Peptide Modifications Differentially Alter G Protein-Coupled Receptor Internalization and Signaling Bias
Mäde, Veronika, Babilon, Stefanie, Jolly, Navjeet, Wanka, Lizzy, Bellmann-Sickert, Kathrin, Diaz Gimenez, Luis E., Mörl, Karin, Cox, Helen M., Gurevich, Vsevolod V., Beck-Sickinger, Annette G.
Published in Angewandte Chemie International Edition (15.09.2014)
Published in Angewandte Chemie International Edition (15.09.2014)
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Journal Article
Arrestin-3 binds the MAP kinase JNK3α2 via multiple sites on both domains
Zhan, Xuanzhi, Perez, Alejandro, Gimenez, Luis E., Vishnivetskiy, Sergey A., Gurevich, Vsevolod V.
Published in Cellular signalling (01.04.2014)
Published in Cellular signalling (01.04.2014)
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Journal Article
A G Protein-biased Designer G Protein-coupled Receptor Useful for Studying the Physiological Relevance of Gq/11-dependent Signaling Pathways
Hu, Jianxin, Stern, Matthew, Gimenez, Luis E., Wanka, Lizzy, Zhu, Lu, Rossi, Mario, Meister, Jaroslawna, Inoue, Asuka, Beck-Sickinger, Annette G., Gurevich, Vsevolod V., Wess, Jürgen
Published in The Journal of biological chemistry (08.04.2016)
Published in The Journal of biological chemistry (08.04.2016)
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Journal Article
Role of Receptor-attached Phosphates in Binding of Visual and Non-visual Arrestins to G Protein-coupled Receptors
Gimenez, Luis E., Kook, Seunghyi, Vishnivetskiy, Sergey A., Ahmed, M. Rafiuddin, Gurevich, Eugenia V., Gurevich, Vsevolod V.
Published in The Journal of biological chemistry (16.03.2012)
Published in The Journal of biological chemistry (16.03.2012)
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Journal Article
Structure of the Hsp110:Hsc70 Nucleotide Exchange Machine
Schuermann, Jonathan P., Jiang, Jianwen, Cuellar, Jorge, Llorca, Oscar, Wang, Liping, Gimenez, Luis E., Jin, Suping, Taylor, Alexander B., Demeler, Borries, Morano, Kevin A., Hart, P. John, Valpuesta, Jose M., Lafer, Eileen M., Sousa, Rui
Published in Molecular cell (25.07.2008)
Published in Molecular cell (25.07.2008)
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Journal Article
Modulation of methuselah expression targeted to Drosophila insulin‐producing cells extends life and enhances oxidative stress resistance
Gimenez, Luis E. D., Ghildyal, Parakashtha, Fischer, Kathleen E., Hu, Hongxiang, Ja, William W., Eaton, Benjamin A., Wu, Yimin, Austad, Steven N., Ranjan, Ravi
Published in Aging cell (01.02.2013)
Published in Aging cell (01.02.2013)
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Journal Article
Targeting the central melanocortin system for the treatment of metabolic disorders
Sweeney, Patrick, Gimenez, Luis E., Hernandez, Ciria C., Cone, Roger D.
Published in Nature reviews. Endocrinology (01.09.2023)
Published in Nature reviews. Endocrinology (01.09.2023)
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Journal Article
Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding
Yu, Jing, Gimenez, Luis E, Hernandez, Ciria C, Wu, Yiran, Wein, Ariel H, Han, Gye Won, McClary, Kyle, Mittal, Sanraj R, Burdsall, Kylie, Stauch, Benjamin, Wu, Lijie, Stevens, Sophia N, Peisley, Alys, Williams, Savannah Y, Chen, Valerie, Millhauser, Glenn L, Zhao, Suwen, Cone, Roger D, Stevens, Raymond C
Published in Science (American Association for the Advancement of Science) (24.04.2020)
Published in Science (American Association for the Advancement of Science) (24.04.2020)
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Journal Article
The unique structural characteristics of the Kir 7.1 inward rectifier potassium channel: a novel player in energy homeostasis control
Hernandez, Ciria C, Gimenez, Luis E, Dahir, Naima S, Peisley, Alys, Cone, Roger D
Published in American Journal of Physiology: Cell Physiology (01.03.2023)
Published in American Journal of Physiology: Cell Physiology (01.03.2023)
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Journal Article
Mmp14-dependent remodeling of the pericellular-dermal collagen interface governs fibroblast survival
Sabeh, Farideh, Li, Xiao-Yan, Olson, Adam W, Botvinick, Elliot, Kurup, Abhishek, Gimenez, Luis E, Cho, Jung-Sun, Weiss, Stephen J
Published in The Journal of cell biology (02.09.2024)
Published in The Journal of cell biology (02.09.2024)
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Journal Article
The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia
Sweeney, Patrick, Bedenbaugh, Michelle N, Maldonado, Jose, Pan, Pauline, Fowler, Katelyn, Williams, Savannah Y, Gimenez, Luis E, Ghamari-Langroudi, Masoud, Downing, Griffin, Gui, Yijun, Hadley, Colleen K, Joy, Stephen T, Mapp, Anna K, Simerly, Richard B, Cone, Roger D
Published in Science translational medicine (21.04.2021)
Published in Science translational medicine (21.04.2021)
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Journal Article
The GPCR accessory protein MRAP2 regulates both biased signaling and constitutive activity of the ghrelin receptor GHSR1a
Rouault, Alix A J, Rosselli-Murai, Luciana K, Hernandez, Ciria C, Gimenez, Luis E, Tall, Gregory G, Sebag, Julien A
Published in Science signaling (07.01.2020)
Published in Science signaling (07.01.2020)
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Journal Article
Membrane orientation and oligomerization of the melanocortin receptor accessory protein 2
Chen, Valerie, Bruno, Antonio E., Britt, Laura L., Hernandez, Ciria C., Gimenez, Luis E., Peisley, Alys, Cone, Roger D., Millhauser, Glenn L.
Published in The Journal of biological chemistry (27.11.2020)
Published in The Journal of biological chemistry (27.11.2020)
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Journal Article
Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design
Gimenez, Luis E., Martin, Charlotte, Yu, Jing, Hollanders, Charlie, Hernandez, Ciria C., Wu, Yiran, Yao, Deqiang, Han, Gye Won, Dahir, Naima S., Wu, Lijie, Van der Poorten, Olivier, Lamouroux, Arthur, Mannes, Morgane, Zhao, Suwen, Tourwé, Dirk, Stevens, Raymond C., Cone, Roger D., Ballet, Steven
Published in Journal of medicinal chemistry (22.02.2024)
Published in Journal of medicinal chemistry (22.02.2024)
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Journal Article
Subthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in mice
Dahir, Naima S, Gui, Yijun, Wu, Yanan, Sweeney, Patrick R, Rouault, Alix Aj, Williams, Savannah Y, Gimenez, Luis E, Sawyer, Tomi K, Joy, Stephen T, Mapp, Anna K, Cone, Roger D
Published in The Journal of clinical investigation (15.07.2024)
Published in The Journal of clinical investigation (15.07.2024)
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Journal Article
Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structure
Martin, Charlotte, Gimenez, Luis E., Williams, Savannah Y., Jing, Yu, Wu, Yiran, Hollanders, Charlie, Van der Poorten, Olivier, Gonzalez, Simon, Van Holsbeeck, Kevin, Previti, Santo, Lamouroux, Arthur, Zhao, Suwen, Tourwe, Dirk, Stevens, Raymond C., Cone, Roger D., Ballet, Steven
Published in Journal of medicinal chemistry (14.01.2021)
Published in Journal of medicinal chemistry (14.01.2021)
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Journal Article
Silent scaffolds: inhibition OF c-Jun N-terminal kinase 3 activity in cell by dominant-negative arrestin-3 mutant
Breitman, Maya, Kook, Seunghyi, Gimenez, Luis E, Lizama, Britney N, Palazzo, Maria C, Gurevich, Eugenia V, Gurevich, Vsevolod V
Published in The Journal of biological chemistry (01.06.2012)
Published in The Journal of biological chemistry (01.06.2012)
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