saša, Goričar, Katja, Dolžan, Vita
Published in HELIYON (30.10.2024)
Published in HELIYON (30.10.2024)
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Effect of dual glucose-dependent insulinotropic peptide/glucagon-like peptide-1 receptor agonist on weight loss in subjects with obesity
Zaffina, Isabella, Pelle, Maria Chiara, Armentaro, Giuseppe, Giofrè, Federica, Cassano, Velia, Sciacqua, Angela, Arturi, Franco
Published in Frontiers in endocrinology (Lausanne) (22.02.2023)
Published in Frontiers in endocrinology (Lausanne) (22.02.2023)
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Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy
Agardh, Elisabet, Lundstig, Annika, Perfilyev, Alexander, Volkov, Petr, Freiburghaus, Tove, Lindholm, Eero, Rönn, Tina, Agardh, Carl-David, Ling, Charlotte
Published in BMC medicine (06.08.2015)
Published in BMC medicine (06.08.2015)
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