Identification, structural, and biophysical characterization of a positive modulator of human Kv3.1 channels
Chen, Yun-Ting, Hong, Mee Ra, Zhang, Xin-Jun, Kostas, James, Li, Yuxing, Kraus, Richard L, Santarelli, Vincent P, Wang, Deping, Gomez-Llorente, Yacob, Brooun, Alexei, Strickland, Corey, Soisson, Stephen M, Klein, Daniel J, Ginnetti, Anthony T, Marino, Michael J, Stachel, Shawn J, Ishchenko, Andrii
Published in Proceedings of the National Academy of Sciences - PNAS (17.10.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (17.10.2023)
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Journal Article
Lead optimization of cathepsin K inhibitors for the treatment of Osteoarthritis
Ginnetti, Anthony T., Paone, Daniel V., Nanda, Kausik K., Li, Jing, Busuek, Marina, Johnson, Scott A., Lu, Jun, Soisson, Stephen M., Robinson, Ronald, Fisher, John, Webber, Andrea, Wesolowski, Gregg, Ma, Bennett, Duong, Le, Carroll, Steven, Burgey, Christopher S., Stachel, Shawn J.
Published in Bioorganic & medicinal chemistry letters (15.10.2022)
Published in Bioorganic & medicinal chemistry letters (15.10.2022)
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Journal Article
Identification of potent inhibitors of the sortilin-progranulin interaction
Stachel, Shawn J., Ginnetti, Anthony T., Johnson, Scott A., Cramer, Paige, Wang, Yi, Bukhtiyarova, Marina, Krosky, Daniel, Stump, Craig, Hurzy, Danielle M., Schlegel, Kelly-Ann, Cooke, Andrew J., Allen, Samantha, O'Donnell, Gregory, Ziebell, Michael, Parthasarathy, Gopal, Getty, Krista L., Ho, Thu, Ou, Yangsi, Jovanovska, Aneta, Carroll, Steve S., Pausch, Mark, Lumb, Kevin, Mosser, Scott D., Voleti, Bhavya, Klein, Daniel J., Soisson, Stephen M., Zerbinatti, Celina, Coleman, Paul J.
Published in Bioorganic & medicinal chemistry letters (01.09.2020)
Published in Bioorganic & medicinal chemistry letters (01.09.2020)
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Journal Article
Identification of second-generation P2X3 antagonists for treatment of pain
Ginnetti, Anthony T., Paone, Daniel V., Stauffer, Shaun R., Potteiger, Craig M., Shaw, Anthony W., Deng, James, Mulhearn, James J., Nguyen, Diem N., Segerdell, Carolyn, Anquandah, Juliana, Calamari, Amy, Cheng, Gong, Leitl, Michael D., Liang, Annie, Moore, Eric, Panigel, Jacqueline, Urban, Mark, Wang, Jixin, Fillgrove, Kerry, Tang, Cuyue, Cook, Sean, Kane, Stefanie, Salvatore, Christopher A., Graham, Samuel L., Burgey, Christopher S.
Published in Bioorganic & medicinal chemistry letters (01.05.2018)
Published in Bioorganic & medicinal chemistry letters (01.05.2018)
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Journal Article
Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease
Mudhasani, Rajini R, Golden, Joseph W, Adam, Gregory C, Hartingh, Timothy J, Kota, Krishna P, Ordonez, David, Quackenbush, Corey R, Tran, Julie P, Cline, Curtis, Williams, Janice A, Zeng, Xiankun, Olsen, David B, Lieberman, Linda A, Boyce, Christopher, Ginnetti, Anthony, Meinig, J Matthew, Panchal, Rekha G, Mucker, Eric M
Published in Microbiology spectrum (02.04.2024)
Published in Microbiology spectrum (02.04.2024)
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Journal Article
Structure-Guided Design and Procognitive Assessment of a Potent and Selective Phosphodiesterase 2A Inhibitor
Stachel, Shawn J, Berger, Richard, Nomland, Ashley B, Ginnetti, Anthony T, Paone, Daniel V, Wang, Deping, Puri, Vanita, Lange, Henry, Drott, Jason, Lu, Jun, Marcus, Jacob, Dwyer, Michael P, Suon, Sokreine, Uslaner, Jason M, Smith, Sean M
Published in ACS medicinal chemistry letters (09.08.2018)
Published in ACS medicinal chemistry letters (09.08.2018)
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Journal Article
Virtual screening for early identification of potent and selective histone deacetylase 6 inhibitor series
Stachel, Shawn J., Wang, Deping, Ginnetti, Anthony T., Niroomand, Shahriar, Ma, Lei, Hu, Yinghui, Fay, John F., Lemaire, Wei, Krosky, Daniel J., Ramirez, Andres D., Zariwala, Hatim A., Coleman, Paul J.
Published in Bioorganic & medicinal chemistry letters (15.11.2023)
Published in Bioorganic & medicinal chemistry letters (15.11.2023)
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Journal Article
Cryo-EM structure of a voltage-gated potassium channel Kv3.1 in complex with a novel potentiator reveals a new binding site suggesting the mechanism of action
Chen, Yun-Ting, Heo, Mee Ra, Zhan, Xin-Jun, Kostas, James, Li, Yuxing, Kraus, Richard, Santarelli, Vincent, Gomez-Llorente, Yacob, Klein, Daniel, Ginnetti, Anthony, Marino, Michael, Stachel, Shawn, Ishchenko, Andrii
Published in Acta crystallographica. Section A, Foundations and advances (07.07.2023)
Published in Acta crystallographica. Section A, Foundations and advances (07.07.2023)
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NAV1.8 억제제로서의 2-아미노-N-헤테로아릴-니코틴아미드
CHOBANIAN HARRY R, BUNGARD CHRISTOPHER JAMES, ARASAPPAN ASHOK, BURGEY CHRISTOPHER S, LIU JIAN, SUEN LAI LINDA M, COX JASON M, PERKINS JAMES J, BELL IAN M, BRESLIN MICHAEL J, LIU HONG, GUIADEEN DEODIAL GUY, JONES KRISTEN L. G, GINNETTI ANTHONY T, STACHEL SHAWN J, WU ZHE, LAYTON MARK E
Year of Publication 08.07.2021
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Year of Publication 08.07.2021
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PIPERIDINONE CARBOXAMIDE AZAINDANE CGRP RECEPTOR ANTAGONISTS
BELL IAN M, FRALEY MARK E, MITCHELL HELEN J, GINNETTI ANTHONY, WANG CHENG, PAONE DANIEL V, STAAS DONNETTE D, STEVENSON HEATHER E, GALLICCHIO STEVEN N, ZARTMAN C. BLAIR
Year of Publication 05.08.2013
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Year of Publication 05.08.2013
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PYRROLIDINE OREXIN RECEPTOR AGONISTS
GINNETTI, Anthony, BOGEN, Stephane, L, CLAUSEN, Dane James, STACHEL, Shawn, J, YANG, Dexi, RUDD, Michael, T, BRESLIN, Michael, J, STUMP, Craig, A
Year of Publication 17.08.2022
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Year of Publication 17.08.2022
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PYRROLIDINE OREXIN RECEPTOR AGONISTS
Clausen, Dane James, Rudd, Michael T, Yang, Dexi, Breslin, Michael J, Stachel, Shawn J, Bogen, Stephane L, Ginnetti, Anthony, Stump, Craig A
Year of Publication 12.05.2022
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Year of Publication 12.05.2022
Patent
PYRROLIDINE OREXIN RECEPTOR AGONISTS
GINNETTI, Anthony, BOGEN, Stephane, L, CLAUSEN, Dane James, STACHEL, Shawn, J, YANG, Dexi, RUDD, Michael, T, BRESLIN, Michael, J, STUMP, Craig, A
Year of Publication 22.12.2021
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Year of Publication 22.12.2021
Patent
P2X3 receptor antagonists for treatment of pain
Burgey, Christopher, S, Paone, Daniel, V, Nguyen, Diem, N, Ginnetti, Anthony, Deng, Zhengwu, J, Shaw, Anthony, W
Year of Publication 13.01.2021
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Year of Publication 13.01.2021
Patent