Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells
KONECNY, Gottfried E, PEGRAM, Mark D, KEITH, Barry R, GILMER, Tona M, BERGER, Mark, PODRATZ, Karl C, SLAMON, Dennis J, VENKATESAN, Natarajan, FINN, Richard, GUORONG YANG, RAHMEH, Martina, UNTCH, Michael, RUSNAK, David W, SPEHAR, Glenn, MULLIN, Robert J
Published in Cancer research (Chicago, Ill.) (01.02.2006)
Published in Cancer research (Chicago, Ill.) (01.02.2006)
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A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): Relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells
WOOD, Edgar R, TRUESDALE, Anne T, ALLIGOOD, Krystal J, RUSNAK, David W, GILMER, Tona M, SHEWCHUK, Lisa, MCDONALD, Octerloney B, YUAN, Derek, HASSELL, Anne, DICKERSON, Scott H, ELLIS, Byron, PENNISI, Christopher, HORNE, Earnest, LACKEY, Karen
Published in Cancer research (Chicago, Ill.) (15.09.2004)
Published in Cancer research (Chicago, Ill.) (15.09.2004)
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The Effects of the Novel, Reversible Epidermal Growth Factor Receptor/ErbB-2 Tyrosine Kinase Inhibitor, GW2016, on the Growth of Human Normal and Tumor-derived Cell Lines in Vitro and in Vivo
Rusnak, D W, Lackey, K, Affleck, K, Wood, E R, Alligood, K J, Rhodes, N, Keith, B R, Murray, D M, Knight, W B, Mullin, R J, Gilmer, T M
Published in Molecular cancer therapeutics (01.12.2001)
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Published in Molecular cancer therapeutics (01.12.2001)
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The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: Potential therapy for cancer
RUSNAK, David W, AFFLECK, Karen, JOWETT, Amanda, STABLES, Jeremy, TOPLEY, Peter, WOOD, Edgar R, BRIGNOLA, Perry S, KADWELL, Sue H, REEP, Bryan R, MULLIN, Robert J, ALLIGOOD, Krystal J, KEITH, Barry R, COCKERILL, Stuart G, CROSBY, Renae M, MURRAY, Doris M, KNIGHT, W. Blaine, GILMER, Tona M, LACKEY, Karen, STUBBERFIELD, Colin, HARRIS, Robert, PAGE, Martin, SMITH, Kathryn J, GUNTRIP, Stephen B, CARTER, Malcolm C, SHAW, Robert J
Published in Cancer research (Chicago, Ill.) (01.10.2001)
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Published in Cancer research (Chicago, Ill.) (01.10.2001)
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S5-3: Basement Membrane Localized Tumor Cells Are Protected from HER2−Targeted Therapy In Vivo
Zoeller, JJ, Bronson, RT, Gilmer, TM, Selfors, LM, Lu, Y, Mills, GB, Brugge, JS
Published in Cancer research (Chicago, Ill.) (15.12.2011)
Published in Cancer research (Chicago, Ill.) (15.12.2011)
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Abstract P4-08-05: Basement membrane localized tumor cells are protected from HER2-targeted therapy in vivo
Zoeller, JJ, Bronson, RT, Gilmer, TM, Selfors, LM, Lu, Y, Apple, SK, Press, MF, Hurvitz, SA, Slamon, DJ, Mills, GB, Brugge, JS
Published in Cancer research (Chicago, Ill.) (15.12.2012)
Published in Cancer research (Chicago, Ill.) (15.12.2012)
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Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen
Smith, Martin L., I.-Tsuen Chen, Zhan, Qimin, Bae, Insoo, Chen, Chaw-Yuan, Gilmer, Tona M., Kastan, Michael B., O'Connor, Patrick M., Fornace, Albert J.
Published in Science (American Association for the Advancement of Science) (25.11.1994)
Published in Science (American Association for the Advancement of Science) (25.11.1994)
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Identification of Both Positive and Negative Domains within the Epidermal Growth Factor Receptor COOH-terminal Region for Signal Transducer and Activator of Transcription (STAT) Activation
Xia, Ling, Wang, Lijuan, Chung, Alicia S, Ivanov, Stanimir S, Ling, Mike Y, Dragoi, Ana M, Platt, Adam, Gilmer, Tona M, Fu, Xin-Yuan, Chin, Y Eugene
Published in The Journal of biological chemistry (23.08.2002)
Published in The Journal of biological chemistry (23.08.2002)
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Discovery and Biological Evaluation of Potent Dual ErbB-2/EGFR Tyrosine Kinase Inhibitors: 6-Thiazolylquinazolines
Gaul, Micheal D, Guo, Yu, Affleck, Karen, Cockerill, G.Stuart, Gilmer, Tona M, Griffin, Robert J, Guntrip, Stephen, Keith, Barry R, Knight, Wilson B, Mullin, Robert J, Murray, Doris M, Rusnak, David W, Smith, Kathryn, Tadepalli, Sarva, Wood, Edgar R, Lackey, Karen
Published in Bioorganic & medicinal chemistry letters (24.02.2003)
Published in Bioorganic & medicinal chemistry letters (24.02.2003)
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A simple method for predicting serum protein binding of compounds from IC50 shift analysis for in vitro assays
RUSNAK, David W, ZHIHONG LAI, LANSING, Timothy J, RHODES, Nelson, GILMER, Tona M, COPELAND, Robert A
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
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The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization
Goldman, SC, Chen, CY, Lansing, TJ, Gilmer, TM, Kastan, MB
Published in The American journal of pathology (01.05.1996)
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Published in The American journal of pathology (01.05.1996)
Journal Article
Characterization of human Gadd45, a p53-regulated protein
Carrier, F, Smith, M L, Bae, I, Kilpatrick, K E, Lansing, T J, Chen, C Y, Engelstein, M, Friend, S H, Henner, W D, Gilmer, T M
Published in The Journal of biological chemistry (23.12.1994)
Published in The Journal of biological chemistry (23.12.1994)
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Potent dipeptide inhibitors of the pp60(c-src) SH2 domain
Pacofsky, GJ, Lackey, K, Alligood, KJ, Berman, J, Charifson, PS, Crosby, RM, Dorsey, GF, Feldman, PL, Gilmer, TM, Hummel, CW, Jordan, Mohr, C, Shewchuk, LM, Sternbach, DD, Rodriguez, M
Published in Journal of medicinal chemistry (21.05.1998)
Published in Journal of medicinal chemistry (21.05.1998)
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Journal Article
ras mutations and expression in head and neck squamous cell carcinomas
Yarbrough, W G, Shores, C, Witsell, D L, Weissler, M C, Fidler, M E, Gilmer, T M
Published in The Laryngoscope (01.11.1994)
Published in The Laryngoscope (01.11.1994)
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Induction of Gene Amplification by Arsenic
Lee, Te-Chang, Tanaka, Noriho, Lamb, Patricia W., Gilmer, Tona M., Barrett, J. Carl
Published in Science (American Association for the Advancement of Science) (01.07.1988)
Published in Science (American Association for the Advancement of Science) (01.07.1988)
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Defective potassium currents in ataxia telangiectasia fibroblasts
Rhodes, N, D'Souza, T, Foster, C D, Ziv, Y, Kirsch, D G, Shiloh, Y, Kastan, M B, Reinhart, P H, Gilmer, T M
Published in Genes & development (01.12.1998)
Published in Genes & development (01.12.1998)
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