Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts
Guaitoli, Giambattista, Raimondi, Francesco, Gilsbach, Bernd K., Gómez-Llorente, Yacob, Deyaert, Egon, Renzi, Fabiana, Li, Xianting, Schaffner, Adam, Jagtap, Pravin Kumar Ankush, Boldt, Karsten, von Zweydorf, Felix, Gotthardt, Katja, Lorimer, Donald D., Yue, Zhenyu, Burgin, Alex, Janjic, Nebojsa, Sattler, Michael, Versées, Wim, Ueffing, Marius, Ubarretxena-Belandia, Iban, Kortholt, Arjan, Gloeckner, Christian Johannes
Published in Proceedings of the National Academy of Sciences - PNAS (26.07.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (26.07.2016)
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Revisiting the Roco G-protein cycle
Terheyden, Susanne, Ho, Franz Y, Gilsbach, Bernd K, Wittinghofer, Alfred, Kortholt, Arjan
Published in Biochemical journal (01.01.2015)
Published in Biochemical journal (01.01.2015)
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Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations
Gilsbach, Bernd K, Ho, Franz Y, Vetter, Ingrid R, van Haastert, Peter J. M, Wittinghofer, Alfred, Kortholt, Arjan
Published in Proceedings of the National Academy of Sciences - PNAS (26.06.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (26.06.2012)
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Journal Article
C2GAP2 is a common regulator of Ras signaling for chemotaxis, phagocytosis, and macropinocytosis
Xu, Xuehua, Pots, Henderikus, Gilsbach, Bernd K, Parsons, Dustin, Veltman, Douwe M, Ramachandra, Sharmila G, Li, Haoran, Kortholt, Arjan, Jin, Tian
Published in Frontiers in immunology (29.11.2022)
Published in Frontiers in immunology (29.11.2022)
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Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations
Rudi, Katharina, Ho, Franz Y, Gilsbach, Bernd K, Pots, Henderikus, Wittinghofer, Alfred, Kortholt, Arjan, Klare, Johann P
Published in Bioscience reports (01.10.2015)
Published in Bioscience reports (01.10.2015)
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Regulation of LRRK2: insights from structural and biochemical analysis
Gilsbach, Bernd K., Eckert, Marita, Gloeckner, Christian Johannes
Published in Biological chemistry (27.06.2018)
Published in Biological chemistry (27.06.2018)
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Journal Article
Structural Characterization of LRRK2 Inhibitors
Gilsbach, Bernd K, Messias, Ana C, Ito, Genta, Sattler, Michael, Alessi, Dario R, Wittinghofer, Alfred, Kortholt, Arjan
Published in Journal of medicinal chemistry (14.05.2015)
Published in Journal of medicinal chemistry (14.05.2015)
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Journal Article
First model of dimeric LRRK2: the challenge of unrevealing the structure of a multidomain Parkinson's-associated protein
Guaitoli, Giambattista, Gilsbach, Bernd K, Raimondi, Francesco, Gloeckner, Christian Johannes
Published in Biochemical Society transactions (15.12.2016)
Published in Biochemical Society transactions (15.12.2016)
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Biochemical and kinetic properties of the complex Roco G-protein cycle
Wauters, Lina, Terheyden, Susanne, Gilsbach, Bernd K., Leemans, Margaux, Athanasopoulos, Panagiotis S., Guaitoli, Giambattista, Wittinghofer, Alfred, Gloeckner, Christian Johannes, Versées, Wim, Kortholt, Arjan
Published in Biological chemistry (27.11.2018)
Published in Biological chemistry (27.11.2018)
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