Suppression of the gut microbiome ameliorates age‐related arterial dysfunction and oxidative stress in mice
Brunt, Vienna E., Gioscia‐Ryan, Rachel A., Richey, James J., Zigler, Melanie C., Cuevas, Lauren M., Gonzalez, Antonio, Vázquez‐Baeza, Yoshiki, Battson, Micah L., Smithson, Andrew T., Gilley, Andrew D., Ackermann, Gail, Neilson, Andrew P., Weir, Tiffany, Davy, Kevin P., Knight, Rob, Seals, Douglas R.
Published in The Journal of physiology (01.05.2019)
Published in The Journal of physiology (01.05.2019)
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Journal Article
Mitochondria‐targeted antioxidant (MitoQ) ameliorates age‐related arterial endothelial dysfunction in mice
Gioscia‐Ryan, Rachel A., LaRocca, Thomas J., Sindler, Amy L., Zigler, Melanie C., Murphy, Michael P., Seals, Douglas R.
Published in The Journal of physiology (15.06.2014)
Published in The Journal of physiology (15.06.2014)
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Journal Article
Lifelong voluntary aerobic exercise prevents age‐ and Western diet‐ induced vascular dysfunction, mitochondrial oxidative stress and inflammation in mice
Gioscia‐Ryan, Rachel A., Clayton, Zachary S., Zigler, Melanie C., Richey, James J., Cuevas, Lauren M., Rossman, Matthew J., Battson, Micah L., Ziemba, Brian P., Hutton, David A., VanDongen, Nicholas S., Seals, Douglas R.
Published in The Journal of physiology (01.02.2021)
Published in The Journal of physiology (01.02.2021)
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Journal Article
Initiation of 3,3‐dimethyl‐1‐butanol at midlife prevents endothelial dysfunction and attenuates in vivo aortic stiffening with ageing in mice
Casso, Abigail G., VanDongen, Nicholas S., Gioscia‐Ryan, Rachel A., Clayton, Zachary S., Greenberg, Nathan T., Ziemba, Brian P., Hutton, David A., Neilson, Andrew P., Davy, Kevin P., Seals, Douglas R., Brunt, Vienna E.
Published in The Journal of physiology (01.11.2022)
Published in The Journal of physiology (01.11.2022)
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Journal Article
Short‐term interleukin‐37 treatment improves vascular endothelial function, endurance exercise capacity, and whole‐body glucose metabolism in old mice
Ballak, Dov B., Brunt, Vienna E., Sapinsley, Zachary J., Ziemba, Brian P., Richey, James J., Zigler, Melanie C., Johnson, Lawrence C., Gioscia‐Ryan, Rachel A., Culp‐Hill, Rachel, Eisenmesser, Elan Z., D'Alessandro, Angelo, Dinarello, Charles A., Seals, Douglas R.
Published in Aging cell (01.01.2020)
Published in Aging cell (01.01.2020)
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Journal Article
Exercise training decreases whole‐body and tissue iron storage in adults with obesity
Ryan, Benjamin J., Foug, Katherine L., Gioscia‐Ryan, Rachel A., Varshney, Pallavi, Ludzki, Alison C., Ahn, Cheehoon, Schleh, Michael W., Gillen, Jenna B., Chenevert, Thomas L., Horowitz, Jeffrey F.
Published in Experimental physiology (01.04.2021)
Published in Experimental physiology (01.04.2021)
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Journal Article
Skeletal muscle ferritin abundance is tightly related to plasma ferritin concentration in adults with obesity
Ryan, Benjamin J., Foug, Katherine L., Gioscia‐Ryan, Rachel A., Ludzki, Alison C., Ahn, Cheehoon, Schleh, Michael W., Gillen, Jenna B., Chenevert, Thomas L., Horowitz, Jeffrey F.
Published in Experimental physiology (01.11.2020)
Published in Experimental physiology (01.11.2020)
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Journal Article
Plasma ferritin concentration is positively associated with in vivo fatty acid mobilization and insulin resistance in obese women
Ryan, Benjamin J., Pelt, Douglas W., Guth, Lisa M., Ludzki, Alison C., Gioscia‐Ryan, Rachel A., Ahn, Chiwoon, Foug, Katherine L., Horowitz, Jeffrey F.
Published in Experimental physiology (01.11.2018)
Published in Experimental physiology (01.11.2018)
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Journal Article
Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans
Brunt, Vienna E, Gioscia-Ryan, Rachel A, Casso, Abigail G, VanDongen, Nicholas S, Ziemba, Brian P, Sapinsley, Zachary J, Richey, James J, Zigler, Melanie C, Neilson, Andrew P, Davy, Kevin P, Seals, Douglas R
Published in Hypertension (Dallas, Tex. 1979) (01.07.2020)
Published in Hypertension (Dallas, Tex. 1979) (01.07.2020)
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Journal Article
Targeting mitochondrial fitness as a strategy for healthy vascular aging
Rossman, Matthew J, Gioscia-Ryan, Rachel A, Clayton, Zachary S, Murphy, Michael P, Seals, Douglas R
Published in Clinical science (1979) (26.06.2020)
Published in Clinical science (1979) (26.06.2020)
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Journal Article
Sodium nitrite supplementation improves motor function and skeletal muscle inflammatory profile in old male mice
Justice, Jamie N, Gioscia-Ryan, Rachel A, Johnson, Lawrence C, Battson, Micah L, de Picciotto, Natalie E, Beck, Hannah J, Jiang, Hong, Sindler, Amy L, Bryan, Nathan S, Enoka, Roger M, Seals, Douglas R
Published in Journal of applied physiology (1985) (15.01.2015)
Published in Journal of applied physiology (1985) (15.01.2015)
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Journal Article
Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older Adults
Rossman, Matthew J, Santos-Parker, Jessica R, Steward, Chelsea A.C, Bispham, Nina Z, Cuevas, Lauren M, Rosenberg, Hannah L, Woodward, Kayla A, Chonchol, Michel, Gioscia-Ryan, Rachel A, Murphy, Michael P, Seals, Douglas R
Published in Hypertension (Dallas, Tex. 1979) (01.06.2018)
Published in Hypertension (Dallas, Tex. 1979) (01.06.2018)
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Journal Article
Moderate-Intensity Exercise and High-Intensity Interval Training Affect Insulin Sensitivity Similarly in Obese Adults
Ryan, Benjamin J, Schleh, Michael W, Ahn, Cheehoon, Ludzki, Alison C, Gillen, Jenna B, Varshney, Pallavi, Van Pelt, Douglas W, Pitchford, Lisa M, Chenevert, Thomas L, Gioscia-Ryan, Rachel A, Howton, Suzette M, Rode, Thomas, Hummel, Scott L, Burant, Charles F, Little, Jonathan P, Horowitz, Jeffrey F
Published in The journal of clinical endocrinology and metabolism (01.08.2020)
Published in The journal of clinical endocrinology and metabolism (01.08.2020)
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Journal Article
The autophagy enhancer spermidine reverses arterial aging
LaRocca, Thomas J., Gioscia-Ryan, Rachel A., Hearon, Christopher M., Seals, Douglas R.
Published in Mechanisms of ageing and development (01.07.2013)
Published in Mechanisms of ageing and development (01.07.2013)
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Journal Article
Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans
Brunt, Vienna E, Casso, Abigail G, Gioscia-Ryan, Rachel A, Sapinsley, Zachary J, Ziemba, Brian P, Clayton, Zachary S, Bazzoni, Amy E, VanDongen, Nicholas S, Richey, James J, Hutton, David A, Zigler, Melanie C, Neilson, Andrew P, Davy, Kevin P, Seals, Douglas R
Published in Hypertension (Dallas, Tex. 1979) (01.08.2021)
Published in Hypertension (Dallas, Tex. 1979) (01.08.2021)
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Journal Article
The gut microbiome–derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging
Brunt, Vienna E., LaRocca, Thomas J., Bazzoni, Amy E., Sapinsley, Zachary J., Miyamoto-Ditmon, Jill, Gioscia-Ryan, Rachel A., Neilson, Andrew P., Link, Christopher D., Seals, Douglas R.
Published in GeroScience (01.02.2021)
Published in GeroScience (01.02.2021)
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Journal Article
Suppression of trimethylamine N-oxide with DMB mitigates vascular dysfunction, exercise intolerance, and frailty associated with a Western-style diet in mice
Brunt, Vienna E., Greenberg, Nathan T., Sapinsley, Zachary J., Casso, Abigail G., Richey, James J., VanDongen, Nicholas S., Gioscia-Ryan, Rachel A., Ziemba, Brian P., Neilson, Andrew P., Davy, Kevin P., Seals, Douglas R.
Published in Journal of applied physiology (1985) (01.10.2022)
Published in Journal of applied physiology (1985) (01.10.2022)
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Journal Article
Inorganic Nitrite Supplementation Improves Endothelial Function With Aging: Translational Evidence for Suppression of Mitochondria-Derived Oxidative Stress
Rossman, Matthew J, Gioscia-Ryan, Rachel A, Santos-Parker, Jessica R, Ziemba, Brian P, Lubieniecki, Kara L, Johnson, Lawrence C, Poliektov, Natalie E, Bispham, Nina Z, Woodward, Kayla A, Nagy, Erzsebet E, Bryan, Nathan S, Reisz, Julie A, D'Alessandro, Angelo, Chonchol, Michel, Sindler, Amy L, Seals, Douglas R
Published in Hypertension (Dallas, Tex. 1979) (01.04.2021)
Published in Hypertension (Dallas, Tex. 1979) (01.04.2021)
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Journal Article